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Weight Loss 2007
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1. Should medicare reimburse providers for weight loss interventions?
Match Strength: 10.483

This issue of the American Psychologist (April 2007) includes two reviews of the literature on the effects of behavioral programs to reduce body weight. One review (T. Mann et al., 2007) concentrates on dietary interventions and finds little evidence that diets are of benefit. The second review (L. H. Powell, J. E. Calvin III, & J. E. Calvin Jr., 2007) concentrates on multicomponent interventions and reports some significant achievements of behavioral interventions. Although the reviews come to different conclusions about the value of supporting weight loss interventions, there appears to be ... Read More »
» Published in Am Psychol. 2007 Apr;62(3):217-9.

2. Retention rates and weight loss in a commercial weight loss program.
Match Strength: 9.666

Objective:To evaluate and describe retention rates and weight loss in clients participating in a commercial weight loss program.Subjects:A total of 60 164 men and women ages 18-79 years who enrolled in the Jenny Craig Platinum program between May 2001 and May 2002.Methods:Retention rates, mean weight loss and percent weight loss were calculated on a weekly basis for the 52-week period following initial enrollment in the weight loss program. Clients were categorized based on final week of participation in the program (weeks 1-4, weeks 5-13, weeks 14-26, weeks 27-39 and weeks 40-52) and weight ... Read More »
» Published in Int J Obes (Lond). 2007 Feb;31(2):292-8. Epub 2006 Jun 6.

3. Comparison of a phone vs clinic approach to achieve 10% weight loss.
Match Strength: 9.472

Objective:To compare the efficacy of a phone vs a traditional face-to-face clinic approach to achieve 10% weight loss and weight maintenance.Design:Twenty-six week, randomized, controlled trial.Subjects:Twenty-four men and 72 women, ages 25-68 years, with a body mass index (BMI) of 33.2+/-3.8.Measurements:Weight loss at 12 weeks and weight maintenance at 26 weeks were the primary outcomes. Attendance, meal replacements (MRs), fruits/vegetables (F/V), and physical activity (PA) were measured weekly for process evaluation.Results:Median weight loss (range) from baseline at 12 weeks was ... Read More »
» Published in Int J Obes (Lond). 2007 Feb 27;

4. Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation.
Match Strength: 8.896

Fourteen patients were treated over 2 years with cervical vagus nerve stimulation (VNS) for adjunctive therapy of severe, treatment-resistant depression. Here, we report the serendipitous observation that this treatment was associated with highly significant, gradual weight loss despite the patients' report of not dieting or exercising. The weight loss was proportional to the initial BMI, that is, the more severe the obesity, the greater the weight loss. Weight loss did not correlate with changes in mood symptoms. The vagus nerve carries visceral information to and from the brain; modulation ... Read More »
» Published in Int J Obes (Lond). 2007 Jun 12;

5. Use of Dietary Supplements for Weight Loss in the United States: Results of a National Survey.
Match Strength: 8.772

We examined dietary supplement use for weight loss and perceptions about safety, efficacy, and regulatory oversight of these products. A random digit-dialed telephone survey was conducted in 2005-2006, with a representative sample of 3,500 US adults. The survey assessed the beliefs and practices related to weight control. Outcome measures included the prevalence of dietary supplement use for weight reduction, demographic profile of supplement users, and knowledge about safety, efficacy, and regulation of dietary supplements. Of the adults who made a serious weight-loss attempt (n = 1,444), 33 ... Read More »
» Published in Obesity (Silver Spring). 2008 Jan 24

6. Effect of group racial composition on weight loss in african americans.
Match Strength: 8.688

Objective:We do not know how racial composition of a group influences behavior change for African Americans (AAs) in group-based weight loss programs. We tested the hypothesis that AA who participate in all AA weight loss intervention groups will lose more weight than AA who participate in mixed race groups.Methods and Procedures:This observational study was ancillary to Phase 1 of the Weight Loss Maintenance Study, a multi-center trial of strategies to maintain weight loss after a 20-week behavior modification program. Three of four centers recruited several all-AA intervention groups. ... Read More »
» Published in Obesity (Silver Spring). 2008 Feb;16(2):306-10.

7. The role of patients' expectations and goals in the behavioral and pharmacological treatment of obesity.
Match Strength: 8.596

Objective:To investigate weight loss expectations and goals among obese treatment seekers and to examine the relationships of these expectations and goals to treatment outcomes.Method:Participants were 180 obese men and women (age 43.8+/-10.1 years; body mass index 37.6+/-4.2 kg/m(2)) who received one of four-year-long treatments that combined behavioral and pharmacological methods. Before treatment, they reported the amount of weight they realistically expected to lose after 4, 12, 26 and 52 weeks of treatment, as well as their ultimate weight loss goals. Expectations and goals were compared ... Read More »
» Published in Int J Obes (Lond). 2007 May 1;

8. Weight maintenance, behaviors and barriers among previous participants of a university-based weight control program.
Match Strength: 8.534

Objective:To examine weight loss maintenance among previous participants of a university-based behavioral weight management program and to compare behavioral strategies and perceived barriers between successful and unsuccessful maintainers.Method:Previous program participants (n=179) completed mailed surveys assessing current weight, weight control behaviors and perceived barriers to weight loss maintenance.Results:At 14.1+/-10.8 months following completion of treatment, survey respondents were on average 12.6+/-12.6 kg, or 11.3+/-10.7%, below baseline weight; 76.5% of respondents had ... Read More »
» Published in Int J Obes (Lond). 2007 Dec 4

9. Physical Activity and Weight Management Across the Lifespan.
Match Strength: 8.459

This review discusses key findings and recommendations related to the role of physical activity in weight gain prevention, weight loss, and weight-loss maintenance across the lifespan. For weight gain prevention, epidemiological and clinical studies suggest that regular physical activity is critical, with increases above the recommended 30 min daily for health (e.g., to 45 to 60 min daily) potentially desirable for curtailing weight gain. For weight loss, clinical studies suggest that physical activity interventions alone usually produce only modest results. Combining physical activity with ... Read More »
» Published in Annu Rev Public Health. 2006 Dec 14;

10. Cholesterol metabolism and body composition in women: the effects of moderate weight loss.
Match Strength: 8.241

Objective:To determine how moderate weight loss protocol through diet and exercise may affect changes in body composition, to determine the effects of weight loss on cholesterol metabolism and to examine the relationship between cholesterol metabolism and changes in body composition.Design:Thirty-five otherwise healthy, hypercholesterolemic women completed a 24-week weight loss study. A 20% decrease in energy intake through diet and a 10% increase in energy expenditure by exercise were combined with motivational strategies to encourage weight loss. The diet was self-selected and comprised of ... Read More »
» Published in Int J Obes (Lond). 2007 Jan 30;

11. Glucose homeostasis predicts weight gain: prospective and clinical evidence.
Match Strength: 7.772

BACKGROUND: The potential long-term impact of low glycaemia on body fat accumulation has not been verified. Therefore, we examined the effects of low glucose concentrations on long-term energy balance and weight gain in humans. METHODS: Two sets of analyses were realized in order to verify this objective. First, Study 1 consisted of 259 participants between 20 and 65 years of age selected from Phase 2 of the Quebec Family Study (QFS). The association between glucose concentrations at the end of an oral glucose tolerance test (OGTT) and changes in body mass was analysed prospectively (mean ... Read More »
» Published in Diabetes Metab Res Rev. 2008 Feb;24(2):123-9.

12. Thalidomide for the treatment of histiocytic sarcoma after hematopoietic stem cell transplant.
Match Strength: 7.737

Histiocytic sarcoma (HS) is a rare neoplasm of uncertain etiology. Most recently, the diagnostic criteria for this entity have been revised with inclusion of diagnostic modalities such as immunohistochemical and cytogentic techniques. HS tends to have an aggressive clinical course and presents with systemic symptoms of fever, weight loss, adenopathy, hepatosplenomegly, rash, and pancytopenia. Thalidomide is a promising agent that may exert a therapeutic benefit in HS. We report a case of a 48-year-old female with HS who presented with fever, weight loss, fatigue, generalized anasarca, and ... Read More »
» Published in Am J Hematol. 2007 Jul 6;

13. Influence of weight loss on outcomes in patients with head and neck cancer undergoing concomitant chemoradiotherapy.
Match Strength: 7.591

BACKGROUND.: The purpose of this study was to determine the influence of weight loss on outcome in patients with head and neck cancer undergoing concomitant chemoradiotherapy (CCRT): treatment interruption, infections, mortality, and hospital readmission rate. METHODS.: Forty patients with head and neck cancer were enrolled. All patients were counseled to follow a nutritional program during CCRT. Body weight was evaluated at baseline, at the end, and 30 days after radiochemotherapy. RESULTS.: Ninety percent of compliant patients with nutritional program maintained body weight (mean, 1 +/- 2.4 ... Read More »
» Published in Head Neck. 2007 Dec 20

14. Using motivational interviewing as a supplement to obesity treatment: a stepped-care approach.
Match Strength: 7.544

OBJECTIVE: This investigation was designed to improve behavioral weight loss program (BWLP) treatment outcomes by providing stepped care (SC) to individuals experiencing difficulties with weight loss during treatment. SC entails transition to more intensive treatments when less intensive treatments fail to meet treatment goals. In a BWLP, motivational interviewing (MI) may increase participants' motivation toward behavioral change and thus complement the acquisition of behavioral change skills. It was hypothesized that BWLP+SC (MI) participants (i.e., participants who failed to meet weight ... Read More »
» Published in Health Psychol. 2007 May;26(3):369-74.

15. Weight loss and quality of life improvement in obese subjects treated with sibutramine: a double-blind randomized multicenter study.
Match Strength: 7.515

BACKGROUND AND AIM: Obesity affects cardiovascular risk and also quality of life (QoL). The aim of this study was to test weight loss and impact on QoL after sibutramine treatment in obese subjects. METHODS: Double-blind randomized trial on 309 outpatients (51 males, 258 females; age 41.8 +/- 10.9 years, BMI 35.0 +/- 3.1 kg/m(2)) randomized to sibutramine (n = 154) or to placebo (n = 155) treatment. A combination of sibutramine 10 mg or matching placebo and a balanced hypocaloric diet was given for 6 months with monthly evaluations. The main outcome measures were weight loss, the impact of ... Read More »
» Published in Ann Nutr Metab. 2007;51(1):75-81. Epub 2007 Mar 15.

16. Medicare's Search for Effective Obesity Treatments: Diets Are Not the Answer.
Match Strength: 7.487

The prevalence of obesity and its associated health problems have increased sharply in the past 2 decades. New revisions to Medicare policy will allow funding for obesity treatments of proven efficacy. The authors review studies of the long-term outcomes of calorie-restricting diets to assess whether dieting is an effective treatment for obesity. These studies show that one third to two thirds of dieters regain more weight than they lost on their diets, and these studies likely underestimate the extent to which dieting is counterproductive because of several methodological problems, all of ... Read More »
» Published in Am Psychol. 2007 Apr;62(3):220-33.

17. Cultural conflicts in the weight loss experience of overweight Latinos.
Match Strength: 7.472

Objective:In spite of the high prevalence of obesity in the Latino population, there is limited recent information that can be used by health-care providers to develop culturally appropriate weight loss strategies for this population. Therefore, we describe weight loss experiences, attitudes and barriers in overweight Latino adults.Design:Qualitative study using focus group methodologySubjects:Twenty-one overweight adults (body mass index >/=25, age >/=20 years) self-identified as Latinos.Methods:Subjects participated in one of three focus groups. Reccurring themes within group ... Read More »
» Published in Int J Obes (Lond). 2007 Feb;31(2):328-33. Epub 2006 May 23.

18. Impact of weight loss on the metabolic syndrome.
Match Strength: 7.420

Objective:To evaluate the effects of weight loss on the risk of having metabolic syndrome after 1 year of treatment with lifestyle modification alone, pharmacotherapy alone (sibutramine) or the combination of the two.Design:Randomized, controlled, 1-year clinical trial.Patients:One hundred and eighty women and 44 men, 18-65 years of age, with a body mass index of 30-45 kg/m(2), free of uncontrolled hypertension or type 1 or 2 diabetes.Intervention:Fifteen milligrams of sibutramine per day alone, lifestyle modification counseling alone, sibutramine plus lifestyle modification counseling or ... Read More »
» Published in Int J Obes (Lond). 2007 Mar 13;

19. The clinical significance of loss of control over eating in overweight adolescents.
Match Strength: 7.338

OBJECTIVE:: Given limited data on the diagnostic validity of binge eating disorder (BED) in adolescents, this study sought to characterize overweight adolescents according to types of overeating episodes. METHOD:: Ninety-six adolescents (ages 13-17 years) with recurrent binge eating (BE), loss of control with or without overeating (subclinical BE; SUB), overeating without loss of control (OE), and no overeating or loss of control episodes (CONTROL) were compared on weight/shape concerns and depressive symptoms using ANCOVA and post-hoc least squares difference tests. RESULTS:: BE and SUB ... Read More »
» Published in Int J Eat Disord. 2007 Dec 19

20. Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content.
Match Strength: 7.312

Objective:To investigate the effect of including seafood and fish oils, as part of an energy-restricted diet, on weight loss in young overweight adults.Design:Randomized controlled trial of energy-restricted diet varying in fish and fish oil content was followed for 8 weeks. Subjects were randomized to one of four groups: (1) control (sunflower oil capsules, no seafood); (2) lean fish (3 x 150 g portions of cod/week); (3) fatty fish (3 x 150 g portions of salmon/week); (4) fish oil (DHA/EPA capsules, no seafood). The macronutrient composition of the diets was similar between the groups and the ... Read More »
» Published in Int J Obes (Lond). 2007 May 15;

21. Allometric relationship between changes of visceral fat and total fat mass.
Match Strength: 7.284

Objective:To elucidate the mathematical relationship between changes of visceral adipose tissue (VAT) and total body fat mass (FM) during weight loss.Design:We hypothesized that changes of VAT mass are allometrically related to changes of FM, regardless of the type of weight-loss intervention, as defined by the differential equation dVAT/dFM=k x VAT/FM, where k is a dimensionless constant. We performed a systematic search of the published literature for studies that included measurements of VAT changes via magnetic resonance imaging (MRI) or computed tomography (CT) imaging along with ... Read More »
» Published in Int J Obes (Lond). 2007 Dec 18

22. Challenging Oral Contraception after Weight Loss by Bariatric Surgery.
Match Strength: 7.279

As surgical weight loss becomes more commonly performed in fertile women, adequate contraception is more frequently becoming an issue. The purpose of this article is to appraise the literature to ascertain whether the use of oral contraception is effective and adequate after bariatric surgery. The literature search revealed that the combination of lower oral contraception dosages and surgical gastrointestinal disturbances might place patients at higher risks of unintended pregnancy. Until clinical trials show its efficacy, physicians should use oral contraception with prudence after bariatric ... Read More »
» Published in Gynecol Obstet Invest. 2007 Feb 22;64(2):100-102

23. Healthy habits: efficacy of simple advice on weight control based on a habit-formation model.
Match Strength: 7.248

Objective:To evaluate the efficacy of a simple weight loss intervention, based on principles of habit formation.Design:An exploratory trial in which overweight and obese adults were randomized either to a habit-based intervention condition (with two subgroups given weekly vs monthly weighing; n=33, n=36) or to a waiting-list control condition (n=35) over 8 weeks. Intervention participants were followed up for 8 months.Participants:A total of 104 adults (35 men, 69 women) with an average BMI of 30.9 kg m(-2).Intervention:Intervention participants were given a leaflet containing advice on habit ... Read More »
» Published in Int J Obes (Lond). 2007 Dec 11

24. Indications for Sleeve Gastrectomy as a Primary Procedure for Weight Loss in the Morbidly Obese.
Match Strength: 7.226

BACKGROUND: Single-stage laparoscopic sleeve gastrectomy (LSG) may represent an additional surgical option for morbid obesity. METHODS: We performed a retrospective review of a prospectively maintained database of LSG performed from November 2004 to April 2007 as a one-stage primary restrictive procedure. RESULTS: One hundred forty-eight LSGs were performed as primary procedures for weight loss. The mean patient age was 42 years (range, 13-79), mean body mass index of 43.4 kg/m(2) (range, 35-75), mean operative time of 60 min (range, 58-190), and mean blood loss of 60 ml (range, 0-300). One ... Read More »
» Published in J Gastrointest Surg. 2008 Feb 9

25. Effective obesity treatments.
Match Strength: 7.163

To curb the epidemic of obesity in the United States, revised Medicare policy allows support for efficacious obesity treatments. This review summarizes the evidence from rigorous randomized trials (9 lifestyle trials, 5 drug trials, and 2 surgical trials) on the efficacy and risk- benefit profile of lifestyle, drug, and surgical interventions aimed at promoting sustained (= 2 years) reductions in weight. Both lifestyle and drug interventions consistently produced an approximate 7-lb (3.2-kg) weight loss that was sustained for 2 years and was associated with improvements in diabetes, blood ... Read More »
» Published in Am Psychol. 2007 Apr;62(3):234-46.

26. Effects of a Low-Fat versus a Low-Carbohydrate Diet on Adipocytokines in Obese Adults.
Match Strength: 7.161

Background and Aims: There are few studies addressing the effect of weight loss on circulating levels of adipocytokines. The aim of our study was to determine whether different diets would have different weight loss effects and to examine the changes in adipocytokine levels. Methods: A population of 90 obesity non-diabetic outpatients was analyzed in a prospective way. The patients were randomly allocated to two groups: (a) diet I (low-fat diet), and (b) diet II (low-carbohydrate diet). At baseline and after 3 months on the diet, adipocytokines were evaluated. Results: 43 patients were ... Read More »
» Published in Horm Res. 2007 Feb 6;67(6):296-300

27. Drug treatment of the overweight patient.
Match Strength: 7.013

Three medications with approval for long-term use in the treatment of obesity are currently available in the United States. Sibutramine (U.S. Food and Drug Administration [FDA] approved in 1997), orlistat (FDA approved in 1999), and rimonabant (available in Europe and given FDA approvable status in 2006 and expected to be marketed in 2007) represent modern approaches to medications used adjunctively for weight management. As demonstrated in large clinical trials of 2 to 4 years' duration, these medications significantly increase weight loss compared with placebo; weight loss with these drugs ... Read More »
» Published in Gastroenterology. 2007 May;132(6):2239-52.

28. Compliance, Behavior Change, and Weight Loss With Orlistat in an Over-the-Counter Setting.
Match Strength: 6.975

Objective:The study was conducted to provide information on how consumers would use orlistat 60 mg, especially in terms of product dosing, in a setting without physician supervision.Methods and Procedures:A 3-month, open-label, naturalistic study was conducted in an over-the-counter (OTC) setting in 18 pharmacies. Consumers >/=18 years were allowed to purchase orlistat packages containing a bottle of orlistat 60 mg plus educational materials, which provided lifestyle information and tools to encourage successful weight loss. Data were collected at pharmacy visits and during telephone ... Read More »
» Published in Obesity (Silver Spring). 2008 Jan 24

29. Changes in plasma amino Acid levels do not predict satiety and weight loss on diets with modified macronutrient composition.
Match Strength: 6.943

OBJECTIVE: Serotonin mediates satiety in the central nervous system. Brain serotonin content depends on the plasma ratio of tryptophan (Trp) to large neutral amino acids (LNAA) and may be affected by diet composition. We examined whether high-carbohydrate or high-protein diets induce satiety and weight loss by altering plasma concentrations of these amino acids. METHODS: In study 1 (n = 16, BMI = 27.0 +/- 2.3), we compared plasma Trp and LNAA concentrations averaged over 24 h after 2 weeks of consuming isocaloric diets containing either 45 or 65% of total energy as carbohydrate. In study 2 (n ... Read More »
» Published in Ann Nutr Metab. 2007;51(2):182-7. Epub 2007 May 30.

30. Malnutrition after oesophageal cancer surgery in Sweden.
Match Strength: 6.906

BACKGROUND: Oesophageal cancer resection carries a risk of nutritional disorders. The aim of this study was to estimate weight change after surgery in a population-based setting and to identify nutritional problems that might correlate with weight loss. METHODS: Data were collected through the Swedish Esophageal and Cardia Cancer Register, a nationwide registry of oesophageal cancer surgery. Patients who underwent oesophageal cancer surgery between 2001 and 2004 were followed up until April 2005, and data on patient and tumour characteristics and surgical treatment were collected. Six months ... Read More »
» Published in Br J Surg. 2007 Dec;94(12):1496-500.

31. Carbohydrate versus Energy Restriction: Effects on Weight Loss, Body Composition and Metabolism.
Match Strength: 6.887

Background/Aims: To compare weight loss, body composition, and metabolic changes in response to carbohydrate versus dietary energy restriction (DER) in obese mice. Methods: One hundred C57BL/6 mice were randomized into five groups of 20. The group of high-carbohydrate (HC) mice consumed an HC diet ad libitum and the group of high-fat (HF) mice consumed an HF diet ad libitum for 14 weeks. Additional groups consumed the HF diet for 7 weeks ad libitum and during weeks 8-14 were switched to either a low-carbohydrate diet (LC) consumed ad libitum, the HC diet pair-fed (PF) to the energy intake of ... Read More »
» Published in Ann Nutr Metab. 2007 Jun 18;51(3):232-243

32. Sexual function and obesity.
Match Strength: 6.833

Objective:To review the literature on the relationship between obesity and sexual function.Method:A search in the medical literature from 1966 and onwards was carried out through Medline and Embase for publications on obesity, in combination with Medical Subject Heading words related to sexual function and dysfunction.Comments:Four prospective and seven cross-sectional studies were found describing association between obesity and erectile dysfunction (ED). One cross-sectional study was found describing obesity and female sexual dysfunction (FSD). The prospective studies on ED all demonstrated ... Read More »
» Published in Int J Obes (Lond). 2007 Mar 20;

33. Grazing and Loss of Control Related to Eating: Two High-risk Factors Following Bariatric Surgery.
Match Strength: 6.816

Background:Gastric restrictive surgery induces a marked change in eating behavior. However, the relationship between preoperative and postoperative eating behavior and weight loss outcome has received limited attention.Objective:This study assessed a range of eating behaviors before and 1 year after laparoscopic adjustable gastric banding (LAGB) and explored the nature and extent of change in eating patterns, their clinical associates, and impact on weight loss.Methods and Procedures:A 12-month observational study assessed presurgical and postsurgical binge eating disorder (BED), uncontrolled ... Read More »
» Published in Obesity (Silver Spring). 2008 Jan 17

34. Effect of weight loss on the postprandial response to high-fat and high-carbohydrate meals in obese women.
Match Strength: 6.756

Objective:To assess the effect of weight loss on the plasma lipid and remnant-like lipoprotein cholesterol (RLPc) response to a high-fat or a high-carbohydrate meal in a population of obese women.Design:Nutritional intervention study.Subjects:Sixteen obese women (mean body mass index (BMI): 37.6+/-5 kg/m(2)).Methods:Subjects were asked to follow an energy-restricted diet (800 kcal/day) for 7 weeks, followed by a 1-week maintenance diet. Before and after weight loss, each participant was given (in random order) two iso-energetic meals containing either 80% fat and 20% protein (the high-fat meal ... Read More »
» Published in Eur J Clin Nutr. 2007 Jan 17;

35. Planning to lose weight: Randomized controlled trial of an implementation intention prompt to enhance weight reduction among overweight and obese women.
Match Strength: 6.750

Objective: The trial investigates the effects of augmenting an established weight-reduction intervention with implementation intention prompts. Design: Fifty-five overweight or obese women (ages 18 to 76 years; body mass index from 25.28 to 48.33) enrolled in a commercial weight reduction program were randomly assigned to either an implementation intention prompt or a control condition. Data were collected twice, with a time gap of 2 months. Main Outcome Measures: The primary outcome was participants' change in weight and body mass index from preintervention to follow-up. Results: Repeated ... Read More »
» Published in Health Psychol. 2007 Jul;26(4):507-12.

36. Defined weight expectations in overweight women: anthropometrical, psychological and eating behavioral correlates.
Match Strength: 6.720

Objective:To examine associations between defined weight expectations and anthropometric profile and to identify psychological and eating behavioral factors that characterize women having more realistic weight expectations.Methods:A nonrandom sample of 154 overweight/obese women completed the 'Goals and Relative Weight Questionnaire', which assessed four weight expectations: (1) dream weight (whatever wanted to weight); (2) happy weight (would be happy to achieve); (3) acceptable weight (could accept even if not happy with it); and (4) disappointed weight (would not view as a successful ... Read More »
» Published in Int J Obes (Lond). 2007 Jun 5;

37. Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study.
Match Strength: 6.704

Objective:To examine trends and effects of weight loss treatment on health-related quality of life (HRQL) in the severely obese over 10 years.Design:Swedish obese subjects (SOS) intervention study is a controlled, longitudinal trial of the health effects of weight loss in the severely obese.Subjects:A total of 655 of 851 surgically treated and 621 of 852 conventionally treated obese men (body mass index, BMI>/=34) and women (BMI>/=38) who completed 10 years of the study.Measurements:HRQL was assessed before treatment and after 0.5, 1, 2, 3, 4, 6, 8 and 10 years.Results:HRQL change during ... Read More »
» Published in Int J Obes (Lond). 2007 Mar 13;

38. Health service utilization for eating disorders: Findings from a community-based study.
Match Strength: 6.703

BACKGROUND:: Prior use of health services was examined in a community sample of women with bulimic-type eating disorders. METHOD:: Participants (n = 159) completed a structured interview for the assessment of eating disorder psychopathology as well as questions concerning treatment-seeking and type of treatment received. RESULTS:: Whereas a minority (40.3%) of participants had received treatment for an eating problem, most had received treatment for a general mental health problem (74.2%) and/or weight loss (72.8%), and all had used one or more self-help treatments. Where treatment was ... Read More »
» Published in Int J Eat Disord. 2007 Jul;40(5):399-408.

39. Long-term effects of consumption of a novel fat emulsion in relation to body-weight management.
Match Strength: 6.657

Objective:To assess weight maintenance after weight loss by consumption of yoghurt with a novel fat emulsion (Olibra) including effects on body composition, resting energy expenditure (REE), fat oxidation, hunger feelings and satiety hormones.Design:A randomized, placebo-controlled, double-blind, parallel design. A 6-week weight loss period (2.1 MJ/day) was followed by 18 weeks weight maintenance with test (Olibra) or placebo yoghurt.Subjects:Fifty overweight women (age: 18-58 years, body mass index (BMI) 25-32 kg/m(2)).Measurements:In weeks 1, 7 and 25, a satiety test with questionnaires and ... Read More »
» Published in Int J Obes (Lond). 2007 Feb 13;

40. Stimulation of Cholecystokinin-A Receptors With GI181771X does not Cause Weight Loss in Overweight or Obese Patients.
Match Strength: 6.619

Cholecystokinin (CCK) decreases meal size through activation of CCK-A receptors on vagal afferents. We tested the hypothesis that the selective CCK-A agonist GI181771X induces weight loss in obese patients. Patients with body mass index >/=30 or >/=27 kg/m(2) with concomitant risk factors were randomized to 24-week, double-blind treatment with different GI181771X doses or matching placebo together with a hypocaloric diet. The primary efficacy end point was the absolute change in body weight. To monitor pancreatic and gallbladder effects, patients underwent abdominal ultrasound and ... Read More »
» Published in Clin Pharmacol Ther. 2007 Jun 27;

41. Impaired immune responses in tuberculosis patients are related to weight loss that coexists with an immunoendocrine imbalance.
Match Strength: 6.474

The study's objective was to examine whether factors related to the host status may bear some relation with the profile of the immune response displayed by tuberculosis (TB) patients. The in vitro immune response (antigen-driven lymphoproliferation and cytokine production) and the presence of alcoholism or disease-related factors, like heart and respiratory rates, and weight loss (body mass index, BMI) were investigated in 31 males with active, untreated TB. Compared to 16 age-matched healthy males, TB patients presented depressed lymphoproliferation and increased IL-10 and TGF-beta production ... Read More »
» Published in Neuroimmunomodulation. 2007;14(3-4):193-9. Epub 2007 Dec 5.

42. Impact of Obesity on Health-related Quality of Life in Schizophrenia and Bipolar Disorder.
Match Strength: 6.450

Objective:Studies have reported that up to 60% of individuals with schizophrenia and 68% of those with bipolar disorder are overweight/obese. This paper explores the health-related quality of life (HRQOL) of individuals with schizophrenia or bipolar disorder as a function of obesity status.Methods and Procedures:Two hundred and eleven participants were recruited from four psychiatric programs (outpatient, day treatment, case management, and psychosocial rehabilitation). HRQOL was assessed using both a general measure (Medical Outcomes Study Short-Form-36 (SF-36)) and a weight-related measure ... Read More »
» Published in Obesity (Silver Spring). 2008 Jan 24

43. Decreased basal levels of glucagon-like peptide-1 after weight loss in obese subjects.
Match Strength: 6.439

OBJECTIVE: Basal glucagon-like peptide-1 (GLP-1) concentrations seem to be attenuated in obese subjects, although statistical significance is unclear. Only a few studies have investigated the effect of weight reduction on GLP-1 concentrations and have found unclear results. The aim of the present study was to determine whether subjects who lose weight on a hypocaloric diet experience the same change in circulating GLP-1 levels as subjects who do not lose weight. MATERIAL AND METHODS: A population of 99 obese nondiabetic outpatients was analyzed in a prospective way. Weight and blood pressure ... Read More »
» Published in Ann Nutr Metab. 2007;51(2):134-8. Epub 2007 May 29.

44. Safety and Efficacy of Laparoscopic Adjustable Gastric Banding in the Elderly.
Match Strength: 6.430

Objective:Bariatric surgery is not usually recommended in the elderly. The aim of this study is to evaluate the safety and efficacy of laparoscopic adjustable gastric banding (LAGB) in older patients registered in the database of the Italian Group for Lap-Band Gruppo Italiano Lap-Band (GILB).Methods and Procedures:GILB is a centralized database which collects operative and follow-up data from 26 Italian surgical centers who utilize the Lap-Band System as a restrictive procedure. Patients >/=60 years were selected from the database of the GILB and analyzed according to co-morbidities, ... Read More »
» Published in Obesity (Silver Spring). 2008 Feb;16(2):334-338.

45. CLINICAL Review # : low body weight mediates the relationship between HIV infection and low bone mineral density: a meta-analysis.
Match Strength: 6.415

CONTEXT: HIV infection has been associated with low bone mineral density (BMD) in many cross-sectional studies, although longitudinal studies have not demonstrated accelerated bone loss. The cross-sectional studies may have been confounded by the failure to control for low body weight in HIV-infected patients. OBJECTIVE: Our objective was to determine whether low body weight might explain the association of HIV infection with low BMD. DATA SOURCES: MEDLINE and EMBASE were searched for English language studies published from 1966 to March 2007, and conference abstracts prior to 2007 were hand ... Read More »
» Published in J Clin Endocrinol Metab. 2007 Dec;92(12):4522-8. Epub 2007 Oct 9.

46. Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck, and gastrointestinal tract.
Match Strength: 6.376

BACKGROUND.: Animal models suggest that cyclooxygenase-2 (COX-2) inhibitors may be beneficial in suppressing cancer cachexia. We investigated the effect of short-course celecoxib on body composition, inflammation, and quality of life (QOL) in patients with cancer cachexia in a phase II clinical pilot trial. METHODS.: Eleven cachectic patients with head and neck or gastrointestinal cancer were randomly assigned to receive placebo or celecoxib for 21 days while awaiting the initiation of cancer therapy. Body composition, resting energy expenditure, QOL, physical function, and inflammatory ... Read More »
» Published in Head Neck. 2007 Jul 5;

47. Birth Characteristics, Maternal Reproductive History, and the Risk of Infant Leukemia: A Report from the Children's Oncology Group.
Match Strength: 6.332

Leukemias with MLL gene rearrangements predominate in infants (<1 year of age), but not in older children, and may have a distinct etiology. High birth weight, higher birth order, and prior fetal loss have, with varying consistency, been associated with infant leukemia, but no studies have reported results with respect to MLL status. Here, we report for the first time such an analysis. During 1999 to 2003, mothers of 240 incident cases (113 MLL(+), 80 MLL(-), and 47 indeterminate) and 255 random digit dialed controls completed a telephone interview. Odds ratios and 95% confidence intervals ... Read More »
» Published in Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):128-34.

48. Analysis of Pancreatic Adenocarcinoma Tumor Staging and Resection according to Previous Body Mass Index and Diabetes Duration.
Match Strength: 6.329

Background/Aims: Obesity and diabetes mellitus (DM) are associated with pancreatic cancer. The present study evaluated tumor staging and resectionof pancreatic adenocarcinoma (PaC) according to previous Body Mass Index (BMI), BMI on admission and DM duration. Methods: A retrospective analysis of 151 consecutive patients with PaC was performed: 73 were evaluated according to BMI preceding tumor-related weight loss and BMI on admission; 118 according to DM diagnosis; and 38 were assessed according to DM duration (less than 1 year [recent-onset] versus more than 2 years [long-standing]). Results: ... Read More »
» Published in Pancreatology. 2007 Jun 21;7(2-3):187-193

49. Randomized controlled trial comparing a low-fat diet with a weight-reduction diet in breast cancer-related lymphedema.
Match Strength: 6.304

BACKGROUND: Obesity is considered a risk factor for lymphedema of the arm resulting from breast cancer treatment (BCRL) as well as a poor prognostic factor in response to lymphedema treatment. The aim of the study was to compare the effect of 2 dietary interventions on excess arm volume in BCRL. METHODS: A total of 64 women with BCRL were randomized to 1 of 3 groups for 24 weeks: 1) weight reduction through reduced energy intake; 2) low-fat diet with no change in energy intake (isoenergetic); 3) control group with no dietary change from habitual intake. RESULTS: The primary outcome measure was ... Read More »
» Published in Cancer. 2007 May 15;109(10):1949-56.

50. Chronic clozapine treatment in female rats does not induce weight gain or metabolic abnormalities but enhances adiposity: Implications for animal models of antipsychotic-induced weight gain.
Match Strength: 6.228

The ability of clozapine to induce weight gain in female rats was investigated in three studies with progressively lowered doses of clozapine. In an initial preliminary high dose study, clozapine at 6 and 12 mg/kg (i.p., b.i.d.) was found to induce weight loss. In a subsequent intermediate dose study, we obtained no evidence for clozapine-induced weight gain despite using identical procedures and doses of clozapine (1-4 mg/kg, i.p., b.i.d.) with which we have observed olanzapine-induced weight gain, hyperphagia, enhanced adiposity and metabolic changes [Cooper G, Pickavance L, Wilding J, ... Read More »
» Published in Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):428-36. Epub 2007 Sep 22.

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