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Peer Reviewed Scientific Research Reports.
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1. Excessive weight gain in cardiac transplant recipients.
Match Strength: 9.848
BACKGROUND: Substantial weight gain frequently occurs after cardiac transplant (CT) and increases the risk of secondary disease. It is unclear, however, if weight gain after CT is related to glucocorticoid immunosuppressive therapy. METHODS: A retrospective chart review was performed on the first 200 patients undergoing CT and the first 200 patients undergoing renal transplant (RT) at Columbia Presbyterian Medical Center, starting in January 2000. Patients who survived 1 year and had their weight recorded at transplant were included in the study. Rejection episodes and prednisone treatment was ... Read More »
» Published in J Heart Lung Transplant. 2006 Jan;25(1):36-41. Epub 2005 Nov 17.
2. Birth Weight and Infant Growth: Optimal Infant Weight Gain versus Optimal Infant Weight.
Match Strength: 9.421
Objective: Infant growth assessment often focuses on "optimal" infant weights and lengths at specific ages, while de-emphasizing infant weight gain. Objective of this study was to examine infant growth patterns by measuring infant weight gain relative to birth weight. Methods: We conducted this study based on data collected in a prospective cohort study including 3,302 births with follow up examinations of infants between the ages of 8 and 18 months. All infants were participants in the Louisiana State Women, Infant and Children Supplemental Food Program between 1999 and 2001. Growth was ... Read More »
» Published in Matern Child Health J. 2007 Jan;11(1):57-63. Epub 2006 Sep 28.
3. Lithium increases body weight of rats: relation to thymolysis.
Match Strength: 8.603
Lithium treatment of patients and laboratory animals causes increased body weight. Lithium also elevates the plasma corticosterone levels of rats. Our purpose was to correlate the gain of body weight with the effects of lithium on the thymus gland, the organ most susceptible to stress and to elevated corticosterone levels. Toward this end, it was also necessary to establish a reliable and reproducible model by use of an inbred strain of rats. Female rats of the inbred Lewis strain were injected subcutaneously with lithium chloride or saline for an 18-day period. Necropsies were performed one ... Read More »
» Published in Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jan;30(1):155-8. Epub 2005 Oct 18.
4. A family-based approach to preventing excessive weight gain.
Match Strength: 8.532
OBJECTIVE: Preventing weight gain in adults and excessive weight gain in children is a high priority. We evaluated the ability of a family-based program aimed at increasing steps and cereal consumption (for breakfast and snacks) to reduce weight gain in children and adults. RESEARCH METHODS AND PROCEDURES: Families (n = 105) with at least one 8- to 12-year-old child who was at-risk-for-overweight or overweight (designated as the target child) were recruited for the study. Eighty-two families were randomly assigned to receive the family-based intervention and 23 families to the control ... Read More »
» Published in Obesity (Silver Spring). 2006 Aug;14(8):1392-401.
5. Dietary quality predicts adult weight gain: findings from the Framingham Offspring Study.
Match Strength: 8.338
OBJECTIVE: We tested the hypothesis that dietary quality, measured by adherence to the Dietary Guidelines, was related to weight change in adults. RESEARCH METHODS AND PROCEDURES: Dietary intake was assessed among 2245 adult men and women (average age, 49 to 56 years) in the Framingham Offspring cohort. Three-day dietary records were collected in 1984 to 1988 and again in 1991 to 1996. Weight change was measured over 8 years after each assessment. A five-point diet quality index (DQI) was computed based on mean nutrient intake levels from each set of diet records. One DQI point was contributed ... Read More »
» Published in Obesity (Silver Spring). 2006 Aug;14(8):1383-91.
6. Combined effects of maternal smoking status and dietary intake related to weight gain and birth size parameters.
Match Strength: 8.251
OBJECTIVE: To investigate the interaction of smoking status and dietary intake during pregnancy and its relationship to maternal weight gain and birth size parameters. DESIGN: An observational prospective study. SETTING: Free-living conditions. POPULATION: Four hundred and eight healthy pregnant Icelandic women. METHODS: Maternal smoking status, lifestyle factors and dietary habits were evaluated with questionnaires. Intake of foods and supplements was also estimated with a semiquantitative food frequency questionnaire for the previous 3 months. All questionnaires were filled out between 11 ... Read More »
» Published in BJOG. 2006 Nov;113(11):1296-302. Epub 2006 Sep 27.
7. Effect of dietary calcium intake on weight gain in type 2 diabetic patients following initiation of insulin therapy.
Match Strength: 7.953
OBJECTIVES: This pilot study analyses weight gain in type 2 diabetic patients at initiation of insulin therapy, according to daily calcium intake. METHODS: Type 2 diabetic patients consecutively admitted for initiation of insulin therapy were studied between January and March 2004 in a monocenter study. Dietary intake was assessed by a 7-day food history before insulin treatment (initial visit) and 4 to 6 months later (final visit). RESULTS: Thirty-one patients were studied (18 males and 13 females; mean age 62+/-9 years, with diabetes duration 14+/-10 years). Weight significantly increased ... Read More »
» Published in Diabetes Metab. 2006 Sep;32(4):358-63.
8. Development of growth and body mass index after pediatric renal transplantation.
Match Strength: 7.812
Suboptimal final height and marked weight gain after renal transplantation (RTx) are common and may result in obesity. Steroid free immunosuppression has been advocated to improve growth and limit weight gain. We evaluated retrospectively the evolution of growth and body mass index (BMI) after renal transplantation to study risk factors for weight gain under steroid based treatment. Sixty-four pediatric patients (age 9.9 +/- 5.0 yr) were included in the study. To allow comparison between different age groups, standard deviation scores (SDS) for height and BMI for height age were calculated at ... Read More »
» Published in Pediatr Transplant. 2005 Aug;9(4):445-9.
9. Dietary patterns and changes in body weight in women.
Match Strength: 7.413
OBJECTIVE: Our objective was to examine the association between adherence to dietary patterns and weight change in women. RESEARCH METHODS AND PROCEDURES: Women (51,670, 26 to 46 years old) in the Nurses' Health Study II were followed from 1991 to 1999. Dietary intake and body weight were ascertained in 1991, 1995, and 1999. A Western pattern, characterized by high intakes of red and processed meats, refined grains, sweets and desserts, and potatoes, and a prudent pattern, characterized by high intakes of fruits, vegetables, whole grains, fish, poultry, and salad dressing, were identified with ... Read More »
» Published in Obesity (Silver Spring). 2006 Aug;14(8):1444-53.
10. No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation.
Match Strength: 7.365
The underlying mechanisms of antipsychotic (AP)-induced weight gain are unknown, but both central and peripheral AP target receptors could potentially be involved. This study used radioligand binding assays to compare the binding affinities of clozapine, olanzapine and haloperidol for candidate receptors potentially involved in AP-induced weight gain. Selected candidates derived from known pathways involved in body weight regulation included receptors classified as anorexigenic (bombesin receptor subtype 3, calcitonin gene-related peptide receptor, cholecystokinin receptor, melanocortin-4 ... Read More »
» Published in Pharmacogenomics J. 2006 Sep 19;
11. Thiazolidinediones, insulin resistance and obesity: Finding a balance.
Match Strength: 7.313
The clinical efficacy of currently available thiazolidinediones (TZDs) in improving glycaemic control and ameliorating several risk factors for cardiovascular disease (linked to their insulin-sensitising actions as well as direct vascular effects) is well established. Treatment-associated weight gain, however, which has been identified as a class effect of the TZDs, is seen in a number of patients. The magnitude of weight gain correlates in part with improved metabolic control, i.e. better responders are more prone to increases in body weight. The cardiovascular risk associated with obesity ... Read More »
» Published in Int J Clin Pract. 2006 Oct;60(10):1272-80.
12. Serum insulin, leptin, and neuropeptide y levels in epileptic children treated with valproate.
Match Strength: 7.153
Weight gain is a common side effect of valproate treatment. The potential mechanisms of valproate-associated weight gain are not yet clear. Decreased blood glucose level, impairment of beta-oxidation of fatty acids, and increased insulin levels are some of the possible mechanisms. The aim of the present study is to evaluate the role of insulin, leptin, and neuropeptide Y in valproate-related weight gain in epileptic children. In 20 epileptic children treated with valproate before treatment and after a follow-up period of 3 and 6 months, body mass index and fasting insulin glucose ratio were ... Read More »
» Published in J Child Neurol. 2005 Oct;20(10):848-51.
13. Effect of mineralocorticoids on interdialytic weight gain in hemodialysis patients with perdialytic hypotension.
Match Strength: 7.079
Fludrocortisone is recommended in patients with orthostatic hypotension and a benefit has been suggested in hemodialysis patients with severe hypokaliemia. We report 2 patients who suffered from chronic severe perdialytic hypotension resistant to midodrine and who were treated in a long-term period with fludrocortisone. A rise of post-dialytic BP was observed with a decrease of the interdialytic weight gain (IWG). We suggest that the IWG decrease is induced by a lessening of the renin angiotensin aldosterone system that could be less stimulated at the end of the dialysis session because of a ... Read More »
» Published in Hemodial Int. 2005 Oct;9(4):338-40.
14. Maternal body composition, offspring blood pressure and the hypothalamic-pituitary-adrenal axis.
Match Strength: 6.979
We tested the hypothesis that women who are thin or have poor pregnancy weight gain have offspring with higher blood pressure and examined whether this link is mediated by increased secretion of cortisol. We studied a cohort of 388 children born in Kingston, Jamaica. From hospital records we obtained information about their mother's body mass index (BMI) and weight gain during pregnancy. At age 8.5 years we measured the children's fasting plasma cortisol concentrations and blood pressure and assessed their mother's anthropometry. There were no relationships between the mother's BMI or weight ... Read More »
» Published in Paediatr Perinat Epidemiol. 2005 Jul;19(4):294-302.
15. Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trial.
Match Strength: 6.909
CONTEXT: Reduced energy intake is a primary factor in HIV-associated wasting. Megestrol acetate (MA) stimulates appetite and weight gain. However, much of the weight gained is fat, possibly as a result of MA-induced hypogonadism. OBJECTIVE: The objective of the study was to determine whether coadministration of testosterone with MA could enhance lean body mass (LBM) accrual and evaluate the effects of MA, alone or combined with testosterone, on sexual functioning and the hypothalamic-pituitary-adrenal axis. DESIGN: This was a randomized, double-blind, placebo-controlled, multicenter trial. ... Read More »
» Published in J Clin Endocrinol Metab. 2007 Feb;92(2):563-70. Epub 2006 Nov 7.
16. The effects of sympathectomy and dexamethasone in rats ingesting sucrose.
Match Strength: 6.907
Both high-sucrose diet and dexamethasone (D) treatment increase plasma insulin and glucose levels and induce insulin resistance. We showed in a previous work (Franco-Colin, et al. Metabolism 2000; 49:1289-1294) that combining both protocols for 7 weeks induced less body weight gain in treated rats without affecting mean daily food intake. Since such an effect may be explained by an increase in caloric expenditure, possibly due to activation of the sympathetic nervous system by sucrose ingestion, in this work, and using 10% sucrose in the drinking water, male Wistar rats were divided into 4 ... Read More »
» Published in Int J Biol Sci. 2006;2(1):17-22. Epub 2006 Mar 4.
17. An investigation of hypothalamic-pituitary-adrenal axis hyperactivity in anorexia nervosa: the role of CRH and AVP.
Match Strength: 6.855
We hypothesised that hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in anorexia nervosa (AN) is associated with (a) elevated arginine vasopressin (AVP) activity and (b) enhanced pituitary sensitivity to AVP, as it is in depressive illness. 16 Healthy women and 18 women with active AN participated in a combined dexamethasone (DXM)/corticotrophin releasing hormone (CRH) challenge test and an AVP challenge test. This combination of tests is designed to assess the functional contribution of AVP to HPA axis activity. 10 of the active AN group repeated participation after weight gain. The ... Read More »
» Published in J Psychiatr Res. 2007 Jan-Feb;41(1-2):131-43. Epub 2006 Feb 7.
18. Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice.
Match Strength: 6.778
Neuropeptide Y (NPY) stimulates feeding and weight gain, but deletion of the NPY gene does not affect food intake and body weight in mice bred on a mixed genetic background. We reasoned that the orexigenic action of NPY would be evident in C57Bl/6J mice susceptible to obesity. NPY deficiency has no significant effect in mice fed a normal rodent diet. However, energy expenditure is elevated during fasting, and hyperphagia and weight gain are blunted during refeeding. Expression of agouti-related peptide (AGRP) in the hypothalamus is increased in NPY knockout (NPYko) than wild-type mice, but ... Read More »
» Published in Diabetes. 2006 Nov;55(11):3091-8.
19. The evolution of weight and body composition in renal transplant recipients: Two-year longitudinal study.
Match Strength: 6.670
Previous series have reported weight gain after kidney transplantation. However few studies have investigated the body composition after kidney transplantation, particularly during longitudinal follow-up. In this prospective study, we assessed the changes in body composition after kidney transplantation. We also analyzed the effect of steroid withdrawal from the immunosuppressive regimen on weight gain and body composition.METHODS: Thirty-eight cadaveric kidney transplant recipients were followed for 2 years posttransplant. Total and segmental body composition were measured by dual energy X ... Read More »
» Published in Transplant Proc. 2006 Dec;38(10):3517-9.
20. Central leptin gene therapy blocks ovariectomy-induced adiposity.
Match Strength: 6.593
OBJECTIVE: In this study, we tested the hypothesis that insufficiency of leptin restraint in the hypothalamus is responsible for promoting weight gain and adiposity after ovariectomy (ovx). Whether increasing leptin transgene expression can overcome the diminution in leptin restraint was evaluated in ovx rats. RESEARCH METHODS AND PROCEDURES: Enhanced leptin or green fluorescent protein (GFP; control) transgene expression was induced by a single intracerebroventricular injection of recombinant adeno-associated viral vector encoding either leptin gene (rAAV-lep) or GFP gene (rAAV-GFP; control) ... Read More »
» Published in Obesity (Silver Spring). 2006 Aug;14(8):1312-9.
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