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Weight Gain Obesity
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1. Is It Possible to Prevent Obesity?
Match Strength: 14.541

No-one is immune to obesity, but those with a family history of obesity, or those who have in the past lost weight, are particularly liable to excessive weight gain. There is no useful way of identifying that portion of the population which is at particularly high risk of obesity so that preventive measures can be focussed on that subgroup. Prevention of obesity therefore requires early detection and treatment of excessive weight gain. For various reasons the age range 5-12 years is particularly advantageous for correcting obesity in children, since normal weight-for-height can be achieved ... Read More »
» Published in Infusionstherapie. 1990 Feb;17(1):28-31.

2. Psychiatric Medication-Induced Obesity: a Review
Match Strength: 14.277

A majority of psychiatric medications are known to generate weight gain and ultimately obesity in some patients. There is much speculation about the prevalence of weight gain and the degree of weight gain during acute and longitudinal treatment with these agents. There is newer literature looking at the aetiology of this weight gain and the potential treatments being used to alleviate this side-effect. We found solid evidence that weight gain is often associated with the mood stabilizers, and antipsychotics and antidepressants. Only few weight neutral or weight loss producing psychotropics are ... Read More »
» Published in Obes Rev. 2004 May;5(2):115-21.

3. Adult obesity does not predict 6-year weight gain in men: the aerobics center longitudinal study.
Match Strength: 14.110

OBJECTIVE: To determine the longitudinal relation between history of adult obesity and the 6-year trajectory of weight change in men. RESEARCH METHODS AND PROCEDURES: Subjects were healthy, affluent men (n = 761) between the ages of 20 and 78 years who completed at least four comprehensive medical exams at the Cooper Clinic between 1987 and 2003. Maximum adult weight was reported, and current height was measured at baseline. Body weight and cardiorespiratory fitness were measured at all examinations. Adult obesity status was determined from self-reported maximum weight and measured height at ... Read More »
» Published in Obesity (Silver Spring). 2007 Jun;15(6):1571-7.

4. Weight Gain in the Treatment of Mood Disorders
Match Strength: 13.805

Overweight and obesity have become an urgent public health problem in the United States: approximately 61% of the adult population (97 million adults) are overweight or obese, where overweight is defined as a body mass index (BMI) >/= 25 and obesity is defined as a BMI >/= 30. Overweight and obesity increase the risk for developing many serious chronic diseases such as cardiovascular disease, type 2 diabetes, hypertension, dyslipidemia, and certain cancers. Increased morbidity due to obesity-related disorders begins within the normal weight range. Weight gain in adulthood per se, even in ... Read More »
» Published in J Clin Psychiatry. 2003;64 Suppl 8:22-9.

5. Adolescent gestational weight gain: does it contribute to obesity?
Match Strength: 13.638

Does gestational weight gain have an impact on the future weight pattern of adolescent mothers? Pregnant adolescents gain weight with childbearing, and weight retention following pregnancy potentially contributes to long-term overweight and obesity, but the literature to date has focused on the effect of gestational weight on the neonate and not on the mother. In 1990, the Institute of Medicine (IOM) released recommendations for weight gain during pregnancy. According to these recommendations, young adolescents (< or =16 years old) should gain weight at the upper end of the recommendations, ... Read More »
» Published in MCN Am J Matern Child Nurs. 2006 Mar-Apr;31(2):101-5.

6. Dietary Obesity: Brown Fat Denervation Fails to Alter Development Or Recovery
Match Strength: 13.486

We assessed the effect of scapular brown adipose tissue (BAT) denervation on dietary obesity in adult female Sprague-Dawley rats. In rats maintained for 32 days on an obesity-inducing regimen, BAT denervation produced significant reductions in food intake (83.4 vs. 94.4 kcal/day), weight gain (66.0 vs. 103.5 g), and carcass fat (19.3 vs. 27.6%). A subgroup of denervates consuming as many calories as controls (94.1 kcal/day) failed to gain more weight (92.2 g) or accumulate more fat (25.4%) than controls. In rats developing obesity for 32 days followed by 8 days on laboratory chow, weight ... Read More »
» Published in Am J Physiol. 1986 Jun;250(6 Pt 2):R1108-16.

7. Sleep duration, general and abdominal obesity, and weight change among the older adult population of Spain.
Match Strength: 13.454

BACKGROUND: Short sleep duration is associated with obesity and weight gain among children and young adults. However, there are few studies on the elderly, with conflicting results. OBJECTIVE: We examined the association of habitual sleep duration with obesity and weight change among the population aged >/=60 y in Spain. DESIGN: This prospective study was conducted from 2001 to 2003 on 3576 persons whose habitual sleep duration was self-reported in 2001. The outcomes were obesity [body mass index (BMI; in kg/m(2)) >/=30], severe obesity (BMI >/=35), and abdominal obesity (waist ... Read More »
» Published in Am J Clin Nutr. 2008 Feb;87(2):310-6.

8. Impact of Perinatal Weight Change on Long-Term Obesity and Obesity-Related Illnesses
Match Strength: 13.269

OBJECTIVE: To estimate the impact of perinatal weight change on obesity, weight gain, and development of obesity-related illnesses 15 years after pregnancy. METHODS: Pregnancy-related factors and weights of 795 women were recorded at first prenatal visit and 6 months postpartum and were available through medical record review at 4, 10, and 15 years. Obesity-related illnesses were recorded 15 years later. RESULTS: A total of 484 (61%) original cohort members were available for follow-up. Weight gain during pregnancy, weight loss by 6 months postpartum, and baseline body mass index (BMI) were ... Read More »
» Published in Obstet Gynecol. 2005 Dec;106(6):1349-56.

9. Musculoskeletal Fitness and Weight Gain in Canada.
Match Strength: 13.178

BACKGROUND:: Obesity is a growing health issue in Canada, and identifying the determinants of weight gain is important for the development of appropriate prevention strategies. PURPOSE:: To quantify the association between musculoskeletal fitness (MSF) and subsequent weight gain and development of obesity. METHODS:: The sample included 606 participants (20-69 yr; 291 men, 315 women) from the Physical Activity Longitudinal Study (PALS), a follow-up of participants from the 1981 Canadian Fitness Survey. Standardized assessments of height, weight, MSF (push-ups, sit-ups, grip strength, and trunk ... Read More »
» Published in Med Sci Sports Exerc. 2007 Jan;39(1):38-43.

10. Pregnancy Weight Gain and Postpartum Loss: Avoiding Obesity While Optimizing the Growth and Development of the Fetus
Match Strength: 13.135

Weight gain during pregnancy may contribute to obesity development. Concerns about possible adverse effects of pregnancy weight gain on later maternal weight and on labor and delivery must be rigorously evaluated in light of possible benefits for fetal growth and development. Birth-weight rises with increased pregnancy weight gain, and perinatal and neonatal mortality fall as birthweight increases in both preterm and term infants. The lowest mortality is observed at 3500 to 4500 g in infants of white women. Although often thought to be at high risk, infants termed "macrosomic" include infants ... Read More »
» Published in J Am Med Womens Assoc. 2001 Spring;56(2):53-8.

11. Psychological workload and weight gain among women with and without familial obesity.
Match Strength: 13.110

OBJECTIVE: High job demands and low job influence may be associated with subsequent weight gain. Predisposition to obesity may further modify such associations. The purpose of the study was to determine whether familial predisposition to obesity modified associations between psychological workload and 6-year weight changes among nurses. RESEARCH METHODS AND PROCEDURES: A total of 6404 Danish nurses 45 to 65 years old, who belonged to the workforce in both 1993 and 1999, answered a questionnaire on psychological workload, body weight, and familial obesity. Women were considered to be ... Read More »
» Published in Obesity (Silver Spring). 2006 Mar;14(3):458-63.

12. Childhood Versus Adult Onset Obesity in a Comprehensive, Multidisciplinary Weight Reduction Program
Match Strength: 13.084

The weight loss of 16 obese patients (greater than 130% ideal body weight) who participated for three months in a comprehensive, multidisciplinary weight reduction program was studied. Patients were divided into two groups based on the reported time of onset of their obesity. Childhood-onset obesity was defined in this study as marked weight gain by the age of 11. Adult-onset obesity was defined as weight gain occurring at 18 years of age or later. Each group of patients consisted of two males and six females. The childhood-onset obesity group lost significantly more weight than the adult ... Read More »
» Published in J Am Coll Nutr. 1982;1(2):187-92.

13. Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study.
Match Strength: 13.073

Adult weight gain and central obesity can increase breast cancer risk. We determined the prevalence of adult weight gain and central obesity amongst women with a family history (FH) as compared to women with a population risk to determine whether adiposity could contribute to their increased risk. Adult weight gain, waist and waist:hip ratio (WHR) were determined amongst 475 women (aged 20-60 years) attending a regional FH breast cancer risk clinic, compared to 312 age matched women at population risk. Patterns of adult weight gain did not differ between women with and without a FH of breast ... Read More »
» Published in Fam Cancer. 2007 Apr 12;

14. Smoking cessation, obesity and weight concerns in black women: a call to action for culturally competent interventions.
Match Strength: 12.976

Approximately 20.8% of black women and 23.1% of white women smoke, and significantly more blacks (37.4%) than whites (22.4%) are obese. Although the average amount of weight gain after quitting smoking is 6-8 lbs for women, blacks tend to gain substantially more weight. This large increase in postcessation weight gain in blacks may further augment the health risks that blacks face in conjunction with obesity. Interventions that promote smoking cessation, while simultaneously reducing weight concerns or weight gain has been proposed as a strategy to help weight-concerned women quit smoking. ... Read More »
» Published in J Natl Med Assoc. 2005 Dec;97(12):1630-8.

15. Weight Gain Associated with Neuroleptic Medication: a Review
Match Strength: 12.928

In this article we review the empirical literature on weight gain associated with neuroleptic drug use. Weight gain, which appears to be associated with an increase in appetite, is variable but likely to be larger initially and then plateau. Clozapine and low-potency phenothiazines are associated with the largest gains and molindone with weight loss, but the mechanism is not known. Amantadine and fenfluramine may reverse weight gain to some degree. Dietary fat seems to play an important role in obesity, and research is needed to increase the data base and elucidate possible mechanisms. Studies ... Read More »
» Published in Schizophr Bull. 1995;21(3):463-72.

16. Coherent, Preventive and Management Strategies for Obesity
Match Strength: 12.919

The increased risk of morbidity and mortality from obesity, central body fat and weight gain, and the benefits of weight reduction argue that the cost associated with obesity could be beneficially affected by prevention of weight gain or induction of weight loss. Genetic, metabolic and demographic predictors of weight gain have been identified that allow the selection of high risk individuals. Among the metabolic predictors are a low metabolic rate, insulin sensitivity and a high respiratory quotient. Demographic predictors include current smokers, certain dieting behaviours, lower ... Read More »
» Published in Ciba Found Symp. 1996;201:228-46; discussion 246-54.

17. Nutrition and Obesity: Prevention and Treatment
Match Strength: 12.900

The increased risk of morbidity and mortality from obesity, central body fat, and weight gain, and the beneficial effects of weight reduction argue that the cost associated with obesity could be beneficially affected by prevention of weight gain or induction of weight loss. Genetic, metabolic, and demographic predictors of weight gain have been identified that allow selection of high-risk individuals. Among the metabolic predictors are a low metabolic rate, insulin sensitivity, and a high respiratory quotient. Demographic predictors include current smokers, certain dieting behaviors, lower ... Read More »
» Published in Nutr Metab Cardiovasc Dis. 1999 Aug;9(4 Suppl):21-32.

18. Fetal, infant and childhood growth: relationships with body composition in Brazilian boys aged 9 years.
Match Strength: 12.898

BACKGROUND: Early growth rate has been linked to later obesity categorised by body mass index (BMI), but the development of body composition has rarely been studied. METHODS: We tested the hypotheses that (1) birthweight and weight gain in (2) infancy or (3) childhood are associated with later body composition, in 172 Brazilian boys followed longitudinally since birth. Growth was assessed using measurements of weight and height at birth, 6 months, and 1 and 4 y. Measurements at 9 y comprised height, weight and body composition using foot-foot impedance. RESULTS: Birthweight was associated with ... Read More »
» Published in Int J Obes (Lond). 2005 Oct;29(10):1192-8.

19. Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children.
Match Strength: 12.843

Hyperinsulinemia is commonly associated with obesity, but it has not been determined which defect comes first. Some have proposed that hyperinsulinemia may precede obesity in populations prone to NIDDM, such as Pima Indians or Pacific Islanders. In contrast, longitudinal studies in adults show that insulin sensitivity and low fasting insulin concentrations are associated with increased weight gain, whereas insulin resistance seems to protect against weight gain. The present study examined whether fasting plasma hyperinsulinemia is a risk factor for weight gain in prepubertal children in the ... Read More »
» Published in Diabetes. 1997 Aug;46(8):1341-5.

20. Weight Gain Following Treatment of Hyperthyroidism
Match Strength: 12.841

OBJECTIVE: Patients frequently express concern that treating hyperthyroidism will lead to excessive weight gain. This study aimed to determine the extent of, and risk factors for, weight gain in an unselected group of hyperthyroid patients. DESIGN AND SUBJECTS: We investigated 162 consecutive hyperthyroid patients followed for at least 6 months. Height, weight, clinical features, biochemistry and management were recorded at each clinic visit. RESULTS: Documented weight gain was 5.42 +/- 0.46 kg (mean +/- SE) and increase in BMI was 8.49 +/- 0.71%, over a mean 24.2 +/- 1.6 months. Pre-existing ... Read More »
» Published in Clin Endocrinol (Oxf). 2001 Aug;55(2):233-9.

21. Weight Change in the Postpartum Period. a Review of the Literature
Match Strength: 12.816

Women who gain excessive weight during pregnancy are at risk for postpartum weight retention and long-term obesity. Familiarity with current research related to postpartum weight loss can aid the nurse-midwife in providing sound, clinical advice to women at risk for postpartum weight retention. This article provides a review of current literature and research studies related to postpartum weight loss, weight retention, and weight gain. An overview of gestational weight gain and fetal growth, recommendations of the Institute of Medicine, complications of maternal obesity, postpartum weight-loss ... Read More »
» Published in J Nurse Midwifery. 1995 Sep-Oct;40(5):418-23.

22. Recent Weight Changes and Weight Cycling as Predictors of Subsequent Two Year Weight Change in a Middle-Aged Cohort
Match Strength: 12.682

OBJECTIVE: To evaluate the influence of recent weight changes (weight gain, loss and cycling) on subsequent weight changes. DESIGN: Prospective cohort study with 2 y of follow-up. Data analysis with a polytomous logistic regression model. SUBJECTS: A total of 18 001 non-smoking subjects, 6689 men and 11 312 women, from the general population. MEASUREMENTS: Body height and weight measurements and interview data on lifestyle habits and medical history at baseline. For follow-up, self-administered questionnaires for assessment of body weight and incident diseases. RESULTS: Recent changes in body ... Read More »
» Published in Int J Obes Relat Metab Disord. 2002 Mar;26(3):403-9.

23. Rates of Weight Change for Black and White Americans Over a Twenty Year Period
Match Strength: 12.628

OBJECTIVE: To examine the rate of weight gain over time among Americans by age, gender, and race. PARTICIPANTS: Scientific sample of 5117 Americans, ages 25-74 y in 1971 followed for 20 y. RESULTS: Rates of weight gain estimated by mixed effects models are highest among young adults and rates of weight loss are greatest among older adults. The overall shape of the growth curves are similar for men and women, black and white, in terms of both weight gain and weight loss. Rates are also affected by baseline body mass index (BMI=wt in kg/height in m(2)). CONCLUSIONS: Americans gain weight until ... Read More »
» Published in Int J Obes Relat Metab Disord. 2003 Apr;27(4):498-504.

24. Bipolar Disorder, Obesity, and Pharmacotherapy-Associated Weight Gain
Match Strength: 12.590

BACKGROUND: Bipolar disorder, overweight, and obesity are each national public health problems. Overweight and obesity also appear to be related to mood disorders, and patients with bipolar disorder, in particular, may be at greater risk for overweight and obesity than individuals in the general population. This risk may be due to factors associated with the illness itself and/or with medications used to treat bipolar disorder. METHOD: We conducted a MEDLINE literature search of all English-language articles (1966-2002) using the keywords lithium, olanzapine, valproate, valproic acid, ... Read More »
» Published in J Clin Psychiatry. 2003 Dec;64(12):1426-35.

25. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions.
Match Strength: 12.574

In a systematic review, we identified 21 separate studies with data on the association between rapid infancy weight gain, up to age 2 y, and subsequent obesity risk. Uniformly all studies reported significant positive associations. We transformed the reported effect sizes to a standard infancy weight gain exposure, and found that further differences in study design accounted for much of the variation in risk. An accompanying paper by Melinda Yeung reminds us that there are benefits of postnatal catch-up growth in certain populations, and suggests that genetic and nutritional factors could ... Read More »
» Published in Acta Paediatr. 2006 Aug;95(8):904-8. Comment on: Acta Paediatr. 2006 Aug;95(8):909-17.

26. Beliefs About Weight Gain and Attitudes Toward Relapse in a Sample of Women and Men with Obesity
Match Strength: 12.554

OBJECTIVE: The purpose of this study was to examine beliefs regarding reasons for weight gain, likely responses to weight loss relapse, notions of reasonable weight loss, and correlations between beliefs and attitudes in a large nonclinical sample of men and women with obesity. RESEARCH METHODS AND PROCEDURES: Participants were 3,394 white women (n=1,674) and men (n=1,720) with obesity who had responded to a survey about body image and eating behaviors conducted by Consumer Reports magazine. RESULTS: Women and men indicated that the most important reasons for their weight gain were lack of ... Read More »
» Published in Obes Res. 1998 May;6(3):231-7.

27. Obesity and gestational weight gain: cesarean delivery and labor complications.
Match Strength: 12.551

OBJECTIVE: To assess the association between pre-gestational obesity and weight gain with cesarean delivery and labor complications. METHODS: A total of 4,486 women 20-28 weeks pregnant attending general prenatal care clinics of the national health system in Brazil from 1991 to 1995 were enrolled and followed up through birth. Body mass index categories based on prepregnancy weight and total weight gain were calculated. Associations between body mass index categories and labor complications were adjusted through logistic regression analysis. RESULTS: Obesity was present in 308 (6.9%) patients. ... Read More »
» Published in Rev Saude Publica. 2006 Jun;40(3):457-65. Epub 2006 Jun 23.

28. Excess Pregnancy Weight Gain and Long-Term Obesity: One Decade Later
Match Strength: 12.534

OBJECTIVE: To estimate the impact of excess pregnancy weight gain and failure to lose weight by 6 months postpartum on excess weight 8-10 years later. METHODS: Seven hundred ninety-five women were observed through pregnancy and 6 months postpartum to examine factors that affect weight loss. Weight was recorded 10 years later through a medical record review to examine the impact of retained weight on long-term obesity. Overall weight change at last follow-up and body mass index (BMI) were examined by pregnancy weight gain appropriateness according to the Institute of Medicine guidelines for ... Read More »
» Published in Obstet Gynecol. 2002 Aug;100(2):245-52.

29. Metabolic predictors of weight gain.
Match Strength: 12.423

Human obesity is the result of both environmental and genetic factors. In this manuscript, we briefly review the metabolic factors predicting body weight gain in Pima Indians, a population prone to obesity. The metabolic predictors of weight gain are: 1) a low metabolic rate, 2) low levels of physical activity, 3) low rates of fat oxidation, 4) insulin sensitivity, 5) low sympathetic nervous system activity, and 6) low plasma leptin concentrations. In contrast, obesity is associated with high metabolic rate, high fat oxidation, low insulin sensitivity and high plasma leptin concentration. This ... Read More »
» Published in Int J Obes Relat Metab Disord. 1999 Feb;23 Suppl 1:37-41.

30. Pharmacokinetics and Drug Interactions of the Sedative Hypnotics
Match Strength: 12.386

Weight gain is a common side effect associated with antidepressant, anxiolytic, and antipsychotic drug use. Obesity is a risk factor for several other disorders, including hypertension, diabetes, and coronary artery disease. To date, there have been few safe, well-tolerated, and effective pharmacological agents available to alleviate weight gain in general, and virtually no studies specific to psychiatric drug-induced weight gain. This case series looks at the use of orlistat, a reversible inhibitor of lipases approved by the US Food and Drug Administration for obesity management, ... Read More »
» Published in Psychopharmacol Bull. 2003 Winter;37(1):5-9.

31. The long-term impact of adolescent gestational weight gain.
Match Strength: 12.291

This study involved 330 primiparous Black adolescents. The purpose of the study was to examine predictors of body mass index (BMI) change in Black adolescents 6 and 9 years after they gave birth. Predictors were gestational weight gain, pre-pregnant BMI, and age (p < .001). For older adolescents (ages 18-19), gestational weight gain was the only predictor of BMI change (p = .008). Regardless of pre-pregnant BMI category, adolescents whose gestational weight gain exceeded Institute of Medicine (IOM) recommendations were 4.6 times more likely to be obese than those whose weight gain was ... Read More »
» Published in Res Nurs Health. 2008 Jan 7

32. Preventing Obesity: a Life Cycle Perspective
Match Strength: 12.284

Traditional approaches to treating overweight and obese adults by focusing on individual weight loss have not been effective in stemming the tide of obesity in the population. Recent research has identified critical factors that, as they accumulate and interact over an individual's life span, may put a person at risk for obesity. These factors include rapid weight gain in infancy and childhood, early puberty, and excessive weight gain in pregnancy. Based on this research, a life cycle perspective can be used to develop comprehensive interventions that address the multiple determinants of ... Read More »
» Published in J Am Diet Assoc. 2006 Jan;106(1):97-102.

33. Obesity and weight gain are associated with increased incidence of hyperinsulinemia in non-diabetic men.
Match Strength: 12.281

We investigated the temporal relationships between obesity, weight change and hyperinsulinemia in a population-based 4-year follow-up study of 695 middle-aged, non-diabetic, and normoinsulinemic men. Thirty-eight men developed hyperinsulinemia during the follow-up (fasting serum insulin > or = 12.0 mU/l). In logistic regression analysis adjusting for other risk factors, men with body mass index of > or = 26.7 kg/m2 (highest third) had a 6.6-fold (p = 0.001) risk of developing hyperinsulinemia, compared with men with body mass index of < 24.4 kg/m2 (lowest third). Correspondingly, men with ... Read More »
» Published in Horm Metab Res. 2002 Sep;34(9):492-8.

34. Effects of Weight Cycling Induced By Diet Cycling in Rats Differing in Susceptibility to Dietary Obesity
Match Strength: 12.273

OBJECTIVE: Although the majority of evidence in rodents does not support the view that weight cycling (consisting of bouts of food restriction and refeeding) promotes obesity, the effects of weight cycling on body weight regulation remain controversial. We have previously demonstrated that some rats within a strain are more susceptible to develop obesity than others when given free access to a high-fat diet. In this study, we tested the hypothesis that rats most susceptible to weight gain on a high-fat diet would also be most susceptible to weight gain as a consequence of weight cycling. ... Read More »
» Published in Obes Res. 1999 Mar;7(2):215-22.

35. Skeletal muscle glucose metabolism in obesity-prone and obesity-resistant rats.
Match Strength: 12.180

Ad libitum access to a high-fat (HF) diet produces a wide range of weight gain in rats. Rats most susceptible to weight gain on such a diet (obesity prone; OP) are more insulin resistant after 4-5 wk of diet exposure than are those most resistant (obesity resistant; OR) to weight gain. To investigate whether skeletal muscle glucose metabolism contributes to insulin resistance in this model, insulin-stimulated glucose metabolism was assessed in the perfused hindquarter of rats exposed to either a low-fat (LF, n = 6) or HF diet for 5 wk. Delineation of OP (n = 6) and OR (n = 6) rats was based on ... Read More »
» Published in Am J Physiol. 1993 Jun;264(6 Pt 2):R1224-8.

36. Could a virus contribute to weight gain?
Match Strength: 12.169

Objective:Obesity is a serious public health problem associated with increased morbidity and mortality. Although the causes for obesity are unclear, it seems that environmental, genetic, neural and endocrine factors contribute to its development. However, the rapid global spread of obesity resembles epidemiologically the spread of an infectious disease. Thus far, little consideration has been given to the possibility that the epidemic of obesity could be due to an infectious agent. Seven viruses and a scrapie agent have been implicated in obesity.Design:This review evaluates the infectious ... Read More »
» Published in Int J Obes (Lond). 2007 Apr 10;

37. Gestational weight gain and child adiposity at age 3 years.
Match Strength: 12.161

OBJECTIVE: The purpose of this study was to examine the associations of gestational weight gain with child adiposity. STUDY DESIGN: Using multivariable regression, we studied associations of total gestational weight gain and weight gain according to 1990 Institute of Medicine guidelines with child outcomes among 1044 mother-child pairs in Project Viva. RESULTS: Greater weight gain was associated with higher child body mass index z-score (0.13 units per 5 kg [95% CI, 0.08, 0.19]), sum of subscapular and triceps skinfold thicknesses (0.26 mm [95% CI, 0.02, 0.51]), and systolic blood pressure (0 ... Read More »
» Published in Am J Obstet Gynecol. 2007 Apr;196(4):322.e1-8.

38. Weight Gain Profiles of New Anti-Psychotics: Public Health Consequences
Match Strength: 12.150

Anti-psychotic medications are an important therapeutic option for many individuals with schizophrenia. Recently, a growing interest has been observed on weight gain, which is now a well-known adverse effect of many anti-psychotics. As obesity is frequently a comorbid condition with schizophrenia, patients with schizophrenia are inherently at increased risk of developing obesity-related conditions such as cardiovascular disease and type 2 diabetes. The consequences of excessive weight gain (obesity) associated with anti-psychotic drugs are likely to include adverse effects on health, social ... Read More »
» Published in Obes Rev. 2003 Aug;4(3):129-38.

39. Effective Management of Obesity
Match Strength: 12.141

Successful treatment of obesity usually requires multiple interventions. The choice of therapies should be guided by the initial assessment of a patient's degree of obesity and comorbid conditions, if present. A variety of interventions can achieve short-term weight loss, but rebound weight gain is common when therapy is stopped. Thus, programs for weight maintenance are critical to ultimate success ... Read More »
» Published in J Fam Pract. 2003 Jan;52(1):34-42. Comment in: J Fam Pract. 2003 Aug;52(8):635.

40. Obesity, Weight Gain, Large Weight Changes, and Adenomatous Polyps of the Left Colon and Rectum
Match Strength: 12.107

Epidemiologic studies of colorectal neoplasia have usually examined body mass index as a risk factor, but not other aspects of obesity. During 1991-1993, the authors obtained weight histories and comprehensive covariate data from men and women aged 50-75 years who underwent sigmoidoscopy at a health maintenance organization in southern California. Using 483 cases with adenomas and 483 controls, measures of obesity (body mass index), positive energy balance (net weight gain in the past 10 years), and weight variability (large weight changes) were each independently related to adenoma prevalence ... Read More »
» Published in Am J Epidemiol. 1998 Apr 1;147(7):670-80.

41. Development of hyperinsulinemia and insulin resistance during the early stage of weight gain.
Match Strength: 12.104

Objective: Obesity is associated with insulin resistance and hyperinsulinemia which is considered to be a core component in the pathophysiology of obesity related co-morbidities. As yet it is unknown if insulin resistance and hyperinsulinemia already develop during weight gain within the normal range. Methods: In 10 healthy male subjects the effect of intentional weight gain by 2 BMI-points was examined on insulin. C-peptide and glucose levels following a meal, 75g glucose and a two-step hyperglycemic clamp increasing plasma glucose by 1.38 and 2.75mmol/l, respectively. Results: Baseline ... Read More »
» Published in Am J Physiol Endocrinol Metab. 2008 Jan 2

42. Drug-Induced Weight Gain
Match Strength: 11.935

Drug-induced weight gain is a serious side effect of many commonly used drugs leading to noncompliance with therapy and to exacerbation of comorbid conditions related to obesity. Improved glycemic control achieved by insulin, insulin secretagogues or thiazolidinedione therapy is generally accompanied by weight gain. It is a problematic side effect of therapy due to the known deleterious effect of weight gain on glucose control, increased blood pressure and worsening lipid profile. Weight gain may be lessened or prevented by adherence to diet and exercise or combination therapy with metformin. ... Read More »
» Published in Drugs Today (Barc). 2005 Aug;41(8):547-55.

43. Rate Of Weight Gain, Weight Fluctuation, And Incidence Of Niddm
Match Strength: 11.912

The relationships of rate of weight gain and weight fluctuation to incidence of non-insulin-dependent diabetes mellitus (NIDDM) were examined in Pima Indians. The 1,458 subjects were participants in a prospective study with examinations approximately every 2 years. Rate of weight gain was defined as the slope of the regression line of weight with time for two or more consecutive examinations > or = 2 years apart and weight fluctuation as the root-mean-square departure from this line for four examinations. Among men, incidence of NIDDM was strongly and significantly related to rate of weight ... Read More »
» Published in Diabetes. 1995 Mar;44(3):261-6.

44. Early weaning is related to weight and rate of weight gain in infancy.
Match Strength: 11.903

BACKGROUND: Evidence relating to the effect of early weaning on infant weight and weight gain is conflicting. The aim of this paper is to compare weight and weight gain in two groups of infants; one group weaned before 4 months (early weaned), the other weaned at 4 months or after. METHODS: Feeding practices were assessed through semistructured interviews with mothers of 1-year-old infants. Weight at birth, 8 weeks and 7 months were taken from an administrative database (Child Health System), and an additional measure of weight was taken at 14 months. RESULTS: Infants weaned early were heavier ... Read More »
» Published in Child Care Health Dev. 2008 Jan;34(1):59-64.

45. Weight gain in craniopharyngioma--a model for hypothalamic obesity.
Match Strength: 11.879

OBJECTIVES: To evaluate (1) the pattern of post-operative weight gain and (2) the risk factors associated with the development of post-operative weight gain and obesity in children treated for craniopharyngioma. STUDY DESIGN: The records of 43 children who had primary craniopharyngioma resection were reviewed. Neurological, endocrine, anthropometric and radiological risk factors for the development of obesity and for post-operative increase in BMI SDS were analyzed. RESULTS: Twenty-five patients (58%) became obese post-operatively. Obesity was significantly associated with higher BMI SDS at ... Read More »
» Published in J Pediatr Endocrinol Metab. 2006 Feb;19(2):121-7.

46. The Menopause and Obesity
Match Strength: 11.869

In summary, menopause tends to be associated with an increased risk of obesity and a shift to an abdominal fat distribution with associated increase in health risks. Changes in body composition at menopause may be caused by the decrease in circulating estrogen, and, for fat distribution shifts, the relative increase in the androgen-estrogen ratio is likely to be important. Clinicians need to be aware of the likelihood of weight gain during the perimenopausal and postmenopausal years because behavioral strategies for weight loss can be effectively used in this population. Weight loss or ... Read More »
» Published in Prim Care. 2003 Jun;30(2):317-25.

47. Weight Gain Associated with Atypical Antipsychotic Use in Children and Adolescents: Prevalence, Clinical Relevance, and Management
Match Strength: 11.719

Atypical antipsychotics are increasingly prescribed to children and adolescents with neuropsychiatric disorders. Although their profile of potent antagonism at specific serotonin and dopamine receptors offers certain advantages compared with typical antipsychotics, their use has been associated with various adverse effects, including significant weight gain. This adverse effect is of particular concern in children and adolescents, secondary to the immediate and long-term health risks associated with weight gain, including obesity, diabetes mellitus, and hyperlipidemia. Indeed, from 1963 to ... Read More »
» Published in Paediatr Drugs. 2004;6(1):33-44.

48. Drug-Induced Weight Gain
Match Strength: 11.685

Drug-induced weight gain is a serious side effect of many commonly used drugs leading to noncompliance with therapy and to exacerbation of comorbid conditions related to obesity. Improved glycemic control achieved by insulin, insulin secretagogues or thiazolidinedione therapy is generally accompanied by weight gain. It is a problematic side effect of therapy due to the known deleterious effect of weight gain on glucose control, increased blood pressure and worsening lipid profile. Weight gain may be lessened or prevented by adherence to diet and exercise or combination therapy with metformin. ... Read More »
» Published in Timely Top Med Cardiovasc Dis. 2005 Oct 28;9:E31.

49. Pregnancy Weight Retention in Morbid Obesity
Match Strength: 11.671

Recent hypotheses suggest that for women who develop morbid obesity, increases in weight associated with pregnancy may represent a significant contribution to their obesity status. The effects of multiple pregnancies on weight gain were studied in 96 morbidly obese women (< 13.6 kg over ideal weight at ages 20-24 or before an earlier first pregnancy and currently > 44.5 kg over ideal weight) and 115 random control women from the Utah population. Self-reported weights for each pregnancy included: prepregnancy, greatest during pregnancy, and 6 weeks following delivery, which were validated ... Read More »
» Published in Obes Res. 1995 Mar;3(2):121-30.

50. Nature and strength of epidemiological evidence for origins of childhood and adulthood obesity in the first year of life.
Match Strength: 11.663

Increased interest in early life origins of chronic disease, a concept often referred to as programming, has resulted in several studies investigating the origins of childhood or adulthood obesity during infancy. Rapid infancy weight gain as a risk factor and breastfeeding as a protective factor for later obesity have been most thoroughly studied. The association between rapid infancy weight gain and later obesity is supported by several observational studies, but not by the two, relatively small, randomized trials. This association is strong, suggests a dose-response effect and has biological ... Read More »
» Published in Int J Obes (Lond). 2007 Jul;31(7):1035-1043.

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