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Peer Reviewed Scientific Research Reports.
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1. Vitamin D, aging, and the 2005 Dietary Guidelines for Americans.
Match Strength: 7.793
The 2005 Dietary Guidelines for Americans recommend that older adults, people with dark skin, and those exposed to insufficient ultraviolet radiation (i.e., sunlight) consume extra vitamin D from vitamin D-fortified foods and/or supplements. Individuals in these high-risk groups should consume 25 microg (1000 IU) of vitamin D daily to maintain adequate blood concentrations of 25-hydroxyvitamin D, the biomarker for vitamin D status. This review considers recommendations for vitamin D-rich foods and dietary supplements, as well as specific problems with self-prescribing sun exposure or ... Read More »
» Published in Nutr Rev. 2006 Sep;64(9):410-21.
2. Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice.
Match Strength: 6.872
This study was designed to determine the effects of vitamin C deficiency on the immune response to infection with influenza virus. l-Gulono-gamma-lactone oxidase gene-inactivated mice (gulo-/- mice) require vitamin C supplementation for survival. Five-wk-old male and female gulo-/- mice were provided water or water containing 1.67 mmol/L vitamin C for 3 wk before inoculation with influenza A/Bangkok/1/79. There were no differences in lung influenza virus titers between vitamin C-adequate and -deficient mice; however, lung pathology in the vitamin C-deficient mice was greater at 1 and 3 d after ... Read More »
» Published in J Nutr. 2006 Oct;136(10):2611-6.
3. Vitamin E in humans: an explanation of clinical trial failure.
Match Strength: 6.220
OBJECTIVE: To describe the potential benefits and hazards of vitamin E supplementation and present a rational basis for understanding the conflicting results among randomized clinical trials, epidemiologic investigations, and animal studies on the use of vitamin E to prevent atherosclerosis. METHODS: We conducted a retrospective review of the pertinent literature found in PubMed from 1981 through August 2005. The published data are analyzed and summarized. RESULTS: The possible factors implicated for failure of vitamin E therapy include the following: (1) the inclusion of patients without ... Read More »
» Published in Endocr Pract. 2006 Sep-Oct;12(5):576-82.
4. Improvement in human semen quality after oral supplementation of vitamin C.
Match Strength: 6.167
This study was carried out to monitor the effect of oral supplementation of vitamin C on various semen parameters in oligospermic, infertile, otherwise healthy individuals. Various semen parameters, including sperm motility, sperm count, and sperm morphology, were studied before and after the vitamin C treatment. A total of 13 infertile patients were included. Their ages ranged between 25 and 35 years. They had no genital infection or varicocele. Physical examination and other routine laboratory investigations were normal. General semen analysis revealed oligozoospermia (mean sperm count was ... Read More »
» Published in J Med Food. 2006 Fall;9(3):440-2.
5. Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
Match Strength: 5.959
The impact of vitamin A supplementation on childhood diarrhea may be determined by the regulatory effect supplementation has on the mucosal immune response in the gut. Previous studies have not addressed the impact of vitamin A supplementation on the production of monocyte chemoattractant protein 1 (MCP-1), an essential chemokine involved in pathogen-specific mucosal immune response. Fecal MCP-1 concentrations, determined by an enzyme-linked immuno absorption assay, were compared among 127 Mexican children 5-15 mo of age randomized to receive a vitamin A supplement (<12 mo of age, 20,000 IU ... Read More »
» Published in J Nutr. 2006 Oct;136(10):2600-5.
6. Kinetic study on the photostability of riboflavin in the presence of barbituric acid.
Match Strength: 5.614
The photochemical fate of riboflavin (vitamin B2) in the presence of barbituric acid was examined employing polarographic detection of dissolved oxygen and steady-state and time-resolved spectroscopy. Under visible light, riboflavin reacts with barbituric acid--the latter being transparent to this type of photo-irradiation--via radicals and reactive oxygen species, such as singlet molecular oxygen [O2(1delta(g))] and superoxide radical anion, which are generated from the excited triplet state of the vitamin. As a result, both the vitamin and barbituric acid are photodegraded. Kinetic and ... Read More »
» Published in Redox Rep. 2006;11(4):153-8.
7. Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity.
Match Strength: 5.425
OBJECTIVE: Obesity is a well-known risk factor for vitamin D deficiency. We evaluated the interrelationship between vitamin D status, body size, and glucose homeostasis, measured by HbA1c (A1C). RESEARCH DESIGN AND METHODS: Data are from the survey of the 45-year-old 1958 British birth cohort (2002-2004). Information on A1C, 25-hydroxyvitamin D [25(OH)D; an indicator of vitamin D status], and BMI was collected from 7,198 Caucasian subjects. RESULTS: 25(OH)D was < 75 nmol/l in 80% of the obese subjects (BMI > or = 30 kg/m2) versus 68% of the other subjects (P < 0.0001). Serum 25(OH)D ... Read More »
» Published in Diabetes Care. 2006 Oct;29(10):2244-6.
8. Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women.
Match Strength: 5.058
OBJECTIVE: Adequate folate intake may be important for breast cancer prevention. Its protective effect may be influenced by factors associated with folate metabolism. We sought to evaluate folate intake in relation to breast cancer risk and examine whether the relation is affected by alcohol and intake of vitamin B(2) and B(12). METHODS: A prospective cohort analysis of folate intake was conducted among 62,739 postmenopausal women in the French E3N cohort who had completed a validated food frequency questionnaire in 1993. During nine years' follow-up, 1,812 cases of pathology-confirmed breast ... Read More »
» Published in Cancer Causes Control. 2006 Nov;17(9):1209-13.
9. Cumulative antioxidant defense against oxidative challenge in galactose-induced cataractogenesis in Wistar rats.
Match Strength: 5.001
Natural dietary ingredients are known for their antioxidant activity. Of such, curcumin, the active principle of turmeric, at 0.01% in the diet proved as pro-oxidative in galactose-induced cataract in vivo. The purpose of this study was to investigate the effect of vitamin E (VE), a well-known antioxidant, in combination with curcumin on the onset and maturation of galactose induced cataract. Periodic slit-lamp microscope examination indicated that in combination with vitamin-E, 0.01% curcumin (G-IV) delayed the onset and maturation of galactose-induced cataract. Biochemical analyses revealed ... Read More »
» Published in Indian J Exp Biol. 2006 Sep;44(9):733-9.
10. Two-dimensional crystallization of human vitamin K-dependent gamma-glutamyl carboxylase.
Match Strength: 4.964
Planar-tubular two-dimensional (2D) crystals of human vitamin K-dependent gamma-glutamyl carboxylase grow in the presence of dimyristoyl phosphatidylcholine (DMPC). Surprisingly, these crystals form below the phase transition temperature of DMPC and at the unusually low molar lipid-to-protein (LPR) ratio of 1, while 2D crystals are conventionally grown above the phase transition temperature of the reconstituting lipid and significantly higher LPRs. The crystals are up to 0.75mum in the shorter dimension of the planar tubes and at least 1mum in length. Due to the planar-tubular nature of the ... Read More »
» Published in J Struct Biol. 2007 Feb;157(2):437-42. Epub 2006 Aug 15.
11. Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma.
Match Strength: 4.949
Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). We hypothesized that genetic polymorphisms of VDR are associated with risk of CM. In a hospital-based case-control study of 602 non-Hispanic white CM patients and 603 cancer-free control subjects frequency matched by age and sex, we genotyped two VDR polymorphisms (TaqI and FokI) and assessed their association with CM risk. We found that a ... Read More »
» Published in J Invest Dermatol. 2007 Feb;127(2):276-80. Epub 2006 Sep 21.
12. Renal tubular acidosis type 2 with Fanconi's syndrome, osteomalacia, osteoporosis, and secondary hyperaldosteronism in an adult consequent to vitamin D and calcium deficiency: effect of vitamin D and calcium citrate therapy.
Match Strength: 4.900
OBJECTIVE: To describe a unique example of renal tubular acidosis type 2 (RTA 2) in conjunction with Fanconi's syndrome and osteomalacia consequent to vitamin D and calcium deficiency in an adult without underlying gastrointestinal disease. METHODS: We review the clinical, hormonal, histomorphometric, and micro-computed tomographic findings and the response to therapy with vitamin D and calcium in our patient. RESULTS: On admission, a 33-year-old African American woman had the following laboratory findings: serum ionized calcium 3.8 mg/dL (0.95 mmol/L), venous pH 7.26, bicarbonate 20 mEq/L, ... Read More »
» Published in Endocr Pract. 2006 Sep-Oct;12(5):559-67.
13. Folate, vitamin B12 and total homocysteine levels in neonates from Brazil.
Match Strength: 4.722
Objective:To determine folates, vitamin B12 and total homocysteine levels among neonates from mothers of low or high socioeconomic status.Design:We carried out a cross-sectional transversal study comprising 143 neonates from two maternity hospitals in the city of Salvador, Northeast of Brazil. Cord blood samples were obtained at the time of delivery from newborns from low (group 1, n=77) or high (group 2, n=66) socioeconomic status. The vitamin B12 and folates were analyzed by electrochemiluminescence immunoassay and by a competitive test using a natural folate-binding protein (FBP), ... Read More »
» Published in Eur J Clin Nutr. 2006 Sep 20;
14. Protective effect of alpha-tocopherol on oxidative stress in experimental pulmonary fibrosis in rats.
Match Strength: 4.655
The study was undertaken to investigate the influence of alpha-tocopherol (vitamin E) on malondialdehyde (MDA) and glutathione (GSH) levels and catalase (CAT) activity in lung of rats with bleomycin-induced pulmonary fibrosis (PF). Fourteen Wistar-albino rats were randomly divided into two groups of seven animals each. The first group was treated intra-tracheally with bleomycin hydrochloride (BM group); the second group was also instilled with BM but received injections of alpha-tocopherol twice a week (BM + E group). The third group was treated in the same manner with saline solution only, ... Read More »
» Published in Cell Biochem Funct. 2006 Sep 18;
15. Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal.
Match Strength: 4.559
The natural vitamin E tocotrienol (TCT) possesses biological properties not shared by tocopherols (TCP). Nanomolar alpha-TCT, not alpha-TCP, is potently neuroprotective (JBC 275:13049; 278:43508; Stroke 36:2258). The report that the affinity of TTP to bind (alpha-TCT is an order of magnitude lower than that for alpha-TCP questions the bioavailability of orally taken TCT to tissues. Oral supplementation of TCT for 3 years in nine generations of female and male rat was studied. Ten vital organs were examined. To gain insight into the turnover of alpha-TCT in tissues, a subset of supplemented ... Read More »
» Published in Free Radic Res. 2006 Jul;40(7):763-71.
16. Sialic acid and oxidizability of lipid and proteins and antioxidant status in patients with coronary artery disease.
Match Strength: 4.342
The aim of this study was to investigate the possible relationship between serum total sialic acid (TSA) concentration, recently shown to be a cardiovascular risk factor, and lipid and protein oxidation and antioxidant status and the severity of coronary artery disease (CAD) according to the obstructive vessel number in patients. The study was carried out on a total of 200 patients (142 men and 58 women) who were hospitalized for elective coronary angiographic evaluation with complaint of typical angina pectoris. According to the results of angiography, 150 patients had angiographically proven ... Read More »
» Published in Cell Biochem Funct. 2006 Sep 27;
17. Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study.
Match Strength: 4.281
OBJECTIVES: To assess the risk of serious upper gastrointestinal bleeding associated with the newer antithrombotic agents used alone or in combination with other antithrombotic drugs; to describe the trends in use of antithrombotic drugs in the background population. DESIGN: Population based case-control study. SETTING: Funen County, Denmark (population 470,000). SUBJECTS: 1443 cases of serious upper gastrointestinal bleeding identified during 2000-4; 57,720 age and sex matched controls. MAIN OUTCOME MEASURE: Exposure to low dose aspirin, clopidogrel, dipyridamole, vitamin K antagonists, and ... Read More »
» Published in BMJ. 2006 Oct 7;333(7571):726. Epub 2006 Sep 19. Comment in: BMJ. 2006 Oct 7;333(7571):712-3.
18. The vitamin D receptor as a therapeutic target.
Match Strength: 4.254
The vitamin D receptor (VDR) is a member of the large family of nuclear receptor transcription factors and specifically binds the micronutrient-derived hormone 1alpha,25(OH)2D3. A central endocrine role for this receptor in bone health was established at the beginning of the 20th century. Over the last 25 years, additional roles, perhaps through autocrine and paracrine mechanisms, have been established for VDR to regulate cell proliferation and differentiation, and more recently to exert immunomodulatory and antimicrobial functions. These findings, from in vitro and in vivo experiments, have ... Read More »
» Published in Expert Opin Ther Targets. 2006 Oct;10(5):735-48.
19. The potential for prostate cancer chemoprevention.
Match Strength: 4.086
The dramatic international variation in prostate cancer incidence and mortality rates suggests that changeable environmental factors exert an influence. This has prompted a search for ways to prevent the disease. Epidemiologic studies suggest that dietary factors such as the carotenoid lycopene, selenium, vitamin E, and high intake of fat have roles in prostate cancer risk. Several studies show that impairment of androgen synthesis lowers the risk of prostate cancer. 5-alpha-reductase inhibitors such as finasteride have been shown to decrease prostate size by decreasing androgenic stimulation ... Read More »
» Published in Rev Urol. 2002;4 Suppl 5:S11-7.
20. New approaches to the treatment of advanced prostate cancer.
Match Strength: 3.734
Several presentations by attendees of the 11th International Prostate Cancer Update addressed recent advances in prostate cancer treatment. A study that examined whether a relationship exists between neuroendocrine (NE) cell differentiation and hormone-refractory prostate cancer (HRPC) concluded that the appearance of NE cells in prostatic carcinoma is an important phenomenon in the development of HRPC. Exisuland, a selective apoptotic antineoplastic drug, was compared to placebo in a recent study and was found to significantly inhibit the increase of prostate-specific antigen in patients who ... Read More »
» Published in Rev Urol. 2001;3 Suppl 2:S69-78.
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