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Peer Reviewed Scientific Research Reports.
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1. Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebo-controlled study.
Match Strength: 4.720
PURPOSE: Previous reports have suggested that hormone replacement therapy (HRT) could increase seizure activity in women with epilepsy. We sought to determine whether adding HRT to the medication regimen of postmenopausal women with epilepsy was associated with an increase in seizure frequency. METHODS: This was a randomized, double-blind, placebo-controlled trial of the effect of HRT on seizure frequency in postmenopausal women with epilepsy, taking stable doses of antiepileptic drugs (AEDs), and within 10 years of their last menses. After a 3-month prospective baseline, subjects were ... Read More »
» Published in Epilepsia. 2006 Sep;47(9):1447-51.
2. Comparison of the effects of a new conjugated oral estrogen, estradiol-3beta-glucoside, with oral micronized 17beta-estradiol in postmenopausal women.
Match Strength: 4.487
The objective of this article is to evaluate the pharmacokinetics of serum estrone and estradiol levels in women who were taking either 17beta-estradiol-3beta-glucoside (E(2)-3beta-glucoside) or 17beta-estradiol (E(2)) daily and to examine the effects of E(2)-3beta-glucoside and E(2) on postmenopausal symptoms, gonadotropins, hepatic metabolism, and coagulation factors. Healthy postmenopausal women on estrogen who had undergone a hysterectomy were recruited. Subjects were randomly assigned to receive equivalent doses of either E(2)-3beta-glucoside or micronized E(2) for 28 days. ... Read More »
» Published in Transl Res. 2006 Oct;148(4):164-70.
3. Effects of carbamazepine and oxcarbazepine on the reproductive endocrine function in women with epilepsy.
Match Strength: 3.846
PURPOSE: The aim of the study was to compare the effects of carbamazepine (CBZ) and oxcarbazepine (OXC) on the reproductive endocrine function in women with epilepsy. OXC is a novel antiepileptic drug (AED), and the occurrence of reproductive dysfunction in women treated with OXC monotherapy for epilepsy has not been studied previously. METHODS: Thirty-five women with epilepsy were examined in the Department of Neurology at Oulu University Hospital. Sixteen patients were treated with CBZ monotherapy, and nineteen patients were treated with OXC monotherapy. The subjects were clinically examined ... Read More »
» Published in Epilepsia. 2006 Sep;47(9):1441-6.
4. Beta-blocker medication usage in older women after myocardial infarction.
Match Strength: 3.760
PURPOSE: The purpose of this study was to assess demographic characteristics of women prescribed beta-blocker (beta-blocker) medication and compare to those not using beta-blocker medication, and to determine if there are differences in depression and fatigue among women who used beta-blockers compared to nonusers 6-12 months after myocardial infarction (MI). DATA SOURCES: This was a descriptive cross-sectional study of 84 women (61 using beta-blockers and 23 not using beta-blockers) aged 65 and older who were 6-12 months post-MI. Women had their height and weight measured and completed a ... Read More »
» Published in J Am Acad Nurse Pract. 2006 Oct;18(10):463-70.
5. Fibrinolytic response to exercise in women using third-generation oral contraceptives.
Match Strength: 3.446
The use of oral contraceptives (OC) is associated with an increased risk of thrombosis, suggesting OC exert procoagulant and/or antifibrinolytic effects. Given that physical exercise physiologically leads to an activation of blood coagulation and fibrinolysis, this study tested the hypothesis that OC might compromise the fibrinolytic response to exercise. Fibrinolytic variables were measured in 10 women (24 +/- 2 years) using OC (a formulation containing 30 micro g ethinylestradiol and 150 micro g desogestrel) and in 11 women without OC (mean +/- SD, 27 +/- 3 years) before, during and after a ... Read More »
» Published in Blood Coagul Fibrinolysis. 2006 Oct;17(7):563-8.
6. Insulin resistance in pheochromocytoma improves more by surgical rather than by medical treatment.
Match Strength: 3.415
Pheochromocytoma, a neuroendocrine tumor, is often associated with hyperglycemia. To investigate the underlying pathogenetic mechanisms, five patients (3 women and 2 men, aged 49+/-2.5, mean+/-SD) with benign adrenal pheochromocytoma were studied with an oral glucose tolerance test (OGTT) and the euglycaemic clamp technique. They were studied preoperatively without taking any medication (stage I), after taking an alpha adrenergic receptor blocking agent (stage II), after taking both an alpha and a beta adrenergic receptor blocking agent (stage III), and after surgical removal of the tumor ... Read More »
» Published in Hormones (Athens). 2003 Jan-Mar;2(1):61-6.
7. Sensation seeking, self-esteem, and unprotected sex in college students.
Match Strength: 3.118
This descriptive correlational study examined the relationships of sexual sensation seeking, self-esteem, and self-efficacy in condom use, stages of change, and alcohol consumption to HIV risk-taking behaviors among college students. A total of 159 students completed an online survey in 2004. Instruments included the Sexual Sensation Seeking Scale, College Alcohol Problems Scale, Condom Use Scale, and Rosenberg Self-Esteem Scale. High sensation seekers had higher self-esteem, more self-efficacy in condom usage, fewer problems associated with alcohol consumption, and belonged to Greek ... Read More »
» Published in J Assoc Nurses AIDS Care. 2006 Sep-Oct;17(5):23-31.
8. Transforming growth factor-beta: taking control of T cells' life and death.
Match Strength: 2.914
To determine how transforming growth factor-beta (TGF-beta) controls T cell function, Marie et al. (2006) and Li et al. (2006a) created mice with T cells lacking TGF-beta signaling receptors. Both report that TGF-beta signaling by T cells is absolutely essential for tolerance and homeostasis. Publication Types: ... Read More »
» Published in Immunity. 2006 Sep;25(3):399-401. Comment on: Immunity. 2006 Sep;25(3):441-54., Immunity. 2006 Sep;25(3):455-71.
9. From differential display to DNA microarrays--a personal account.
Match Strength: 2.895
This article is a tribute to Dr. Arthur Pardee, one of the most innovative and brilliant scientists of our time, on the occasion of his 85th birthday. In this partially perspective and partially review piece, I look back how fate, by twist and turn, has led me eventually to his lab at Harvard where we worked out the Differential Display technology from scratch, how the method has revolutionized the field of gene expression analysis and where DD is taking us in the "era" of DNA microarrays. (c) 2006 Wiley-Liss, Inc. Publication Types: ... Read More »
» Published in J Cell Physiol. 2006 Dec;209(3):653-8.
10. Taking criticism.
Match Strength: 2.804
The manner in which criticism is dealt with is one of the important behaviors to master in a healthcare work environment: 1.) respond calmly, 2) use a problem solving approach, 3) avoid blaming others, 4) increase the complainers feelings of power, 4) increase feelings of power, 5) communicate respect, 6) do not respond to criticism with an e-mail, 7) forgive the complainer and not hold a grudge; and 8) let the buck stop as soon as possible, and 9) take criticism seriously. Dealing with criticism will never be easy. It just isn't! But using a reasoned approach will help, and get us back to why ... Read More »
» Published in J Pract Nurs. 2006 Summer;56(2):21-3; quiz 24-5.
11. Vaccination: an opportunity to enhance early adolescent preventative services.
Match Strength: 2.768
New vaccines are being developed that will be recommended for adolescents Adolescence is a time period when adolescent-parent dynamics change and when adolescents may be confronted with increasing opportunities to engage in risk-taking behaviors such as sexual behavior and substance use. Despite clear recommendations regarding preventative counseling, many adolescents do not receive adequate preventive care. In this manuscript, we provide suggestions as to how a new vaccination schedule can be used to enhance preventative services to both adolescents and their parents. Publication Types: ... Read More »
» Published in J Adolesc Health. 2006 Oct;39(4):461-4. Epub 2006 Jul 10.
12. Treatment of giant cell arteritis using induction therapy with high-dose glucocorticoids: a double-blind, placebo-controlled, randomized prospective clinical trial.
Match Strength: 2.720
OBJECTIVE: Glucocorticoid (GC) therapy for giant cell arteritis (GCA) is effective but requires prolonged administration, resulting in adverse side effects. The goal of the current study was to test the hypothesis that induction treatment with high-dose pulse intravenous (IV) methylprednisolone permits a shorter course of therapy. METHODS: Twenty-seven patients with biopsy-proven GCA were enrolled in a randomized, double-blind, placebo-controlled study to receive IV methylprednisolone (15 mg/kg of ideal body weight/day) or IV saline for 3 consecutive days. All patients were started on 40 mg ... Read More »
» Published in Arthritis Rheum. 2006 Oct;54(10):3310-8. Comment in: Arthritis Rheum. 2006 Oct;54(10):3071-4.
13. Functional rehabilitation and brain tumour patients. A review of outcome.
Match Strength: 2.491
The increasing prevalence of brain tumours and longer duration of survival achieved by recent advances in treatment prompt a critical analysis of the impact of functional rehabilitation on patients with brain tumours. In this review brain tumours and outcome of brain tumour patients are discussed from a rehabilitation perspective, taking into account not only life expectancy but also the direct and indirect causes of functional impairment. Results of functional rehabilitation and factors involved in its effectiveness are presented and analysed to serve as a basis to neurologists involved in ... Read More »
» Published in Neurol Sci. 2006 Sep;27(4):240-4.
14. Increased bacterial burden and infection: the story of NERDS and STONES.
Match Strength: 2.477
PURPOSE: The purpose of this article is to provide practitioners with an overview of wound infection/inflammation and bacterial balance and to offer a guide to assessment and treatment of chronic wounds. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses who assess and treat wound infections. OBJECTIVES: After reading this article and taking this test, the participant should be able to: 1. Discuss factors associated with infection of the chronic wound, including the concept of bacterial balance and burden. 2. Identify signs of infection in the chronic ... Read More »
» Published in Adv Skin Wound Care. 2006 Oct;19(8):447-61; quiz 461-3.
15. The incorporation of nucleoside analogs by human immunodeficiency virus type 1 reverse transcriptase decreases in the presence of polyamines.
Match Strength: 2.454
Nucleoside analogs (NAs) are an important class of anti-retroviral compounds used against human immunodeficiency virus (HIV). We have analyzed the potential effect of polyamines on the incorporation of NAs during DNA synthesis by HIV type-1 (HIV-1) reverse transcriptase (RT). The polyamines exert the ability to decrease the incorporation of various dideoxynucleoside triphosphates (ddATP, ddTTP or ddCTP) with both RNA/DNA and DNA/DNA substrates in the following order: spermine>spermidine>putrescine. The reduction is a sequence-independent effect, taking place at different sequence context ... Read More »
» Published in FEBS Lett. 2006 Oct 2;580(22):5363-70. Epub 2006 Sep 11.
16. Teleradiology in Singapore--taking stock and looking ahead.
Match Strength: 2.450
Teleradiology will have a significant impact on the delivery of healthcare and the practice of medicine. In order to ensure a positive outcome, the expected benefits, limitations and potential pitfalls of teleradiology must be carefully considered. For Singapore, teleradiology can be used to facilitate a quantum leap in the standards of radiological services. This can be achieved through the development of an integrated, nationwide, high-speed radiology network which will allow patients to have access to high-quality and responsive subspecialty radiology expertise located throughout the ... Read More »
» Published in Ann Acad Med Singapore. 2006 Aug;35(8):552-6.
17. G quadruplex-based FRET probes with the thrombin-binding aptamer (TBA) sequence designed for the efficient fluorometric detection of the potassium ion.
Match Strength: 2.383
The dual-labeled oligonucleotide derivative, FAT-0, carrying 6- carboxyfluorescein (FAM) and 6-carboxytetramethylrhodamine (TAMRA) labels at the 5' and 3' termini of the thrombin-binding aptamer (TBA) sequence 5'-GGT TGG TGT GGT TGG-3', and its derivatives, FAT-n (n=3, 5, and 7) with a spacer at the 5'-end of a TBA sequence of T(m)A (m=2, 4, and 6) have been designed and synthesized. These fluorescent probes were developed for monitoring K(+) concentrations in living organisms. Circular dichroism, UV-visible absorption, and fluorescence studies revealed that all FAT-n probes could form ... Read More »
» Published in Chembiochem. 2006 Nov;7(11):1730-7.
18. The analyst's countertransference to the psychoanalytic process.
Match Strength: 2.383
There is countertransference, not just to individual patients, but to the process of psychoanalysis itself. The analytic process is a contentious topic. Disagreements about its nature can arise from taking it as a unitary concept that should have a single definition whereas, in fact, there are several strands to its meaning. The need for the analyst's free associative listening, as a counterpart to the patient's free associations, implies resistance to the analytic process in the analyst as well as the patient. The author gives examples of the self-analysis that this necessitates. The most ... Read More »
» Published in Int J Psychoanal. 2006 Oct;87(Pt 5):1183-98.
19. Heritable and environmental components in cervical tumors.
Match Strength: 2.281
The familial risk of 18,199 women with invasive and/or in situ cervix cancers when compared with that of 72,796 women free of cervical tumors was analyzed. The risk of cervical tumors was significantly higher for women with a mother and/or sister(s) with cervical tumors (odds ratio (OR) = 1.79, 95% CI: 1.71-1.88) than with an affected grandmother and/or aunt(s) (OR = 1.28, 1.22-1.35). This risk did not differ according to the family side of the affected relative. Taking the familial risk of 1.28 for second-degree relatives as the best estimate of a true heritable effect for 25% of gene sharing ... Read More »
» Published in Int J Cancer. 2006 Dec 1;119(11):2699-701.
20. The genomics of new drugs in sickle cell disease.
Match Strength: 2.234
The quality of life of patients with sickle cell disease in developed countries has improved significantly over the past two decades. Currently available measures to prevent the painful crises and the complications of the disease include the use of penicillin prophylaxis, antipneumonococcal vaccine, folate administration, chronic red cell transfusions in patients with cerebrovascular disease, iron chelating agents, fetal hemoglobin-enhancing agents, such as hydroxyurea, decitabine and butyrate, drugs that augment the endogenous nitric oxide levels and agents that restore red cell dehydration. ... Read More »
» Published in Pharmacogenomics. 2006 Sep;7(6):909-17.
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