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Peer Reviewed Scientific Research Reports.
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1. Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre.
Match Strength: 7.038
The effect of daily administration of oligofructose (OF) on 7-19 months old healthy children intestinal microflora, intestinal tolerance and well-being was assessed in a double blind placebo controlled study. The study comprised 8 days of observation, 21 days of supplementation, and 15 days of post-supplementation. Exclusion criteria included antibiotic use and intake of other prebiotic and probiotic at any time following enrolment. Faecal flora was analysed by culture methods, and health information was recorded daily. Bifidobacteria, tended to slightly increase with OF supplementation, but ... Read More »
» Published in Int J Food Microbiol. 2007 Jan 1;113(1):108-13. Epub 2006 Sep 22.
2. Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials.
Match Strength: 5.551
OBJECTIVES: To assess the effectiveness of calcium supplementation for improving bone mineral density in healthy children and to determine if any effect is modified by other factors and persists after supplementation stops. DESIGN: Meta-analysis. DATA SOURCES: Electronic bibliographic databases, hand searching of conference proceedings, and contacting authors for unpublished data. REVIEW METHODS: We included randomised placebo controlled trials of calcium supplementation in healthy children that lasted at least three months and had bone outcomes measured after at least six months of follow-up. ... Read More »
» Published in BMJ. 2006 Oct 14;333(7572):775. Epub 2006 Sep 15. Comment in: BMJ. 2006 Oct 14;333(7572):763-4.
3. Effect of soluble fiber or fructooligosaccharide supplementation upon trinitrobenzenesulphonic acid induced colitis in rats.
Match Strength: 5.387
PURPOSE: To evaluate the effect of soluble fiber or fructooligosaccharide (FOS) supplementation upon trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats. METHODS: 64 Wistar rats were given water, soluble fiber or FOS intragastrically during 14 days prior to colitis induction with TNBS (n=48) or rectal enema with water (n=16; control group). On the 7th or 14th day following colitis induction the rats were weighed and euthanized in order to determine the colon weight/length ratio and macroscopic and microscopic scores. RESULTS: On the 7th day following colitis induction the body weight ... Read More »
» Published in Acta Cir Bras. 2006 Sep-Oct;21(5):315-20.
4. Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal.
Match Strength: 5.334
The natural vitamin E tocotrienol (TCT) possesses biological properties not shared by tocopherols (TCP). Nanomolar alpha-TCT, not alpha-TCP, is potently neuroprotective (JBC 275:13049; 278:43508; Stroke 36:2258). The report that the affinity of TTP to bind (alpha-TCT is an order of magnitude lower than that for alpha-TCP questions the bioavailability of orally taken TCT to tissues. Oral supplementation of TCT for 3 years in nine generations of female and male rat was studied. Ten vital organs were examined. To gain insight into the turnover of alpha-TCT in tissues, a subset of supplemented ... Read More »
» Published in Free Radic Res. 2006 Jul;40(7):763-71.
5. Androgen supplementation and prostate cancer risk: strategies for pretherapy assessment and monitoring.
Match Strength: 4.810
Since in men androgen levels decrease with age and result in symptoms of hypogonadism, the use of testosterone supplementation to treat symptoms resulting from hypogonadism is increasing. One potential complication of this treatment is the possibility of an increased risk of prostate cancer. Although most authorities agree that androgen is involved in the exacerbation of existing carcinoma of the prostate, the action of androgens on the carcinogenic process is not well understood. Attempts to demonstrate a correlation between hormone levels and prostate cancer have yielded inconsistent results ... Read More »
» Published in Rev Urol. 2003;5 Suppl 1:S29-33.
6. Intravenous glutamine supplementation to head trauma patients leaves cerebral glutamate concentration unaffected.
Match Strength: 4.747
OBJECTIVE: There is reluctance to use glutamine-containing i.v. nutrition for neurosurgical patients, as this may result in elevated intracerebral glutamate levels, which are thought to be associated with neuronal injury and cell swelling, causing an increase in ICP and an unfavourable outcome. As general ICU patients benefit from i.v. glutamine supplementation in terms of reduced mortality and morbidity, neurosurgical patients might also be candidates for such treatment, if the possible relation between i.v. glutamine supplementation and a possible increase in cerebral glutamate could be ... Read More »
» Published in Intensive Care Med. 2006 Nov;32(11):1741-6. Epub 2006 Sep 23.
7. Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
Match Strength: 4.709
The impact of vitamin A supplementation on childhood diarrhea may be determined by the regulatory effect supplementation has on the mucosal immune response in the gut. Previous studies have not addressed the impact of vitamin A supplementation on the production of monocyte chemoattractant protein 1 (MCP-1), an essential chemokine involved in pathogen-specific mucosal immune response. Fecal MCP-1 concentrations, determined by an enzyme-linked immuno absorption assay, were compared among 127 Mexican children 5-15 mo of age randomized to receive a vitamin A supplement (<12 mo of age, 20,000 IU ... Read More »
» Published in J Nutr. 2006 Oct;136(10):2600-5.
8. Effect of ionophore supplementation on the incidence of Escherichia coli O157:H7 and Salmonella and antimicrobial susceptibility of fecal coliforms in Stocker cattle.
Match Strength: 4.646
To examine the effect of ionophore supplementation on fecal shedding of Escherichia coli O157:H7 and Salmonella, crossbred beef calves (n=113; mean body weight [BW], 243 kg) were fed a mineral supplement with ionophore (1.76 g lasalocid/kg) for 61 days (d). Control calves received an identical mineral supplement without lasalocid. Calves were pastured on fescue/bermudagrass paddocks and supplemented with a corn/wheat midds/soybean meal supplement (1.5% of BW/d). Upon arrival, cattle were fed a commercial receiving ration containing 1 g chlorotetracycline/kg for 10 d. Sick calves were ... Read More »
» Published in Foodborne Pathog Dis. 2006 Fall;3(3):284-91.
9. Improvement in human semen quality after oral supplementation of vitamin C.
Match Strength: 4.636
This study was carried out to monitor the effect of oral supplementation of vitamin C on various semen parameters in oligospermic, infertile, otherwise healthy individuals. Various semen parameters, including sperm motility, sperm count, and sperm morphology, were studied before and after the vitamin C treatment. A total of 13 infertile patients were included. Their ages ranged between 25 and 35 years. They had no genital infection or varicocele. Physical examination and other routine laboratory investigations were normal. General semen analysis revealed oligozoospermia (mean sperm count was ... Read More »
» Published in J Med Food. 2006 Fall;9(3):440-2.
10. Beneficial effects of docosahexaenoic acid on active avoidance performance in 1K-1C hypertensive rats.
Match Strength: 4.459
The present study evaluated the role of chronic docosahexaenoic acid (DHA) supplementation on active avoidance learning task performance in experimental hypertension. Male Wistar rats were randomly divided into five experimental groups as follows: control, sham, DHA treated, 1K-1C hypertensive, and 1K-1C hypertensive+DHA treated. Hypertension was induced in 1K-1C rats via placing a silver clip (0.20-mm ID) around the left renal artery following a right uninephrectomy. DHA (36 mg/kg/day) was given to the treatment groups for 60 days by gastric gavage. Arterial blood pressure was measured by ... Read More »
» Published in Neurobiol Learn Mem. 2007 Jan;87(1):159-65. Epub 2006 Sep 18.
11. OC8 Effect of Progesterone Supplementation During Early Foetal Period in Neospora caninum Seropositive Dairy Cows.
Match Strength: 4.266
Neospora caninum infection is a major risk factor for abortion in cattle. The aim of this study was to evaluate the influence of progesterone supplementation from days 35 to 63 of gestation on abortion in 351 N. caninum seropositive dairy cows. Animals were assigned randomly to Treatment (n = 180), receiving progesterone with an intravaginal device (PRID) fitted at pregnancy diagnosis (day 35), or to Control group (n = 171). Total abortions were similar for both groups (30% vs 29% for the Control and Treatment group, respectively). Logistic regression procedures were performed using abortion ... Read More »
» Published in Reprod Domest Anim. 2006 Oct;41 Suppl 2:104.
12. Fatty acids and coccidiosis: effects of dietary supplementation with different oils on coccidiosis in chickens.
Match Strength: 4.152
This study was undertaken to investigate the effects of dietary oils on coccidiosis of chickens infected with Eimeria tenella. Five hundred and four 1-day-old male Arbor Acres chicks were randomly assigned to seven groups. Seven diets were supplemented with poultry oil at 25 and 45 g/kg, corn oil at 25 and 45 g/kg, fish oil at 25 and 45 g/kg, and without oils, respectively, from 1 to 42 days of age. Chickens were inoculated by gavage with 3 x 10(5) sporulated oocysts at 21 days of age. Diets supplemented with oils at 45 g/kg resulted in higher body weight gain than with oils at 25 g/kg or ... Read More »
» Published in Avian Pathol. 2006 Oct;35(5):373-8.
13. Luteal hormonal profile of oocyte donors stimulated with a GnRH antagonist compared with natural cycles.
Match Strength: 3.828
The effect of gonadotrophin-releasing hormone (GnRH) antagonist treatment on luteal phase hormonal profile has not yet been fully investigated. Cycle characteristics of 23 fertile donors stimulated with recombinant FSH and the GnRH antagonist, ganirelix 0.25, for IVF and receiving no kind of luteal supplementation were compared with control, natural cycles. Luteal luteinizing hormone (LH) serum concentrations as well area under the curve (AUC) for LH were significantly higher in natural cycles. In addition, luteal phase length was longer in natural cycles compared with donor cycles. ... Read More »
» Published in Reprod Biomed Online. 2006 Sep;13(3):326-30.
14. Effects of L-arginine oral supplements in pregnant spontaneously hypertensive rats.
Match Strength: 3.470
PURPOSE: To evaluate the effects of L-arginine oral supplementation in spontaneously hypertensive pregnant rats (SHR). METHODS: Thirty SHR and ten Wistar-EPM-1 virgin female rats were used in the study. Before randomization, females were caged with males of the same strain (3:1). Pregnancy was confirmed by sperm-positive vaginal smear (Day 0). Wistar-EPM-1 rats served as counterpart control (C-1). SHR rats were randomized in 4 groups (n=10): Group Control 2, non-treated rats; Group L-Arginine treated with L-arginine 2%; Group Alpha-methyldopa treated with Alpha-methyldopa 33 mg/Kg; Group L ... Read More »
» Published in Acta Cir Bras. 2006 Sep-Oct;21(5):291-5.
15. Genomic-independent action of thyroid hormones on NTPDase activities in Sertoli cell cultures from congenital hypothyroid rats.
Match Strength: 3.462
The Sertoli cells play an essential role in the maintenance and control of spermatogenesis. The ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) and 5'-nucleotidase activities can modulate the extracellular adenine nucleotide levels, controlling nucleotide-mediated signaling events in Sertoli cells. Since thyroid hormones (TH) and adenine nucleotides and nucleosides play important modulatory roles in Sertoli cell proliferation and differentiation, the aim of our study was to investigate the effect of hypothyroidism upon the NTPDase and 5'-nucleotidase activities in Sertoli cell ... Read More »
» Published in Life Sci. 2006 Dec 3;80(1):51-8. Epub 2006 Aug 23.
16. Antioxidant micronutrients in major trauma and burns: evidence and practice.
Match Strength: 3.431
There has been a growing interest in micronutrients as a result of their essential role in endogenous antioxidant defense mechanisms and immunity. Critically ill burn and trauma patients are characterized by an increased free radical production, which is proportional to the severity of the injury. In addition, they are at high risk of negative trace element balances, which contribute to the imbalance in endogenous antioxidant capacity and the extension of primary lesions. Although selenium, zinc, and vitamin C and E status are altered in all injured patients, patients with major burns are ... Read More »
» Published in Nutr Clin Pract. 2006 Oct;21(5):438-49.
17. A double-blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm-endemic area of Peru.
Match Strength: 3.393
OBJECTIVE: To assess the effect on birthweight of antenatal mebendazole plus iron vs. placebo plus iron in a highly hookworm-endemic area. METHODS: Double-blind, randomized controlled trial set in rural and peri-urban communities in the Peruvian Amazon region. A total of 1042 second trimester pregnant women between the ages of 18 and 44 years were recruited from April to November 2003, and followed to July 2004. Women were randomly assigned to receive either mebendazole (500 mg single dose) plus iron supplements (60 mg elemental iron daily) or placebo plus iron supplements. The primary outcome ... Read More »
» Published in Trop Med Int Health. 2006 Oct;11(10):1485-95.
18. Effect of a metabolically created systemic acidosis on calcium homeostasis and the diurnal variation in urine pH in the non-lactating pregnant dairy cow.
Match Strength: 3.353
Reducing the dietary cation-anion difference (DCAD) has been shown to be an effective means of preventing parturient paresis in confinement systems where cows are offered a total mixed ration containing DCAD-reducing mineral compounds (anionic salts). Such a supplementation strategy is not possible in cows being group fed forages precalving, and little is known about the effect of supplementing these cows with large amounts of anionic salts twice daily.Eight non-lactating, pregnant Holstein-Friesian cows were allocated to two levels of DCAD (-20 and +18 meq/100 g DM) for 24 d, with an ... Read More »
» Published in J Dairy Res. 2006 Sep 15;:1-6
19. Role of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats.
Match Strength: 3.352
Polychlorinated biphenyls (PCB) are widespread, lipophilic environmental pollutants which have been identified as contaminants in almost every component of the global ecosystem including fish, wildlife, and human adipose tissue, breast milk, and serum. Several studies have shown that PCBs can cause oxidative damage to biomolecules, in the form of lipid peroxidation, modulation of antioxidant enzymes, and oxidative stress. In the present study, we have sought to investigate the effects of alpha-tocopherol (vitamin E) on antioxidant status of PCB-induced toxicity in male Wistar rats. The ... Read More »
» Published in Food Chem Toxicol. 2006 Dec;44(12):2040-6. Epub 2006 Aug 10.
20. Analysis of morbidity in liver transplant recipients following human albumin supplementation: a retrospective pilot study.
Match Strength: 3.294
OBJECTIVES: To assess incidence of morbidity (i.e., documented infection, acute renal failure, acute graft rejection, acute cardiovascular events, and hospital readmission rates) 6 months following liver transplantation using linear regression as a function of cumulative albumin dose. DESIGN: Retrospective chart review. SETTING: A 473-bed tertiary care teaching facility with a solid-organ transplantation center. PATIENTS: Forty liver transplant recipients examined from January 1 to December 31, 2003. MEASUREMENTS AND RESULTS: Data from 40 liver transplant recipients were collected. Mean ... Read More »
» Published in Prog Transplant. 2006 Sep;16(3):197-205.
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