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Peer Reviewed Scientific Research Reports.
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1. School vending machine use and fast-food restaurant use are associated with sugar-sweetened beverage intake in youth.
Match Strength: 5.882
OBJECTIVE: To examine associations between use of school vending machines and fast-food restaurants and youth intake of sugar-sweetened beverages. DESIGN: A cross-sectional observational study. SUBJECTS/SETTING: From a group randomized obesity intervention, we analyzed baseline data from 1,474 students in 10 Massachusetts middle schools with vending machines that sold soda and/or other sweetened drinks. MAIN OUTCOME MEASURES: Daily sugar-sweetened beverage consumption (regular soda, fruit drinks, and iced tea), purchases from school vending machines, and visits to fast-food restaurants in the ... Read More »
» Published in J Am Diet Assoc. 2006 Oct;106(10):1624-30.
2. Influence of glyphosate on Rhizoctonia and Fusarium root rot in sugar beet.
Match Strength: 5.855
This study tests the effect of glyphosate application on disease severity in glyphosate-resistant sugar beet, and examines whether the increase in disease is fungal or plant mediated. In greenhouse studies of glyphosate-resistant sugar beet, increased disease severity was observed following glyphosate application and inoculation with certain isolates of Rhizoctonia solani Kuhn and Fusarium oxysporum Schlecht. f. sp. betae Snyd. & Hans. Significant increases in disease severity were noted for R. solani AG-2-2 isolate R-9 and moderately virulent F. oxysporum isolate FOB13 on both cultivars ... Read More »
» Published in Pest Manag Sci. 2006 Dec;62(12):1182-92.
3. Consumption of soft drinks and hyperactivity, mental distress, and conduct problems among adolescents in Oslo, Norway.
Match Strength: 4.643
OBJECTIVES: We examined whether high levels of consumption of sugar-containing soft drinks were associated with mental distress, hyperactivity, and conduct problems among adolescents. METHODS: A cross-sectional population-based survey was conducted with 10th-grade students in Oslo, Norway (n = 5498). We used the Hopkins Symptom Checklist and the Strengths and Difficulties Questionnaire to assess mental health outcomes. RESULTS: There was a J-shaped dose-response relationship between soft drink consumption and mental distress, conduct problems, and total mental health difficulties score; that ... Read More »
» Published in Am J Public Health. 2006 Oct;96(10):1815-20.
4. Electrochemical determination of sugars by use of multilayer thin films of ferrocene-appended glycogen and concanavalin A.
Match Strength: 4.509
Multilayer thin films containing concanavalin A (Con A) and ferrocene-appended glycogen (FcGly) were prepared by a layer-by-layer deposition Con A and FcGly by biological affinity (lectin-sugar interaction) on a glassy-carbon electrode. The electrochemical response of the Con A-FcGly film-coated electrode to sugars was investigated. A cyclic voltammogram (CV), typical of redox species confined to the surface of the electrode, was obtained. The peak current (resulting from the electric charge involved in the redox reaction) in the CV from the electrode decreased on addition of sugars in the ... Read More »
» Published in Anal Bioanal Chem. 2006 Nov;386(6):1899-904. Epub 2006 Sep 27.
5. Gas phase noncovalent protein complexes that retain solution binding properties: Binding of xylobiose inhibitors to the beta-1, 4 exoglucanase from cellulomonas fimi.
Match Strength: 4.496
Tandem mass spectrometry has been used to compare gas-phase and solution binding of three small-molecule inhibitors to the wild type and three mutant forms of the catalytic domain of Cex, an enzyme that hydrolyses xylan and xylo-oligosaccharides. The inhibitors, xylobiosyl-deoxynojirimycin, xylobiosyl-isofagomine lactam, and xylobiosyl-isofagomine consist of a common distal xylose linked to different proximal aza-sugars. The three mutant forms of the enzyme contain the substitutions Asn44Ala, Gln87Met, and Gln87Tyr that alter the binding interactions between Cex and the distal sugar of each ... Read More »
» Published in J Am Soc Mass Spectrom. 2007 Jan;18(1):64-73. Epub 2006 Sep 26.
6. Anthocyanin absorption and antioxidant status in pigs.
Match Strength: 4.496
The effect of a simultaneous intake of food or flavonoids on anthocyanins absorption and antioxidant status in pigs was investigated. Twelve male pigs at 27.1 +/- 0.7 kg BW fitted with jugular venous cannulae were maintained in individual metabolic crates. The animals were each given one of three dietary treatments in random order: blackcurrant powder (BC) to give a dose of 100 mg total ACNs/kg BW mixed either with water and sugar (Diet A), cereal (Weet-Bix), milk, and sugar (Diet B), or cereal, milk, sugar, and an additional flavonol (rutin, approximately 100 mg/kg BW) (Diet C). The four ... Read More »
» Published in J Agric Food Chem. 2006 Oct 4;54(20):7940-6.
7. A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.
Match Strength: 4.251
The fruA gene of Streptococcus mutans encodes for a secreted fructan hydrolase (fructanase), an established virulence determinant required for releasing D-fructose from levan- and inulin-type fructans. Expression of fruA is under the control of carbon catabolite repression and is induced by growth in fructans. In this report, we identified an operon in S. mutans UA159 encoding a two-component system flanked by two predicted carbohydrate-binding proteins that is absolutely required for the expression of fruA. All four genes were found to be required for optimal growth of S. mutans on inulin ... Read More »
» Published in Mol Microbiol. 2006 Oct;62(1):187-200.
8. Nucleotide-sugar transporters: structure, function and roles in vivo.
Match Strength: 4.008
The glycosylation of glycoconjugates and the biosynthesis of polysaccharides depend on nucleotide-sugars which are the substrates for glycosyltransferases. A large proportion of these enzymes are located within the lumen of the Golgi apparatus as well as the endoplasmic reticulum, while many of the nucleotide-sugars are synthesized in the cytosol. Thus, nucleotide-sugars are translocated from the cytosol to the lumen of the Golgi apparatus and endoplasmic reticulum by multiple spanning domain proteins known as nucleotide-sugar transporters (NSTs). These proteins were first identified ... Read More »
» Published in Braz J Med Biol Res. 2006 Sep;39(9):1149-58.
9. Mutational analysis of the Medicago glycosyltransferase UGT71G1 reveals residues that control regioselectivity for (iso)flavonoid glycosylation.
Match Strength: 3.850
The plant glycosyltransferase UGT71G1 from the model legume barrel medic (Medicago truncatula) glycosylates flavonoids, isoflavonoids, and triterpenes. It can transfer glucose to each of the five hydroxyl groups of the flavonol quercetin, with the 3'-O-glucoside as the major product, and to the A-ring 7-hydroxyl of the isoflavone genistein. The sugar donor and acceptor binding pockets are located in the N and C termini, respectively, of the recently determined crystal structure of UGT71G1. The residues forming the binding pockets of UGT71G1 were systematically altered by site-directed ... Read More »
» Published in J Biol Chem. 2006 Nov 10;281(45):34441-7. Epub 2006 Sep 18.
10. Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes.
Match Strength: 3.739
N-acetylglucosaminyltransferase (GnT)-IV catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-glycans. Two human GnT-IV isozymes (GnT-IVa and GnT-IVb) had been identified, which exhibit different expression profiles among human tissues and cancer cell lines. To clarify the enzymatic properties of the respective enzymes, their kinetic parameters were determined using recombinant full-length enzymes expressed in COS7 cells. The K (m) of human GnT-IVb for UDP-GlcNAc was estimated to be 0.24 mM, which is 2-fold higher than that of human ... Read More »
» Published in Glycoconj J. 2006 Nov;23(7-8):473-80.
11. Structure of an AAGU tetraloop and its contribution to substrate selection by yeast RNase III.
Match Strength: 3.545
RNase III enzymes are a highly conserved family of proteins that specifically cleave double-stranded RNA (dsRNA). These proteins are involved in a variety of cellular functions, including the processing of many non-coding RNAs, mRNA decay, and RNA interference. In yeast Rnt1p, a dsRNA-binding domain (dsRBD) recognizes its substrate by interacting with stems capped with conserved AGNN tetraloops. The enzyme uses the tetraloop to cut 14nt to 16nt away into the stem in a ruler-like mechanism. The solution structure of Rnt1p dsRBD complexed to one of its small nucleolar (sno) RNA substrate ... Read More »
» Published in J Mol Biol. 2006 Oct 20;363(2):322-31. Epub 2006 Aug 16.
12. Hydro-MRI of the small bowel: effect of contrast volume, timing of contrast administration, and data acquisition on bowel distention.
Match Strength: 3.499
OBJECTIVE: The purpose of this study was to assess oral contrast agents, volumes of the agents, and time points of data acquisition in regard to small-bowel distention and patient acceptance. SUBJECTS AND METHODS: Six healthy volunteers underwent imaging on 16 different days. Four volumes (450, 900, 1,350, and 1,800 mL) of each of the four contrast compounds (0.2% locust bean gum plus 2.5% mannitol, VoLumen containing 2.0% sorbitol, VoLumen containing 1.4% sorbitol, and tap water) were used. Two-dimensional true fast imaging with steady-state free precession data sets were acquired at 5-minute ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):W375-85.
13. Polyhydroxylated homoazepanes and 1-deoxy-homonojirimycin analogues: Synthesis and glycosidase inhibition study.
Match Strength: 3.438
The Johnson-Claisen rearrangement of D-gluco and L-ido-derived allylic orthoesters afforded gamma,delta-unsaturated ester that on ester reduction, epoxidation, regioselective oxirane opening by sodium azide and hydrogenation led to sugar amino alcohols--immediate precursors for 1-deoxy-homonojirimycin 3a,b, and polyhydroxylated homoazepanes 4a,b. Our synthetic approach and glycosidase inhibitory activity is reported. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Org Biomol Chem. 2006 Oct 7;4(19):3675-80. Epub 2006 Aug 22.
14. Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents.
Match Strength: 3.243
The synthesis of a new class of 9-(S)-dihydroerythromycin derivatives and their anti-inflammatory activity on in vivo PMA assay are described. Modifying the desosamine sugar on the C-3' amino group, it was possible to differentiate between anti-biotic and anti-inflammatory action. The compounds are completely devoid of anti-microbial effects but their anti-inflammatory properties are enhanced. These results strongly suggest the potential of macrolides as a new class of anti-inflammatory agents ... Read More »
» Published in Bioorg Med Chem Lett. 2006 Nov 15;16(22):5801-4. Epub 2006 Sep 18.
15. A diet quality index for American preschoolers based on current dietary intake recommendations and an indicator of energy balance.
Match Strength: 3.164
OBJECTIVE: Based on current dietary intake recommendations and a recommendation to limit sedentary activity in preschoolers, an overall diet quality index for preschoolers (RC-DQI) incorporating a component for energy balance to measure adequacy of nutrition for growth, development, and disease prevention was developed. DESIGN/SUBJECTS: The newly developed index was used in nationally representative samples of 2- to 5-year-olds in the US Department of Agriculture Continuing Survey of Food Intakes by Individuals 1994-96 and 1998 (n=5,437). Index components included added sugar, total fat, ... Read More »
» Published in J Am Diet Assoc. 2006 Oct;106(10):1594-604. Comment in: J Am Diet Assoc. 2006 Oct;106(10):1533.
16. Access to piperidine imino-C-glycosides via stereoselective thiazole-based aminohomologation of pyranoses.
Match Strength: 2.971
The access to piperidine homoazasugars (dideoxyiminoheptitols) from pyranoses via formal one-carbon chain elongation and exchange of the ring oxygen with the NH group is described. The key process involves the stereoselective addition of 2-thiazolylmagnesium bromide to an N-glycosylhydroxylamine, i.e., a hidden open-chain sugar nitrone. The N-thiazolylalkylhydroxylamine formed in this way is reduced to amine, and this transformed into a substituted piperidine via intramolecular cyclization by an S(N)2 process. Cleavage of the thiazole residue attached to C2 of the piperidine ring reveals the ... Read More »
» Published in J Org Chem. 2006 Sep 29;71(20):7574-82.
17. Expression of rice acyl-CoA oxidase isoenzymes in response to wounding.
Match Strength: 2.805
To elucidate the role of acyl-CoA oxidase (ACX; EC 184.108.40.206) in plants, the expression patterns of rice ACXs in response to wounding were characterized. Three isogenes of ACX were identified in the rice genome. The deduced proteins of OsACX1, OsACX2 and OsACX3 consist of 669, 699 and 685 amino acid residues, respectively. The results from reverse transcriptase-PCR indicate that OsACX1 is expressed in leaves, stems, and roots, but was barely detectable in germinating seeds. OsACX2 was expressed predominantly in seeds. Only OsACX1 was upregulated by wounding, both locally and systemically. The ... Read More »
» Published in J Plant Physiol. 2006 Sep 23;
18. High molecular weight melanoidins from coffee brew.
Match Strength: 2.516
The composition of high molecular weight (HMw) coffee melanoidin populations, obtained after ethanol precipitation, was studied. The specific extinction coefficient (K(mix)) at 280, 325, 405 nm, sugar composition, phenolic group content, nitrogen content, amino acid composition, and non-protein nitrogen (NPN) content were investigated. Results show that most HMw coffee melanoidins are soluble at high ethanol concentrations. The amino acid composition of the HMw fractions was similar, while 17% (w/w) of the nitrogen was NPN, probably originating from degraded amino acids/proteins and now part ... Read More »
» Published in J Agric Food Chem. 2006 Oct 4;54(20):7658-66.
19. Effects of treatment for diabetes mellitus on circulating vascular progenitor cells.
Match Strength: 2.456
The circulating endothelial progenitor cells (EPCs) have an important role in angiogenesis, and the smooth muscle progenitor cells (SMPCs) participate in atherosclerosis. However, little is known about the effects of treatment of diabetes mellitus (DM) on EPCs and SMPCs. Therefore, we investigated the relations between the number of circulating vasucular progenitor cells before and after the treatment for DM. Ten previously untreated DM patients were enrolled in this study. Blood samples were collected before and after treatment. The peripheral mononuclear cells were purified and cultured to ... Read More »
» Published in J Pharmacol Sci. 2006 Sep;102(1):96-102.
20. Lectin binding in the ependymal cells of the cephalic portion of the nervous system in the chick embryo.
Match Strength: 2.414
The content, distribution and changes of the glycoconjugates oligosaccharides in the ependymal cells of the cephalic portion of the nervous system, in the chick embryo from 5 days of incubation till hatching and in the 3 days old chicken, were investigated. For this purpose a battery of six HRP-conjugated lectins were used (WGA, SBA, UEA I, LTA, PNA, ConA). Enzyme and chemical treatments were performed on some sections prior to staining with HRP-lectins. Our findings showed a large amount of all the investigated sugar residues at the apical portion of the ependymal cells, for the whole ... Read More »
» Published in Ital J Anat Embryol. 2006 Apr-Jun;111(2):83-96.
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