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Peer Reviewed Scientific Research Reports.
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1. The Great Lakes Regional Stroke Network experience.
Match Strength: 7.117
Stroke is a leading cause of disability and the third leading cause of death among adults in the United States and in the Great Lakes states of Illinois, Indiana, Michigan, Minnesota, Ohio, and Wisconsin. The Great Lakes Regional Stroke Network was created to enhance collaboration and coordination among the Great Lakes states to reduce the burden of stroke and stroke-related disparities associated with race, sex, and geography. Three priorities were identified for reducing the effects of stroke in the Great Lakes region: 1) build epidemiologic capacity to improve stroke prevention and control ... Read More »
» Published in Prev Chronic Dis. 2006 Oct;3(4):A128. Epub 2006 Sep 15.
2. Experimental model of hemorrhagic stroke: rabbit immunization with HL-60 promyelocytic cell differentiation factor.
Match Strength: 6.926
Rabbits immunized with synthetic HLDF differentiation factor developed hemorrhagic stroke with thrombosis of small cerebral vessels and destruction of vascular endotheliocytes. The severity of stroke correlated with serum level of antibodies to differentiation factor. The role of different sites of HLDF molecule in the induction of clinical signs of hemorrhagic stroke was studied ... Read More »
» Published in Bull Exp Biol Med. 2006 Feb;141(2):272-4.
3. Temporal patterns of body temperatures in the acute stage of stroke.
Match Strength: 6.749
OBJECTIVE: The present study aimed to describe the day-by-day temporal patterns of body temperatures in acute stroke and to delineate the differences in serial daily changes in body temperatures between intracerebral hemorrhage (ICH) and cerebral infarct (CI). METHODS: We retrospectively enrolled 90 patients (32 with ICH and 58 with CI), admitted within 12 hours after the onset of stroke. Body temperatures were measured as the tympanic temperatures during the initial 6 days of hospitalization. Patients with clinical infections were excluded. The severity of stroke was assessed by Scandinavian ... Read More »
» Published in Acta Neurol Taiwan. 2006 Sep;15(3):177-83.
4. Future costs of stroke in the Netherlands: the impact of stroke services.
Match Strength: 6.650
OBJECTIVES: In the next decades, the number of stroke patients is expected to increase. Furthermore, organizational changes, such as stroke services, are expected to be implemented on a large scale. The purpose of this study is to estimate the future healthcare costs by taking into account the expected increase of stroke patients and a nationwide implementation of stroke services. METHODS: By means of a dynamic multistate life table, the total number of stroke patients can be projected. The model calculates the annual number of patients by age and gender. The total healthcare costs are ... Read More »
» Published in Int J Technol Assess Health Care. 2006 Fall;22(4):518-24.
5. Changes of brachial flow-mediated vasodilation in different ischemic stroke subtypes.
Match Strength: 6.433
The relationship between endothelial dysfunction and stroke subtypes is unclear. We prospectively measured brachial flow-mediated vasodilation (FMD) in 143 patients with acute ischemic stroke and 40 controls. The overall stroke patients had impaired FMD, but only lacunar infarction had significantly impaired FMD vs the controls. Impaired FMD was an independent predictor for lacunar infarction. Ischemic stroke is associated with endothelial dysfunction, which is more conspicuous in lacunar infarction. Publication Types: Comparative Study, Research Support, Non-U.S. Gov ... Read More »
» Published in Neurology. 2006 Sep 26;67(6):1056-8.
6. Five-year survival-after first-ever stroke.
Match Strength: 6.391
The aim of the study was to analyze the 5-year survival after first-ever ischemic stroke and intracerebral hemorrhage. In this study 836 patients were analyzed with a first-ever stroke admitted at the Department of Neurology Tuzla, Bosnia and Herzegovina, from January 1(st) 1997 to December 31(st) 1998. Of these 613 (73,3%) were ischemic strokes and 223 intracerebral hemorrhages (26,7%) Subarachnoid hemorrhages were excluded. After hospitalization surviving patients examined periodically, and a final examination was performed 5 years after the stroke. Overall, case-fatility at the first month ... Read More »
» Published in Bosn J Basic Med Sci. 2006 Aug;6(3):17-22.
7. Successful implementation of the National Institutes of Health Stroke Scale on a stroke/neurovascular unit.
Match Strength: 6.370
The National Institutes of Health Stroke Scale (NIHSS) is accepted as the definitive clinical examination to assess stroke severity. This project examined barriers to implementation and NIHSS use by registered nurses on a stroke/neurovascular Unit. Staff members were surveyed to determine nurse-perceived barriers to the routine use of the NIHSS. Survey results were used to create interventions including staff education, emphasis on NIHSS assessment during interdisciplinary rounds, and use of pocket cards. When the survey was redistributed 9 months later to verify results of the quality ... Read More »
» Published in J Neurosci Nurs. 2006 Sep;38(4 Suppl):309-15.
8. Caregiving in rural African American families for older adult stroke survivors.
Match Strength: 6.246
Stroke disproportionately affects African Americans, but stroke caregiving research on this group is missing from the literature. The purpose of this grounded theory study was to examine rural African American family caregiving for older adult stroke survivors. Eight African American families participated in the study. The sample included 8 stroke survivors, 8 primary caregivers, and 18 secondary caregivers. Data were generated through interactive interviews and focused observations that took place in caregivers' or stroke survivors' homes. A multistep data analysis technique incorporating the ... Read More »
» Published in J Neurosci Nurs. 2006 Sep;38(4 Suppl):270-81, 330.
9. Integrating self-efficacy and aging theories to promote behavior change and reduce stroke risk.
Match Strength: 6.184
The increasing incidence of stroke has resulted in the establishment of secondary stroke prevention clinics. Such clinics have successfully reduced wait-to-treatment times for individuals diagnosed with transient ischemic attack or minor stroke. In addition to improving access to consultation, diagnosis, and treatment, healthcare clinics need to implement behavioral risk-reduction programs tailored to older adults to help them better adhere to treatment regimens. The integration of two social-psychological theories--(a) self-efficacy and (b) selection, optimization, and compensation-provide ... Read More »
» Published in J Neurosci Nurs. 2006 Sep;38(4 Suppl):300-8.
10. Computer access for people after stroke.
Match Strength: 6.136
This article will focus on computer access options for people who have had a stroke. The role of the occupational therapist and assistive technology specialist in evaluation, prescription, and training will be addressed. Options related to physical, perceptual, or cognitive impairments (following a stroke) to allow for access to the computer or to increase efficiency will be discussed. Alternative hardware, software options, and modifications to the operating system will be described. Publication Types: ... Read More »
» Published in Top Stroke Rehabil. 2006 Summer;13(3):22-30.
11. Evolving therapeutic approaches to treating acute ischemic stroke.
Match Strength: 6.020
Stroke contributes significantly to death, disability, and healthcare costs; however, recombinant tissue plasminogen activator (rt-PA) is the only approved thrombolytic therapy for acute ischemic stroke. One area of development for new ischemic stroke treatment options is focused on neuroprotection of viable tissue in the ischemic vascular bed. The ischemic penumbra is recognizable on MRI by decreased perfusion, in contrast to the core area of ischemia, which includes diffusion and perfusion abnormalities. Understanding the mechanisms of neuronal death, including the role of excitotoxic ... Read More »
» Published in J Neurol Sci. 2006 Nov 15;249(2):101-9. Epub 2006 Sep 26.
12. Effects of policosanol on patients with ischemic stroke: a pilot open study.
Match Strength: 5.668
Stroke is a major health problem worldwide. Its pharmacological management includes thrombolytic therapy for the acute phase and antiplatelet drugs for stroke recovery and prevention. Statins can help in the acute phase and in preventing stroke in secondary prevention patients. Policosanol is a cholesterol-lowering drug with concomitant antiplatelet effects, with protective effects in stroke models. This observational study investigated the effects of policosanol (20 mg/day) administered during the acute phase and for 5 years later on the neurological recovery of patients with ischemic stroke ... Read More »
» Published in J Med Food. 2006 Fall;9(3):378-85.
13. Successful Intra-Arterial Thrombolysis for Acute Ischemic Stroke in the Immediate Postpartum Period: Case Report.
Match Strength: 5.542
Stroke in pregnancy and the puerperium is a rare but potentially devastating event. We present the case of a previously healthy woman who underwent a cesarean delivery and experienced a middle cerebral artery thrombosis in the immediate postpartum period that was subsequently lysed with intra-arterial urokinase. The patient made a complete neurologic recovery. To the best of our knowledge, this is the first reported case of successful intra-arterial thrombolysis for ischemic stroke in the postpartum period ... Read More »
» Published in Cardiovasc Intervent Radiol. 2006 Sep 19;
14. Do racial disparities exist in access to inpatient stroke rehabilitation in the state of Maryland?
Match Strength: 5.451
OBJECTIVE: Black patients tend to have a greater number and severity of stroke cases. The literature on access to rehabilitative services shows mixed results ranging from no disparities to limited access among minority populations. This study evaluated the association of race and acute discharge to inpatient stroke rehabilitation in Maryland, a diagnostic related group-and postacute care prospective payment system-exempt state. DESIGN: Data from the Maryland Health Services and Cost Review Commission database for 2000 was used to conduct a cross sectional retrospective review to determine the ... Read More »
» Published in Am J Phys Med Rehabil. 2006 Oct;85(10):814-9.
15. Two cases of spontaneous middle cerebral arterial dissection causing ischemic stroke.
Match Strength: 5.347
Spontaneous middle cerebral arterial dissection (MCAD) is a rare cause of ischemic stroke. We report two cases of isolated spontaneous MCAD causing ischemic stroke. MCAD should be considered when a young patient has a middle cerebral artery territory infarct with stenosis at the origin of the middle cerebral artery. We discuss noninvasive radiological techniques for the diagnosis of MCAD. Publication Types: Case Reports, Research Support, Non-U.S. Gov ... Read More »
» Published in J Neurol Sci. 2006 Dec 1;250(1-2):162-6. Epub 2006 Sep 12.
16. Evidence of publication bias in reporting acute stroke clinical trials.
Match Strength: 5.281
OBJECTIVE: To ascertain the extent of publication bias in the reporting of acute stroke clinical trials. METHODS: We identified controlled acute ischemic stroke clinical trials reported in English over a 45-year period from 1955 to 1999 through systematic search of MEDLINE, the Cochrane Controlled Stroke Trials Register, and additional databases. We analyzed trial methodology, quality, outcome, study sponsorship, and timing of publication to identify various forms of publication bias, including nonpublication bias, abbreviated publication bias, and time-lag bias. RESULTS: One hundred seventy ... Read More »
» Published in Neurology. 2006 Sep 26;67(6):973-9.
17. Causal attributions and health behavior choices among stroke and transient ischemic attack survivors.
Match Strength: 5.206
To reduce the risk of a recurring event in patients who have suffered an initial stroke or transient ischemic attack (TIA), nurses are challenged with implementing and promoting changes in lifestyle and adherence to treatment regimens. Assessing patients' beliefs about the cause of the stroke or TIA is important to understanding their subsequent health behaviors. This study describes the causal attributions and health behavior choices of 9 participants following a stroke or TIA. Attributions were categorized as internal or external and cross-tabulated by controllability. The attributions were ... Read More »
» Published in J Neurosci Nurs. 2006 Sep;38(4 Suppl):288-95.
18. Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats.
Match Strength: 5.116
Recent studies suggest that proliferation in the adult forebrain subventricular zone increases in response to a forebrain stroke and intraventricular infusions of growth factors enhance this response. The potential for growth factor infusions to regenerate the damaged motor cortex and promote recovery of motor function after stroke has not been examined. Here, we report that intraventricular infusions of epidermal growth factor and erythropoietin together, but not individually, promote substantial regeneration of the damaged cerebral cortex and reverse impairments in spontaneous and skilled ... Read More »
» Published in J Cereb Blood Flow Metab. 2006 Sep 20;
19. Problems and associated feelings experienced by family caregivers of stroke survivors the second and third month postdischarge.
Match Strength: 5.098
This study identified problems and associated feelings experienced by family caregivers of stroke survivors during the second and third month after discharge from a rehabilitation facility to home. Safety was the most frequent problem identified by family caregivers. Other problems were managing activities of daily living (ADLs) and cognitive, behavioral, and emotional changes by stroke survivors. About half of caregivers expressed more positive feelings toward managing these problems by week 8 and the majority expressed these feelings by week 12. Publication Types: Research Support, N.I.H., ... Read More »
» Published in Top Stroke Rehabil. 2006 Summer;13(3):66-74.
20. The tissue factor pathway in ischemic stroke.
Match Strength: 5.044
To explore the role of the the tissue factor (TF) pathway in ischemic stroke. We measured blood concentrations of markers of the TF pathway [TF antigen, free tissue factor pathway inhibitor antigen (TFPIf) and activity (TFPIac), and activated factor VII (FVIIa)] within 7 days (acute phase) and after 3-6 months (convalescence) in 150 patients with first-ever ischemic stroke and 150 community controls. During the acute phase, TF antigen and TFPIf were not significantly altered but TFPIac was increased (mean 1.27 versus 1.13 U/ml, P = 0.04) and FVIIa was decreased in cases compared with controls ... Read More »
» Published in Blood Coagul Fibrinolysis. 2006 Oct;17(7):527-32.
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