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Peer Reviewed Scientific Research Reports.
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1. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53.
Match Strength: 5.302
The in vitro relationship between human p53 DNA binding domain (p53 DBD) and FA was investigated. We found that saturated and monounsaturated long-chain FA inhibited the double-stranded DNA (dsDNA) binding activity of p53 DBD. The strongest inhibitors of saturated and unsaturated FA were docosanoic acid (22:0) and cis-12-heneicosenoic acid (21:1n-9), respectively. n-Octadecane, trans-unsaturated FA, and FAME had no influence on the binding activity of p53 DBD, showing that the FA structures such as one or no double bond of cis configuration, hydrocarbon chain of length C20 to C22, and free ... Read More »
» Published in Lipids. 2006 Jun;41(6):521-7.
2. Direct volatilization of naphthalene to the atmosphere at a phytoremediation site.
Match Strength: 3.941
Phytoremediation systems are known to reduce groundwater contamination by at least three major mechanisms: plant uptake, phytovolatilization, and enhanced rhizosphere bioremediation. The potential for such systems to enhance a fourth remediation pathway--direct surface volatilization of contaminants through the subsurface and into the atmosphere-has not yet been investigated in the field. A vertical flux chamber was used to measure direct surface volatilization of naphthalene over nine months at a creosote-contaminated site in Oneida, Tennessee, where a phytoremediation system of poplar trees ... Read More »
» Published in Environ Sci Technol. 2006 Sep 1;40(17):5560-6.
3. Air flow paths and porosity/permeability change in a saturated zone during in situ air sparging.
Match Strength: 3.888
This study develops methods to estimate the change in soil characteristics and associated air flow paths in a saturated zone during in situ air sparging. These objectives were achieved by performing combined in situ air sparging and tracer testing, and comparing the breakthrough curves obtained from the tracer gas with those obtained by a numerical simulation model that incorporates a predicted change in porosity that is proportional to the air saturation. The results reveal that revising the porosity and permeability according to the distribution of gas saturation is helpful in breakthrough ... Read More »
» Published in J Hazard Mater. 2006 Aug 12;
4. The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes.
Match Strength: 3.707
The inhibitory effect of saturated fatty acids (SFAs): palmitic acid (PA), stearic acid (SA) and polyunsaturated fatty acids (PUFAs): linoleic acid (LA), linolenic acid (LN), arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on six human drug-metabolizing enzymes (CYP1A2, 2C9, 2C19, 2D6, 2E1 and 3A4) was studied. Supersomes from baculovirus-expressing single isoforms were used as the enzyme source. Phenacetin O-deethylation (CYP1A2), diclofenac 4-hydroxylation (CYP2C9), mephenytoin 4-hydroxylation (CYP2C19), dextromethorphan O-demethylation (CYP2D6), ... Read More »
» Published in Life Sci. 2006 Nov 25;79(26):2432-40. Epub 2006 Aug 23.
5. Cholesterol and saturated fat intake determine the effect of polymorphisms at ABCG5/ABCG8 genes on lipid levels in children.
Match Strength: 3.581
PURPOSE: Analysis of mutations in genes of the cholesterol metabolic pathway has not completely explained the interindividual variability of blood cholesterol concentrations attributed to gene-nutrient interactions. Thus, we analyzed polymorphisms in the ABCG5 and ABCG8 genes, involved in the regulation of intestinal cholesterol absorption, with special interest in a potential interaction with diet to determine lipid levels. METHODS: The polymorphisms ABCG5 C1950G (Gln604Glu) and ABCG8 C1895T (Ala640Val) were determined by polymerase chain reaction and restriction analysis in 1227 healthy ... Read More »
» Published in Genet Med. 2006 Sep;8(9):594-9.
6. MR arthrography in the differential diagnosis of type II superior labral anteroposterior lesion and sublabral recess.
Match Strength: 3.198
OBJECTIVE: The objective of our study was to assess the utility of five MR arthrographic findings in differentiating type II superior labral anteroposterior (SLAP) lesion from superior sublabral recess. MATERIALS AND METHODS: The MR arthrograms of 55 patients (57 cases) with either type II SLAP lesion (34 cases) or superior sublabral recess (23 cases) who underwent arthroscopic surgery and MR arthrography were retrospectively reviewed. Two independent reviewers searched for the extension, direction, and shape of high signal intensity in the superior labrum on MR arthrograms. In addition, the ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):887-93.
7. Health identities: from expert patient to resisting consumer.
Match Strength: 2.789
This article explores the formation of 'health identities': embodied subjectivities that emerge out of complex psychosocial contexts of reflexive modernity, in relation to data on health and illness practices among groups of people and patients using medical technologies including weight-loss drugs and the erectile dysfunction drug sildenafil (Viagra). We examine a range of health identities, from the 'expert patient'--a person who broadly adopts a biomedical model of health and illness, to a 'resisting consumer', who fabricates a health identity around lay experiential models of health and ... Read More »
» Published in Health (London). 2006 Oct;10(4):461-79.
8. Proximate composition, fatty acid analysis and protein digestibility-corrected amino acid score of three Mediterranean cephalopods.
Match Strength: 2.777
Proximate composition, fatty acid analysis and protein digestibility-corrected amino acid score (PDCAAS) in three commercially important cephalopods of the Mediterranean sea (cuttlefish, octopus and squid) were determined. The results of the proximate analysis showed that these species had very high protein:fat ratios similar to lean beef. Docosahexaenoic, palmitic and eicosipentaenoic acid were the most abundant fatty acids among analyzed species. The amount of n-3 fatty acids was higher than that of saturated, monounsaturated and n-6 fatty acids. Despite the fact that cephalopods contain ... Read More »
» Published in Mol Nutr Food Res. 2006 Oct;50(10):967-70.
9. Determination of lipid phase transition temperatures in hybrid bilayer membranes.
Match Strength: 2.738
The main gel-to-liquid-crystal (LC) phase transition temperature, T(m), of the lipid monolayer in hybrid bilayer membranes (HBMs) was investigated using vibrational sum frequency spectroscopy (VSFS). In the gel phase, the acyl chains of the lipid molecules assume an ordered, all-trans configuration, whereas in the LC phase, the acyl chains exhibit a significant number of disordered gauche conformers. VSFS has unique sensitivity to the order/disorder transitions in the acyl chains and was used to determine T(m) for a series of saturated phosphatidylcholine lipids on octadecanethiolate self ... Read More »
» Published in Langmuir. 2006 Sep 26;22(20):8333-6.
10. Antagonistic interactions of kleisins and DNA with bacterial Condensin MukB.
Match Strength: 2.714
MukBEF is a bacterial SMC (structural maintenance of chromosome) complex required for faithful chromosome segregation in Escherichia coli. The SMC subunit of the complex, MukB, promotes DNA condensation in vitro and in vivo; however, all three subunits are required for the function of MukBEF. We report here that MukEF disrupts MukB x DNA complex. Preassembled MukBEF was inert in DNA binding or reshaping. Similarly, the association of MukEF with DNA-bound MukB served to displace MukB from DNA. When purified from cells, MukBEF existed as a mixture of MukEF-saturated and unsaturated complexes. ... Read More »
» Published in J Biol Chem. 2006 Nov 10;281(45):34208-17. Epub 2006 Sep 18.
11. Effects of alcohols on multi-bubble sonoluminescence spectra.
Match Strength: 2.685
Spectra of multi-bubble sonoluminescence (MBSL) were measured in argon-saturated water and ethanol solutions in the concentration range 2-100mM at the frequencies of 116kHz and 1.0MHz. The spectral peaks from OH-radical emission near 310nm were observed at relatively low ultrasonic power at both frequencies. The sub-peaks at 290 and 340 nm were also observed, which are attributed to OH-radical vibronic transition. The MBSL spectra from ethanol solutions indicated that the quenching of OH-radical emission was more efficient than that of underlying continuous spectrum. The continuous spectrum ... Read More »
» Published in Ultrasonics. 2006 Dec 22;44 Suppl 1:e421-5. Epub 2006 Sep 11.
12. Effect of Cymbopogon citratus L. essential oil on growth and morphogenesis of Saccharomyces cerevisiae ML2-strain.
Match Strength: 2.628
The growth of Saccharomyces cerevisiae was completely inhibited using 2.0 microl/ml or 4.0 microl/ml of Cymbopogon citratus essential oil applied by fumigation or contact method in Sabouraud's broth medium, respectively. This oil was found also to be fungicidal at the same concentrations. The sublethal doses 1.0 and 3.0 microl/ml inhibited about 98% of yeast growth after 24 hr of incubation as compared with the control. Microscopic observations using Light Microscope (LM), Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) showed morphogenic and ultrastructure ... Read More »
» Published in J Basic Microbiol. 2006;46(5):375-86.
13. Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs.
Match Strength: 2.539
The sodium-calcium exchanger (NCX) is a critical mediator of calcium homeostasis. In the heart, NCX1 predominantly operates in forward mode to extrude Ca(2+); however, reverse-mode NCX1 activity during ischemia/reperfusion (IR) contributes to Ca(2+) loading and electrical and contractile dysfunction. IR injury has also been associated with altered fat metabolism and accumulation of long-chain acyl CoA esters. Here, we show that acyl CoAs are novel, endogenous activators of reverse-mode NCX1 activity, exhibiting chain length and saturation dependence, with longer chain saturated acyl moieties ... Read More »
» Published in EMBO J. 2006 Oct 4;25(19):4605-14. Epub 2006 Sep 14.
14. Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions.
Match Strength: 2.367
Mutations in cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel, cause cystic fibrosis. To investigate interactions of CFTR in living cells, we measured the diffusion of quantum dot-labeled CFTR molecules by single particle tracking. In multiple cell lines, including airway epithelia, CFTR diffused little in the plasma membrane, generally not moving beyond 100-200 nm. However, CFTR became mobile over micrometer distances after 1) truncations of the carboxy terminus, which contains a C-terminal PDZ (PSD95/Dlg/ZO-1) binding motif; 2) blocking PDZ ... Read More »
» Published in Mol Biol Cell. 2006 Dec;17(12):4937-45. Epub 2006 Sep 20.
15. Impact of antinucleants on transdermal delivery of testosterone from a spray.
Match Strength: 2.329
The goal was to explore whether the incorporation of antinucleant polymers into a testosterone spray formulation could stabilize a putative supersaturated state and improve the delivery of the drug across the skin. Several antinucleants were screened using differential scanning calorimetry (DSC) and two candidates showed particular promise: a cyclodextrin derivative (RAMEB) and a vinylpyrrolidone/vinyl acetate copolymer (Kollidon VA64). These agents also improved significantly the long-term stability of saturated solutions of the drug. Further, using the method of mixed cosolvents, it was ... Read More »
» Published in J Pharm Sci. 2007 Jan;96(1):84-92.
16. Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet.
Match Strength: 2.324
Stearoyl-coenzyme A desaturase 1-deficient (SCD1(-/-)) mice have impaired MUFA synthesis. When maintained on a very low-fat (VLF) diet, SCD1(-/-) mice developed severe hypercholesterolemia, characterized by an increase in apolipoprotein B (apoB)-containing lipoproteins and the appearance of lipoprotein X. The rate of LDL clearance was decreased in VLF SCD1(-/-) mice relative to VLF SCD1(+/+) mice, indicating that reduced apoB-containing lipoprotein clearance contributed to the hypercholesterolemia. Additionally, HDL-cholesterol was dramatically reduced in these mice. The presence of increased ... Read More »
» Published in J Lipid Res. 2006 Dec;47(12):2668-80. Epub 2006 Sep 27.
17. Heart rate variability during high-intensity field exercise in female distance runners.
Match Strength: 2.304
The purposes of this study were to demonstrate the transition of heart rate variability (HRV) during trials in the field and to examine the relationship between peak frequency of high-frequency band (HF) and stride frequency. Ten healthy long-distance college female runners (age 19-21 years) performed a 3000 m realistic time trial. The time-series power spectrum analysis by maximum entropy method was used to evaluate cardiac autonomic nervous activity during the race. Cross-correlation coefficients were calculated to estimate the degree of linear co-ordination between the central peak ... Read More »
» Published in Scand J Med Sci Sports. 2006 Oct;16(5):314-20.
18. Thawing of frozen vegetables observed by a small dedicated MRI for food research.
Match Strength: 2.293
The thawing process for boiled and frozen edible vegetables was traced by a dedicated MRI for food research. The MRI system is small, with a 1.0-T static magnetic field, and can be placed in an ordinary research room with a light air conditioner. Images of green soybeans, broad beans, okra, asparagus and taro were measured by the spin-echo method (echo time=7 ms) with 0.1 or 0.2 s and 1 s repetition times. The images appeared along with the thawing time, and signals uniformly covered the sliced plane of the samples in the thawed condition. Information about the thawing process and tissue ... Read More »
» Published in Magn Reson Imaging. 2006 Oct;24(8):1111-9. Epub 2006 Sep 6.
19. Gallium uptake by transferrin and interaction with receptor 1.
Match Strength: 2.221
The kinetics and thermodynamics of Ga(III) exchange between gallium mononitrilotriacetate and human serum transferrin as well as those of the interaction between gallium-loaded transferrin and the transferrin receptor 1 were investigated in neutral media. Gallium is exchanged between the chelate and the C-site of human serum apotransferrin in interaction with bicarbonate in about 50 s to yield an intermediate complex with an equilibrium constant K (1) = (3.9 +/- 1.2) x 10(-2), a direct second-order rate constant k (1) = 425 +/- 50 M(-1) s(-1) and a reverse second-order rate constant k (-1) = ... Read More »
» Published in J Biol Inorg Chem. 2007 Jan;12(1):90-100. Epub 2006 Sep 19.
20. Medium Effects on Zwitterionic-Biradicaloid Intermediates from Two Phenyl-alpha-oxoamides. Irradiations in Fluid and Solid Protic Media, Neat Solid Phases, and the Solid, Smectic, and Isotropic Phases of a Completely Saturated Phospsphonium Salt at Different Temperaturesdouble dagger.
Match Strength: 2.192
The photochemical processes of two N,N-dialkyl phenyl-alpha-oxoamides, N,N-diisopropyl phenyl-alpha-oxoamide (1) and N,N-dibenzyl phenyl-alpha-oxoamide (2), are investigated at different temperatures in methanol and ethylene glycol (to probe the influences of H-bonding and viscosity), in the solid phase of D-sorbitol at room temperature (to compare with the results in the liquid alcohols and to assess the influence of a poorly organized 'stiff' environment), in the neat solid phase (to probe the influence of well-ordered, 'stiff' matrices), and in the solid, smectic A2, and isotropic phases of ... Read More »
» Published in Photochem Photobiol. 2006 Jul 1;
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