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Peer Reviewed Scientific Research Reports.
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1. Evaluating and treating cardiometabolic risk factors: a case discussion.
Match Strength: 6.751
Reducing the risk for coronary heart disease (CHD) requires a comprehensive assessment of cardiometabolic risk factors along with the initiation of nonpharmacologic and pharmacologic therapies to mitigate these risk factors. A case study is presented to illustrate the approach to evaluating a patient and selecting among available and emerging therapeutic modalities to reduce CHD risk ... Read More »
» Published in Pharmacotherapy. 2006 May;26(5 Pt 2):32S-41S.
2. Modifiers of risk of hereditary breast cancer.
Match Strength: 6.190
Mutations in the BRCA1 and BRCA2 genes confer a high lifetime risk of breast and ovarian cancer. The risk varies from individual to individual, and it appears that the risk has increased in recent generations. These observations imply that non-genetic factors may modify the inherited risk. To date, the factors that appear most strongly to modify the risk include reproductive histories and exogenous hormones. Oral contraceptives are associated with a profound reduction in the risk of ovarian cancer, and with little or no increase in the risk of breast cancer. Other modifying factors include age ... Read More »
» Published in Oncogene. 2006 Sep 25;25(43):5832-6.
3. Psoriasis: an opportunity to identify cardiovascular risk.
Match Strength: 6.096
Psoriasis is highly prevalent and is associated with skin-associated complaints as well as arthritis, depression and a lower quality of life. Recently, it has been demonstrated that not only do patients with psoriasis have an increased prevalence of cardiovascular risk factors, but an increased risk of myocardial infarction, and for those with severe disease, increased mortality. Dermatologists and other health professionals need to be cognizant of this association and ensure that cardiovascular risk factors are evaluated and treated appropriately in those patients with psoriasis. We review ... Read More »
» Published in Br J Dermatol. 2009 Jan;160(1):1-7. Epub 2008 Oct 25.
4. Risk factors for dementia in central Nigeria.
Match Strength: 5.748
Little is known about the prevalence of dementia and its associated risk factors in developing countries. Some studies suggest that the prevalence of dementia is lower in developing countries than it is in high-income nations. We sought to determine risk factors for dementia in elderly persons in central Nigeria. Using the standardized Community Screening Instrument for Dementia, we screened a stratified, random community sample of 280 persons aged 65 years and older for dementia. We examined the independent association of known risk factors with dementia using logistic regression. The overall ... Read More »
» Published in Aging Ment Health. 2006 Nov;10(6):616-20.
5. Primer: managing NSAID-induced ulcer complications--balancing gastrointestinal and cardiovascular risks.
Match Strength: 5.728
Ulcer complications associated with the use of NSAIDs, in high-risk patients, are often caused by a failure to identify patients' risk factors, concomitant use of aspirin or multiple NSAIDs, and underutilization of gastroprotective agents. Current data suggest that cyclo-oxygenase 2 (COX2) inhibitors and some nonselective NSAIDs increase the risk of myocardial infarction. Physicians must, therefore, take into account both the gastrointestinal and the cardiovascular risks of individual patients when prescribing NSAIDs. In patients with a low cardiovascular risk, NSAIDs can be prescribed ... Read More »
» Published in Nat Clin Pract Gastroenterol Hepatol. 2006 Oct;3(10):563-73.
6. Cardiovascular disease in rheumatoid arthritis: disease and treatment interactions and their implications on treatment decisions.
Match Strength: 5.655
Cardiovascular disease is highly prevalent in rheumatoid arthritis patients, contributing to significant morbidity and mortality. Few randomized trials are available to guide risk assessment and intervention in these complex patients. This paper discusses traditional atherosclerotic and rheumatoid-related risk factors for cardiovascular disease in these patients, reviews the effect of treatment of cardiovascular risk factors on rheumatoid arthritis activity, and describes the effect of rheumatoid arthritis treatment on risk factors for cardiovascular disease. The authors reviewed the existing ... Read More »
» Published in J Miss State Med Assoc. 2010 Mar;51(3):75-80.
7. Risk factors for prostate cancer.
Match Strength: 5.631
The incidence of prostate cancer in the United States has recently undergone dramatic and unprecedented changes. Exposure to prostate-specific antigen testing has led to a steep increase in reported incidence. The data indicate that the strongest risk factors for prostate cancer are age and African American race/ethnicity. Family history is also an important risk factor for prostate cancer, although only a small proportion of cases will be due to high-penetrance genes such as those at the putative susceptibility loci (eg, ELAC2) recently identified through linkage analysis. International ... Read More »
» Published in Rev Urol. 2002;4 Suppl 5:S3-S10.
8. Influence of cardiac risk factors and medication on length of hospitalization in patients undergoing major vascular surgery.
Match Strength: 5.616
Major vascular surgery is associated with a long in-hospital length of stay (LOS). Cardiac risk factors identify patients with an increased risk. Recent studies have associated statin, aspirin, and beta-blocker therapies with improved postoperative outcome. However, the effect of all these factors on LOS has not been defined. Our aims were to determine the effect of cardiac risk factors and (preventive) statin, aspirin, and beta-blocker therapy on LOS and to deduce from these factors a model that predicts LOS. In total, 2,374 patients from 1990 to 2004 were enrolled. Mean LOS was 18 +/- 9 days ... Read More »
» Published in Am J Cardiol. 2006 May 15;97(10):1423-6. Epub 2006 Mar 23.
9. Risk factors, prevention and treatment of hypertension in pregnancy.
Match Strength: 5.582
Hypertensive diseases in pregnancy are common and are associated with significant maternal and perinatal mortality and morbidity. Risk factors for pre-eclampsia include socio-demographical factors (extremes of reproductive age, socio-economic status, ethnic group), genetic factors, pregnancy factors (multiple pregnancies, primigravidae, previous pre-eclampsia) or personal medical history (obesity, chronic renal disease, chronic hypertension, diabetes mellitus, thrombophilia). These risk factors and Doppler screening can help target interventions such as aspirin and calcium that have been ... Read More »
» Published in Minerva Ginecol. 2005 Aug;57(4):379-88.
10. GI risk factors and use of GI protective agents among patients receiving nonsteroidal antiinflammatory drugs.
Match Strength: 5.543
BACKGROUND: Patient characteristics increase the risk of gastrointestinal (GI) complications associated with nonsteroidal antiinflammatory drugs (NSAIDs). Patients at risk may not be prescribed protective therapies that might mitigate their risk of NSAID-associated GI complications. OBJECTIVE: To assess GI risk among Veterans Affairs (VA) patients on NSAID therapy, determine whether therapy conformed to VA guidelines for lessening the risk of GI complications, and identify patient risk factors associated with conformance. METHODS: Using databases from 3 VA medical centers, we retrospectively ... Read More »
» Published in Ann Pharmacother. 2006 Nov;40(11):1924-31. Epub 2006 Oct 17.
11. Bacteremia due to Pseudomonas aeruginosa: results from a 3-year national study in the Slovak Republic.
Match Strength: 5.522
Risk factors, mortality and antimicrobial susceptibility of Pseudomonas aeruginosa bacteremias isolated from 148 patients from all University Hospitals in Slovakia were analyzed. Only 1.2% of 169 strains of P. aeruginosa were resistant to meropenem, 4.1% to piperacillin/tazobactam, 7.7% to ceftazidime as well as cefepime and 12% to amikacin. More than 30% of P. aeruginosa were resistant to ciprofloxacin. Our analysis of risk factors for antimicrobial resistance to the particular antimicrobials, indicated no difference in risk factors and outcome in cases infected with P. aeruginosa bacteremias ... Read More »
» Published in J Chemother. 2005 Oct;17(5):470-6.
12. Prognostic factors in diffuse large B-cell lymphoma treated by risk-adopted therapy.
Match Strength: 5.502
OBJECTIVE: The International Prognostic Index (IPI) was reported in 1993 and it is now widely used for predicting the outcome in patients with aggressive non-Hodgkin's lymphoma. It defines 5 risk factors and 4 distinct risk groups from retrospective data. In this study, we evaluated the outcome of risk-adopted therapy for diffuse large B-cell lymphoma (DLBCL), the most common aggressive lymphoma, and assessed the possible prognostic factors. METHODS AND PATIENTS: We treated 177 consecutive patients newly diagnosed with DLBCL using therapies determined by putative risk factors. Therapies ... Read More »
» Published in Intern Med. 2006;45(5):247-52. Epub 2006 Apr 3.
13. The effect of novel cardiovascular risk factors on the ethnic-specific odds for peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis (MESA).
Match Strength: 5.500
OBJECTIVES: The purpose of this study was to: 1) determine the significance and magnitude of associations between novel cardiovascular disease (CVD) risk factors and peripheral arterial disease (PAD) after adjustment for traditional risk factors; and 2) ascertain the extent to which novel risk factors explain the excess or lower risk for PAD in different ethnic groups. BACKGROUND: Previous reports have found a significant difference in the risk of PAD by ethnic group, with some of the risk difference attributed to different levels of traditional CVD risk factors. METHODS: A total of 6,814 ... Read More »
» Published in J Am Coll Cardiol. 2006 Sep 19;48(6):1190-7. Epub 2006 Aug 28.
14. Dexamethasone dosing, mechanical ventilation and the risk of cerebral palsy.
Match Strength: 5.286
OBJECTIVE: Risk factors for cerebral palsy (CP) in premature infants include duration of mechanical ventilation and exposure to postnatal dexamethasone (DEX). Since DEX can reduce the duration of mechanical ventilation, limited DEX exposure could be beneficial. METHODS: This was a retrospective, cohort study of infants of less than 1500 g birth weight surviving to discharge between 1 January 1996 and 30 June 2001 who received postnatal dexamethasone. DEX administration was based only on the need for O2 and/or mechanical ventilation. CP was diagnosed at over 10 months post-conceptional age. ... Read More »
» Published in J Matern Fetal Neonatal Med. 2006 Jan;19(1):43-8.
15. Coronary heart disease in HIV-infected patients.
Match Strength: 5.254
Increased risk of coronary heart disease has emerged as a long-term concern among HIV-infected patients receiving antiretroviral therapy. HIV-infected patients may have modifiable risk factors for heart disease that are associated with HIV itself, antiretroviral therapy, or factors unrelated to HIV. Dyslipidemia, insulin resistance, and diabetes mellitus are often multifactorial in origin. Patients with lipodystrophy frequently have a constellation of metabolic changes that may predispose them to accelerated atherosclerosis. There is also concern about contributions of chronic inflammation and ... Read More »
» Published in Curr HIV/AIDS Rep. 2005 Jun;2(2):68-73.
16. Diurnal saliva cortisol levels and relations to psychosocial factors in a population sample of middle-aged Swedish men and women.
Match Strength: 5.237
Whereas psychosocial risk factors increase the risk for disease, psychosocial resources reduce this risk. To examine a possible pathway for these effects, the relations between saliva cortisol levels and psychosocial factors were studied in a random sample of 257 men and women aged 30 to 64 years. Saliva samples were collected at home on waking, 30 min after waking, and in the evening. A flatter diurnal rhythm of cortisol, that is, lower deviations between awakening and evening cortisol levels, was related to high levels of psychosocial risk factors (cynicism, depression, and vital exhaustion) ... Read More »
» Published in Int J Behav Med. 2006;13(3):193-200.
17. Risk factors for diseases of ileal pouch-anal anastomosis after restorative proctocolectomy for ulcerative colitis.
Match Strength: 5.192
BACKGROUND & AIMS: Although pouchitis is considered the most common adverse sequela of ileal pouch-anal anastomosis (IPAA), inflammatory and noninflammatory conditions other than pouchitis are increasingly being recognized. The risk factors for these non-pouchitis conditions, including Crohn's disease (CD) of the pouch, cuffitis, and irritable pouch syndrome (IPS), have not been studied. The aim of this study was to assess risk factors for inflammatory and noninflammatory diseases of IPAA in a tertiary care setting. METHODS: The study consisted of 240 consecutive patients who were classified ... Read More »
» Published in Clin Gastroenterol Hepatol. 2006 Jan;4(1):81-9; quiz 2-3.
18. Clustering of cardiovascular risk factors in rheumatoid arthritis: the rationale for using statins.
Match Strength: 5.189
Atherosclerosis may be more prevalent and more extensive in individuals with rheumatoid arthritis (RA) compared with the general population. Despite the fact that traditional and novel cardiovascular disease (CVD) risk factors are clinically important in these patients, it seems that inflammation--a key feature of RA--plays a crucial role in atherogenesis. Reducing the CVD burden in patients with RA is a more complex process than in the general population, mostly due to inadequate inflammation suppression as well as multiple concomitant drug therapy. Furthermore, there is no current consensus ... Read More »
» Published in Clin Exp Rheumatol. 2007 Jan-Feb;25(1):102-11.
19. A pathogenetic mechanism for COX-2 inhibitor-induced cardiovascular events proposed to be useful in structuring medical testimony in rofecoxib trials.
Match Strength: 5.183
In this communication, a pathogenetic mechanism for COX-2 inhibitor (coxib)-induced cardiovascular events, especially myocardial infarction, will be discussed. This mechanism is proposed to be useful in structuring medical testimony in rofecoxib trials, and specific principles for separating rofecoxib-induced infarctions from the overall group of rofecoxib-related infarctions will be outlined. The proposed mechanism is based on the principles of the altered homeostatic theory, whose basic positions will be summarized. Coxib-induced infarctions apparently have been considered to be "special" ... Read More »
» Published in Med Hypotheses. 2007;69(1):83-9. Epub 2007 Jan 12.
20. Prevalence, risk factors, and outcome of uveitis in juvenile idiopathic arthritis: a long-term followup study.
Match Strength: 5.178
OBJECTIVE: To assess the prevalence, risk factors, and long-term outcome of uveitis in patients with juvenile idiopathic arthritis (JIA). METHODS: An inception cohort of all 1,081 patients diagnosed as having JIA at a single tertiary care center was established. A questionnaire and followup telephone calls were used to confirm the diagnosis of uveitis. Ophthalmologists' records of patients with uveitis were collected. Kaplan-Meier and Cox regression analyses were used to assess risk factors for developing uveitis and for complications of uveitis. RESULTS: After a mean followup time of 6.9 ... Read More »
» Published in Arthritis Rheum. 2007 Feb;56(2):647-57.
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