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Peer Reviewed Scientific Research Reports.
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1. Impaired fat-induced thermogenesis in obese subjects: the NUGENOB study.
Match Strength: 9.967
OBJECTIVES: To study energy expenditure before and 3 hours after a high-fat load in a large cohort of obese subjects (n = 701) and a lean reference group (n = 113). RESEARCH METHODS AND PROCEDURES: Subjects from seven European countries underwent a 1-day clinical study with a liquid test meal challenge containing 95% fat (energy content was 50% of estimated resting energy expenditure). Fasting and 3-hour postprandial energy expenditures, as well as metabolites and hormones, were determined. RESULTS: Obese subjects had a reduced postprandial energy expenditure after the high-fat load, ... Read More »
» Published in Obesity (Silver Spring). 2007 Mar;15(3):653-63.
2. Effects of higher dietary protein intake on energy balance and metabolic control in children with long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) or trifunctional protein (TFP) deficiency.
Match Strength: 7.284
The incidence of overweight and obesity is increasing among children with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) or mitochondrial trifunctional (TFP) deficiency. Traditional treatment includes fasting avoidance and consumption of a low-fat, high-carbohydrate diet. A diet higher in protein and lower in carbohydrate may help to lower total energy intake while maintaining good metabolic control. To determine the short-term safety and efficacy of a high protein diet, subjects were admitted to the General Clinical Research Center and fed an ad-libitum high-protein diet and a high ... Read More »
» Published in Mol Genet Metab. 2007 Jan;90(1):64-9. Epub 2006 Sep 22.
3. Comparison of metabolic monitors in critically ill, ventilated patients.
Match Strength: 6.704
OBJECTIVE: We compared the Deltatrac II, the M-COVX, and the Evita 4 metabolic monitoring devices under clinical conditions. METHODS: A prospective simultaneous clinical comparison was performed in a general intensive care department of a tertiary university hospital in 43 ventilated, critically ill patients. The monitors were compared simultaneously. After 30 min of steady state, oxygen consumption per unit time, carbon dioxide consumption per unit time, resting energy expenditure, and respiratory quotient were recorded for the Deltatrac II; the same parameters in addition to end-tidal carbon ... Read More »
» Published in Nutrition. 2006 Nov-Dec;22(11-12):1077-86. Epub 2006 Sep 14.
4. Age differences in inflammatory and hypermetabolic postburn responses.
Match Strength: 6.670
OBJECTIVE: The aim of this study was to identify contributors to morbidity and death in severely burned patients <4 years of age. METHODS: A total of 188 severely burned pediatric patients were divided into 3 age groups (0-3.9 years, 4-9.9 years, and 10-18 years of age). Resting energy expenditure was measured through oxygen consumption, body composition through dual-energy x-ray absorptiometry, liver size and cardiac function through ultrasonography, and levels of inflammatory markers, hormones, and acute-phase proteins through laboratory chemistry assays. RESULTS: Resting energy expenditure ... Read More »
» Published in Pediatrics. 2008 Mar;121(3):497-507.
5. Positive effects of testosterone and immunochallenge on energy allocation to reproductive organs.
Match Strength: 6.387
A number of studies have suggested the incompatibility of simultaneous increases in immune and reproductive functions. Other research has indicated that immune responses may be modulated depending on the relative benefits of increased survival and prospects for current and future reproduction. We tested the hypothesis that energy allocation to reproductive and other organ systems is not affected by testosterone level and energy expenditure on immune functions. Adult male white-footed mice (Peromyscus leucopus) with or without elevated testosterone levels and with or without immunochallenges ... Read More »
» Published in J Comp Physiol B. 2005 Nov;175(8):543-56. Epub 2005 Nov 11.
6. Corticosterone, locomotor performance, and metabolism in side-blotched lizards (Uta stansburiana).
Match Strength: 6.208
Elevated levels of circulating corticosterone commonly occur in response to stressors in wild vertebrates. A rise in corticosterone, usually in animals of subordinate rank, results in a variety of effects on behavior and physiology. Behavioral and physiological responses to short-term increases in corticosterone are well studied. In contrast, the effects of chronic elevated levels of corticosterone are poorly understood, particularly in lizards. Here, we examined the long-term effects of exogenous corticosterone on locomotor performance, resting and active metabolic rate, and hematocrit in ... Read More »
» Published in Horm Behav. 2007 Apr;51(4):548-54. Epub 2007 Feb 23.
7. Fat oxidation before and after a high fat load in the obese insulin-resistant state.
Match Strength: 5.708
BACKGROUND: Obesity may be associated with a lowered use of fat as a fuel, which may contribute to the enlarged adipose tissue stores. AIM: The aim of the present study was to study fatty acid use in the fasting state and in response to a high fat load in a large cohort of obese subjects (n = 701) and a lean reference group (n = 113). METHODS: Subjects from eight European centers underwent a test meal challenge containing 95 en% fat [energy content 50% of estimated resting energy expenditure (EE)]. Fasting and postprandial fat oxidation and circulating metabolites and hormones were determined ... Read More »
» Published in J Clin Endocrinol Metab. 2006 Apr;91(4):1462-9. Epub 2006 Jan 31.
8. Study on energy metabolism in perioperative infants.
Match Strength: 5.616
OBJECTIVES: To evaluate resting energy expenditure (REE) in surgical infants and define the effects of the degree of stress on its level. SUBJECTS AND METHODS: Between June 1999 and June 2003 forty-five infants awaiting surgery (boys/girls: 32/13) from the Department of Pediatric Surgery were entered in the study. Indirect calorimetry was used to measure the REE of all the patients before operation and 1 - 7 days after operation. Clinical data were collected, including age, weight, height, diagnosis, operative method, site and duration, and first day postoperative C-reactive protein (CRP) ... Read More »
» Published in Eur J Pediatr Surg. 2006 Aug;16(4):227-30.
9. First study of infliximab treatment in patients with chronic obstructive pulmonary disease.
Match Strength: 5.385
RATIONALE: Tumor necrosis factor-alpha is believed to be important in the induction and maintenance of airway inflammation in chronic obstructive pulmonary disease. OBJECTIVES: We aimed to evaluate the effect of the anti-tumor necrosis factor-alpha drug infliximab in patients with chronic obstructive pulmonary disease, with percentage of sputum neutrophils as the primary endpoint. METHODS: We performed an exploratory single-center, double-blind, placebo-controlled, randomized, phase 2 trial in which 22 current smokers with mild-to-moderate chronic obstructive pulmonary disease participated. ... Read More »
» Published in Am J Respir Crit Care Med. 2005 Aug 15;172(4):465-9. Epub 2005 Jun 3.
10. Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa.
Match Strength: 5.359
BACKGROUND: Adiposis dolorosa (AD) is a syndrome of obese and non-obese individuals whose hallmark is lipomatosis: unencapsulated painful fatty masses in subcutaneous fat. Lipomatosis may contain excess collagen and multi-nucleated giant (MNG) cells. Case reports suggest metabolic defects in AD. OBJECTIVES: (1) To determine whether women with AD have altered relative resting energy expenditure (REE per total body mass) compared with controls; and (2) to quantitate lipomatosis-associated collagen, MNGs and tissue and blood cytokines that may influence REE. METHODS: A total of 10 women with AD ... Read More »
» Published in Int J Obes (Lond). 2009 Sep;33(9):1031-8. Epub 2009 Jul 21.
11. Effects of binge eating behavior on fuel oxidation and body composition.
Match Strength: 5.337
OBJECTIVE: To investigate energy expenditure and glucose metabolism after a standard oral glucose load (75 g) in 8 normal weight bulimic women and 8 normal weight control women and to evaluate the relative endocrine implication. DESIGN: Serum glucose and insulin were measured both in basal conditions and after the glucose load; a basal endocrine assessment and body composition was evaluated and glucose induced thermogenesis (GIT) was calculated during 300 min following the glucose load. RESULTS: Serum glucose levels were significantly lower in bulimics both in fasting and in post-prandial ... Read More »
» Published in J Am Coll Nutr. 2005 Aug;24(4):244-9.
12. Energy expenditure, inflammation, and oxidative stress in steady-state adolescents with sickle cell anemia.
Match Strength: 5.242
Sickle cell anemia (HbSS) is characterized by hypermetabolism, chronic inflammation, and increased oxidative stress, but the relationship between these factors is undefined. In this study, we examined indicators of inflammatory process and markers of oxidative damage and their impact on resting energy expenditure (REE) in stable HbSS adolescents (n = 35) and healthy controls carrying normal hemoglobin genotype (HbAA) (n = 39). C-reactive protein (CRP), white blood cell (WBC) count, and proinflammatory cytokines were measured as markers of inflammation and 2,3-dinor-5,6-dihydro-15-F2t ... Read More »
» Published in Pediatr Res. 2007 Feb;61(2):233-8.
13. TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity.
Match Strength: 5.161
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor protein that is processed to yield an incompletely characterized panel of neuropeptides. Until now, it was an unproved assumption that VGF-derived peptides could regulate metabolism. Here, a VGF peptide designated TLQP-21 was identified in rat brain extracts by means of immunoprecipitation, microcapillary liquid chromatography-tandem MS, and database searching algorithms. Chronic intracerebroventricular (i.c.v.) injection of TLQP-21 (15 mug/day for 14 days) increased resting energy expenditure ... Read More »
» Published in Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14584-9. Epub 2006 Sep 18.
14. Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humans.
Match Strength: 4.981
We hypothesized that suppression of endogenous testosterone blunts mRNA expression post strength training (ST). Twenty-two young men were randomized for treatment with the GnRH analogue goserelin (3.6 mg every 4 weeks) or placebo for a period of 12 weeks. The ST period of 8 weeks started at week 4. Strength test, blood sampling, muscle biopsies, and whole-body dual-energy X-ray absorptiometry (DXA) scan were performed at weeks 4 and 12. Muscle biopsies were taken during the final ST session (pre, post 4 h, and post 24 h). Resting serum testosterone decreased significantly (P < 0.01) in the ... Read More »
» Published in J Physiol. 2007 Jan 15;578(Pt 2):579-93. Epub 2006 Nov 9.
15. Influence of maternal pre-pregnancy body composition and diet during early-mid pregnancy on cardiovascular function and nephron number in juvenile sheep.
Match Strength: 4.943
The prenatal diet can program an individual's cardiovascular system towards later higher resting blood pressure and kidney dysfunction, but the extent to which these programmed responses are directly determined by the timing of maternal nutritional manipulation is unknown. In the present study we examined whether maternal nutrient restriction targeted over the period of maximal placental growth, i.e. days 28-80 of gestation, resulted in altered blood pressure or kidney development in the juvenile offspring. This was undertaken in 6-month-old sheep born to mothers fed control (100-150 % of the ... Read More »
» Published in Br J Nutr. 2005 Dec;94(6):938-47.
16. Effect of periconceptional undernutrition and gender on hypothalamic-pituitary-adrenal axis function in young adult sheep.
Match Strength: 4.591
Glucocorticoids are proposed to act as intermediary factors that transcribe the developmental programming sequelae of maternal nutrient restriction (NR). Periconceptional under-nutrition of sheep markedly activates fetal hypothalamic-pituitary-adrenal (HPA) axis activity leading to preterm birth, while transient undernutrition during late gestation in sheep programs adult HPA axis function. To date, no study has examined resting or stimulated HPA axis function in young adult offspring following a periconceptional nutritional challenge. In the present study, 20 ewes were either ... Read More »
» Published in J Endocrinol. 2006 Aug;190(2):203-12.
17. Baseline and stress-induced plasma corticosterone concentrations of mice selectively bred for high voluntary wheel running.
Match Strength: 4.255
The hypothalamic-pituitary-adrenal (HPA) axis is important in regulating energy metabolism and in mediating responses to stressors, including increasing energy availability during physical exercise. In addition, glucocorticoids act directly on the central nervous system and influence behavior, including locomotor activity. To explore potential changes in the HPA axis as animals evolve higher voluntary activity levels, we characterized plasma corticosterone (CORT) concentrations and adrenal mass in four replicate lines of house mice that had been selectively bred for high voluntary wheel ... Read More »
» Published in Physiol Biochem Zool. 2007 Jan-Feb;80(1):146-56. Epub 2006 Nov 13.
18. Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck, and gastrointestinal tract.
Match Strength: 4.103
BACKGROUND: Animal models suggest that cyclooxygenase-2 (COX-2) inhibitors may be beneficial in suppressing cancer cachexia. We investigated the effect of short-course celecoxib on body composition, inflammation, and quality of life (QOL) in patients with cancer cachexia in a phase II clinical pilot trial. METHODS: Eleven cachectic patients with head and neck or gastrointestinal cancer were randomly assigned to receive placebo or celecoxib for 21 days while awaiting the initiation of cancer therapy. Body composition, resting energy expenditure, QOL, physical function, and inflammatory markers ... Read More »
» Published in Head Neck. 2008 Jan;30(1):67-74.
19. The inhibition of mitochondrial complex I (NADH:ubiquinone oxidoreductase) by Zn2+.
Match Strength: 3.757
NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria is a highly complicated, membrane-bound enzyme. It is central to energy transduction, an important source of cellular reactive oxygen species, and its dysfunction is implicated in neurodegenerative and muscular diseases and in aging. Here, we describe the effects of Zn2+ on complex I to define whether complex I may contribute to mediating the pathological effects of zinc in states such as ischemia and to determine how Zn2+ can be used to probe the mechanism of complex I. Zn2+ inhibits complex I more strongly than Mg2+, ... Read More »
» Published in J Biol Chem. 2006 Nov 17;281(46):34803-9. Epub 2006 Sep 15.
20. Elevated peptide YY levels in adolescent girls with anorexia nervosa.
Match Strength: 3.636
BACKGROUND: Peptide YY (PYY) is an intestinally derived anorexigen that acts via the Y2 receptor, and Y2 receptor deletion in rodents increases bone formation. Anorexia nervosa (AN) is associated with a deliberate reduction in food intake and low bone density, but endocrine modulators of food intake in AN are not known. In addition, known regulators of bone turnover, such as GH, cortisol, and estrogen, explain only a fraction of the variability in bone turnover marker levels. HYPOTHESES: We hypothesized that PYY may be elevated in AN compared with controls and may contribute to decreased food ... Read More »
» Published in J Clin Endocrinol Metab. 2006 Mar;91(3):1027-33. Epub 2005 Nov 8.
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