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Weight Loss 2007
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1. Should medicare reimburse providers for weight loss interventions?
Match Strength: 10.622

This issue of the American Psychologist (April 2007) includes two reviews of the literature on the effects of behavioral programs to reduce body weight. One review (T. Mann et al., 2007) concentrates on dietary interventions and finds little evidence that diets are of benefit. The second review (L. H. Powell, J. E. Calvin III, & J. E. Calvin Jr., 2007) concentrates on multicomponent interventions and reports some significant achievements of behavioral interventions. Although the reviews come to different conclusions about the value of supporting weight loss interventions, there appears to be ... Read More »
» Published in Am Psychol. 2007 Apr;62(3):217-9.

2. Retention rates and weight loss in a commercial weight loss program.
Match Strength: 9.621

Objective:To evaluate and describe retention rates and weight loss in clients participating in a commercial weight loss program.Subjects:A total of 60 164 men and women ages 18-79 years who enrolled in the Jenny Craig Platinum program between May 2001 and May 2002.Methods:Retention rates, mean weight loss and percent weight loss were calculated on a weekly basis for the 52-week period following initial enrollment in the weight loss program. Clients were categorized based on final week of participation in the program (weeks 1-4, weeks 5-13, weeks 14-26, weeks 27-39 and weeks 40-52) and weight ... Read More »
» Published in Int J Obes (Lond). 2007 Feb;31(2):292-8. Epub 2006 Jun 6.

3. Comparison of a phone vs clinic approach to achieve 10% weight loss.
Match Strength: 9.438

Objective:To compare the efficacy of a phone vs a traditional face-to-face clinic approach to achieve 10% weight loss and weight maintenance.Design:Twenty-six week, randomized, controlled trial.Subjects:Twenty-four men and 72 women, ages 25-68 years, with a body mass index (BMI) of 33.2+/-3.8.Measurements:Weight loss at 12 weeks and weight maintenance at 26 weeks were the primary outcomes. Attendance, meal replacements (MRs), fruits/vegetables (F/V), and physical activity (PA) were measured weekly for process evaluation.Results:Median weight loss (range) from baseline at 12 weeks was ... Read More »
» Published in Int J Obes (Lond). 2007 Feb 27;

4. Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation.
Match Strength: 8.887

Fourteen patients were treated over 2 years with cervical vagus nerve stimulation (VNS) for adjunctive therapy of severe, treatment-resistant depression. Here, we report the serendipitous observation that this treatment was associated with highly significant, gradual weight loss despite the patients' report of not dieting or exercising. The weight loss was proportional to the initial BMI, that is, the more severe the obesity, the greater the weight loss. Weight loss did not correlate with changes in mood symptoms. The vagus nerve carries visceral information to and from the brain; modulation ... Read More »
» Published in Int J Obes (Lond). 2007 Jun 12;

5. The role of patients' expectations and goals in the behavioral and pharmacological treatment of obesity.
Match Strength: 8.564

Objective:To investigate weight loss expectations and goals among obese treatment seekers and to examine the relationships of these expectations and goals to treatment outcomes.Method:Participants were 180 obese men and women (age 43.8+/-10.1 years; body mass index 37.6+/-4.2 kg/m(2)) who received one of four-year-long treatments that combined behavioral and pharmacological methods. Before treatment, they reported the amount of weight they realistically expected to lose after 4, 12, 26 and 52 weeks of treatment, as well as their ultimate weight loss goals. Expectations and goals were compared ... Read More »
» Published in Int J Obes (Lond). 2007 May 1;

6. Physical Activity and Weight Management Across the Lifespan.
Match Strength: 8.440

This review discusses key findings and recommendations related to the role of physical activity in weight gain prevention, weight loss, and weight-loss maintenance across the lifespan. For weight gain prevention, epidemiological and clinical studies suggest that regular physical activity is critical, with increases above the recommended 30 min daily for health (e.g., to 45 to 60 min daily) potentially desirable for curtailing weight gain. For weight loss, clinical studies suggest that physical activity interventions alone usually produce only modest results. Combining physical activity with ... Read More »
» Published in Annu Rev Public Health. 2006 Dec 14;

7. Cholesterol metabolism and body composition in women: the effects of moderate weight loss.
Match Strength: 8.210

Objective:To determine how moderate weight loss protocol through diet and exercise may affect changes in body composition, to determine the effects of weight loss on cholesterol metabolism and to examine the relationship between cholesterol metabolism and changes in body composition.Design:Thirty-five otherwise healthy, hypercholesterolemic women completed a 24-week weight loss study. A 20% decrease in energy intake through diet and a 10% increase in energy expenditure by exercise were combined with motivational strategies to encourage weight loss. The diet was self-selected and comprised of ... Read More »
» Published in Int J Obes (Lond). 2007 Jan 30;

8. Thalidomide for the treatment of histiocytic sarcoma after hematopoietic stem cell transplant.
Match Strength: 7.839

Histiocytic sarcoma (HS) is a rare neoplasm of uncertain etiology. Most recently, the diagnostic criteria for this entity have been revised with inclusion of diagnostic modalities such as immunohistochemical and cytogentic techniques. HS tends to have an aggressive clinical course and presents with systemic symptoms of fever, weight loss, adenopathy, hepatosplenomegly, rash, and pancytopenia. Thalidomide is a promising agent that may exert a therapeutic benefit in HS. We report a case of a 48-year-old female with HS who presented with fever, weight loss, fatigue, generalized anasarca, and ... Read More »
» Published in Am J Hematol. 2007 Jul 6;

9. Using motivational interviewing as a supplement to obesity treatment: a stepped-care approach.
Match Strength: 7.526

OBJECTIVE: This investigation was designed to improve behavioral weight loss program (BWLP) treatment outcomes by providing stepped care (SC) to individuals experiencing difficulties with weight loss during treatment. SC entails transition to more intensive treatments when less intensive treatments fail to meet treatment goals. In a BWLP, motivational interviewing (MI) may increase participants' motivation toward behavioral change and thus complement the acquisition of behavioral change skills. It was hypothesized that BWLP+SC (MI) participants (i.e., participants who failed to meet weight ... Read More »
» Published in Health Psychol. 2007 May;26(3):369-74.

10. Weight loss and quality of life improvement in obese subjects treated with sibutramine: a double-blind randomized multicenter study.
Match Strength: 7.500

BACKGROUND AND AIM: Obesity affects cardiovascular risk and also quality of life (QoL). The aim of this study was to test weight loss and impact on QoL after sibutramine treatment in obese subjects. METHODS: Double-blind randomized trial on 309 outpatients (51 males, 258 females; age 41.8 +/- 10.9 years, BMI 35.0 +/- 3.1 kg/m(2)) randomized to sibutramine (n = 154) or to placebo (n = 155) treatment. A combination of sibutramine 10 mg or matching placebo and a balanced hypocaloric diet was given for 6 months with monthly evaluations. The main outcome measures were weight loss, the impact of ... Read More »
» Published in Ann Nutr Metab. 2007;51(1):75-81. Epub 2007 Mar 15.

11. Medicare's Search for Effective Obesity Treatments: Diets Are Not the Answer.
Match Strength: 7.499

The prevalence of obesity and its associated health problems have increased sharply in the past 2 decades. New revisions to Medicare policy will allow funding for obesity treatments of proven efficacy. The authors review studies of the long-term outcomes of calorie-restricting diets to assess whether dieting is an effective treatment for obesity. These studies show that one third to two thirds of dieters regain more weight than they lost on their diets, and these studies likely underestimate the extent to which dieting is counterproductive because of several methodological problems, all of ... Read More »
» Published in Am Psychol. 2007 Apr;62(3):220-33.

12. Cultural conflicts in the weight loss experience of overweight Latinos.
Match Strength: 7.451

Objective:In spite of the high prevalence of obesity in the Latino population, there is limited recent information that can be used by health-care providers to develop culturally appropriate weight loss strategies for this population. Therefore, we describe weight loss experiences, attitudes and barriers in overweight Latino adults.Design:Qualitative study using focus group methodologySubjects:Twenty-one overweight adults (body mass index >/=25, age >/=20 years) self-identified as Latinos.Methods:Subjects participated in one of three focus groups. Reccurring themes within group ... Read More »
» Published in Int J Obes (Lond). 2007 Feb;31(2):328-33. Epub 2006 May 23.

13. Impact of weight loss on the metabolic syndrome.
Match Strength: 7.405

Objective:To evaluate the effects of weight loss on the risk of having metabolic syndrome after 1 year of treatment with lifestyle modification alone, pharmacotherapy alone (sibutramine) or the combination of the two.Design:Randomized, controlled, 1-year clinical trial.Patients:One hundred and eighty women and 44 men, 18-65 years of age, with a body mass index of 30-45 kg/m(2), free of uncontrolled hypertension or type 1 or 2 diabetes.Intervention:Fifteen milligrams of sibutramine per day alone, lifestyle modification counseling alone, sibutramine plus lifestyle modification counseling or ... Read More »
» Published in Int J Obes (Lond). 2007 Mar 13;

14. Challenging Oral Contraception after Weight Loss by Bariatric Surgery.
Match Strength: 7.313

As surgical weight loss becomes more commonly performed in fertile women, adequate contraception is more frequently becoming an issue. The purpose of this article is to appraise the literature to ascertain whether the use of oral contraception is effective and adequate after bariatric surgery. The literature search revealed that the combination of lower oral contraception dosages and surgical gastrointestinal disturbances might place patients at higher risks of unintended pregnancy. Until clinical trials show its efficacy, physicians should use oral contraception with prudence after bariatric ... Read More »
» Published in Gynecol Obstet Invest. 2007 Feb 22;64(2):100-102

15. Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content.
Match Strength: 7.287

Objective:To investigate the effect of including seafood and fish oils, as part of an energy-restricted diet, on weight loss in young overweight adults.Design:Randomized controlled trial of energy-restricted diet varying in fish and fish oil content was followed for 8 weeks. Subjects were randomized to one of four groups: (1) control (sunflower oil capsules, no seafood); (2) lean fish (3 x 150 g portions of cod/week); (3) fatty fish (3 x 150 g portions of salmon/week); (4) fish oil (DHA/EPA capsules, no seafood). The macronutrient composition of the diets was similar between the groups and the ... Read More »
» Published in Int J Obes (Lond). 2007 May 15;

16. Effects of a Low-Fat versus a Low-Carbohydrate Diet on Adipocytokines in Obese Adults.
Match Strength: 7.173

Background and Aims: There are few studies addressing the effect of weight loss on circulating levels of adipocytokines. The aim of our study was to determine whether different diets would have different weight loss effects and to examine the changes in adipocytokine levels. Methods: A population of 90 obesity non-diabetic outpatients was analyzed in a prospective way. The patients were randomly allocated to two groups: (a) diet I (low-fat diet), and (b) diet II (low-carbohydrate diet). At baseline and after 3 months on the diet, adipocytokines were evaluated. Results: 43 patients were ... Read More »
» Published in Horm Res. 2007 Feb 6;67(6):296-300

17. Effective obesity treatments.
Match Strength: 7.162

To curb the epidemic of obesity in the United States, revised Medicare policy allows support for efficacious obesity treatments. This review summarizes the evidence from rigorous randomized trials (9 lifestyle trials, 5 drug trials, and 2 surgical trials) on the efficacy and risk- benefit profile of lifestyle, drug, and surgical interventions aimed at promoting sustained (= 2 years) reductions in weight. Both lifestyle and drug interventions consistently produced an approximate 7-lb (3.2-kg) weight loss that was sustained for 2 years and was associated with improvements in diabetes, blood ... Read More »
» Published in Am Psychol. 2007 Apr;62(3):234-46.

18. Drug treatment of the overweight patient.
Match Strength: 7.012

Three medications with approval for long-term use in the treatment of obesity are currently available in the United States. Sibutramine (U.S. Food and Drug Administration [FDA] approved in 1997), orlistat (FDA approved in 1999), and rimonabant (available in Europe and given FDA approvable status in 2006 and expected to be marketed in 2007) represent modern approaches to medications used adjunctively for weight management. As demonstrated in large clinical trials of 2 to 4 years' duration, these medications significantly increase weight loss compared with placebo; weight loss with these drugs ... Read More »
» Published in Gastroenterology. 2007 May;132(6):2239-52.

19. Changes in plasma amino Acid levels do not predict satiety and weight loss on diets with modified macronutrient composition.
Match Strength: 6.932

OBJECTIVE: Serotonin mediates satiety in the central nervous system. Brain serotonin content depends on the plasma ratio of tryptophan (Trp) to large neutral amino acids (LNAA) and may be affected by diet composition. We examined whether high-carbohydrate or high-protein diets induce satiety and weight loss by altering plasma concentrations of these amino acids. METHODS: In study 1 (n = 16, BMI = 27.0 +/- 2.3), we compared plasma Trp and LNAA concentrations averaged over 24 h after 2 weeks of consuming isocaloric diets containing either 45 or 65% of total energy as carbohydrate. In study 2 (n ... Read More »
» Published in Ann Nutr Metab. 2007;51(2):182-7. Epub 2007 May 30.

20. Carbohydrate versus Energy Restriction: Effects on Weight Loss, Body Composition and Metabolism.
Match Strength: 6.887

Background/Aims: To compare weight loss, body composition, and metabolic changes in response to carbohydrate versus dietary energy restriction (DER) in obese mice. Methods: One hundred C57BL/6 mice were randomized into five groups of 20. The group of high-carbohydrate (HC) mice consumed an HC diet ad libitum and the group of high-fat (HF) mice consumed an HF diet ad libitum for 14 weeks. Additional groups consumed the HF diet for 7 weeks ad libitum and during weeks 8-14 were switched to either a low-carbohydrate diet (LC) consumed ad libitum, the HC diet pair-fed (PF) to the energy intake of ... Read More »
» Published in Ann Nutr Metab. 2007 Jun 18;51(3):232-243

21. Sexual function and obesity.
Match Strength: 6.837

Objective:To review the literature on the relationship between obesity and sexual function.Method:A search in the medical literature from 1966 and onwards was carried out through Medline and Embase for publications on obesity, in combination with Medical Subject Heading words related to sexual function and dysfunction.Comments:Four prospective and seven cross-sectional studies were found describing association between obesity and erectile dysfunction (ED). One cross-sectional study was found describing obesity and female sexual dysfunction (FSD). The prospective studies on ED all demonstrated ... Read More »
» Published in Int J Obes (Lond). 2007 Mar 20;

22. Health service utilization for eating disorders: Findings from a community-based study.
Match Strength: 6.792

BACKGROUND:: Prior use of health services was examined in a community sample of women with bulimic-type eating disorders. METHOD:: Participants (n = 159) completed a structured interview for the assessment of eating disorder psychopathology as well as questions concerning treatment-seeking and type of treatment received. RESULTS:: Whereas a minority (40.3%) of participants had received treatment for an eating problem, most had received treatment for a general mental health problem (74.2%) and/or weight loss (72.8%), and all had used one or more self-help treatments. Where treatment was ... Read More »
» Published in Int J Eat Disord. 2007 Jul;40(5):399-408.

23. Planning to lose weight: Randomized controlled trial of an implementation intention prompt to enhance weight reduction among overweight and obese women.
Match Strength: 6.742

Objective: The trial investigates the effects of augmenting an established weight-reduction intervention with implementation intention prompts. Design: Fifty-five overweight or obese women (ages 18 to 76 years; body mass index from 25.28 to 48.33) enrolled in a commercial weight reduction program were randomly assigned to either an implementation intention prompt or a control condition. Data were collected twice, with a time gap of 2 months. Main Outcome Measures: The primary outcome was participants' change in weight and body mass index from preintervention to follow-up. Results: Repeated ... Read More »
» Published in Health Psychol. 2007 Jul;26(4):507-12.

24. Effect of weight loss on the postprandial response to high-fat and high-carbohydrate meals in obese women.
Match Strength: 6.739

Objective:To assess the effect of weight loss on the plasma lipid and remnant-like lipoprotein cholesterol (RLPc) response to a high-fat or a high-carbohydrate meal in a population of obese women.Design:Nutritional intervention study.Subjects:Sixteen obese women (mean body mass index (BMI): 37.6+/-5 kg/m(2)).Methods:Subjects were asked to follow an energy-restricted diet (800 kcal/day) for 7 weeks, followed by a 1-week maintenance diet. Before and after weight loss, each participant was given (in random order) two iso-energetic meals containing either 80% fat and 20% protein (the high-fat meal ... Read More »
» Published in Eur J Clin Nutr. 2007 Jan 17;

25. Defined weight expectations in overweight women: anthropometrical, psychological and eating behavioral correlates.
Match Strength: 6.703

Objective:To examine associations between defined weight expectations and anthropometric profile and to identify psychological and eating behavioral factors that characterize women having more realistic weight expectations.Methods:A nonrandom sample of 154 overweight/obese women completed the 'Goals and Relative Weight Questionnaire', which assessed four weight expectations: (1) dream weight (whatever wanted to weight); (2) happy weight (would be happy to achieve); (3) acceptable weight (could accept even if not happy with it); and (4) disappointed weight (would not view as a successful ... Read More »
» Published in Int J Obes (Lond). 2007 Jun 5;

26. Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study.
Match Strength: 6.678

Objective:To examine trends and effects of weight loss treatment on health-related quality of life (HRQL) in the severely obese over 10 years.Design:Swedish obese subjects (SOS) intervention study is a controlled, longitudinal trial of the health effects of weight loss in the severely obese.Subjects:A total of 655 of 851 surgically treated and 621 of 852 conventionally treated obese men (body mass index, BMI>/=34) and women (BMI>/=38) who completed 10 years of the study.Measurements:HRQL was assessed before treatment and after 0.5, 1, 2, 3, 4, 6, 8 and 10 years.Results:HRQL change during ... Read More »
» Published in Int J Obes (Lond). 2007 Mar 13;

27. Long-term effects of consumption of a novel fat emulsion in relation to body-weight management.
Match Strength: 6.646

Objective:To assess weight maintenance after weight loss by consumption of yoghurt with a novel fat emulsion (Olibra) including effects on body composition, resting energy expenditure (REE), fat oxidation, hunger feelings and satiety hormones.Design:A randomized, placebo-controlled, double-blind, parallel design. A 6-week weight loss period (2.1 MJ/day) was followed by 18 weeks weight maintenance with test (Olibra) or placebo yoghurt.Subjects:Fifty overweight women (age: 18-58 years, body mass index (BMI) 25-32 kg/m(2)).Measurements:In weeks 1, 7 and 25, a satiety test with questionnaires and ... Read More »
» Published in Int J Obes (Lond). 2007 Feb 13;

28. Stimulation of Cholecystokinin-A Receptors With GI181771X does not Cause Weight Loss in Overweight or Obese Patients.
Match Strength: 6.630

Cholecystokinin (CCK) decreases meal size through activation of CCK-A receptors on vagal afferents. We tested the hypothesis that the selective CCK-A agonist GI181771X induces weight loss in obese patients. Patients with body mass index >/=30 or >/=27 kg/m(2) with concomitant risk factors were randomized to 24-week, double-blind treatment with different GI181771X doses or matching placebo together with a hypocaloric diet. The primary efficacy end point was the absolute change in body weight. To monitor pancreatic and gallbladder effects, patients underwent abdominal ultrasound and ... Read More »
» Published in Clin Pharmacol Ther. 2007 Jun 27;

29. Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck, and gastrointestinal tract.
Match Strength: 6.466

BACKGROUND.: Animal models suggest that cyclooxygenase-2 (COX-2) inhibitors may be beneficial in suppressing cancer cachexia. We investigated the effect of short-course celecoxib on body composition, inflammation, and quality of life (QOL) in patients with cancer cachexia in a phase II clinical pilot trial. METHODS.: Eleven cachectic patients with head and neck or gastrointestinal cancer were randomly assigned to receive placebo or celecoxib for 21 days while awaiting the initiation of cancer therapy. Body composition, resting energy expenditure, QOL, physical function, and inflammatory ... Read More »
» Published in Head Neck. 2007 Jul 5;

30. Decreased basal levels of glucagon-like peptide-1 after weight loss in obese subjects.
Match Strength: 6.420

OBJECTIVE: Basal glucagon-like peptide-1 (GLP-1) concentrations seem to be attenuated in obese subjects, although statistical significance is unclear. Only a few studies have investigated the effect of weight reduction on GLP-1 concentrations and have found unclear results. The aim of the present study was to determine whether subjects who lose weight on a hypocaloric diet experience the same change in circulating GLP-1 levels as subjects who do not lose weight. MATERIAL AND METHODS: A population of 99 obese nondiabetic outpatients was analyzed in a prospective way. Weight and blood pressure ... Read More »
» Published in Ann Nutr Metab. 2007;51(2):134-8. Epub 2007 May 29.

31. Birth Characteristics, Maternal Reproductive History, and the Risk of Infant Leukemia: A Report from the Children's Oncology Group.
Match Strength: 6.337

Leukemias with MLL gene rearrangements predominate in infants (<1 year of age), but not in older children, and may have a distinct etiology. High birth weight, higher birth order, and prior fetal loss have, with varying consistency, been associated with infant leukemia, but no studies have reported results with respect to MLL status. Here, we report for the first time such an analysis. During 1999 to 2003, mothers of 240 incident cases (113 MLL(+), 80 MLL(-), and 47 indeterminate) and 255 random digit dialed controls completed a telephone interview. Odds ratios and 95% confidence intervals ... Read More »
» Published in Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):128-34.

32. Analysis of Pancreatic Adenocarcinoma Tumor Staging and Resection according to Previous Body Mass Index and Diabetes Duration.
Match Strength: 6.330

Background/Aims: Obesity and diabetes mellitus (DM) are associated with pancreatic cancer. The present study evaluated tumor staging and resectionof pancreatic adenocarcinoma (PaC) according to previous Body Mass Index (BMI), BMI on admission and DM duration. Methods: A retrospective analysis of 151 consecutive patients with PaC was performed: 73 were evaluated according to BMI preceding tumor-related weight loss and BMI on admission; 118 according to DM diagnosis; and 38 were assessed according to DM duration (less than 1 year [recent-onset] versus more than 2 years [long-standing]). Results: ... Read More »
» Published in Pancreatology. 2007 Jun 21;7(2-3):187-193

33. Randomized controlled trial comparing a low-fat diet with a weight-reduction diet in breast cancer-related lymphedema.
Match Strength: 6.305

BACKGROUND: Obesity is considered a risk factor for lymphedema of the arm resulting from breast cancer treatment (BCRL) as well as a poor prognostic factor in response to lymphedema treatment. The aim of the study was to compare the effect of 2 dietary interventions on excess arm volume in BCRL. METHODS: A total of 64 women with BCRL were randomized to 1 of 3 groups for 24 weeks: 1) weight reduction through reduced energy intake; 2) low-fat diet with no change in energy intake (isoenergetic); 3) control group with no dietary change from habitual intake. RESULTS: The primary outcome measure was ... Read More »
» Published in Cancer. 2007 May 15;109(10):1949-56.

34. Perinatal outcome of quadruplet pregnancies in relation to chorionicity.
Match Strength: 6.217

Objective:To compare the perinatal outcome of quadruplets in relation to chorionicity.Patients and methods:In this retrospective study, the maternal, neonatal and chorionicity data were collected from 24 sets of quadruplet pregnancies delivered between January 1985 and December 2001. Perinatal and neonatal data were evaluated in relation to chorionicity.Results:Sixteen pregnancies were quadra-chorionic quadramniotic (QC) and eight had at least one monochorionic pair (TC). The median gestational age at delivery was 31 weeks (23 to 34 weeks) with overall perinatal mortality rate of 177 per 1000 ... Read More »
» Published in J Perinatol. 2007 Jan;27(1):15-21.

35. Changes in thoracic gas volume with air-displacement plethysmography after a weight loss program in overweight and obese women.
Match Strength: 6.210

Objective:This study was designed to compare measured and predicted thoracic gas volume (V (TG)) after weight loss and to analyze the effect of body composition confounders such as waist circumference (WC) on measured V (TG) changes.Design:Prospective intervention study.Setting:Outpatient University Laboratory, Lisbon, Portugal.Subjects:Eighty-five overweight and obese women (body mass index=30.0+/-3.5 kg/m(2); age=39.0+/-5.7 years) participating in a 16-month university-based weight control program designed to increase physical activity and improve diet.Methods:Body weight (Wb), body volume ... Read More »
» Published in Eur J Clin Nutr. 2007 Mar 28;

36. Clinical significance of adaptive thermogenesis.
Match Strength: 6.112

The epidemic of obesity is developing faster than the scientific understanding of an efficient way to overcome it, as reflected by the low success rate of short- and long-term weight loss interventions. From a clinical standpoint, this suggests that the body tends to defend a set point of possible genetic origin in the context of a weight-reducing program. As described in this paper, this limited therapeutic success may depend on adaptive thermogenesis, which represents in this case the decrease in energy expenditure (EE) beyond what could be predicted from the changes in fat mass or fat-free ... Read More »
» Published in Int J Obes (Lond). 2007 Feb;31(2):204-12.

37. Evaluation of the developmental toxicity of lenalidomide in rabbits.
Match Strength: 6.085

BACKGROUND: Lenalidomide, a thalidomide analog, is indicated for treatment of patients with deletion-5q myelodysplastic syndromes or multiple myeloma. NZW rabbits were used because of sensitivity to thalidomide's teratogenicity. METHODS: Range-finding and pulse-dosing studies preceded a full developmental toxicity study in New Zealand white (NZW) rabbits (25/group) given lenalidomide (0, 3, 10, or 20 mg/kg/day) or thalidomide (180 mg/kg/day) by stomach tube on gestation days (GD) 7-19. Clinical signs, body weights, and feed consumption were recorded daily from GD 7. On GD 29, standard maternal ... Read More »
» Published in Birth Defects Res B Dev Reprod Toxicol. 2007 Jun;80(3):188-207.

38. Obesity, physical activity and the risk of pancreatic cancer in a large Japanese cohort.
Match Strength: 6.076

It is unclear whether body mass index (BMI) and physical activity are associated with the risk of pancreatic cancer in Asian populations. We examined these associations in the Japanese Collaborative Cohort Study for Evaluation of Cancer Risk. Our cohort study included 110,792 Japanese men and women at enrollment (1988-1990). Data on height, body weight (at baseline and at age 20 years) and physical activity were obtained from a questionnaire. Cox proportional hazards models were used to estimate the relative risks of pancreatic cancer mortality. We observed a total of 402 pancreatic cancer ... Read More »
» Published in Int J Cancer. 2007 Feb 15;

39. Health-related quality of life after gastric banding.
Match Strength: 6.058

BACKGROUND:: Bariatric surgery ameliorates obesity-associated diseases, resulting in psychological and social benefits. Long-term studies of its effects on quality of life (QOL) assessed with well established instruments are lacking. This prospective study investigated the long-term effects of gastric banding on health-related QOL using an obesity-specific validated measure. METHODS:: The Health Related Quality of Life (HRQL) questionnaire was completed by 50 severely obese patients before surgery and at 1, 2.5 and 5 years after gastric banding. Ninety-eight subjects with normal weight, ... Read More »
» Published in Br J Surg. 2007 Feb 20;

40. Preventing weight gain: a population cohort study of the nature and effectiveness of mid-age women's weight control practices.
Match Strength: 5.988

Objective:To examine women's weight control practices and their effectiveness in preventing weight gain.Design:Retrospective cohort study of weight control practices and 2-year weight change among mid-age women participating in the Australian Longitudinal Study on Women's Health (ALSWH).Subjects:11 589 Australian women (aged 47-52 years).Measurements:The prevalence and types of self-reported weight control practices used were assessed by a nine-item instrument. Two-year weight change was self-reported and adjusted for baseline body mass index (BMI) and other potential confounders.Results ... Read More »
» Published in Int J Obes (Lond). 2007 Jan 30;

41. Characterization, degradation, and mechanical strength of poly(D,L-lactide-co-epsilon-caprolactone)-poly(ethylene glycol)-poly(D,L-lactide-co-epsilon-caprolactone).
Match Strength: 5.981

A series of three biocompatible P(CL-co-LA)-PEG-P(CL-co-LA) copolymers were synthesized using ring-opening polymerization and characterized by (1)H-NMR, gel permeation chromatography, DSC, dynamic-mechanical analysis, and X-ray diffraction. The number of monomer units was kept constant, while the D,L-LA fraction was varied so as to constitute 0, 30, or 70% of the end segments. The molecular weights were sufficiently high to eventually permit 3D scaffold preparation. A degradation study was carried out over 26 weeks, and the effect of monomer composition on the rate of degradation as well as on ... Read More »
» Published in J Biomed Mater Res A. 2007 May 14;

42. Energy Expenditures and Food Intakes of Lactating Women in Guatemala
Match Strength: 5.950

PIP: Total energy expenditures and intakes were simultaneously assessed in 18 lactating women (10 months postpartum) and compared to 6 similarly-sized nonlactating, nonpregnant but multiparious women living in the same rural villag in the Guatemalan highlands. Energy intakes were estimated by the 24-hour recal method for each of 4 consecutive days. Energy expenditures were determined for 2 days by monitoring heart rate throughout the day and relating heart rate to oxygen consumption by individually-determined regression lines. The mean energy intake for the 4 consecutive days was estimated ... Read More »
» Published in Am J Clin Nutr. 1980 Apr;33(4):892-902.

43. Cystic pancreatic tumors (CPT): Predictors of malignant behavior.
Match Strength: 5.896

BACKGROUND AND OBJECTIVES: Due to widespread use of imaging studies, increasing cystic pancreatic tumor (CPT) cases are being detected. The diagnosis of malignancy in CPT cases requires pancreatectomy. Clinical and laboratory characteristics of CPT may predict underlying malignancy. METHODS: CPT cases treated between 1994 and 2004 at our institution were included. Pseudocysts were excluded. Serous cystadenoma (SCA), mucinous cystadenoma (MCA), intrapapillary mucinous tumor, cystic endocrine tumor, and lymphoepithelial cysts were classified as benign or pre-malignant. Serous cystadenocarcinoma ... Read More »
» Published in J Surg Oncol. 2007 Feb 23;95(3):221-228

44. Long-term health and psychosocial outcomes from surgically induced weight loss: results obtained in patients not attending protocolled follow-up visits.
Match Strength: 5.892

Objective:Obesity management is focused at weight loss to obtain health, psychological and social benefits. Outcomes from controlled trials, however, do not reflect the everyday routine practice. Therefore, we aimed to investigate the results from surgically induced weight loss in patients devoid of a protocol-wise follow-up, who were visited at home.Patients and methods:Patients who underwent a vertical banded gastroplasty or a gastric bypass between 1980 and 1997 were eligible. Body weight and height were measured. Patients filled out questionnaires on health status (Nottingham Health ... Read More »
» Published in Int J Obes (Lond). 2007 Feb;31(2):299-307. Epub 2006 Jun 6.

45. Effects of bioactive peptide, valyl-prolyl-proline (VPP), and lactobacillus helveticus fermented milk containing VPP on bone loss in ovariectomized rats.
Match Strength: 5.876

BACKGROUND: Valyl-prolyl-proline (VPP), a bioactive peptide formed during the fermentation with Lactobacillus helveticus LBK-16H (L. helveticus), has been shown to increase bone formation in vitro. The aim of the study was to determine whether VPP and L. helveticus fermented milk prevent bone loss in ovariectomized (OVX) rats. METHODS: During the 12-week intervention study, the OVX rats received VPP in water or L. helveticus fermented milk, containing VPP. Sham-operated rats receiving water acted as controls. The trabecular and cortical bone mineral density were determined by peripheral ... Read More »
» Published in Ann Nutr Metab. 2007;51(1):65-74. Epub 2007 Mar 15.

46. Hypodipsic hypernatremia after hypothalamic infarct.
Match Strength: 5.802

Background: Hypothalamic hypodipsic syndrome is a rare condition, secondary to a defect in hypothalamic osmoreceptors that leads to impairment of water homeostasis and chronic hyperosmolality. It is frequently associated with defective osmoregulated vasopressin secretion and diabetes insipidus, and the combination results in a greater risk of hypernatremia. The principles of management consist of regulating vasopressin and water intake in relation to changes in daily body weight. Methods and Results: This case report concerns a patient who, after a postoperative cerebral infarction, developed ... Read More »
» Published in Horm Res. 2007;67 Suppl 1:180-3. Epub 2007 Feb 15.

47. Bariatric surgery for pediatric extreme obesity: now or later?
Match Strength: 5.756

Obesity is a multifactorial disease of epidemic and global proportions that poses the most significant threat to the health of our younger generations. Those who are the most extremely affected bear the largest burden of health problems. In the US, extreme obesity affects approximately 9 million adults and 2 million children, and is associated with both immediate health problems and later health risk, including premature mortality. Present medical and behavioral interventions for extreme obesity in adults and children rarely result in the significant, durable weight loss necessary to improve ... Read More »
» Published in Int J Obes (Lond). 2007 Jan;31(1):1-14.

48. Influence of TiO(2) and Ag(2)O addition on tricalcium phosphate ceramics.
Match Strength: 5.667

Degradation of implanted ceramics allows for bone in-growth and eventual replacement with natural tissue. Calcium phosphate-based materials have gained the most significant attention because of their excellent biocompatibility and compositional similarities to natural bone. Adding various dopants to these ceramics significantly influences critical properties. In this study, tricalcium phosphate (TCP) compacts were fabricated via uniaxial compression with four compositions: (i) pure TCP, (ii) TCP with 1.0 wt % TiO(2), (iii) TCP with 0.5 wt % Ag(2)O, and (iv) ternary of TCP and 1.0 wt % TiO(2), ... Read More »
» Published in J Biomed Mater Res A. 2007 Jan 31;

49. What is the quality of reporting in weight loss intervention studies? A systematic review of randomized controlled trials.
Match Strength: 5.650

Background:Despite the large number of randomized controlled trials (RCTs) assessing weight loss interventions, no study has assessed the quality of reporting in these trials.Purpose:To assess the quality of reporting of RCTs of weight loss interventions and to identify predictors of reporting quality.Methods:The RCTs assessed were derived from a published systematic review of trials investigating the efficacy of weight loss interventions. For our study, two reviewers independently rated the quality of reporting in these trials, based on the Consolidated Standards for Reporting of Trials ... Read More »
» Published in Int J Obes (Lond). 2007 Apr 24;

50. Preparation and characterization of nano-hydroxyapatite/chitosan/konjac glucomannan composite.
Match Strength: 5.612

Nano-hydroxyapatite (n-HA)/chitosan (CS)/konjac glucomannan (KGM) composite was prepared by coprecipitation method and investigated by thermal gravitivity/differentiate thermal analysis, Fourier transform infrared spectroscopy, X-ray diffraction, inductively coupled plasma emission spectroscopy, scanning electron microscopy, and energy dispersive X-ray analyzer. The analyses showed that the three phases of n-HA, CS, and KGM combined closely to each other. Further, in vitro tests were conducted to investigate the degradation and bioactivity of the composite. During immersion in simulated body ... Read More »
» Published in J Biomed Mater Res A. 2007 Jun 13;

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