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Stroke
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1. Has Ontario's Stroke System really made a difference?
Match Strength: 8.948

The progress that has been made in preventing and treating stroke since 2000, when the Joint Stroke Strategy Working Group tabled its blueprint report, Towards an Integrated Stroke Strategy, is very encouraging. The evaluation results demonstrate that the Ontario Stroke System has had positive measurable impacts on access to stroke-related services, the integration and coordination of stroke care, treatment for stroke, and client and provider satisfaction ... Read More »
» Published in Healthc Q. 2006;9(4):50-9, 2.

2. Educational approach on stroke training in Europe.
Match Strength: 8.378

According to the European Stroke Initiative (EUSI), stroke care is best delivered within a stroke unit by a specialized multidisciplinary stroke team led by stroke specialists. At present, there is no guideline or consensus regarding training requirements or clinical standards that stroke specialists should achieve. It is envisaged that stroke specialists in training would need to acquire adequate knowledge and competency across three major areas of stroke care: acute stroke, stroke rehabilitation, and stroke prevention. With an EUSI document, the European Association of Young Neurologists and ... Read More »
» Published in Clin Exp Hypertens. 2006 Apr-May;28(3-4):433-7.

3. C-reactive protein, stroke, and statins.
Match Strength: 8.109

C-reactive protein (CRP) is an important indicator and player in inflammatory diseases such as stroke. It may be involved in the earliest stages of stroke. Monitoring the levels of CRP may help in the prevention and treatment of stroke. Statin drugs may be useful in lowering CRP levels and the incidence of stroke. Publication Types: ... Read More »
» Published in Crit Care Nurs Q. 2007 Apr-Jun;30(2):161-5.

4. Microembolic signals after 7 days but not within 24 hours of stroke onset should be predictor of stroke recurrence.
Match Strength: 8.028

BACKGROUND AND PURPOSE: Microembolic signals (MES) on transcranial Doppler ultrasonography (TCD) are occasionally detected in acute ischemic stroke patients and gradually decrease over time. If MES is detectable at 7 days after stroke onset, embolic source lesions may still be active. We hypothesized that presence of MES at 7 days after stroke onset is strongly associated with stroke recurrence. METHODS: Subjects comprised 143 patients with acute ischemic stroke who were prospectively examined for the presence of MES using TCD both within 24 h and at 7 days after stroke onset. Stroke ... Read More »
» Published in J Neurol Sci. 2007 Jun 21;

5. The effect of diabetes and stroke at baseline and during follow-up on stroke mortality.
Match Strength: 7.982

AIMS/HYPOTHESIS: The aim of this study was to compare the magnitude of the effect of diabetes and stroke at baseline and during follow-up on risk of stroke mortality. MATERIALS AND METHODS: Study cohorts included 25,155 Finnish men and 26,423 women aged 25-74 years. Data on diabetes and stroke history at baseline, their incidence during follow-up, and stroke death were obtained from national registers. RESULTS: During a mean follow-up of 18.9 years, 838 stroke deaths were recorded. In the baseline study, hazard ratios (HRs) for stroke mortality were 5.26 for men with prior diabetes only, 4.76 ... Read More »
» Published in Diabetologia. 2006 Oct;49(10):2309-16. Epub 2006 Aug 1.

6. Igg Anti-Cardiolipin Antibodies-Markers of Inflammation in Diabetic Patients with Ischemic Stroke
Match Strength: 7.954

Some researchers investigated the role of anticardiolipin antibodies in the pathogenesis of the ischemic stroke. The objective of the study was to evaluate the relationship between the prevalence of the IgG anti-cardiolipin antibodies (IgG aCL) and ischemic stroke in patients with diabetes mellitus. IgG aCL were prospectively investigated in 87 diabetic patients with ischemic stroke (mean age 78.5 years) and in 68 diabetic patients without ischemic stroke (mean age 72.8 years). IgG aCL were determined by ELISA. Twenty-three out of 87 diabetic patients without ischemic stroke had IgG aCL and 25 ... Read More »
» Published in Rom J Intern Med. 2003;41(3):277-81.

7. Post-stroke seizure and post-stroke epilepsy.
Match Strength: 7.929

Post-stroke seizure and post-stroke epilepsy are common causes of hospital admissions, either as a presenting feature or as a complication after a stroke. They require appropriate management and support in long term. With an increasingly ageing population, and age itself being an independent risk factor for stroke, the incidence and prevalence of post-stroke seizure and post-stroke epilepsy is likely to increase. This article examines aetiology, clinical presentation, and presents a management outline of these conditions with particular focus on adults. The aim of this review article is to ... Read More »
» Published in Postgrad Med J. 2006 Sep;82(971):568-72.

8. Family history of stroke and severity of neurologic deficit after stroke.
Match Strength: 7.857

BACKGROUND: A family history of stroke is an independent risk factor for stroke. OBJECTIVE: To assess whether severity of neurologic deficit after stroke is associated with a family history of stroke. METHODS: The Ischemic Stroke Genetics Study, a five-center study of first-ever symptomatic ischemic stroke, assessed case subjects prospectively for a family history of stroke-affected first-degree relatives. Certified adjudicators used the NIH Stroke Scale (NIHSS) to determine the severity of neurologic deficit. RESULTS: A total of 505 case subjects were enrolled (median age, 65 years; 55% male) ... Read More »
» Published in Neurology. 2006 Oct 24;67(8):1396-402.

9. Acute stroke.
Match Strength: 7.809

The treatment of patients with acute stroke is reviewed. Evidence of the existence of an ischemic penumbra in humans is presented. Different approaches to treatment of acute stroke include restoring blood flow by thrombolysis, neuroprotection, and early secondary prevention with aspirin. The evidence for each of these approaches is reviewed. Organization of stroke services, and particularly the use of stroke units, have been shown to significantly improve stroke outcome and these data are presented ... Read More »
» Published in Int Psychogeriatr. 2003;15 Suppl 1:161-6.

10. Awareness of stroke risk in chagasic stroke patients.
Match Strength: 7.772

BACKGROUND: Reduction in stroke risk may depend on the general population's knowledge of stroke. In South America, chagasic myocardiopathy is independently associated with ischemic stroke. OBJECTIVE: The aim of this study was to evaluate awareness of Chagas' disease (CD) as a stroke risk factor and to determine the frequency of stroke patients that are diagnosed as having CD after stroke. METHODS: Eighty CD stroke patients and 140 non-chagasic stroke patients (53.2% males; mean age 60 years), consecutively admitted to the hospital during 2005 were interviewed with a questionnaire. Demographic ... Read More »
» Published in J Neurol Sci. 2007 Jun 14;

11. Migraine and cerebrovascular disease.
Match Strength: 7.733

The association between migraine and stroke is complex and bidirectional. Epidemiological studies suggest that migraine may be a risk factor for stroke; magnetic resonance studies suggest that white matter abnormalities may be more frequent in migraine patients than in controls; and stroke may occur during the course of a migraine with aura (MA) attack (migrainous stroke). However, the relationship between migraine, aura and stroke is complex and mechanisms other than a direct cause/effect relationship are possible. Migraine aura may be the consequence, rather than the cause of cerebral ... Read More »
» Published in Neurol Sci. 2007 May;28 Suppl 2:S156-60.

12. Stroke in Italy: a disease to prevent.
Match Strength: 7.662

Stroke, a disease determining an increasing socioeconomic burden in aging populations, represents the second cause of mortality worldwide and the third cause of mortality in western countries. In our study, crude annual incidence rate of stroke was 293/ 100,000. Several conditions and life-style factors have been identified as risk factors for stroke. Their recognition is important to prevent stroke. Atherothrombosis contributes a large proportion of cases; however, conventional stroke risk factors do not fully account for the risk of stroke, and often stroke victims with documented ... Read More »
» Published in Clin Exp Hypertens. 2006 Apr-May;28(3-4):199-203.

13. Comprehensive stroke care: an overview.
Match Strength: 7.606

Stroke is a global epidemic and an important cause of morbidity and mortality. It ranks next to cardiovascular disease and cancer as a cause of death. "India is likely to suffer huge social and economic burden in the rehabilitation of stroke patients owing to increased life expectancy" and urbanization. Though, there are national programs in malaria eradication and tuberculosis control, there is hardly any governmental support in stroke management and rehabilitation. We propose to formulate stroke-prevention strategies specific to our national needs and covering all the age groups. Allocation ... Read More »
» Published in J Assoc Physicians India. 2006 Jan;54:36-41.

14. Stroke thrombolysis 2006: an update progress in cardiovascular diseases.
Match Strength: 7.544

Acute stroke therapy took a major step forward in 1996 after the approval of Intravenous (IV) tissue plasminogen activator (t-PA) by the US Food and Drug Administration for patients presenting within 3 hours of the onset of stroke symptoms. Since that time, there have been considerable advances in imaging techniques as well as the advent of devices to help in the management of acute stroke patients. As a result, the arsenal to treat acute stroke has grown, and the field of stroke as a subspecialty of neurology has emerged. Despite these advances, only 3% to 8% of eligible patients with acute ... Read More »
» Published in Prog Cardiovasc Dis. 2007 May-Jun;49(6):430-8.

15. Stroke units. The first-year results of Pulido Valente Hospital Stroke Unit.
Match Strength: 7.540

Stroke is a worldwide problem with high incidence, mortality, disability rates and costs. There is clear evidence from systematic reviews of randomized trials that management by a stroke unit saves lives, increases the number of independent survivors and reduces institutionalization. Like coronary care units, stroke units are known to improve outcome by concentrating patients who should be treated by a multidisciplinary stroke team. Despite this clear evidence, only a few patients can benefit from this in Portugal, since the number of beds in stroke units is very small. Here we describe how we ... Read More »
» Published in Rev Port Cardiol. 2004 Oct;23(10):1227-41. Comment in: Rev Port Cardiol. 2004 Oct;23(10):1245-7.

16. Stroke information reported on local television news: a national perspective.
Match Strength: 7.531

BACKGROUND AND PURPOSE: Local television news commonly reports on health. This study aimed to characterize local TV news stroke reporting in America. METHODS: Content analysis of stroke stories reported on 122 US local television stations. All stroke stories were coded for main focus and discussion of risk factors, stroke signs and symptoms, recombinant tissue plasminogen activator, treatment within 3 hours, or recommendation to call 911. RESULTS: Of the 1799 health stories, only 13 stroke stories aired, and the median story length was 24 seconds (interquartile range 21 to 48). Stroke was the ... Read More »
» Published in Stroke. 2006 Jun;37(6):1556-7. Epub 2006 May 4.

17. Primary stroke center: basic components and recommendations.
Match Strength: 7.521

Stroke is the leading cause of disability and the third leading cause of death in the United States. The brain attack coalition (BAC), whose members belong to several professional medical societies, formed a working group to explore the factors and elements that are associated with better clinical outcome after acute stroke. In the year 2000, the BAC published the recommendations for primary stroke centers (PSC). The primary goals for the PSC are to improve and to standardize stroke care. Convinced by the compelling data on the PSC, the Joint Commission on Accreditation of Healthcare ... Read More »
» Published in South Med J. 2006 Jul;99(7):749-52.

18. Is time limit at the minimum swimming velocity of VO2 max influenced by stroking parameters?
Match Strength: 7.520

The aim of this study was to observe the relationship between time limit at the minimum velocity that elicits maximal oxygen consumption (TLim-v VO2 max) and stroke rate, stroke length, and stroke index. 13 men and 10 women, highly trained swimmers, performed an intermittent incremental test for v VO2 max assessment and an all-out swim to estimate TLim-v VO2 max. The mean +/- SD TLim-v VO2 max, v VO2 max, stroke rate, stroke length, and stroke index values were 233.36 +/- 53.92 sec., 1.40 +/- .06 meter/sec., 35.58 +/- 2.89 cycles/min., 2.39 +/- .22 meter/cycle, and 3.36 +/- .41 meter2/(cycle x ... Read More »
» Published in Percept Mot Skills. 2006 Aug;103(1):67-75.

19. Subclinical hypothyroidism, hyperhomocysteinemia and dyslipidemia: investigating links with ischemic stroke in Turkish patients.
Match Strength: 7.497

OBJECTIVES: Hyperhomocysteinemia is a risk factor for ischemic stroke. Hypothyroidism may cause hyperhomocysteinemia. To date, no works have examined the association between hypothyroidism and hyperhomocysteinemia in ischemic stroke. We aimed to investigate the roles of hypothyroidism and hyperhomocysteinemia in ischemic stroke, and whether any relationship exists between hypothyroidism and hyperhomocysteinemia in ischemic stroke patients. METHODS: The study included 249 ischemic stroke patients and 102 patients with no history of stroke. Patients were evaluated for conventional risk factors ... Read More »
» Published in Neurol Res. 2007 Jun 19;

20. Stroke awareness among rural residents: the case of West Virginia.
Match Strength: 7.496

Stroke is the leading cause of disability and the third leading cause of death in the United States. There are modifiable and non-modifiable stroke risks and proper management of some of these risks could significantly reduce the risk of stroke incidence. However, proper management of stroke risks requires public awareness of these risks and awareness of appropriate approaches to managing them. In case of stroke incidence, it is also important for patients to be able to recognize stroke symptoms and get immediate emergency medical attention. In this article, stroke awareness is studied as ... Read More »
» Published in Soc Work Health Care. 2005;42(2):73-92.

21. Interleukin-18 in acute ischaemic stroke patients
Match Strength: 7.470

As proinflammatory cytokines released during ischaemia are detrimental to the brain, the study aimed to evaluate serum interleukin-18 (IL-18) levels in stroke patients and to investigate the relation between these and epidemiological and clinical data. The study comprised 23 ischaemic stroke patients and 15 controls. Blood sampling for IL-18 determination and for chemistry, and brain CT were performed within 24 h of stroke, while neurological stroke severity and functional disability were estimated, respectively, with the Scandinavian stroke scale (SSS) and Barthel index (BI) within the same ... Read More »
» Published in Neurol Sci. 2003 Oct;24(3):117-24.

22. Interleukin 1 beta polymorphism (-511) and risk of stroke due to small vessel disease.
Match Strength: 7.466

BACKGROUND: Interleukin 1 (IL-1) is a proinflammatory cytokine involved in atherogenesis and thrombosis. The aim of this study was to investigate the association between the IL-1beta gene polymorphism (-511) and the risk of large vessel disease (LVD) stroke, small vessel disease (SVD) stroke and cardioembolic (CE) stroke. METHODS: We genotyped 115 patients with LVD stroke and 194 matched controls, 122 patients with SVD stroke and 227 controls and 221 patients with CE stroke and 219 controls. The IL-1beta polymorphism was analyzed by a polymerase chain reaction followed by a restriction enzyme ... Read More »
» Published in Cerebrovasc Dis. 2005;20(5):299-303. Epub 2005 Aug 30.

23. Different degrees of right-to-left shunting predict migraine and stroke: data from 420 patients.
Match Strength: 7.442

The authors analyzed the extent of right-to-left shunting in patients with migraine, patients with cryptogenic stroke, and controls. Patients with both migraine and stroke had larger shunts than did patients with migraine without stroke (p = 0.038), patients with no migraine with stroke (p = 0.007), and control patients (p < 0.0001). Patients with migraine have overall larger shunts than nonmigraineurs, particularly if they have had a stroke. Right-to-left shunting may be causally related to migraine and to the increased stroke risk of migraine ... Read More »
» Published in Neurology. 2006 Mar 14;66(5):765-7. Comment in: Neurology. 2006 Sep 12;67(5):919-20; author reply 919-20.

24. Diabetes and stroke: part one--risk factors and pathophysiology.
Match Strength: 7.432

Diabetes is a major risk factor for stroke and is associated with an increase in overall stroke mortality. The metabolic syndrome associated with insulin resistance is also a significant risk factor for stroke. The etiology of stroke in diabetics is frequently microvascular disease from fibrinoid necrosis, which causes small subcortical infarcts designated as lacunar strokes. Diabetics also have an increased incidence of large vessel intracranial vascular disease. Although strict control of blood sugar has not been shown to reduce the overall incidence of stroke in diabetics, careful ... Read More »
» Published in Curr Cardiol Rep. 2006 Feb;8(1):23-8.

25. Comparison of stroke ward care versus mobile stroke teams in the Hungarian stroke database project.
Match Strength: 7.431

Although previous studies have proved that both stroke wards and mobile stroke teams are considerably better than non-specialized stroke care, an unresolved debate in vascular neurology is whether or not stroke wards provide better outcomes in some specific cases to stroke victims. Our prospective, multicenter, cohort study compared dedicated stroke wards versus specialist stroke team care at general hospital wards in 11 centers nationwide for 8743 consecutive stroke events during 18 months. Twenty-eight-day case-fatality rate was 12.6% at stroke wards versus 15.2% at stroke teams for all ... Read More »
» Published in Eur J Neurol. 2007 Jul;14(7):757-61.

26. Prevalence and predictors of pain and fatigue after stroke: a population-based study.
Match Strength: 7.414

Pain and fatigue are two often overlooked symptoms after stroke. Their prevalence and determinants are not well understood. In this study patients with first-ever stroke (n=377) were examined at baseline and after 1 year. General characteristics of the patients, as well as stroke type, stroke severity and risk factors were registered at baseline. After 1 year survivors (n=253) were examined with respect to residual impairment, disability, cognition and depression. They were asked whether they had experienced pain and/or fatigue which had started after the stroke, and which the patient felt to ... Read More »
» Published in Int J Rehabil Res. 2006 Dec;29(4):329-33.

27. Stroke in young adults: report of three cases and review of literature.
Match Strength: 7.404

OBJECTIVE: To highlight the occurrence, and review the literature on stroke in young adults. METHODS: This paper reports three cases of young strokes. Brain imaging was done for two cases. The two were haemorrhagic stroke; one from an identified arteriovenous malformation and the other from a suspected vascular malformation or intracranial aneurysm. The third case was a young man with nephrotic syndrome who presented with clinical features of a thrombotic stroke. A review of the literature on stroke in young adults was done via Medline search for relevant publications. RESULTS: The literature ... Read More »
» Published in Niger Postgrad Med J. 2006 Jun;13(2):157-60.

28. Cerebral palsy secondary to perinatal ischemic stroke.
Match Strength: 7.397

Congenital hemiplegia is the most common form of cerebral palsy in children born at term, and stroke is the number one cause. Neonatal ischemic stroke includes perinatal arterial ischemic stroke, presumed pre- or perinatal stroke, and cerebral sinovenous thrombosis, all of which have emerged as important contributors to cerebral palsy. Of increasing interest is how the overlapping list of associations and risks for stroke and cerebral palsy relate to each other. Stroke-induced injury is focal, and the preservation of normal areas of brain may afford unique opportunities for plastic adaptation. ... Read More »
» Published in Clin Perinatol. 2006 Jun;33(2):367-86.

29. Stroke etiology among Haitians living in Miami.
Match Strength: 7.391

The black Caribbean population continues to grow in the US and little is known about stroke etiologies in that community. We examined stroke subtypes in 175 consecutive Haitian-born patients living in Miami, admitted for acute stroke. Ischemic stroke was diagnosed in 72%. Small vessel occlusion was the most frequent stroke subtype. There was a high prevalence of hypertension, medication noncompliance and intracranial atherosclerosis. Hypertension was the only cardiovascular risk factor significantly associated with small vessel infarction when compared with non-small vessel infarcts. Copyright ... Read More »
» Published in Neuroepidemiology. 2005;25(4):192-5. Epub 2005 Aug 15.

30. Relation between migraine and stroke.
Match Strength: 7.388

A complex bidirectional relation between migraine, mostly migraine with aura (MA), and ischaemic stroke is known. A cerebral infarction can occur during a MA, and MA is a risk factor for ischaemic stroke, particularly in young women. Conversely, cerebral ischaemia can induce MA. Both ischaemic stroke and MA might be consequences of many underlying vascular disorders. Despite the relation between migraine and stroke, migraine as a primary headache disorder is mostly benign. Publication Types: ... Read More »
» Published in Lancet Neurol. 2005 Sep;4(9):533-42.

31. An audit of the impact of implementation of a stroke care pathway in an acute teaching hospital.
Match Strength: 7.375

BACKGROUND: In 2002, a survey of stroke management was conducted in our institution benchmarked against the UK National Stroke Audit 2002. The conclusion was that management of stroke patients lacked organised and specialised care. The introduction of a stroke care pathway was recommended. AIMS: This audit assessed the clinical impact of implementation of a stroke care pathway by the general medical teams in an acute teaching hospital. METHODS: A random sample of 48/131 patients were surveyed in 2002 compared to 55 consecutive patients admitted with stroke in 2005. RESULTS: Despite ... Read More »
» Published in Ir J Med Sci. 2007 Jul-Sep;176(2):75-9. Epub 2007 Apr 20.

32. Trends of stroke subtypes mortality in Sao Paulo, Brazil (1996-2003).
Match Strength: 7.366

The decline of stroke mortality rates has been described in Brazil; however, there is no data about stroke subtypes. We described the changes of stroke mortality rates in the city of Sao Paulo (1996-2003) emphasizing intracerebral hemorrhage and cerebral infarction. We categorized mortality data by gender and 10-year age-strata from 30 to 79 years-old. For men, an annual reduction of all types of stroke (-3.9%), and of stroke subtypes as intracerebral hemorrhage (-3.0%) and cerebral infarction was observed (-2.7%) as well as, a decline of ill-defined stroke (-7.4%). For women, a decline was ... Read More »
» Published in Arq Neuropsiquiatr. 2005 Dec;63(4):951-5. Epub 2005 Dec 15.

33. Insular involvement is associated with QT prolongation: ECG abnormalities in patients with acute stroke.
Match Strength: 7.362

PURPOSE: Aim was to assess the frequencies of electrocardiographic (ECG) abnormalities, including QT prolongation, in acute stroke patients and their association with stroke severity, stroke subtype and location, and cardiovascular risk factors. METHODS: Prospectively, admission 12-lead ECG findings, stroke characteristics, cardiovascular risk factors, and potential QT-prolonging factors were collected in 122 consecutive patients with acute stroke. RESULTS: Eighty-four patients (69%) had ECG abnormalities, most frequently ST changes in 34%, QT prolongation in 31%, and atrial fibrillation in 27 ... Read More »
» Published in Cerebrovasc Dis. 2006;21(1-2):47-53. Epub 2005 Nov 8. Comment in: Cerebrovasc Dis. 2006;22(5-6):461.

34. Mechanisms of action of statins in stroke.
Match Strength: 7.362

Statins decrease the incidence of cardiovascular events and death in patients with coronary artery disease. Moreover, the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study has recently demonstrated that high-dose atorvastatin may also reduce the recurrence of stroke in patients with previous stroke or transitory ischemic attack ... Read More »
» Published in Expert Opin Ther Targets. 2007 Mar;11(3):273-278.

35. Stroke etiology is associated with symptom onset during sleep.
Match Strength: 7.347

BACKGROUND AND OBJECTIVES: Almost every fifth stroke occurs during sleep. Data about characteristics and etiology of stroke during sleep are conflicting. We investigated the association of the activity at stroke onset (onset during night sleep vs. onset while awake) with stroke subtypes of different etiology. METHODS: A total of 1448 patients with first-ever stroke with known time of symptom presentation were prospectively evaluated. Statistical comparisons were performed between patients with stroke during sleep and stroke while awake in terms of demographic features, known risk factors, ... Read More »
» Published in Sleep. 2005 Feb 1;28(2):233-8.

36. Prediction of length of stay for stroke patients.
Match Strength: 7.338

Objectives - To examine the factors that influence acute and total length of stay (LOS) for stroke patients. Materials and methods - The basis of this investigation was a population-based cohort of first-ever stroke patients (n = 388). Subjects were survivors of the initial hospitalization (n = 295). Age, sex, social factors, risk factors, dementia, stroke type, and stroke severity, measured with the NIH stroke scale (NIHSS), were registered. Results - Mean acute LOS was 12 days and mean total LOS was 29 days. Independent predictors of acute LOS were stroke severity, lacunar stroke, prestroke ... Read More »
» Published in Acta Neurol Scand. 2007 Jul;116(1):15-9.

37. Difference in recognition of right and left hemispheric stroke.
Match Strength: 7.337

Symptoms of cerebrovascular events differ depending on the hemisphere in which the lesion arises, thereby affecting disease recognition and management. We aimed to establish whether left and right hemispheric strokes are unequally distributed in inpatients. We obtained data from a large hospital-based stroke registry in Germany. 11,328 patients (56%) had left hemispheric events and 8769 (44%) had right-sided lesions (p<0.0001). Age, stroke severity, and time from symptom onset to admission were significantly associated with left hemispheric stroke, suggesting a selection effect. ... Read More »
» Published in Lancet. 2005 Jul 30-Aug 5;366(9483):392-3. Comment in: Lancet. 2005 Jul 30-Aug 5;366(9483):349-51.

38. Early TNF-alpha levels correlate with ischaemic stroke severity
Match Strength: 7.334

OBJECTIVES: The study aimed to evaluate the levels of an important proinflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) in cerebrospinal fluid (CSF) and serum in acute stroke and to study the relation between those and the neurological stroke severity and functional disability. MATERIAL AND METHODS: The investigations comprised 23 ischaemic stroke patients. CSF and blood samples were obtained 24 h after the onset of stroke, and stored until analysis. Patients were examined according to Scandinavian Stroke Scale (SSS) and to Barthel Index (BI). RESULTS: The patients displayed ... Read More »
» Published in Acta Neurol Scand. 2001 Nov;104(5):288-95.

39. First-ever stroke and outcome in patients admitted to Perugia Stroke Unit: predictors for death, dependency, and recurrence of stroke within the first three months.
Match Strength: 7.332

Predictors of poor outcome after first-ever stroke within 3 months in consecutive patients admitted to our Stroke Unit were defined. Factors included age, sex, risk factors, occurrence of transient ischemic attacks, extension of cerebral infarction, presumed cause of stroke, clinical findings, and demographic characteristics. Multiple regression models were used to analyze predictors of mortality, dependency and stroke recurrence. A total of 435 patients with first-ever stroke were included. Of these, 358 patients had ischemic stroke and 77 hemorrhagic stroke. Three-month mortality rate was 20 ... Read More »
» Published in Clin Exp Hypertens. 2006 Apr-May;28(3-4):287-94.

40. Diabetes and stroke: part one--risk factors and pathophysiology.
Match Strength: 7.331

Diabetes is a major risk factor for stroke and is associated with an increase in overall stroke mortality. The metabolic syndrome associated with insulin resistance is also a significant risk factor for stroke. The etiology of stroke in diabetics is frequently microvascular disease from fibrinoid necrosis, which causes small subcortical infarcts designated as lacunar strokes. Diabetics also have an increased incidence of large vessel intracranial vascular disease. Although strict control of blood sugar has not been shown to reduce the overall incidence of stroke in diabetics, careful ... Read More »
» Published in Curr Cardiol Rep. 2006 Feb;8(1):23-8.

41. Ischemic stroke after electroconvulsive therapy.
Match Strength: 7.319

ABSTRACT: Stroke is an exceptionally rare complication of electroconvulsive therapy since modern anesthesia and appropriate medical screening were instituted in the 1950s. Postictal focal neurological deficits mimicking stroke are common, but the advent of acute stroke therapies has made the differentiation of these from true cerebrovascular events critical. We present the first case report of ischemic stroke after electroconvulsive therapy with radiographic confirmation. Publication Types: Case ... Read More »
» Published in J ECT. 2006 Jun;22(2):150-2. Erratum in: J ECT. 2006 Dec;22(4):280.

42. Safety of abciximab administration during PCI of patients with previous stroke.
Match Strength: 7.319

OBJECTIVES: To examine the frequency of cerebrovascular complications among patients receiving abciximab (AB) undergoing PCI with prior intracranial hemorrhage (ICH) or recent (< 2 years) ischemic strokes. BACKGROUND: AB improves clinical outcomes in high-risk patients undergoing percutaneous coronary intervention (PCI); however, the safety of AB in patients with prior stroke has not been adequately studied. METHODS: A database review of 7,244 consecutive PCIs, from 7/97 to 10/01, identified 6,190 PCIs performed with AB among which 515 interventions were performed in patients with prior ... Read More »
» Published in J Thromb Thrombolysis. 2005 Jun;19(3):147-53.

43. Constructing the stroke: sudden-onset narratives of stroke survivors.
Match Strength: 7.318

In this article, the authors explore the narrative production of stroke from the perspectives of survivors, that is, the stroke itself, not its implications for the individual poststroke. In the vast amount of literature on both sudden onset and chronic illness, the narrative construction of the onset of the illness, for the most part, has been ignored by social scientists, most notably in qualitative research. This is certainly true of stroke. Drawing on existing literature in both chronic illness and the body, the authors extend this to explore the phenomenological construction of stroke ... Read More »
» Published in Qual Health Res. 2005 Sep;15(7):928-41.

44. Relation of atrial shunts to migraine in patients with ischemic stroke and peripheral emboli.
Match Strength: 7.311

This study investigated whether the increased incidence of stroke in young subjects with migraine is because they have an increased prevalence of atrial right-to-left shunts. The investigators report the prevalence of clinically relevant atrial shunts in those with stroke and migraine compared with those with stroke but without migraine and also in historic control groups of subjects who had migraine with aura but no stroke and in population controls. Of 60 consecutive stroke patients, 42 (70%) had large- or medium-sized atrial shunts. Transcatheter shunt closure was performed in 39 patients, ... Read More »
» Published in Am J Cardiol. 2006 Sep 15;98(6):831-3. Epub 2006 Aug 2.

45. Diagnostic challenge--is this really a stroke?
Match Strength: 7.300

BACKGROUND: Although acute stroke most commonly presents with hemiparesis, facial weakness and dysphasia, these symptoms can sometimes be the atypical presentations of other conditions which may be difficult to diagnose. OBJECTIVE: This article presents three cases of stroke mimics and discusses how to improve accuracy in diagnosing stroke in the primary care setting. DISCUSSION: Stroke is a medical emergency and urgent hospital transfer is vital. Hypoglycaemia, hyperglycaemia, epilepsy, multiple sclerosis, hemiplegic migraine, intracranial tumours or infection (meningitis/encephalitis/abscess ... Read More »
» Published in Aust Fam Physician. 2006 Oct;35(10):805-8.

46. Predictors of recurrent stroke in African Americans.
Match Strength: 7.299

BACKGROUND: Stroke incidence and mortality are disproportionately higher among African Americans than among whites. OBJECTIVE: To describe the recurrent stroke characteristics and determine the predictability of known vascular risk factors for stroke recurrence in African Americans. METHODS: The authors followed 1,809 African Americans in the African-American Antiplatelet Stroke Prevention Study with recent noncardioembolic ischemic stroke for recurrent stroke, recurrent stroke subtype, and disability. RESULTS: Of the subjects, 10.6% experienced a recurrent stroke during follow-up. The mean ... Read More »
» Published in Neurology. 2006 Aug 22;67(4):567-71.

47. Living alone following first-ever stroke: a prospective study in Turkey identifying the risk factors and evaluating their effects.
Match Strength: 7.291

INTRODUCTION: The incidence of stroke, death, and dependency rates shows variability between countries and ethnic groups. The cost of management of stroke is extremely high. Thus, determination of controllable risk factors is important. The aim of this study was to evaluate the risk factors and the effects of risk factors on death rates, dependency, and stroke recurrence in hospitalised patients having first-ever stroke. METHOD: A total of 100 patients admitting to our hospital during the period April 2002 to March 2003 inclusive who were diagnosed as stroke according to WHO criteria were ... Read More »
» Published in N Z Med J. 2007 Jun 1;120(1255):U2559.

48. Characteristics of the Frenchay Activities Index one year after a stroke: a population-based study.
Match Strength: 7.284

PURPOSE: To further describe the properties of Frenchay Activities Index (FAI) with special emphasis on relationships with stroke severity and cognition. METHODS: Survivors from a population-based first-ever stroke cohort (n = 246) were assessed with FAI one year post-stroke. At the same time patients were asked about their status pre-stroke. Stroke severity was assessed at baseline with the NIH stroke scale (NIHSS). Cognition was assessed at one year with the Mini Mental State Examination (MMSE). RESULTS: Pre-stroke and post-stroke FAI averaged at 40.1 and 32.4, respectively. There was a ... Read More »
» Published in Disabil Rehabil. 2007 May 30;29(10):785-90.

49. Prevention of stroke recurrence
Match Strength: 7.281

Stroke recurrence can be reduced substantially by intervention with the appropriate stroke preventive(s). Control of blood pressure, use of one of the antiplatelet agents aspirin, aspirin plus extended (modified)-release dipyridamole, or clopidogrel, administration of warfarin for patients with atrial fibrillation and high-risk profiles for stroke, and use of carotid endarterectomy in patients with high grades of symptomatic carotid artery stenosis are all proven therapies for prevention of stroke recurrence. Newer therapies to reduce the risk of infection and inflammation promise to further ... Read More »
» Published in Int Psychogeriatr. 2003;15 Suppl 1:167-71.

50. Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH.
Match Strength: 7.279

Infarction size and infections are important determinants of stroke outcome in humans. Bacterial infections are promoted by stroke-induced immunodeficiency which in experimental stroke is mainly characterized by extensive lymphocyte apoptosis and dysfunction. Pharmacological inhibition of caspases may improve stroke outcome not only by reducing apoptotic brain damage but also by attenuating stroke-induced immunodeficiency. We investigated the effects of systemic administration of the novel, non-toxic caspase-inhibitor quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone (Q-VD ... Read More »
» Published in Exp Neurol. 2007 May 21;

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