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Rheumatoid Arthritis
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1. Raising rheumatoid factor cutoff helps distinguish rheumatoid arthritis.
Match Strength: 13.813

The presence of rheumatoid factor (RF) is one of the clinical criteria for the diagnosis of rheumatoid arthritis (RA). The cutoff point of RF assays is usually based on a reference level obtained from normal subjects in the same population as the patients. We evaluated 63 rheumatoid arthritis (RA), 25 other arthritis patients and 110 blood donors. Their rheumatoid factors (RF) ranged from < 9.9 to 2,264, < 9.9 to 262, and < 9.9 to 66 mIU/ml, respectively. The sensitivity at different cutoff points of 15, 20, and 25 mIU/ml was 92.1%, 90.5%, and 88.9%, respectively. The specificity at ... Read More »
» Published in Asian Pac J Allergy Immunol. 2005 Jun-Sep;23(2-3):165-8.

2. The molecular pathogenesis of collagen-induced arthritis in mice--a model for rheumatoid arthritis
Match Strength: 13.540

The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for development of new therapies for rheumatoid arthritis, as exemplified by the most recent advancement using TNFalpha neutralization treatment. The collagen-induced arthritis model, however, represents only certain pathways leading to arthritis and there is no consensus on how they operate. Nevertheless, we are beginning to understand the immune recognition structures, such as MHC molecules, ... Read More »
» Published in Ageing Res Rev. 2002 Feb;1(1):135-47.

3. Myocardial Dysfunction in Rheumatoid Arthritis: Epidemiology and Pathogenesis
Match Strength: 13.515

Data from population- and clinic-based epidemiologic studies of rheumatoid arthritis patients suggest that individuals with rheumatoid arthritis are at risk for developing clinically evident congestive heart failure. Many established risk factors for congestive heart failure are over-represented in rheumatoid arthritis and likely account for some of the increased risk observed. In particular, data from animal models of cytokine-induced congestive heart failure have implicated the same inflammatory cytokines produced in abundance by rheumatoid synovium as the driving force behind maladaptive ... Read More »
» Published in Arthritis Res Ther. 2005;7(5):195-207. Epub 2005 Aug 24.

4. Abnormal electronystagmography in rheumatoid arthritis.
Match Strength: 13.398

OBJECTIVE: Although sensorineural hearing loss has been widely investigated in those with rheumatoid arthritis, studies assessing the vestibular system in patients with rheumatoid arthritis are limited. The aim of this study was to assess the vestibular system in patients with rheumatoid arthritis. METHODS: The study consisted of 43 patients with rheumatoid arthritis and 30 healthy controls. Otorhinolaryngologic and neurotologic examinations, pure-tone audiometry, impedancemetry, electronystagmography including smooth pursuit, saccade, positional, and caloric tests were performed in all ... Read More »
» Published in Auris Nasus Larynx. 2006 Dec 6;

5. Evolving concepts of rheumatoid arthritis
Match Strength: 13.381

Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of disability. It existed in early Native American populations several thousand years ago but might not have appeared in Europe until the 17th century. Early theories on the pathogenesis of rheumatoid arthritis focused on autoantibodies and immune complexes. T-cell-mediated antigen-specific responses, T-cell-independent cytokine networks, and aggressive tumour-like behaviour of rheumatoid synovium have also been implicated. More recently, the contribution of autoantibodies has returned to the forefront. Based ... Read More »
» Published in Nature. 2003 May 15;423(6937):356-61.

6. MRI of the cervical spine: rheumatoid arthritis compared with cervical spondylosis
Match Strength: 13.374

This study is a comparison of the cervical spine MR images from 26 patients with rheumatoid arthritis of the cervical spine with those from an age and sex matched group suffering from cervical spondylosis. Erosion of bone and major atlanto-axial subluxation were confined to rheumatoid arthritis. Soft tissue changes revealed by MRI included distortion of normal ligaments and bursae around the dens, particularly in rheumatoid arthritis. Abnormal masses of soft tissue were found in both groups, but those suggesting acute inflammation were much more frequent in rheumatoid arthritis than in ... Read More »
» Published in Clin Radiol. 1991 Aug;44(2):71-6.

7. Is early rheumatoid arthritis the same disease process as late rheumatoid arthritis?
Match Strength: 13.313

Thoughts on treatment for the early control of synovitis have stimulated research on pathobiological events at the site of inflammation in patients with early rheumatoid arthritis. Several studies have thus been conducted to examine synovial biopsy samples at various stages of the disease. The most important conclusion from these studies is that all features of chronic synovial inflammation can be observed in so-called early rheumatoid arthritis. This suggests that no arguments exist for the effect of therapeutic intervention on synovitis varying in different phases of rheumatoid arthritis. In ... Read More »
» Published in Best Pract Res Clin Rheumatol. 2001 Mar;15(1):17-26.

8. Tropical pyomyositis in a case of rheumatoid arthritis.
Match Strength: 13.276

Tropical pyomyositis is very rarely associated with rheumatoid arthritis. We report tropical pyomyositis involving gastrocnemius muscle in both the legs with eosinophilia and elevated serum IgG and IgE levels in a case of rheumatoid arthritis. We suggest that the possibility of pyomyositis should be considered in all cases of rheumatoid arthritis presenting with muscle pain, fever and leucocytosis. Publication Types: Case ... Read More »
» Published in Trans R Soc Trop Med Hyg. 2006 Sep;100(9):895-8. Epub 2006 Feb 17.

9. The Use of Anakinra, an Interleukin-1 Receptor Antagonist, in the Treatment of Rheumatoid Arthritis
Match Strength: 13.273

Interleukin-1 (IL-1) is a primary cytokine that is involved in the pathogenesis of rheumatoid arthritis; it contributes to inflammation and joint destruction. Anakinra (Kineret) is an IL-1 receptor antagonist that blocks the biologic activity of IL-1. It was approved by the U.S. Food and Drug Administration (FDA) for the treatment of rheumatoid arthritis in 2001. Anakinra is safe and effective in the treatment of rheumatoid arthritis, both as monotherapy and in combination with other disease-modifying antirheumatic drugs.This article reviews the preclinical, clinical, and postmarketing data on ... Read More »
» Published in Rheum Dis Clin North Am. 2004 May;30(2):365-80, vii.

10. Rheumatoid factors in the pathogenesis of rheumatoid arthritis
Match Strength: 13.264

Rheumatoid factors (RF) participate in the pathogenesis of rheumatoid arthritis by formation of immune complexes. IgM-RF form complement activating immune complexes with IgG-containing antigen-antibody complexes. IgG-RF form unique immune complexes without the presence of separate antigen molecules. The specificities of RF in rheumatoid arthritis have subtle differences from RF formed by B cell neoplasms. Immune deposits in rheumatoid articular cartilage have high potential for generating inflammation and contain RF. The immune deposits in articular cartilage need to be characterized further, ... Read More »
» Published in J Rheumatol Suppl. 1992 Jan;32:46-9.

11. Serum selenium, serum alpha-tocopherol, and the risk of rheumatoid arthritis.
Match Strength: 13.233

Antioxidant micronutrients have been hypothesized to provide protection against rheumatoid arthritis. We investigated serum selenium and serum alpha-tocopherol for their prediction of subsequent development of rheumatoid arthritis in a case-control study nested within a Finnish cohort of 18,709 adult men and women who had neither arthritis nor a history of it at the baseline examination in 1973-1978; by late 1989, 122 had developed rheumatoid arthritis. Of the incident cases, 34 were rheumatoid factor-negative. Three controls per each incident case were individually matched for sex, age, and ... Read More »
» Published in Epidemiology. 2000 Jul;11(4):402-5.

12. Rheumatoid arthritis and schizophrenia: a negative association at a dimensional level
Match Strength: 13.145

There is wide evidence for a decreased risk of rheumatoid arthritis in patients with schizophrenia. Nevertheless, very few studies have looked at the risk of schizophrenia in a group of patients with rheumatoid arthritis. We prospectively investigated, with the SCL-90R, 220 consecutive outpatients with rheumatoid arthritis and 196 consecutive outpatients with various medical conditions, half of them suffering from psoriatic arthritis (a medical condition close to rheumatoid arthritis). The SCL-90R appears to be a valuable tool to distinguish patients with schizophrenia from the outpatients of ... Read More »
» Published in Schizophr Res. 2004 Jan 1;66(1):21-9.

13. Rest Therapy for Rheumatoid Arthritis
Match Strength: 13.119

Rest therapy in rheumatoid arthritis has long been controversial. Available evidence indicates that exercise increases joint inflammation and destruction and rest reduces inflammation. Hospitalization may produce improvement in inflammation, which is sometimes marked. Fatigue, a frequent and often prominent symptom of rheumatoid arthritis, is a guide to therapy. Sufficient rest to prevent fatigue combined with appropriate physical therapy would be expected to improve the treatment of rheumatoid arthritis ... Read More »
» Published in Mayo Clin Proc. 1978 Mar;53(3):141-5.

14. Serum Copper and Caeruloplasmin Are Higher in Seropositive Than Seronegative Rheumatoid Arthritis
Match Strength: 13.089

Increased serum copper (sCu) and alpha 2 caeruloplasmin (alpha 2 sCP) concentrations have been reported in patients with rheumatoid arthritis and other inflammatory conditions. Close parallel changes of sCu and alpha 2 sCP in rheumatoid arthritis have recently been observed by us in 30 subjects. The 'IgM rheumatoid factor positive (IgM-RF)' patients showed higher sCu and alpha 2 sCP concentrations when compared with 'IgM-RF negative'. Moreover a significant correlation was found between sCu alpha 2 sCP and other humoral indexes altered in rheumatoid arthritis. Therefore it seems useful, as ... Read More »
» Published in Eur J Rheumatol Inflamm. 1983;6(2):163-7.

15. Recurrent postpartum episodic rheumatoid arthritis.
Match Strength: 12.962

It is well known that rheumatoid arthritis improves in the majority of patients during pregnancy and that aggravation of disease symptoms occurs within the first 6 months postpartum. We report a female patient who had 4 postpartum episodes of transient polyarthritis typical of rheumatoid arthritis with positive serum rheumatoid factor and anti-CCP antibodies. All bouts resolved within 4 to 10 weeks after onset without any symptoms in between the episodes. Publication Types: Case ... Read More »
» Published in J Clin Rheumatol. 2006 Aug;12(4):196-8.

16. Palmar rheumatoid nodulosis associated with local pressure
Match Strength: 12.914

Rheumatoid nodulosis is a term used to describe adult patients with rheumatoid arthritis with little or no clinical joint inflammation who have numerous subcutaneous nodules indistinguishable from those of patients with active rheumatoid arthritis. This paper reports the case of a woman with quiescent rheumatoid arthritis who developed palmar nodulosis three weeks after the strenuous activity of painting her apartment. This case illustrates the direct association between the appearance of nodulosis and physical pressure despite inactive disease ... Read More »
» Published in Ann Rheum Dis. 1992 Aug;51(8):1005-6.

17. Consensus statement on the use of rituximab in patients with rheumatoid arthritis.
Match Strength: 12.878

A large number of experts experienced in the treatment of rheumatoid arthritis were involved in formulating a consensus statement on the use of B cell-targeted treatment with rituximab in patients with rheumatoid arthritis. The statement was supported by data from randomised controlled clinical trials and the substantial literature on oncology. The statement underwent three rounds of discussions until its ultimate formulation. It should guide clinicians in the use of this newly approved biological agent in treating patients with rheumatoid arthritis ... Read More »
» Published in Ann Rheum Dis. 2007 Feb;66(2):143-50. Epub 2006 Oct 26.

18. Pregnancy outcomes in women with rheumatoid arthritis in Washington State.
Match Strength: 12.871

OBJECTIVE: To determine whether rheumatoid arthritis (RA) is associated with increased adverse obstetric or neonatal outcomes. STUDY DESIGN AND SETTING: Washington State birth records and hospital discharge data between 1987 and 2001 identified a cohort of women with rheumatoid arthritis and a comparison group of women without rheumatoid arthritis. Pregnancy and neonatal outcomes were compared using general linear models for common outcomes, calculating approximate relative risks and 95% confidence intervals. RESULTS: There were 243 women with rheumatoid arthritis and 2,559 controls. Infants ... Read More »
» Published in Matern Child Health J. 2006 Jul;10(4):361-6.

19. Septic arthritis in a patient with juvenile rheumatoid arthritis
Match Strength: 12.856

The acute flare of joint inflammation in the child with known juvenile rheumatoid arthritis causes concern primarily regarding the need for additional or modified medical treatment. Acute joint inflammation in an otherwise healthy child creates concern regarding the existence of joint infection. In the early phase of disease, the clinical findings and symptoms of an inflamed joint attributable to juvenile rheumatoid arthritis or infection may be similar and difficult to differentiate from the other. Juvenile rheumatoid arthritis usually is well controlled by medical interventions, however, the ... Read More »
» Published in Clin Orthop Relat Res. 2004 Jan;(418):219-21.

20. Current Understanding of Rheumatoid Arthritis
Match Strength: 12.820

A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, artery walls, cardial structures, and sclera of the eye. Structural analysis of tissue obtained by biopsy and operation in rheumatoid arthritis patients reveals a complicated mosaic of different components, which are together responsible for the clinical symptoms and destructive ... Read More »
» Published in Inflammation. 1984 Jun;8 Suppl:S27-42.

21. The Balneotherapy of Rheumatoid Arthritis
Match Strength: 12.802

Balneotherapy as a special form of physiotherapy has, with other measures, a definite place in the plan of treatment for rheumatoid arthritis. The range of indication for a specific application is extremely wide. It can be introduced with different therapeutic objectives and be adapted to the situation prevailing during the course of rheumatoid arthritis. Careful analysis of the individual case is necessary, in which duration, intensity of the disease, activity of the disease process, progression and stage are taken into account. An acute episode of rheumatoid arthritis with high activity of ... Read More »
» Published in Rheumatol Rehabil. 1979;Suppl:86-7.

22. Abatacept
Match Strength: 12.786

New therapies, in particular the tumor necrosis factor-alpha-blocking drugs, have led to improved control of inflammation in rheumatoid arthritis for a proportion of patients. There remains a need for therapies for patients who do not respond to these drugs or in whom they are contraindicated or not tolerated. There is evidence that T cells are involved in the initiation and perpetuation of rheumatoid arthritis. Abatacept is the first in a new class of drugs targeted at T-cell function in autoimmune disease: the costimulation blockers. It has shown safety and efficacy in rheumatoid arthritis. ... Read More »
» Published in Drugs Today (Barc). 2006 Feb;42(2):87-93.

23. Abatacept.
Match Strength: 12.786

New therapies, in particular the tumor necrosis factor-alpha-blocking drugs, have led to improved control of inflammation in rheumatoid arthritis for a proportion of patients. There remains a need for therapies for patients who do not respond to these drugs or in whom they are contraindicated or not tolerated. There is evidence that T cells are involved in the initiation and perpetuation of rheumatoid arthritis. Abatacept is the first in a new class of drugs targeted at T-cell function in autoimmune disease: the costimulation blockers. It has shown safety and efficacy in rheumatoid arthritis. ... Read More »
» Published in Drugs Today (Barc). 2006 Feb;42(2):87-93.

24. TNF alpha is an effective therapeutic target for rheumatoid arthritis.
Match Strength: 12.700

Rheumatoid arthritis is the most common of a number of diseases in which inflammation and tissue destruction is driven by an autoimmune process. Current therapy is inadequate, and this has prompted major research efforts, both in academia and industry, to understand more about the pathogenesis, and hence provide the rationale for new therapeutic strategies. Here we review our studies of cytokine expression and regulation in rheumatoid joints, which has culminated in demonstrating that TNF alpha blockade, using a chimeric (human IgG1/K, mouse Fv) anti-TNF alpha antibody, cA2, markedly ... Read More »
» Published in Ann N Y Acad Sci. 1995 Sep 7;766:272-8.

25. Phenotype of peripheral blood lymphocytes and serum immunoglobulin concentration in patients with early rheumatoid arthritis.
Match Strength: 12.645

We studied the phenotype of peripheral blood lymphocytes and serum immunoglobulin concentration in patients with early rheumatoid arthritis and rheumatoid arthritis of more than 12 months duration. Subpopulations of CDIgM+, CD25+, and HLA-DR+ lymphocytes and IgA concentration differed in these groups of patients with rheumatoid arthritis. The count of lymphocytes carrying CDIgM+ and HLA-DR+ receptors correlated with activity of rheumatoid arthritis ... Read More »
» Published in Bull Exp Biol Med. 2006 Jan;141(1):84-6.

26. Impact of parental history on patients' cardiovascular mortality in rheumatoid arthritis.
Match Strength: 12.643

BACKGROUND: Patients with rheumatoid arthritis are at increased risk of death from cardiovascular disease (CVD). This risk is influenced by the inflammatory activity of the rheumatoid arthritis as well as by traditional risk factors for CVD. However, little is known about whether or to what extent hereditary factors for CVD contribute additional risk in patients with rheumatoid arthritis. OBJECTIVE: To assess the clinical impact of a parental history of CVD in patients with rheumatoid arthritis. METHODS: Population based cohort study of 10,805 Swedish patients with rheumatoid arthritis aged 16 ... Read More »
» Published in Ann Rheum Dis. 2006 Jun;65(6):741-5. Epub 2005 Oct 25.

27. Lymphedema of the leg associated with rheumatoid arthritis
Match Strength: 12.638

A 14-year-old boy with a two year history of seronegative rheumatoid arthritis developed left leg lymphedema and subsequently a severe episode of lymphangitis. The diagnosis of "rheumatoid lymphedema" was confirmed by lymphscintigraphy and conventional lymphography. Treatment consisted of bedrest and antibiotic drugs. When the signs of inflammation had subsided, therapy with corticosteroids was started with improvement of both joint pain and leg swelling. Whereas lymphedema associated with rheumatoid arthritis has been described in the upper limb of adults, to our knowledge this is the first ... Read More »
» Published in Lymphology. 1991 Jun;24(2):68-70.

28. A Spontaneous Rheumatoid Arthritis-Like Disease in Mrl/L Mice
Match Strength: 12.603

MRL/l mice spontaneously develop an arthritis very similar in many respects to human rheumatoid arthritis. A detailed morphologic and serologic analysis of this disease revealed the following: (a) a 75% incidence of synovial and periarticular inflammation, very similar to human rheumatoid arthritis, in 5-6 mo-old females, (b) close associations between presence of joint inflammation and subsynovial and/or periarticular vasculitis, and (c) a close correlation between presence of circulating IgM rheumatoid factor (RF) and demonstrable synovial and/or joint pathology, i.e., 95% of mice with ... Read More »
» Published in J Exp Med. 1982 Jun 1;155(6):1690-701.

29. Rheumatoid Nodulosis: Is It a Different Subset of Rheumatoid Arthritis?
Match Strength: 12.562

Rheumatoid nodulosis is an entity that describes a particular variant of polyarthritis associated with early manifestations of palindromic rheumatism, radiologic subchondral bone cysts, and subcutaneous rheumatoid nodules. This study describes the clinical, radiologic, histologic, crystallographic, and laboratory findings, as well as the outcome in a group of 16 patients with rheumatoid nodulosis that were followed for a period of 1-12 years. Six of these patients had an aggressive course and developed classic erosive polyarticular rheumatoid arthritis, while the others continued having ... Read More »
» Published in J Clin Rheumatol. 2003 Oct;9(5):296-305.

30. Pathogenesis of rheumatoid arthritis: how early is early?
Match Strength: 12.546

Studies of cytokine expression in rheumatoid arthritis have provided key insights into the pathogenesis of disease and have offered clues for effective therapy. Patterns of T-cell products in chronic rheumatoid synovitis suggest that T helper type 1 cells contribute to the perpetuation of disease. However, there is no guarantee that the mechanisms of late disease are identical to very early rheumatoid arthritis. Evaluation of the cytokine profile at the earliest time points after onset of symptoms could identify novel targets that prevent progression to chronic arthritis. Publication Types: ... Read More »
» Published in Arthritis Res Ther. 2005;7(4):157-9. Epub 2005 Jun 17. Comment on: Arthritis Res Ther. 2005;7(4):R784-95.

31. An introduction to the EULAR-OMERACT rheumatoid arthritis MRI reference image atlas.
Match Strength: 12.507

This article gives a short overview of the development and characteristics of the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS), followed by an introduction to the use of the EULAR-OMERACT rheumatoid arthritis MRI reference image atlas. With this atlas, MRIs of wrist and metacarpophalangeal joints of patients with rheumatoid arthritis can be scored for synovitis, bone oedema, and bone erosion, guided by standard reference images. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Ann Rheum Dis. 2005 Feb;64 Suppl 1:i3-7.

32. Early rheumatoid arthritis.
Match Strength: 12.412

PURPOSE OF REVIEW: This review provides novel and updated information on pathogenesis, referral, and clinical characteristics as well as therapeutic approaches in early rheumatoid arthritis. RECENT FINDINGS: Early referral is important, but new classification criteria for early rheumatoid arthritis need to be elaborated. Predictive markers for rheumatoid arthritis are still confined to autoantibodies; respective algorithms have been presented. Other biomarkers will still have to prove their usefulness. Magnetic resonance imaging and sonography do not appear to sufficiently distinguish between ... Read More »
» Published in Curr Opin Rheumatol. 2006 May;18(3):282-8.

33. Psychoimmunology and rheumatoid arthritis: concepts and methodologies
Match Strength: 12.408

The recent growth of knowledge about the immune-neuroendocrine network has important implications for future research into psychosomatic hypotheses about the aetiology of rheumatoid arthritis. The available evidence suggests that three phases of the aetiological process in rheumatoid arthritis need to be considered separately because of the different role that psychological and social variables may play at different points of the disease. These are the loss of immunological tolerance, the onset of joint inflammation and the long-term disease course. It is suggested that future studies will ... Read More »
» Published in Int J Psychiatry Med. 1990;20(3):307-22.

34. Reducing the Cardiovascular Disease Burden in Rheumatoid Arthritis
Match Strength: 12.367

Rheumatoid arthritis is associated with an increase in cardiovascular mortality and morbidity; this increase is independent of traditional cardiovascular risk factors. Effective treatment of rheumatoid arthritis with disease-modifying antirheumatic drugs appears to reduce cardiovascular mortality. The optimal approach to prevention of cardiovascular disease in rheumatoid arthritis is evolving, but will include a combination of: cardiovascular risk factor screening and management; effective and sustained control of joint and systemic inflammation; and a high index of suspicion for silent ... Read More »
» Published in Med J Aust. 2006 Mar 20;184(6):287-90.

35. Elevated C3 Anaphylatoxin Levels in Synovial Fluids From Patients with Rheumatoid Arthritis
Match Strength: 12.343

Because cleavage products of the third component of complement augment inflammation and may contribute to arthritis, we used a competitive inhibition radioimmunoassay to measure levels of the low molecular weight cleavage products of the third component of complement, C3a and C3adesArg, in 72 synovial fluid samples. Mean levels of C3a/C3adesArg were more than sevenfold higher in 41 patients who had rheumatoid arthritis than in 15 patients who had degenerative joint disease or 5 patients who had traumatic arthritis. Striking elevations were also present in 2 patients who had acute gouty ... Read More »
» Published in Arthritis Rheum. 1985 Oct;28(10):1089-95.

36. Rheumatoid Arthritis and Pregnancy
Match Strength: 12.284

Although some 70% of patients with rheumatoid arthritis remit during pregnancy, the mechanism for this is not known. A variety of mechanisms have been invoked but none appear to be sufficiently established as an explanation. The most likely explanation is that a factor, or factors, cause the inhibition of release of lymphokines which thereby have a suppressive effect on rheumatoid inflammation ... Read More »
» Published in Clin Exp Rheumatol. 1988 Apr-Jun;6(2):179-82.

37. Igg As Antigen in Human Rheumatoid Disease
Match Strength: 12.249

Although the events underlying the expression of rheumatoid factor in patients with rheumatoid arthritis remain unknown, evidence from both human and animal studies has suggested a role for altered or complexed IgG. Similarly, altered or complexed IgG may also participate in initiating and sustaining inflammation in this disease. Potentially relevant differences in the glycosylation and conformation of rheumatoid IgG compared to IgG from healthy individuals have been detected by several investigators. The latter observations have raised new possibilities concerning mechanisms underlying the ... Read More »
» Published in Scand J Rheumatol Suppl. 1988;75:133-9.

38. Influence of human leucocyte antigen-DRB1 on the susceptibility to rheumatoid arthritis and on the production of anti-cyclic citrullinated peptide antibodies in a Portuguese population.
Match Strength: 12.240

OBJECTIVE: To clarify the influence of the HLA-DRB1 locus on the susceptibility to rheumatoid arthritis and the production of anti-cyclic citrullinated peptide antibodies (anti-CCP) in a Portuguese population. METHODS: 141 patients with rheumatoid arthritis fulfilling the American College of Rheumatology 1987 revised criteria for rheumatoid arthritis were compared with 150 healthy controls. Human leucocyte antigen (HLA)-DRB1 locus genotyping was assessed by polymerase chain reaction reverse probing assays and sequence-specific primers. Anti-CCP antibodies were quantified by ELISA in patients ... Read More »
» Published in Ann Rheum Dis. 2007 Feb;66(2):246-8. Epub 2006 Jun 22.

39. The role of megakaryocytes in skeletal homeostasis and rheumatoid arthritis.
Match Strength: 12.232

PURPOSE OF REVIEW: This review provides an update on the role of megakaryocytes in skeletal homeostasis, and discusses these findings in the context of rheumatoid arthritis. RECENT FINDINGS: Thrombocytosis is a common complication of rheumatoid arthritis, and is presumably caused by an up-regulation in megakaryocytopoiesis. In general, patients with rheumatoid arthritis exhibit localized joint bone erosion with systemic bone loss, and rheumatoid arthritis patients with thrombocytosis tend to have more severe disease. Interestingly, in addition to their role in rheumatoid arthritis with ... Read More »
» Published in Curr Opin Rheumatol. 2006 Jul;18(4):405-10.

40. Cutaneous abnormalities in rheumatoid arthritis compared with non-inflammatory rheumatic conditions.
Match Strength: 12.231

BACKGROUND: Cutaneous abnormalities are common in rheumatoid arthritis, but exact prevalence estimates are yet to be established. Some abnormalities may be independent and coincidental, whereas others may relate to rheumatoid arthritis or its treatment. OBJECTIVES: To determine the exact nature and point prevalence of cutaneous abnormalities in patients with rheumatoid arthritis compared with those in patients with non-inflammatory rheumatic disease. METHODS: 349 consecutive outpatients for rheumatology (205 with rheumatoid arthritis and 144 with non-inflammatory rheumatic conditions) were ... Read More »
» Published in Ann Rheum Dis. 2006 Oct;65(10):1341-5. Epub 2006 Feb 13.

41. From reactive arthritis to rheumatoid arthritis
Match Strength: 12.227

Reactive arthritis was initially described as a sterile synovitis, without microbial components present in the joint tissue. It has, however, become evident that bacterial degradation products, and even bacterial DNA, are present in the synovium of patients with this disease. Since intestinal pathogens are important causes of reactive arthritis, and since cellular homing allows transport of bacterial products from the gut to synovium, we have approached the etiology of rheumatoid arthritis from this point of view. A series of observations has led to a hypothesis that patients with rheumatoid ... Read More »
» Published in J Autoimmun. 2001 May;16(3):369-71.

42. Laryngeal Rheumatoid Arthritis
Match Strength: 12.214

The classic sequence of pathologic changes associated with rheumatoid arthritis as they affect the cricothyroid and cricoarytenoid joints of five larynges is described. Although several previous reports have drawn attention to the presence of rheumatoid arthritis in the larnx, the current study emphasizes that the small joints of the larynx may be involved by the full spectrum of pathologic changes and that both cricothyroid and cricoarytenoid joints are equally prone to the various stages of inflammation, joint destruction and ankylosis that characterize the disease elsewhere. Rheumatoid ... Read More »
» Published in Laryngoscope. 1980 Feb;90(2):296-303.

43. Antibodies against human 60 kDa heat shock protein are not associated with cardiovascular disease in patients with rheumatoid arthritis.
Match Strength: 12.195

BACKGROUND: Rheumatoid arthritis is associated with an unexplained increased risk of cardiovascular disease (CVD). Antibodies against human 60 kDa heat shock protein (anti-HSP60) are associated with the presence and severity of CVD. OBJECTIVES: To investigate whether anti-HSP60 antibodies are associated with prevalent CVD in patients with rheumatoid arthritis. METHODS: In a nested case-control design, anti-HSP60 antibody levels were measured in the serum samples of 192 rheumatoid patients. In a regression analysis the association between prevalent CVD and anti-HSP60 antibodies was examined, ... Read More »
» Published in Ann Rheum Dis. 2006 May;65(5):590-4. Epub 2005 Oct 25.

44. Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome.
Match Strength: 12.186

Vertex Pharmaceuticals Inc, in collaboration with Kissei Pharmaceutical Co Ltd, is developing VX-702, one of a series of second-generation, orally active p38 MAP kinase inhibitors, for the potential treatment of inflammation, rheumatoid arthritis and cardiovascular diseases. In June 2005, a phase II clinical trial of VX-702 was initiated in rheumatoid arthritis. In July 2006, Vertex was planning to file an IND in the second half of 2006 ... Read More »
» Published in Curr Opin Investig Drugs. 2006 Nov;7(11):1020-5.

45. Substance P in the serum of patients with rheumatoid arthritis.
Match Strength: 12.185

Serum substance P was assayed in rheumatoid arthritis patients and healthy controls to evaluate whether neurogenic inflammation with substance P release is significant in rheumatoid arthritis. A very sensitive competitive immunoenzymetric assay was used. Mean serum substance P level was significantly higher in rheumatoid arthritis patients than in controls and was not correlated with disease duration, morning stiffness duration, Thompson's articular index, Larsen's radiographic score, or the following laboratory indices of inflammation: erythrocyte sedimentation rate, C-reactive protein, and ... Read More »
» Published in Rev Rhum Engl Ed. 1997 Jan;64(1):18-21.

46. Calorie restricted diet and urinary pentosidine in patients with rheumatoid arthritis
Match Strength: 12.168

Low-energy diets and fasting have suppressive effects on rheumatoid arthritis. It was reported recently that urine levels of pentosidine (i.e., an advanced glycation end product formed by glycosylation) is associated with the activity of rheumatoid arthritis. We conducted a regimen of caloric restriction combined with fasting in patients with rheumatoid arthritis, and then evaluated urinary pentosidine levels. Ten patients with rheumatoid arthritis underwent a 54-day caloric restriction program. Urinary pentosidine levels were measured and the Lansbury Index were determined by examining the ... Read More »
» Published in J Physiol Anthropol Appl Human Sci. 2004 Jan;23(1):19-24.

47. Rheumatoid Scleritis
Match Strength: 12.166

A 59-year-old black female with rheumatoid arthritis developed diffuse anterior scleritis with orbital and adnexal involvement. Computerized axial tomograhy (CAT) demonstrated the location and extent of the lesion. Biopsy of subconjunctival tissue revealed a rheumatoid nodule, characterized by granulomatous inflammation and fibrinoid necrosis. The patient improved rapidly on large doses of systemic corticosteroids. The relationship of scleritis to rheumatoid arthritis is discussed. The histopathologic features of rheumatoid scleritis, its apppearance on the CAT scan, and the management of this ... Read More »
» Published in Ophthalmology. 1981 Dec;88(12):1269-73.

48. Panniculitis: an unusual cutaneous manifestation of rheumatoid arthritis.
Match Strength: 12.141

Specific and nonspecific panniculitis may occur during the course of connective tissue diseases. However, association of panniculitis and rheumatoid arthritis has only rarely been described, and with so few reports, it is difficult to know the significance of this unusual association. We describe 2 patients with rheumatoid arthritis and features of Sjogren syndrome in whom panniculitis developed during the course of the disease. Histologic confirmation of septal panniculitis was established in one case and the panniculitis in this case improved as the arthritis resolved. Publication Types: ... Read More »
» Published in J Clin Rheumatol. 2006 Aug;12(4):190-3.

49. Metabolic syndrome is common among middle-to-older aged Mediterranean patients with rheumatoid arthritis and correlates with disease activity: a retrospective, cross-sectional, controlled, study.
Match Strength: 12.113

OBJECTIVES: Patients with rheumatoid arthritis have an increased risk for cardiovascular disease (CVD). The prevalence of metabolic syndrome (MetS)-a major contributor to CVD-in a cohort of patients with rheumatoid arthritis and its relationship with rheumatoid arthritis related factors is investigated here. METHODS: 200 outpatients with rheumatoid arthritis (147 women and 53 men), with a mean (standard deviation (SD)) age of 63 (11) years, and 400 age and sex-matched controls were studied. MetS was assessed according to the adult treatment panel III criteria and rheumatoid arthritis disease ... Read More »
» Published in Ann Rheum Dis. 2007 Jan;66(1):28-33. Epub 2006 Jun 22.

50. CPPD complicating other forms of inflammatory arthritis.
Match Strength: 12.104

Calcium pyrophosphate deposition (CPPD) disease is confirmed as equally common in rheumatoid arthritis by synovial fluid and macroscopic skeletal examination. Furthermore, differential frequencies in rheumatoid arthritis and spondyloarthropathy provide additional insights to the "lumper-splitter" question ... Read More »
» Published in Clin Rheumatol. 2006 Aug 15;

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