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1. Pediatric hypertension 2001.
Match Strength: 7.123

During the past decade, there has been a surge of interest in childhood and adolescent hypertension. The current review summarizes work published during the past year in the following areas: prenatal and early postnatal causes of hypertension; new information on the genetics of childhood hypertension; the relation of obesity, insulin resistance, and diabetes to hypertension; the use of ambulatory blood pressure monitoring to evaluate childhood hypertension; and advances in drug therapy for children with hypertension. The information obtained during the past year has improved our understanding ... Read More »
» Published in Curr Opin Cardiol. 2002 Jul;17(4):385-9.

2. Management of childhood hypertension: a guide for primary care physicians.
Match Strength: 6.942

Prevalence of pediatric hypertension has increased with the onset of obesity epidemic. Early detection and treatment of childhood hypertension is important due to its link with atherosclerosis in adult life. Accurate measurement of blood pressure is the key for the management and physicians should make effort to rule out the possibility of anxiety associated and white coat hypertension before the final diagnosis of hypertension. Secondary hypertension is more common in children as compared to adults but essential hypertension is also common in older children and adolescents. The younger ... Read More »
» Published in J Ark Med Soc. 2006 Dec;103(6):137-40.

3. Masked hypertension: a common but insidious presentation of hypertension.
Match Strength: 6.801

A patient has masked hypertension when his office blood pressure is less than 140/90 mmHg but his ambulatory or home blood pressure readings are in the hypertensive range. Several recent studies have demonstrated that cardiovascular risk is similar between those with masked hypertension and those with sustained hypertension. The prevalence of masked hypertension in Canada is not known, but data from other countries suggest rates greater than 8%. Physicians need to use careful clinical judgment to identify and treat subjects with masked hypertension. The present review discusses masked ... Read More »
» Published in Can J Cardiol. 2006 May 15;22(7):617-20.

4. The Canadian Hypertension Education Program - a unique Canadian knowledge translation program.
Match Strength: 6.801

The Canadian Hypertension Education Program annually appraises data from hypertension research and updates clinical practice recommendation for the diagnosis and management of hypertension. Enormous effort is devoted to disseminating these recommendations to target groups throughout the country and, through the use of institutional databases, to evaluating their effectiveness in improving the health of Canadians by lowering blood pressure in people with hypertension. The mission of the Canadian Hypertension Education Program is to reduce the impact of hypertension on cardiovascular disease in ... Read More »
» Published in Can J Cardiol. 2007 May 15;23(7):551-5.

5. Renovascular hypertension: clinical concepts.
Match Strength: 6.736

Systemic hypertension is a common disorder in clinical practice and causes significant morbidity and premature death. A small percentage (< 5%) of patients with hypertension may have renovascular hypertension. Strictly speaking, the term renovascular hypertension should be applied only when the blood pressure rises as a consequence of renal ischemia. Thus, the mere presence of renal artery stenosis is not synonymous with renovascular hypertension. Treatment strategies should be directed at ''renovascular hypertension'' rather than an anatomic renal artery stenosis (which may be discovered ... Read More »
» Published in Minerva Med. 2006 Aug;97(4):313-24.

6. Hypertension: trends in prevalence, incidence, and control.
Match Strength: 6.714

Hypertension is the leading cause of cardiovascular disease worldwide. Prior to 1990, population data suggest that hypertension prevalence was decreasing; however, recent data suggest that it is again on the rise. In 1999-2002, 28.6% of the U.S. population had hypertension. Hypertension prevalence has also been increasing in other countries, and an estimated 972 million people in the world are suffering from this problem. Incidence rates of hypertension range between 3% and 18%, depending on the age, gender, ethnicity, and body size of the population studied. Despite advances in hypertension ... Read More »
» Published in Annu Rev Public Health. 2006;27:465-90.

7. Last Developments on Hypertension.
Match Strength: 6.657

The following article reviews some of the most recent data that have come to light in the field of hypertension during the last year, including the long lasting controversy USA/Europe on the definition and treatment of hypertension, the importance of the interrelationship hypertension/sleep apnea syndrome, to conclude by discussing some of the most compelling implications of the main trials that have been published during the last few months ... Read More »
» Published in Rev Esp Cardiol. 2006 Feb;59(Supl.1):78-86.

8. Mineralocorticoid hypertension and hypokalemia.
Match Strength: 6.641

Mineralocorticoid hypertension is hypertension associated with the presence of hypokalemia, metabolic alkalosis, and suppression of plasma renin. Mineralocorticoid hypertension represents only 10% of patients with essential hypertension. However, its recognition is important because it is a potentially reversible cause of hypertension. Primary hyperaldosteronism is the most common form of mineralocorticoid hypertension. It is current clinical practice to use the plasma aldosterone-renin ratio and the absolute plasma aldosterone level as screening tests. Confirmatory suppression tests and ... Read More »
» Published in Semin Nephrol. 2006 Nov;26(6):434-40.

9. Diabetes And Hypertension: The Bad Companions
Match Strength: 6.636

DIABETES AND HYPERTENSION: Diabetes mellitus and hypertension are interrelated diseases that strongly predispose people to atherosclerotic cardiovascular disease. Hypertension is about twice as frequent in individuals with diabetes as in those without. The prevalence of coexisting hypertension and diabetes appears to be increasing in industrialized nations because populations are aging, and both hypertension and non-insulin-dependent diabetes mellitus (NIDDM) increase with age. An estimated 35-75% of diabetic cardiovascular and renal complications can be attributed to hypertension. ESSENTIAL ... Read More »
» Published in J Hypertens Suppl. 1997 Mar;15(2):S55-62.

10. Hypertension and head injury.
Match Strength: 6.496

Systemic hypertension and tachycardia are often observed in the acute phase of traumatic brain injury. What causes systemic hypertension after head injury? Is systemic hypertension somehow beneficial to the injured brain? Are vasodilating drugs the first choice for treatment of systemic hypertension after traumatic brain injury? The occurrence of a hyperadrenergic state, the effects of systemic hypertension on the injured brain, the ideal blood pressure, and the management of systemic hypertension after traumatic brain injury are reviewed herein. Publication Types: ... Read More »
» Published in Curr Hypertens Rep. 2005 Dec;7(6):450-3.

11. Workplace hypertension is associated with obesity and family history of hypertension.
Match Strength: 6.471

Job strain, which is a risk for hypertension and increased left ventricular mass, is thought to cause masked hypertension during work even if blood pressure (BP) is normal at health examinations. To study the prevalence of and factors related to workplace hypertension, 265 public officials (mean age, 41.4+/-10.7 years) measured their own BP at their workplace using semiautomated BP measurement devices. Factors related to workplace hypertension were assessed with multiple regression analysis. Workplace hypertension, defined as a BP no less than 140/90 mmHg, was observed in 23% of subjects (n=61 ... Read More »
» Published in Hypertens Res. 2006 Dec;29(12):969-76.

12. Obesity and hypertension
Match Strength: 6.395

This article has discussed some of the mechanisms involved in the causal relation between obesity and hypertension. Obesity causes a constellation of maladaptive disorders that individually and synergistically contribute to hypertension, among other cardiovascular morbidities. Well-designed population-based studies are needed to assess the individual contribution of each of these disorders to the development of hypertension. In addition, because the control of obesity may eliminate 48% of the hypertension in whites and 28% in blacks, this article has offered an up-to-date on the management of ... Read More »
» Published in Endocrinol Metab Clin North Am. 2003 Dec;32(4):823-54.

13. Reduced nocturnal blood pressure dip and sustained nighttime hypertension are specific markers of secondary hypertension.
Match Strength: 6.392

OBJECTIVE: To investigate with the use of ambulatory blood pressure (BP) monitoring whether nocturnal BP dip and nighttime BP values are different in children with untreated primary and secondary hypertension. STUDY DESIGN: Ambulatory BP monitoring studies from 145 children with untreated hypertension were retrospectively analyzed. Forty-five children had primary hypertension and 100 children had secondary hypertension. RESULTS: Children with secondary hypertension had lower nocturnal BP dip for systolic and diastolic BP in comparison to children with primary hypertension (8% +/- 5% vs 14% +/- ... Read More »
» Published in J Pediatr. 2005 Sep;147(3):366-71.

14. Incidence of Hypertension in a Cohort of Spanish University Graduates: The SUN Study.
Match Strength: 6.345

Hypertension is a major public health problem. However, no estimates of age- and sex-specific incidences are available for the Spanish population. Our objective was to estimate the incidence of hypertension in a cohort of university graduates in Spain. We followed up 5648 individuals aged 25-65 years who were initially free of hypertension, diabetes, and cardiovascular disease for a median of 30 months. New diagnoses of hypertension were identified using mailed questionnaires. We verified all self-reported diagnoses of hypertension. In 18 250 person-years of follow-up, we identified 248 new ... Read More »
» Published in Rev Esp Cardiol. 2006 Dec;59(12):1331-1334.

15. Obesity hypertension.
Match Strength: 6.342

The association between obesity and hypertension is well recognized. However, the exact mechanisms whereby obesity causes hypertension are complex and multifactorial. The current article summarizes some of the known mechanisms responsible for obesity hypertension ... Read More »
» Published in Am J Hypertens. 2002 Feb;15(2 Pt 2):50S-52S.

16. Hypertension in children.
Match Strength: 6.335

Essential, or primary, hypertension is detectable in childhood. Due to the rising rates of childhood obesity, the expression of essential hypertension in childhood is increasing. Despite this trend, the possibility of secondary hypertension should be considered in a child with documented hypertension. Children and adolescents with suspected secondary hypertension may require a more extensive evaluation compared with those expressing characteristics of essential hypertension. Whether the hypertension is determined to be secondary or essential, these children require careful monitoring, ... Read More »
» Published in Pediatr Ann. 2006 Nov;35(11):795-801.

17. Hypertension and the kidney.
Match Strength: 6.327

Hypertension and kidney function are intimately related, with each having significant influences on the other. Given the major role played by the kidney in maintenance of extracellular fluid volume and peripheral vascular resistance, the kidney is justifiably a target of investigation to determine its potential role in essential hypertension. Conversely, hypertension is associated with progressive renal failure, and hypertension-associated end-stage renal disease is the second leading cause of end-stage renal disease in the United States. It is therefore important that we continue to ... Read More »
» Published in Curr Hypertens Rep. 2001 Dec;3(6):511-6.

18. Pulmonary hypertension in children: the twenty-first century.
Match Strength: 6.318

Pulmonary hypertension is an elevation in pulmonary artery pressure that is associated with a spectrum of diseases and causes. Its clinical severity and presentation are widely varied. The field of study has changed immensely over the past several years. Significant knowledge has been gained in the pathophysiology, genetics, and vascular biology associated with pulmonary hypertension. These discoveries have contributed to medical interventions that have improved outcomes associated with pulmonary hypertension. This article reviews pulmonary hypertension in children, focusing on idiopathic ... Read More »
» Published in Pediatr Clin North Am. 2006 Oct;53(5):961-87, x.

19. Baroreflex function in hypertension: consequences for antihypertensive therapy.
Match Strength: 6.312

Studies performed in experimental animal models of hypertension as well as in human hypertension have unequivocally shown that reflex cardiovascular control undergoes profound changes with high blood pressure and participates throughout direct and indirect mechanisms at the development and progression of hypertension-related target organ damage. This explains why investigation of the effects of antihypertensive drugs on neural cardiovascular control has a significant impact on hypertension treatment. This review will examine the main features of cardiovascular reflex control in hypertension ... Read More »
» Published in Prog Cardiovasc Dis. 2006 May-Jun;48(6):407-15.

20. Hypertension as a metabolic disorder--an overview.
Match Strength: 6.305

Hypertension is related to several conditions with abnormalities in carbohydrate and lipid metabolism, such as obesity and impaired glucose tolerance. However, perturbed metabolism is also seen in non-obese hypertensive individuals. In addition, hypertension is linked to impaired fibrinolysis and elevated levels of the plasminogen activator inhibitor of endothelial type (PAI-1). Insulin resistance and hyperinsulinaemia in essential hypertension may be an important cause of these metabolic and fibrinolytic abnormalities. Whether hyperinsulinaemia is the cause of hypertension is currently ... Read More »
» Published in J Intern Med Suppl. 1991;735:1-7.

21. Grand Rounds at the British Hypertension Society: renal artery stenosis.
Match Strength: 6.300

Renal artery angioplasty for renovascular hypertension is a controversial subject with considerable data but few certainties. This article is a summary of the Grand Round on Renovascular Hypertension held at the British Hypertension Society Annual Conference in September 2006.Journal of Human Hypertension advance online publication, 12 July 2007; doi:10.1038/sj.jhh.1002260 ... Read More »
» Published in J Hum Hypertens. 2007 Jul 12;

22. Obesity-related hypertension: mechanisms, cardiovascular risks, and heredity.
Match Strength: 6.287

Recent investigations cast some doubts on the status of insulin resistance as a trigger in hyperinsulinemia-associated hypertension or obesity-related hypertension, or both. Major epidemiological studies have shown that central adiposity is a powerful risk factor for stroke or coronary artery disease when accompanied by hypertension or hypertriglyceridemia. New heredity studies have failed to identify a common gene that may explain obesity-related hypertension ... Read More »
» Published in Curr Opin Nephrol Hypertens. 1995 Jan;4(1):67-71.

23. Reversible pulmonary hypertension post adenotonsillectomy.
Match Strength: 6.240

An 18-month-old boy presented with signs and symptoms of obstructive sleep apnea and pulmonary hypertension of 12 months duration. Confirmatory laboratory studies, in the form of echocardiography and overnight oximetry, were carried out, which showed hypoxemia and severe pulmonary hypertension. He had adenotonsillectomy, which resulted in complete resolution of signs and symptoms of pulmonary hypertension. Chronic upper airway obstruction should not be overlooked as it is a reversible cause of pulmonary hypertension ... Read More »
» Published in Saudi Med J. 2006 Oct;27(10):1582-4.

24. Pre-hypertension as a predictor of hypertension in military aviators: a longitudinal study of 367 men.
Match Strength: 6.239

BACKGROUND: Recently, the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure introduced the term "pre-hypertension" for systolic blood pressure (BP) levels of 120-139 and diastolic BP levels of 80-89 mmHg. Our aim was to establish the prevalence of this novel entity among young subjects, and to assess the rate of progression to hypertension. METHODS: We retrospectively analyzed the data of a group of 367 male aviators who were examined at the age of 18 and who were followed for an average of 18 +/- 7 yr (range 3-37 yr). ... Read More »
» Published in Aviat Space Environ Med. 2006 Nov;77(11):1162-5.

25. Prevalence of hypertension, dyslipidemia, and dyslipidemic hypertension.
Match Strength: 6.236

BACKGROUND. It has been proposed that dyslipidemic hypertension is part of a distinct metabolic syndrome related to insulin resistance. This paper describes the prevalence and cross-sectional relations of dyslipidemic hypertension in a population-based sample of men and women. METHODS. In two southeastern New England communities, 11,199 randomly selected participants were evaluated as part of a cross-sectional surveillance program of coronary heart disease risk factors between 1981 and 1990. RESULTS. The frequency of dyslipidemia was 38% and of hypertension was 26.5%; the conjoint frequency ... Read More »
» Published in J Fam Pract. 1994 Jan;38(1):17-23. Comment in: J Fam Pract. 1994 May;38(5):455-6. J Fam Pract. 1994 May;38(5):455; author reply 456.

26. Proteinuria as a significant determinant of hypertension in a normotensive screened cohort in Okinawa, Japan.
Match Strength: 6.236

To evaluate the influence of proteinuria on the development of hypertension in normotensive screened subjects. We studied 4,428 normotensive subjects without heart disease (2888 men, 1540 women, age 19-89 years) who were participants in a 1-day health evaluation in both 1997 and 2000. The 3-year frequency of developing hypertension was 6.0% in subjects without proteinuria, and 13.5% in subjects with proteinuria. The odds ratio for developing hypertension by age (year) increased approximately 1.6%. Obesity was associated with an approximately 40% increased risk of hypertension; proteinuria ... Read More »
» Published in Hypertens Res. 2006 Sep;29(9):687-93.

27. Diagnosis and management of pulmonary hypertension over the past 100 years.
Match Strength: 6.233

Pulmonary hypertension is a rare disease with a poor prognosis. It was first described in the late 19th century as a clinical-pathological syndrome characterised by obstruction of the small pulmonary arteries and right ventricular hypertrophy in patients presenting with severe dyspnoea and cyanosis. After the development of right heart catheterisation in the second half of the 20th century, it was found that many diseases could cause pulmonary hypertension, which is now recognised to be high blood pressure in the arteries that supply the lungs. In the 1960s, an epidemic of pulmonary ... Read More »
» Published in Respir Med. 2007 Jan 10;

28. Human herpesvirus 8 and pulmonary hypertension.
Match Strength: 6.230

Human herpesvirus 8 (HHV-8) antibodies were detected in 1 of 33 patients with pulmonary hypertension (including in 1 of 16 with idiopathic pulmonary arterial hypertension), 5 of 29 with cystic fibrosis, and 3 of 13 with interstitial lung disease. No relationship between HHV-8 infection and pulmonary hypertension was found. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Emerg Infect Dis. 2005 Sep;11(9):1480-2.

29. Historical perspectives on the management of hypertension.
Match Strength: 6.223

As late as the 1950s, elevated blood pressure was considered by many expert physicians to be necessary for the adequate perfusion of vital organs. Although the morbidity and mortality risks of hypertension were known at that time to insurance companies, which often refused life insurance policies to people with high blood pressure, there was a lag in the recognition of the dangers of hypertension in the medical community. Following the pioneering efforts of researchers who began to treat patients with malignant hypertension, the results of clinical trials and population studies, and the ... Read More »
» Published in J Clin Hypertens (Greenwich). 2006 Aug;8(8 Suppl 2):15-20; quiz 39.

30. Glucose, insulin, and insulin resistance as biochemical predictors of hypertension.
Match Strength: 6.194

Obesity, essential hypertension, and diabetes mellitus share certain metabolic disturbances. The predictive value of disordered glucose metabolism and insulin action for hypertension are discussed. Several studies have examined the relationship between hypertension and glucose metabolism in diverse populations, and tend to indicate a predictive role for insulin and glucose metabolism disturbances in the development of hypertension ... Read More »
» Published in Am J Hypertens. 1991 Nov;4(11):638S-641S.

31. Medical costs of patients with hypertension and/or diabetes: A 10-year follow-up study of National Health Insurance in Shiga, Japan.
Match Strength: 6.187

BACKGROUND AND METHODS: A cohort study investigating medical costs associated with the combination of hypertension and diabetes was conducted. The participants included 4535 community-dwelling Japanese individuals, aged 40-69 years, who were classified into the following four categories: 'Neither hypertension nor diabetes', 'Hypertension alone', 'Diabetes alone' or 'Both hypertension and diabetes'. Medical costs per person per month were compared among the four categories. RESULTS AND CONCLUSION: Of the study population, 1.3% had both hypertension and diabetes. During the 10-year follow-up ... Read More »
» Published in J Hypertens. 2006 Nov;24(11):2305-9.

32. Nutrition Therapy for Hypertension
Match Strength: 6.182

A contemporary approach to hypertension and prevention are covered in this article. It contains important information for clinicians, such as hypertension management, metabolic syndrome issues, lifestyle behavioral management, nutrient issues, weight loss treatments (ie, medications and surgical procedures), the role of physical activity, and pharmacologic treatment. The Dietary Approaches to Stop Hypertension (DASH) trial eating plan is discussed at length, as well as information from recent trials on hypertension, prevention, and treatment ... Read More »
» Published in Curr Diab Rep. 2003 Oct;3(5):404-11.

33. Experts Discuss Cost-Effective Treatment of Hypertension During World Conference in Canada
Match Strength: 6.176

Even though an estimated 3.5 million Canadians are affected by hypertension, speakers at a World Conference on Hypertension Control questioned whether it is generally cost effective to treat younger men and women who have mild hypertension. Nonpharmacologic treatment via weight loss and lifestyle modification should be the first-line treatment, speakers stated. They looked at the basic principles for evaluating the economics of hypertension management and made recommendations on the cost effectiveness of treating various patient groups according to age and severity of their hypertension, and ... Read More »
» Published in CMAJ. 1995 Nov 1;153(9):1332-5.

34. Discordant response of glutathione and thioredoxin systems in human hypertension?
Match Strength: 6.145

Hypertension is frequently associated with oxidative stress caused by high production of reactive oxygen species and compromised antioxidant defenses. Humans with essential hypertension, with or without treatment, and controls were examined (35 hypertensive and 30 normotensive). We noted a discordant response of the glutathione and thioredoxin systems in essential hypertension and to antihypertensive treatment. Further studies examining the significance of these thiols in hypertension outcomes are warranted ... Read More »
» Published in Antioxid Redox Signal. 2007;9(4):507-14.

35. Impact of World Hypertension Day.
Match Strength: 6.123

It is estimated that nearly one billion people are affected by hypertension worldwide, and this figure is predicted to increase to 1.5 billion by 2025. Nearly one-half of this population are unaware of their condition. Hypertension is the primary risk factor for heart disease and stroke. World Hypertension Day (WHD) has been an initiative of the World Hypertension League to raise hypertension awareness. In the past two years, many countries have taken an active part in promoting awareness through a number of initiatives in their respective countries. In Canada, WHD was a resounding success in ... Read More »
» Published in Can J Cardiol. 2007 May 15;23(7):517-9.

36. Nonpharmacologic Interventions Successfully Treat Hypertension in Older Persons
Match Strength: 6.115

A randomized controlled multicenter trial of nonpharmacologic intervention in elderly with treated hypertension concluded that reduced sodium intake and weight loss are feasible, effective, and safe nonpharmacologic treatments for hypertension. This and other trials provide compelling evidence that a variety of dietary interventions are important in the prevention and treatment of hypertension in all age groups ... Read More »
» Published in Nutr Rev. 1998 Nov;56(11):341-3.

37. The Association Between Obesity and Hypertension in Blacks
Match Strength: 6.092

The relationship between obesity (or overweight) and hypertension among blacks warrants careful consideration because of the substantial prevalence of both obesity and hypertension in the black population. Based on the relative risks of hypertension for overweight and nonoverweight persons in the 1976-1980 U.S. National Health and Nutrition Examination Survey, 21% of hypertension in black men and 18% of hypertension in black women can be attributed to overweight. In terms of numbers affected, approximately 330,000 cases of hypertension among black men and 500,000 cases of hypertension among ... Read More »
» Published in Clin Cardiol. 1989 Dec;12(12 Suppl 4):IV72-7.

38. What's new in pediatric hypertension?
Match Strength: 6.088

Research activities in the field of pediatric hypertension have been increasing in recent years, leading to important new findings in the epidemiology, diagnosis, and treatment of hypertension in children. This review summarizes recent work in these areas, focusing on the epidemic of obesity-related hypertension in children, advances in the drug therapy of childhood hypertension, and the increasing use of ambulatory blood pressure monitoring in evaluation of hypertensive children. Each of these three areas will no doubt develop further over the years ahead, resulting in further advances in the ... Read More »
» Published in Curr Hypertens Rep. 2001 Dec;3(6):503-10.

39. Implications of recent heart failure trials for patients with hypertension.
Match Strength: 6.084

There are two major reasons why hypertension is an important risk factor for heart failure. The first is that an elevated blood pressure increases the wall stress in the left ventricle. The second is that hypertension, in a complex manner, contributes to the development of atheromatous vascular disease. Among the more common causes of heart failure are the sequelae of coronary heart disease. The treatment of hypertension modifies the progression to heart failure and the occurrence of coronary events. In patients who have heart failure, hypotension rather than hypertension is a predictor of a ... Read More »
» Published in Curr Cardiol Rep. 2001 Nov;3(6):504-10.

40. Complete resolution of hypertension after decompression of Chiari I malformation.
Match Strength: 6.083

The Chiari I malformation has not been previously linked to sustained hypertension. Other forms of medullary compression have, however, been shown to be associated with elevated arterial pressure. This association has been demonstrated through numerous studies that have implicated compression of the rostral ventrolateral medulla, usually by vascular structures, as a factor responsible for hypertension. We present a case of a young man with a 2-year history of hypertension who was found to have a Chiari I malformation. No other cause for hypertension was found. After subsequent surgical ... Read More »
» Published in Skull Base Surg. 2000;10(3):149-52.

41. Advances in genetic hypertension.
Match Strength: 6.083

PURPOSE OF REVIEW: Mendelian forms of hypertension are rare genetic disorders that cause severe hypertension. This review will explore the recently identified molecular mechanisms and pathogenesis of genetic disorders that cause hypertension in children. RECENT FINDINGS: Hypertension is now believed to be a polygenic disorder resulting from the interaction of multiple genes and the environment. A few forms of severe hypertension have been linked to single genes. The genes responsible for these disorders have all been cloned and all participate in pathways involved in heightened renal sodium ... Read More »
» Published in Curr Opin Pediatr. 2007 Apr;19(2):192-8.

42. Pulmonary hypertension due to recurrent juvenile laryngeal papillomatosis.
Match Strength: 6.069

Although pulmonary hypertension secondary to upper airway obstruction caused by adenotonsillar hyperplasia has been well described, the association between laryngeal papillomatosis and pulmonary hypertension has not previously been documented. We report three patients with pulmonary hypertension due to upper airway obstruction caused by laryngeal papillomatosis. Pulmonary hypertension can contribute to significant preoperative and postoperative morbidity and cause intraoperative complications. Preoperative diagnosis and treatment of pulmonary hypertension is therefore essential in these ... Read More »
» Published in Int J Pediatr Otorhinolaryngol. 2005 Sep;69(9):1279-82. Epub 2005 Apr 26.

43. Epidemiology Of Hypertension And Insulin Resistance Syndrome
Match Strength: 6.069

INSULIN RESISTANCE SYNDROME: Insulin resistance syndrome (syndrome X) indicates that insulin resistance is associated with and may be the cause of several metabolic conditions including hypertension, dyslipidemia, non-insulin dependent diabetes mellitus (NIDDM). HYPERTENSION: Although the association between insulin resistance and hypertension remains somewhat controversial, hypertensive subjects are clearly at increased risk of developing NIDDM. Insulin concentrations are a relatively weak predictor of the development of hypertension. It is possible that the relation between insulin, blood ... Read More »
» Published in J Hypertens Suppl. 1997 Jan;15(1):S25-30.

44. Lacunar Stroke and Masked Hypertension in an Adolescent Male.
Match Strength: 6.063

Hypertension has not been strongly identified as a risk factor in childhood stroke. This report describes a case of a teenager with a lacunar stroke, the type often observed in adults with hypertensive-associated infarction, and masked hypertension. The patient had normal blood pressure on initial presentation, but on further investigation demonstrated ambulatory hypertension with evidence of hypertensive end-organ damage. This case suggests that hypertension may be a risk factor in children with stroke, especially in cases of lacunar infarct. Evaluation for possible hypertension should be ... Read More »
» Published in Pediatr Neurol. 2007 Feb;36(2):125-127.

45. Primary pulmonary hypertension with severe systemic hypertension, Raynaud's phenomenon and relative polycythemia.
Match Strength: 6.060

A 32-year-old Japanese man was hospitalized for evaluation of unconsciousness. He was diagnosed as having primary pulmonary hypertension (PPH) with severe systemic hypertension, Raynaud's phenomenon and relative polycythemia. Hemostatic studies revealed increased coagulation and decreased fibrinolysis, similar to findings of chronic disseminated intravascular coagulation (DIC). Although activation of coagulation and systemic hypertension were improved after treatment with phlebotomy and administration of nifedipine, enerapril and warfarin, pulmonary hypertension was unchanged, suggesting that ... Read More »
» Published in Intern Med. 2001 Sep;40(9):905-10.

46. The future of endothelin-receptor antagonism as treatment for systemic hypertension.
Match Strength: 6.056

Endothelin (ET) is an endogenous peptide secreted predominantly by endothelial cells that mediates its effects via vasoconstriction and hypertrophy of vascular smooth muscle. Because the role of ET has been described in multiple pathologic processes in cardiovascular disease, including hypertension, there has been a strong interest in the development of therapeutic agents that inhibit ET receptors. ET receptor antagonists have shown much promise in disease states such as pulmonary arterial hypertension, essential hypertension, and various forms of secondary hypertension. This review serves to ... Read More »
» Published in Curr Hypertens Rep. 2006 Apr;8(1):35-44.

47. Orthostatic hypertension: when pressor reflexes overcompensate.
Match Strength: 6.054

Orthostatic hypertension--a rise in blood pressure upon assuming upright posture-is an underappreciated and understudied clinical phenomenon. There is currently no widely agreed-upon definition of clinical orthostatic hypertension, the current definitions being operational within the context of particular studies. The underlying pathophysiology is thought to involve activation of the sympathetic nervous system, but the actual etiology is poorly understood. Orthostatic hypertension is observed in association with a variety of other clinical conditions, including essential hypertension, ... Read More »
» Published in Nat Clin Pract Nephrol. 2006 Aug;2(8):424-31.

48. Increased vascular resistance and not salt retention characterizes cyclosporine a-induced hypertension: report in an anuric patient.
Match Strength: 6.050

Cyclosporine A (CsA) use is associated with hypertension in most solid-organ transplant recipients. The mechanisms of CsA-induced hypertension have not been fully elucidated and are still controversial. We present a case of CsA-induced hypertension who was anuric and receiving hemodialysis, and in whom noninvasive cardiothoracic bioimpedence revealed elevated systemic vascular resistance without evidence of fluid-volume overload. We briefly discuss the possible mechanisms of CsA-induced hypertension in light of this information ... Read More »
» Published in Am J Transplant. 2007 Aug;7(8):2042-6. Epub 2007 Jun 18.

49. Isolated uncontrolled hypertension at home and in the office among treated hypertensive patients from the J-HOME study.
Match Strength: 6.039

OBJECTIVES: To evaluate the current status of blood pressure (BP) control as measured at home and in the office, as well as to clarify and compare the prevalence and characteristics of isolated uncontrolled hypertension as measured at home (home hypertension) and in the office (office hypertension). DESIGN: A cross-sectional study. SETTING: Primary care offices in Japan. PARTICIPANTS: A sample of 3400 patients with essential hypertension (mean age, 66 years; males, 45%) receiving antihypertensive treatment. RESULTS: Overall, the mean home systolic BP (SBP)/diastolic BP (DBP) was 140/82 mmHg, ... Read More »
» Published in J Hypertens. 2005 Sep;23(9):1653-60.

50. Methylglyoxal, oxidative stress, and hypertension.
Match Strength: 6.029

Pathogenic mechanisms for essential hypertension are unclear despite striking efforts from numerous research teams over several decades. Increased production of reactive oxygen species (ROS) has been associated with the development of hypertension and the role of ROS in hypertension has been well documented in recent years. In this context, it is important to better understand pathways and triggering factors for increased ROS production in hypertension. This review draws a causative linkage between elevated methylglyoxal level, methylglyoxal-induced production of ROS, and advanced glycation ... Read More »
» Published in Can J Physiol Pharmacol. 2006 Dec;84(12):1229-38.

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