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Green Tea Hypertension
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1. Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model.
Match Strength: 8.064

BACKGROUND: Sprague-Dawley rats fed a fructose-rich diet exhibit insulin resistance and hypertension, a pathologic status resembling human type II diabetes mellitus, and are an excellent laboratory animal model for research on insulin action and the development of hypertension. Since green tea has numerous beneficial effects, we tested its effect on fructose-fed rats. AIM: The present study was therefore designed to further evaluate the effects of green tea supplementation on insulin resistance, hypertension, and the glucose transporters I and IV contents in adipose tissue in the fructose-fed ... Read More »
» Published in Eur J Nutr. 2004 Apr;43(2):116-24. Epub 2004 Jan 6.

2. Habitual green tea consumption and risk of an aneurysmal rupture subarachnoid hemorrhage: a case-control study in Nagoya, Japan.
Match Strength: 7.656

BACKGROUND: Green tea, a popular beverage in Japan, contains many polyphenolic antioxidants, which might prevent cardiovascular disease. This study is designed to determine whether the consumption of green tea is associated with a reduced risk for subarachnoid hemorrhage (SAH) using a case-control study. METHODS: Incident SAH cases (n=201) were identified and individually matched by age (+/-2 years) and gender to hospital (n=201) and community controls (n=201) from April 1992 to March 1997. Habitual regular tea consumption was assessed with a structured questionnaire. Conditional logistic ... Read More »
» Published in Eur J Epidemiol. 2006;21(5):367-71. Epub 2006 May 23.

3. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.
Match Strength: 7.300

Chlorogenic acids (CGA) in green coffee bean extract (GCE) reduce blood pressure in spontaneously hypertensive rats and humans. The authors examined the blood pressure-lowering effect and safety of CGA in patients with mild hypertension through a placebo-controlled, randomized clinical trial. Subjects (n = 28) were randomized to receive treatment with CGA (140 mg/day) from GCE or placebo. Blood pressure, pulse rate, body mass index, routine blood test, hematochemistry, urinalysis, and subjective symptoms were recorded throughout the study. In the CGA group, but not the placebo group, blood ... Read More »
» Published in Clin Exp Hypertens. 2006 Jul;28(5):439-49.

4. Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation.
Match Strength: 7.148

BACKGROUND: Recent evidence suggests that bone marrow (BM)-derived cells may differentiate into vascular cells that participate in arterial repair and/or lesion formation. However, it remains uncertain whether BM-derived cells also can participate in vascular remodeling associated with pulmonary arterial hypertension. METHODS AND RESULTS: The BM of Sprague-Dawley rats was reconstituted with that of green fluorescent protein-transgenic rats. The BM-chimeric rats were injected intraperitoneally with 60 mg/kg monocrotaline after unilateral subpneumonectomy, and they concurrently underwent wire ... Read More »
» Published in Circulation. 2007 Jan 30;115(4):509-17. Epub 2007 Jan 22.

5. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects.
Match Strength: 6.916

A water-soluble green coffee bean extract (GCE) has been shown to be effective against hypertension in both spontaneously hypertensive rats and humans. This multicenter, randomized, double-blind, placebo-controlled, parallel group study evaluated the dose-response relationship of GCE in 117 male volunteers with mild hypertension. Subjects were randomized into four groups: a placebo and three drug groups that received 46 mg, 93 mg, or 185 mg of GCE once a day. After 28 days, systolic blood pressure (SBP) in the placebo, 46 mg, 93 mg, and 185 mg groups was reduced by -1.3+/-3.0 mmHg, -3.2+/-4.6 ... Read More »
» Published in Hypertens Res. 2005 Sep;28(9):711-8.

6. Detection and prevalence of early diabetic retinopathy in juvenile diabetics with diabetes for 10 years or more.
Match Strength: 6.657

PURPOSE: To compare clinical examination using green light with clinical examination using white light in detecting early diabetic retinopathy (DR) in juvenile diabetic patients with disease for 10 or more years. METHODS: All patients were examined clinically using both green light and white light to determine the presence of DR. Each patient underwent seven-field fundus photography, which was used as the defined standard against which the clinical examinations were compared and also to determine the prevalence of DR. Data on age at diagnosis, duration of diabetes mellitus, recent HbA1c levels ... Read More »
» Published in Eye. 2000 Dec;14(Pt 6):847-50. Comment in: Eye. 2001 Oct;15(Pt 5):688-90.

7. KNOCKING DOWN OF THE DIENCEPHALIC THYROTROPIN-RELEASING HORMONE PRECURSOR GENE NORMALIZES OBESITY-INDUCED HYPERTENSION IN THE RAT.
Match Strength: 6.287

We recently showed that diencephalic TRH may mediate central leptin-induced pressor effect. Here, to study the role of TRH in obesity-induced hypertension (OIH), we used a model of OIH produced by a high-fat diet (HFD, 45 days) in male Wistar rats. After 4 weeks, body weight and systolic arterial blood pressure (SABP) increased in HFD animals. Plasma leptin was correlated with peritoneal adipose tissue. Then, we treated OIH animals with an antisense oligodeoxynucleotide and small interfering RNA (siRNA) against the preproTRH. Antisense significantly decreased diencephalic TRH content and SABP ... Read More »
» Published in Am J Physiol Endocrinol Metab. 2007 Jan 16;

8. Ethnic differences in the effect of environmental stressors on blood pressure and hypertension in the Netherlands.
Match Strength: 6.106

ABSTRACT: BACKGROUND: Evidence strongly suggests that the neighbourhood in which people live influences their health. Despite this, investigations of ethnic differences in cardiovascular risk factors have focused mainly on individual-level characteristics. The main purpose of this study was to investigate associations between neighbourhood-level environmental stressors (crime, housing density, nuisance from alcohol and drug misuse, quality of green space and social participation), and blood pressure (BP) and hypertension among different ethnic groups. METHODS: Individual data from the ... Read More »
» Published in BMC Public Health. 2007 Jun 23;7(1):118

9. Splanchnic and systemic hemodynamics in early abstinence and after ethanol administration in non-cirrhotic alcoholic patients.
Match Strength: 5.967

Thirteen asymptomatic chronic alcoholic patients were studied to investigate the early stages of portal hypertension in alcoholic liver disease and the effects of withdrawal and ethanol on hepatic function and hemodynamic variables. None of the patients presented clinical signs of decompensated liver disease, and their liver biopsies showed normal liver or moderate alterations only. In basal conditions and after an intravenous ethanol infusion (1 g/kg body weight), hepatic venous pressure gradient and hepatic blood flow using indocyanine green were measured through hepatic vein catheterization ... Read More »
» Published in J Hepatol. 1994 Apr;20(4):494-9.

10. Preventive effects of green tea catechins on spontaneous stroke in rats.
Match Strength: 5.867

Background: Green tea catechins possess potent antioxidative properties and protect against various oxidative diseases. Malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) develop severe hypertension and spontaneous stroke at early ages. We previously reported that ingestion of green tea catechins prevents cerebral ischemic damage in a middle cerebral artery occlusion and reperfusion rat stroke model, in association with increased plasma epigallocatechin-gallate (EGCG) concentrations. In this study, we examined whether tea catechin intake decreases the incidence of spontaneous ... Read More »
» Published in Med Sci Monit. 2007 Jan 18;13(2):BR40-45

11. Decrease of cone opsin mRNA in experimental ocular hypertension.
Match Strength: 5.709

PURPOSE: This study was designed to test the hypothesis that photoreceptors are adversely affected in glaucoma. As a measure of this effect, we examined the levels of rod opsin, and red/green and blue cone opsin mRNAs in monkeys with experimental ocular hypertension and glaucoma and in human eyes from donors with diagnosed glaucoma. METHODS: Experimental ocular hypertension was induced in one eye of 19 cynomolgous and 2 rhesus monkeys by laser ablation of the trabecular meshwork. In 15 monkeys, the elevated IOP was reduced by trabeculectomy. When the animals had experienced prolonged ... Read More »
» Published in Mol Vis. 2006 Oct 26;12:1272-82.

12. Changes in extracellular matrix in subcutaneous small resistance arteries of patients with primary aldosteronism.
Match Strength: 5.662

CONTEXT AND OBJECTIVE: It has been previously demonstrated that aldosterone may possess a strong profibrotic action in vitro and in animal models of genetic or experimental hypertension. Our aim was to evaluate whether such a profibrotic action is present also in the human microcirculation. DESIGN AND PATIENTS: We investigated 13 patients with primary aldosteronism, seven patients with essential hypertension, and 10 normotensive controls. All subjects were submitted to a biopsy of gluteal sc fat tissue. Small resistance arteries were dissected and mounted on an isometric myograph, and the ... Read More »
» Published in J Clin Endocrinol Metab. 2006 Jul;91(7):2638-42. Epub 2006 Apr 11.

13. A Functional Food Product For the Management of Weight
Match Strength: 5.624

More than half of Americans have a body mass index of 25 kg/m2 or more, which classifies them as overweight or obese. Overweight or obesity is strongly associated with comorbidities such as type 2 diabetes mellitus, hypertension, heart disease, gall bladder disease, and sleep apnea. Clearly, this is a national health concern, and although about 30 to 40% of the obese claim that they are trying to lose weight or maintain weight after weight loss, current therapies appear to have little effect. None of the current popular diets are working, and there is room for innovation. With the advancing ... Read More »
» Published in Crit Rev Food Sci Nutr. 2002 Mar;42(2):163-78.

14. Argon Green (514 Nm) Versus Krypton Red (647 Nm) Modified Grid Laser Photocoagulation For Diffuse Diabetic Macular Edema
Match Strength: 5.615

Between 1984 and 1988, 225 eyes of 132 patients were entered in a prospective, randomized clinical trial to determine if any significant differences exist between treatment with argon green (514 nm) and krypton red (647 nm) modified grid laser photocoagulation for patients with diffuse diabetic maculopathy with or without cystoid macular edema. At the 12- and 24-month follow-up visits, no statistically significant difference was found between the two groups with respect to all of the following: reduction or elimination of macular edema, improvement in visual acuity, worsening of visual acuity, ... Read More »
» Published in Ophthalmology. 1990 Sep;97(9):1101-12; discussion 1112-3.

15. A syndrome resembling idiopathic noncirrhotic portal hypertension in 4 young Doberman pinschers.
Match Strength: 5.436

We describe 4 young male Doberman Pinschers (3 littermates and 1 unrelated dog) with a syndrome resembling idiopathic or noncirrhotic portal hypertension of humans. Each dog was evaluated for a hepatopathy resulting in portal hypertension, development of portosystemic collateral vessels, and hepatic encephalopathy. These dogs differ from previous reports of young dogs with hepatic insufficiency associated with portal hypertension and acquired portal systemic shunting by their lack of intrahepatic arteriovenous fistulae, portal vein atresia, or intrahepatic fibrosis. Clinicopathologic features ... Read More »
» Published in J Vet Intern Med. 1998 May-Jun;12(3):147-56.

16. Gene Transfer of Neuronal Nitric Oxide Synthase into Intracardiac Ganglia Reverses Vagal Impairment in Hypertensive Rats.
Match Strength: 5.397

Hypertension is associated with reduced cardiac vagal activity and decreased atrial guanylate cyclase and cGMP levels. Neuronal production of NO facilitates cardiac parasympathetic transmission, although oxidative stress caused by hypertension may disrupt this pathway. We tested the hypothesis that peripheral vagal responsiveness is attenuated in the spontaneously hypertensive rat (SHR) because of impaired NO-cGMP signaling and that gene transfer of neuronal NO synthase (nNOS) into cholinergic intracardiac ganglia can restore neural function. Cardiac vagal heart rate responses in the isolated ... Read More »
» Published in Hypertension. 2007 Jan 8;

17. Gene Transfer of Neuronal Nitric Oxide Synthase into Intracardiac Ganglia Reverses Vagal Impairment in Hypertensive Rats.
Match Strength: 5.397

Hypertension is associated with reduced cardiac vagal activity and decreased atrial guanylate cyclase and cGMP levels. Neuronal production of NO facilitates cardiac parasympathetic transmission, although oxidative stress caused by hypertension may disrupt this pathway. We tested the hypothesis that peripheral vagal responsiveness is attenuated in the spontaneously hypertensive rat (SHR) because of impaired NO-cGMP signaling and that gene transfer of neuronal NO synthase (nNOS) into cholinergic intracardiac ganglia can restore neural function. Cardiac vagal heart rate responses in the isolated ... Read More »
» Published in Hypertension. 2007 Jan 8;

18. ENDOTHELIAL NITRIC OXIDE SYNTHASE IS A MOLECULAR VASCULAR TARGET FOR THE CHINESE HERB DANSHEN IN HYPERTENSION.
Match Strength: 5.372

Danshen, a Chinese herb, reduces hypertension in Oriental Medicine. We hypothesized that Danshen acts partially through endothelial nitric oxide synthase (eNOS) signaling mechanisms. We tested the hypothesis using tanshinone IIA, an active ingredient of Danshen, and the 2-kidney-1-clip renovascular (2K1C) hypertension model in hamsters. Oral tanshinone (50 microg/100g of body weight) reduced mean arterial pressure (MAP) from 161.2+/-6.9 to 130.0+/-7.8 mmHg (mean+/-SEM; p<0.05) in hypertensive hamsters. MAP in sham-operated hamsters was 114.3+/-9.2 mmHg. Topical tanshinone at 1 microg/ml and ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2006 Dec 15;

19. Diode Laser (810 Nm) Versus Argon Green (514 Nm) Modified Grid Photocoagulation For Diffuse Diabetic Macular Edema
Match Strength: 5.359

OBJECTIVE: To compare argon green (514 nm) versus diode laser (810 nm) modified grid laser photocoagulation treatment in diffuse diabetic macular edema (DDME). DESIGN: Randomized, prospective clinical trial. PARTICIPANTS: Patients with DDME and diabetic retinopathy of fewer than two high-risk characteristics in severity, no previous laser photocoagulation for diabetic macular edema, and no other ocular condition that could interfere with assessment of treatment results. INTERVENTION: One hundred seventy-one eyes of 91 patients were randomized to either argon green (514 nm) or diode laser (810 ... Read More »
» Published in Ophthalmology. 1997 Sep;104(9):1433-41.

20. Prediction of the risk of hepatic failure in patients with portal vein invasion hepatoma after hepatic resection.
Match Strength: 5.206

AIM: Hepatic failure can develop after curative hepatectomy in patients with a hepatocellular carcinoma (HCC) invading the portal vein, because of cirrhosis and excessive tissue loss. This study aimed to identify the risk factors for hepatic failure in such patients. METHOD: Forty patients with an HCC invading the portal vein underwent curative hepatectomy from January 1995 to June 2003. Eight patients developed hepatic failure and died within 3 months. Possible risk factors for this were analysed using univariate and multivariate regression. These included the liver function index, surgical ... Read More »
» Published in Eur J Surg Oncol. 2006 Feb;32(1):72-6. Epub 2005 Oct 24.

21. Long-term inhibition of the central alpha(2B)-adrenergic receptor gene via recombinant AAV-delivered antisense in hypertensive rats.
Match Strength: 5.140

BACKGROUND: Salt-induced hypertension is mediated via the alpha(2B)-adrenergic receptor (AR) subtype. In alpha(2B)-AR gene knockout mice, blood pressure (BP) does not rise with salt loading, and in rats with salt-induced hypertension, BP decreases transiently with antisense (AS) treatment targeting the alpha(2B)-AR gene. The present experiments were designed to explore the possibility of gene transfection in the brain by intracerebroventricular (ICV) delivery of AS-DNA via adeno-associated virus (AAV) to prolong alpha(2B)-AR inhibition and hence reversal of salt-dependent hypertension. METHODS ... Read More »
» Published in Am J Hypertens. 2006 Nov;19(11):1135-43.

22. Tea polyphenols regulate nicotinamide adenine dinucleotide phosphate oxidase subunit expression and ameliorate angiotensin II-induced hyperpermeability in endothelial cells.
Match Strength: 4.953

Out-of-control reactive oxygen species (ROS) signaling is one of the key events in the pathogenesis of endothelial dysfunction and essential hypertension. We observed that tea polyphenols decreased the production of ROS via regulation of the protein expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in bovine carotid artery endothelial cells (BCAECs). Both green tea polyphenols (GTP) and black tea polyphenols (BTP) down-regulated the expression of NADPH oxidase subunits p22phox and p67phox while up-regulating catalase expression (p < 0.05, respectively). Pre-treatment ... Read More »
» Published in Hypertens Res. 2003 Oct;26(10):823-8.

23. ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR.
Match Strength: 4.887

Recently discovered, angiotensin-converting enzyme-2 (ACE2) is an important therapeutic target in the control of cardiovascular diseases as a result of its proposed central role in the control of angiotensin peptides. Thus our objective in the present study was to determine whether ACE2 gene transfer could decrease high blood pressure (BP) and would improve cardiac dysfunctions induced by hypertension in the spontaneously hypertensive rat (SHR) model. Five-day-old SHR and normotensive WKY rats received a single intracardiac bolus injection of lentiviral vector containing either murine ACE2 ... Read More »
» Published in Physiol Genomics. 2006 Oct 3;27(1):12-9. Epub 2006 Jun 20.

24. Epigallocatechin Gallate, a Green Tea Polyphenol, IMPROVES ENDOTHELIAL FUNCTION AND INSULIN SENSITIVITY, REDUCES BLOOD PRESSURE, AND PROTECTS AGAINST MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN Spontaneously Hypertensive Rats (SHR).
Match Strength: 4.867

Epigallocatechin gallate (EGCG), a bioactive polyphenol in green tea, may augment metabolic and vascular actions of insulin. We investigated effects of EGCG treatment to simultaneously improve cardiovascular and metabolic function in SHR rats (model of metabolic syndrome with hypertension, insulin resistance, and overweight). In acute studies, EGCG (1 - 100 microM) elicited dose-dependent vasodilation in mesenteric vascular beds (MVB) from SHR ex vivo, inhibitable by L-NAME (NOS antagonist) or wortmannin (PI 3-kinase inhibitor). In chronic studies, 9-wk old SHR were treated by gavage for 3 ... Read More »
» Published in Am J Physiol Endocrinol Metab. 2007 Jan 16;

25. Modifiable risk factors for age-related macular degeneration.
Match Strength: 4.866

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in Australia and other Western countries. As there is no cure for AMD, and treatments to stop its progression have met with limited success, there is an interest in identifying modifiable risk factors to prevent or slow disease progression. To date, smoking is the only proven modifiable risk factor for AMD. Other factors under study include (i) cardiovascular risk factors such as hypertension, body mass index, and atherosclerosis; and (ii) dietary risk factors including fat and antioxidant intake, but so far ... Read More »
» Published in Med J Aust. 2006 May 1;184(9):455-8.

26. Prone position in mechanically ventilated patients -- the hard or the soft way?
Match Strength: 4.829

Prone positioning may even in patients without abdominal hypertension result in an increased intra-abdominal pressure (IAP). Previous research could not demonstrate a marked increase in IAP associated with cardiovascular, renal, or hepato-splanchnic dysfunction when patients were proned in air-cushioned beds. Michelet and colleagues in this issue of Critical Care report that the increase in IAP in the prone position depends on the used mattress type. Compared with air-cushion beds, conventional foam mattresses resulted in a greater increase in IAP which was associated with a decrease in the ... Read More »
» Published in Crit Care. 2005 Jun;9(3):253-4. Epub 2005 May 5. Comment on: Crit Care. 2005 Jun;9(3):R251-7.

27. Prolonged Q-T(c) interval in mild portal hypertensive cirrhosis.
Match Strength: 4.819

BACKGROUND/AIMS: The Q-T(c) interval is prolonged in a substantial fraction of patients with cirrhosis, thus indicating delayed repolarisation. However, no information is available in mild portal hypertensive patients. We therefore determined the Q-T(c) interval in cirrhotic patients with hepatic venous pressure gradient (HVPG) < 12 mmHg. METHODS: Forty-four patients with cirrhosis and HVPG < 12 mmHg underwent a haemodynamic study. They were compared with 36 cirrhotic patients with clinically significant portal hypertension (HVPG> or = 12 mmHg) and controls without liver disease. ... Read More »
» Published in J Hepatol. 2005 Oct;43(4):637-44.

28. Validity of four indirect methods to measure adherence in primary care hypertensives.
Match Strength: 4.811

High blood pressure (HBP) is one of the most important risk factors for morbidity and mortality in the world. Non-adherence to medication is associated with the lack of control of HBP. The objective of this study was to assess the validity of four indirect methods for measuring adherence to medication to control HBP in primary health care. A random sample of 120 hypertensive patients who were undergoing treatment for at least 2 months in a primary care unit in Florianopolis (Brazil) were included in the study. The independent variables were four indirect methods to measure adherence to ... Read More »
» Published in J Hum Hypertens. 2007 Jul;21(7):579-84. Epub 2007 Apr 19.

29. Visualizing tubular lipid peroxidation in intact renal tissue in hypertensive rats.
Match Strength: 4.767

An imbalance between production of reactive oxygen species (ROS) and antioxidant defense is involved in the pathogenesis of diverse chronic parenchymatous diseases. To identify the primary site of such increased oxidative stress, a lipophilic ROS-sensitive probe (C11-Bodipy 581/591) is introduced, which allows the visualization and quantification of oxidative injury using confocal fluorescence microscopy in living cells. The properties of this probe are such that its emission wavelength irreversibly shifts from red to green upon oxidation. This probe was used to identify the spatiotemporal ... Read More »
» Published in J Am Soc Nephrol. 2002 Dec;13(12):2990-6.

30. Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study.
Match Strength: 4.712

BACKGROUND: Although ecological observations suggest that the Japanese diet may reduce the risk of cardiovascular disease (CVD), the impact of a Japanese dietary pattern upon mortality due to CVD is unclear. METHODS: We prospectively assessed the association between dietary patterns among the Japanese and CVD mortality. Dietary information was collected from 40 547 Japanese men and women aged 40-79 years without a history of diabetes, stroke, myocardial infarction or cancer at the baseline in 1994. RESULTS: During 7 years of follow-up, 801 participants died of CVD. Factor analysis (principal ... Read More »
» Published in Int J Epidemiol. 2007 Feb 22;

31. Coiled-coil targeting of myocilin to intracellular membranes.
Match Strength: 4.674

Mutations in myocilin (MYOC) associate with glaucoma and ocular hypertension. Unfortunately, the specific role of MYOC, a widely expressed protein of unknown function, in ocular hypertension is unknown. Since MYOC localizes both to intracellular membranes and to the cytosol, we tested the hypothesis that MYOC is a cytosolic protein that associates with cellular membranes via its coiled-coil domain. Using green fluorescent protein (GFP) chimeras in expression and metabolic labeling studies, we observed that MYOC's putative signal peptide failed to traffic GFP into the secretory machinery and ... Read More »
» Published in Exp Eye Res. 2006 Dec;83(6):1386-95. Epub 2006 Sep 12.

32. Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor.
Match Strength: 4.304

Our previous studies demonstrated that peripheral overexpression of angiotensin II (ANG II) type 2 receptors (AT(2)R) prevents hypertension-induced cardiac hypertrophy and remodeling without altering high blood pressure. This, coupled with the observations that AT(2)R play a role in the antihypertensive actions of ANG II type 1 receptor (AT(1)R) blockers (ARBs), led us to propose that peripheral overexpression of AT(2)R would improve the antihypertensive action of losartan (Los) in Sprague-Dawley (SD) rats made hypertensive via chronic infusion of ANG II. Here we utilized adenoviral vector ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H727-35. Epub 2006 Nov 3.

33. Treating claudication in 5 words (stop smoking and keep walking) is no longer enough: an audit of risk factor management in patients prescribed exercise therapy in New Zealand.
Match Strength: 4.296

AIM: To assess the documentation and modification of vascular risk factors in patients with intermittent claudication enrolled in an exercise programme in Christchurch, New Zealand. PATIENTS/METHOD: A retrospective review of case notes of patients who presented to the vascular outpatient department with intermittent claudication and were given "Green Prescriptions" for an exercise programme was performed. Referral letters, clinic letters, vascular nurse notes, and handwritten hospital notes were searched for evidence of documentation of risk factors for atherosclerosis. Modification of these ... Read More »
» Published in N Z Med J. 2006 Mar 31;119(1231):U1918.

34. Multifocal posterior uveitis in Crohn's disease.
Match Strength: 4.117

PURPOSE: To report a case of rare posterior eye manifestation of Crohn's disease preceding recurrence of inflammatory bowel disease. METHODS: Case report with ophthalmoscopic findings, fluorescein/indocyanin green angiograms, automated perimetry and multifocal-ERG. RESULTS: The perimetry revealed absolute and relative scotomas corresponding to multifocal inflammatory lesions in the retina and choroid, reduced a/b amplitudes in multifocal-ERG and hypofluorescent dots in angiography. Under oral prednisolone visual defects, ophthalmoscopic and angiographic findings resolved, while a/b amplitudes ... Read More »
» Published in Graefes Arch Clin Exp Ophthalmol. 2006 Jun 21;

35. Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats.
Match Strength: 4.095

Nitric oxide-cGMP pathway can inhibit cardiac norepinephrine (NE) release. Sympathetic hyper-responsiveness in hypertension may result from oxidative stress impairing this pathway. We tested the hypothesis that the gene transfer of neuronal NO synthase (nNOS) could restore sympathetic balance in the spontaneously hypertensive rat (SHR). An adenovirus (5x10(10) particles) constructed with a noradrenergic neuron-specific promoter (PRS x8) encoding nNOS (Ad.PRS-nNOS) or enhanced green fluorescence protein (Ad.PRS-eGFP) was targeted to the right atrial wall by percutaneous injection in age-matched ... Read More »
» Published in Hypertension. 2007 Jul;50(1):69-74. Epub 2007 May 21.

36. Iris colour, optic disc dimensions, degree and progression of glaucomatous optic nerve damage.
Match Strength: 3.879

PURPOSE: To evaluate whether iris colour influences size and shape of the optic nerve head and risk for glaucoma progression. METHODS: The hospital-based observational study included 1973 eyes of 1012 Caucasian subjects with ocular hypertension or chronic open-angle glaucoma. For all patients, colour stereo optic disc photographs were evaluated, and corneal pachymetry and achromatic perimetry were performed. Main outcome measures were optic nerve head parameters, the development or progression of visual field defects and iris colour. RESULTS: In most of the study groups, size of the optic disc ... Read More »
» Published in Clin Experiment Ophthalmol. 2006 Sep-Oct;34(7):654-60.

37. Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract.
Match Strength: 3.782

Hypertension may impact pelvic arterial blood flow resulting in reduction of nitric oxide synthase (NOS) levels. Although doxazosin, an alpha(1)-adrenoceptor antagonist, has been shown to improve erectile dysfunction as well as benign prostatic hyperplasia (BPH) and hypertension, it is not clear whether these improvements using doxazosin are primarily due to direct actions on the prostate, urinary bladder and penis, possibly via inhibition of vascular alpha(1)-adrenoceptors, or other sites of actions. Therefore, we investigated effects of doxazosin to the spontaneously hypertensive rat (SHR) ... Read More »
» Published in Life Sci. 2007 Jun 27;81(3):218-22. Epub 2007 May 21.

38. Antioxidant activity of commonly consumed plant foods of India: contribution of their phenolic content.
Match Strength: 3.664

Antioxidants are important in protection against hypertension, diabetes, cardiovascular diseases and cancer. Polyphenols are potent antioxidants in plant foods, but their contribution to such protective effects is yet to be established. This study attempted to generate a database on the antioxidant activity (AOA) and phenolic content (PC) of some plant foods commonly consumed in India and to assess the contribution of the PC to their AOA. Plant foods belonging to different food groups such as cereals, legumes, oil seeds, oils, green leafy vegetables, other vegetables, spices, roots and tubers ... Read More »
» Published in Int J Food Sci Nutr. 2007 Jun;58(4):250-60.

39. Magnesium Intake and Risk of Type 2 Diabetes in Men and Women
Match Strength: 3.652

OBJECTIVE: To examine the association between magnesium intake and risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: We followed 85,060 women and 42,872 men who had no history of diabetes, cardiovascular disease, or cancer at baseline. Magnesium intake was evaluated using a validated food frequency questionnaire every 2-4 years. After 18 years of follow-up in women and 12 years in men, we documented 4,085 and 1,333 incident cases of type 2 diabetes, respectively. RESULTS: After adjusting for age, BMI, physical activity, family history of diabetes, smoking, alcohol consumption, and history ... Read More »
» Published in Diabetes Care. 2004 Jan;27(1):134-40. Comment in: Diabetes Care. 2004 Jan;27(1):270-1.

40. Essential Fatty Acids In Health And Chronic Disease
Match Strength: 3.631

Human beings evolved consuming a diet that contained about equal amounts of n-3 and n-6 essential fatty acids. Over the past 100-150 y there has been an enormous increase in the consumption of n-6 fatty acids due to the increased intake of vegetable oils from corn, sunflower seeds, safflower seeds, cottonseed, and soybeans. Today, in Western diets, the ratio of n-6 to n-3 fatty acids ranges from approximately 20-30:1 instead of the traditional range of 1-2:1. Studies indicate that a high intake of n-6 fatty acids shifts the physiologic state to one that is prothrombotic and proaggregatory, ... Read More »
» Published in Am J Clin Nutr. 1999 Sep;70(3 Suppl):560S-569S. Comment in: Am J Clin Nutr. 2004 Mar;79(3):523-4.

41. Genetic manipulation of intraspinal plasticity after spinal cord injury alters the severity of autonomic dysreflexia.
Match Strength: 3.630

Severe spinal cord injuries above mid-thoracic levels can lead to a potentially life-threatening hypertensive condition termed autonomic dysreflexia, which is often triggered by painful distension of pelvic viscera (bladder or bowel) and consequent sensory fiber activation, including nociceptive C-fibers. Interruption of tonically active medullo-spinal pathways after injury causes disinhibition of thoracolumbar sympathetic preganglionic neurons, and intraspinal sprouting of nerve growth factor (NGF)-responsive primary afferent fibers is thought to contribute to their hyperactivity. We ... Read More »
» Published in J Neurosci. 2006 Mar 15;26(11):2923-32.

42. Polypoidal choroidal vasculopathy in exudative and haemorrhagic pigment epithelial detachments
Match Strength: 3.569

AIMS: To determine the prevalence of polypoidal choroidopathy in consecutive patients presenting with large haemorrhagic and exudative neurosensory retinal and retinal pigment epithelial detachments (PEDs) of over 2 mm in diameter in the absence of drusen. METHODS: 40 patients were identified over a 5 month period of which 29 had haemorrhagic detachments, and 11 had purely exudative detachments. All had indocyanine green (ICG) angiography, and the presence was sought of large blood vessels in the choroid associated with localised dilated terminals that filled slowly and leaked ICG. RESULTS: In ... Read More »
» Published in Br J Ophthalmol. 2000 May;84(5):479-84.

43. Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis.
Match Strength: 3.560

ABSTRACT: We have recently proposed that lipid peroxidation may be a common mechanistic pathway by which obesity and hypertension lead to increased renal cell cancer risk. During this exercise, we noted a risk factor swap between breast and kidney cancer (oophorectomy and increased parity, detrimental for kidney, beneficial for breast; high blood pressure, detrimental for kidney, beneficial for breast when it occurs during pregnancy; alcohol, beneficial for kidney, detrimental for breast, and so on). We have subsequently proposed the hypothesis that lipid peroxidation represents a protective ... Read More »
» Published in Breast Cancer Res. 2007 Jan 10;9(1):201

44. Multi-Targeted and Aggressive Treatment of Patients with Type 2 Diabetes At High Risk: What Are We Waiting For?
Match Strength: 3.485

Results from many single risk factor intervention trials and the multi-targeted Steno-2 trial in the last few years have provided a strong case that management of type 2 diabetes in all age groups requires a structured and intensified approach that is far more than just glucocentric, an approach addressing additional cardiovascular risk factors including hypertension, dyslipidaemia, sedentary behaviour, smoking and dietary habits causing insulin resistance and pro-inflammation. This type of integrated therapy applied for almost 8 years to high-risk type 2 diabetic patients has cut the relative ... Read More »
» Published in Horm Metab Res. 2005 Apr;37 Suppl 1:76-82.

45. The joint effect of oxidative stress and antioxidants on the risk of an aneurysmal rupture subarachnoid hemorrhage: a case-control study in Japan.
Match Strength: 3.480

PURPOSE: A case-control study was conducted in Japan to examine the joint effects of oxidative stress and antioxidants on the risk of subarachnoid hemorrhage (SAH). METHODS: The study included 201 consecutive patients with first spontaneous SAH aged 30 to 79 years who had aneurysm(s) confirmed by angiography and/or computed tomographic scan and were admitted to two medical hospitals in Nagoya, Japan, from April 1992 to March 1997. Community control subjects were identified and matched to each case by gender and age (+/-2 years). Conditional logistic regression modeling was used to compute odds ... Read More »
» Published in Ann Epidemiol. 2007 May;17(5):359-63.

46. Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?
Match Strength: 3.435

BACKGROUND/AIMS: In liver cirrhosis atrial natriuretic peptide (ANP) decreases portal vascular resistance and tributary flow. The enzyme neutral endopeptidase (NEP) degrades ANP and bradykinin and generates endothelin-1 from big-endothelin. We determined the effects of NEP inhibition by candoxatrilat on hormonal status, liver function and arterial and portal pressures in rats with CCl4-induced cirrhosis. METHODS: Two groups of seven control rats received 1 ml 5% glucose solution alone or containing 10 mg/kg candoxatrilat; three groups of 10 ascitic cirrhotic rats received placebo, 5 or 10 mg ... Read More »
» Published in J Hepatol. 2005 Nov;43(5):791-8. Epub 2005 Jun 20.

47. Effects of Silencing Leukocyte-Type 12/15-Lipoxygenase Using Short Interfering Rnas
Match Strength: 3.399

The leukocyte-type 12/15-lipoxygenase (12/15-LO) has been implicated in the pathogenesis of atherosclerosis, hypertension, and diabetes. 12/15-LO and its products are associated with LDL oxidation, cellular growth, migration, adhesion, and inflammatory gene expression in monocytes/macrophages, endothelial cells, and vascular smooth muscle cells (VSMCs). Our objective, therefore, was to develop novel expression vectors for short interfering RNAs (siRNAs) targeting 12/15-LO to evaluate its functional relevance in macrophages and VSMCs. We used a PCR-based approach to rapidly identify effective ... Read More »
» Published in J Lipid Res. 2005 Feb;46(2):220-9. Epub 2004 Dec 1.

48. Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction.
Match Strength: 3.366

Use of herbal medicines among patients under cardiovascular pharmacotherapy is widespread. In this paper, we have reviewed the literature to determine the possible interactions between herbal medicines and cardiovascular drugs. The Medline database was searched for clinical articles published between January 1996 and February 2003. Forty-three case reports and eight clinical trials were identified. Warfarin was the most common cardiovascular drug involved. It was found to interact with boldo, curbicin, fenugreek, garlic, danshen, devil's claw, don quai, ginkgo, papaya, lycium, mango, PC-SPES ... Read More »
» Published in Int J Cardiol. 2005 Jan;98(1):1-14. Comment in: Int J Cardiol. 2006 Jun 7;110(1):93.

49. Mechanism of nitric oxide action on inhibitory GABAergic signaling within the nucleus tractus solitarii.
Match Strength: 3.320

The cellular mechanisms mediating nitric oxide (NO) modulation of the inhibitory transmission in the nucleus tractus solitarii (NTS) remain unclear, even though this could be extremely important for various physiological and pathological processes. Specifically, in the NTS NO-evoked glutamate and gamma-aminobutyric acid (GABA) release might contribute to pathological hypertension. In cultured rat brainstem slices, NTS GABAergic neurons were targeted using an adenoviral vector to express enhanced green fluorescent protein and studied with a combination of patch clamp and confocal microscopy. ... Read More »
» Published in FASEB J. 2006 Jul;20(9):1537-9. Epub 2006 May 23.

50. Argon Laser Photodynamic Therapy of Human Corneal Neovascularization After Intravenous Administration of Dihematoporphyrin Ether
Match Strength: 3.271

PURPOSE: Long-term evaluation of dihematoporphyrin ether (DHE) safety and efficacy as photodynamic therapy (PDT) for patients with corneal neovascularization (KNV). DESIGN: Prospective multi-center interventional case series. METHODS: Seven patients were enrolled after Institutional Review Board approval and a detailed informed consent were obtained. Eligible patients presented with clinically stable KNV without active vessel progression or inflammation. All patients with severe hypertension, history of renal or hepatic disease, or sensitivity to porphyrins, and those with active keratitis or ... Read More »
» Published in Am J Ophthalmol. 2006 Mar;141(3):524-529.

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