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Green Tea Cancer
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1. Possible role for green tea in ovarian cancer prevention.
Match Strength: 11.008

Ovarian cancer is the leading cause of death from gynecologic cancer. Tea, especially green tea, has shown promise in the prevention of several cancers. Green tea contains a number of compounds, including polyphenols, that have chemopreventive properties. There is much evidence from in vitro and animal studies suggesting that components of tea are associated with decreased risk or progression of ovarian cancer. However, epidemiologic studies have generated inconsistent results. Recent research conducted in China reported reduced risk of ovarian cancer and increased survival post diagnosis with ... Read More »
» Published in Future Oncol. 2005 Dec;1(6):771-7.

2. Green Tea and Its Polyphenolic Catechins: Medicinal Uses in Cancer and Noncancer Applications
Match Strength: 10.058

Can drinking several cups of green tea a day keep the doctor away? This certainly seems so, given the popularity of this practice in East Asian culture and the increased interest in green tea in the Western world. Several epidemiological studies have shown beneficial effects of green tea in cancer, cardiovascular, and neurological diseases. The health benefits associated with green tea consumption have also been corroborated in animal studies of cancer chemoprevention, hypercholesterolemia, artherosclerosis, Parkinson's disease, Alzheimer's disease, and other aging-related disorders. However, ... Read More »
» Published in Life Sci. 2006 Mar 27;78(18):2073-80. Epub 2006 Jan 30.

3. Protective effects of green tea against prostate cancer.
Match Strength: 10.021

Prostate cancer has the third highest incidence of all cancers in men worldwide with incidence and mortality being particularly high in affluent, developed countries. Tea, especially green tea, has demonstrated promise in the prevention of several cancers. Green tea contains several components including catechins, a category of polyphenols that have chemopreventive properties. Although evidence from epidemiological studies is not comprehensive, it is strengthened by animal and in vitro evidence suggesting that consumption of tea is associated with decreased risk or progression of prostate ... Read More »
» Published in Expert Rev Anticancer Ther. 2006 Apr;6(4):507-13.

4. A Prospective Study of Green Tea Consumption and Oral Cancer Incidence in Japan.
Match Strength: 9.883

PURPOSE: To examine the relation of green tea consumption with oral carcinogenesis, we prospectively analyzed data from a nationwide large-scale cohort study in Japan. METHODS: A total of 20,550 men and 29,671 women aged 40-79 years, without any history of oral and pharyngeal cancer at baseline survey, were included in the present study. During a mean follow-up period of 10.3 years, 37 oral cancer cases were identified. The Cox proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (95% CI) for oral cancer according to green tea consumption by sex, ... Read More »
» Published in Ann Epidemiol. 2007 Jun 30;

5. Green tea and the risk of colorectal cancer: pooled analysis of two prospective studies in Japan.
Match Strength: 9.352

BACKGROUND: Although laboratory experiments suggest protective effects of green tea against colorectal cancer, few prospective cohort studies have been conducted.METHODS: We conducted a pooled analysis of two prospective cohort studies among residents in Miyagi Prefecture in rural northern Japan. The first study started in 1984 and included 26,311 subjects. The second study started in 1990 and included 39,604 subjects. The subjects responded to a self-administered questionnaire including an item on green tea consumption. With 7 to 9 years of follow-up, 305 colon and 211 rectal cancers were ... Read More »
» Published in J Epidemiol. 2005 Jul;15(4):118-24.

6. Green tea polyphenols: biology and therapeutic implications in cancer.
Match Strength: 9.257

Multiple lines of evidence, mostly from population-based studies, suggest that green tea consumption is associated with reduced risk of several human malignancies such as cancer and diabetes. Epigallocatechin-3-gallate (EGCG), a major polyphenol found in green tea, is a widely studied chemopreventive agent with potential anticancer activity. Green tea polyphenols inhibit angiogenesis and metastasis, and induce growth arrest and apoptosis through regulation of multiple signaling pathways. Specifically, EGCG regulates expression of VEGF, matrix metalloproteinases, uPA, IGF-1, EGFR, cell cycle ... Read More »
» Published in Front Biosci. 2007 Sep 1;12:4881-99.

7. Smoking, alcohol drinking, green tea consumption and the risk of esophageal cancer in Japanese men.
Match Strength: 9.206

BACKGROUND: Although smoking and alcohol drinking are established risk factors of esophageal cancer, their public health impact is unclear. Furthermore, the effect of green tea is controversial. METHODS: The present study was based on a pooled analysis of two prospective cohort studies. A self-administered questionnaire about health habits was distributed to 9,008 men in Cohort 1 and 17,715 men in Cohort 2, aged 40 years or older, with no previous history of cancer. We identified 38 and 40 patient cases with esophageal cancer among the subjects in Cohort 1 (9.0 years of follow-up) and Cohort 2 ... Read More »
» Published in J Epidemiol. 2006 Sep;16(5):185-92.

8. Does the consumption of green tea reduce the risk of lung cancer among smokers?
Match Strength: 9.113

Experimental and epidemiological studies were reviewed to assess whether the consumption of green tea could reduce the risk of lung cancer in smokers. Articles published since 1990 were located by searching electronic databases PubMed, Ovid and Science Direct, using keywords 'lung cancer', 'tea' and 'smoking' without any restriction on language. After relevant articles had been located, further papers were obtained from their reference lists. Evidence from experimental studies (in vitro animal and human trials) suggested that regular intake of green tea may be protective against tobacco ... Read More »
» Published in Evid Based Complement Alternat Med. 2007 Mar;4(1):17-22. Epub 2006 Oct 24.

9. The combination of green tea and tamoxifen is effective against breast cancer.
Match Strength: 8.893

Epidemiologic data have suggested that green tea may prevent breast cancer. Studies in our laboratory have provided evidence that green tea extract inhibits breast cancer growth by a direct anti-proliferative effect on the tumor cells, as well as by indirect suppressive effects on the tumor-associated endothelial cells. In this study, we asked whether concurrent administration of green tea may add to the anti-tumor effects of standard breast cancer therapy. We observed that green tea increased the inhibitory effect of tamoxifen on the proliferation of the ER (estrogen receptor)-positive MCF-7, ... Read More »
» Published in Carcinogenesis. 2006 Dec;27(12):2424-33. Epub 2006 Jun 19.

10. Chemoprevention of lung cancer by tea.
Match Strength: 8.840

Tea is the second only to water as the most consumed beverage in the world. Both green and black teas have been studied for their health benefits for a variety of diseases, particularly cancer. Lung cancer is the predominant cause of cancer mortality in developed countries. Smokers' risk of lung cancer is 20 times that of persons who have never smoked. Epidemiological studies on the cancer-preventive effects of tea produce inconsistent results, which could in part be attributed to the lack of a universal standard for tea preparations. However, most animal studies indicate that tea has strong ... Read More »
» Published in Mol Nutr Food Res. 2006 Feb;50(2):144-51.

11. A population-based case-control study of lung cancer and green tea consumption among women living in Shanghai, China.
Match Strength: 8.565

Epidemiologic evidence regarding the association between the consumption of green tea and lung cancer is limited and inconclusive, although experimental studies have shown consistently that tea preparations and tea polyphenols may inhibit the induction of a variety of cancers, including lung cancer. In this population-based case-control study, we examined the association between past consumption of green tea and the risk of lung cancer. We identified 649 incident cases of primary lung cancer among women diagnosed from February 1992 through January 1994 using the population-based Shanghai ... Read More »
» Published in Epidemiology. 2001 Nov;12(6):695-700.

12. Epigallocatechin gallate, the main ingredient of green tea induces apoptosis in breast cancer cells.
Match Strength: 8.410

Green tea has been suggested for prevention of cancers. In this study, the effect of the main constituent of green tea, epigallocatechin gallate (EGCG), on apoptosis of breast cancer cells was examined. EGCG induced apoptosis in T-47D cells through caspase cascade and the cells were detained at the G1 phase. The rate of apoptosis and activity of caspase-3 induced by EGCG was time and dose dependent. These findings suggest that EGCG might be useful in treatment and/or prevention of breast cancer by inducing apoptosis ... Read More »
» Published in Front Biosci. 2006 Sep 1;11:2428-33.

13. Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells.
Match Strength: 8.406

Many epidemiological studies have suggested that consumption of green tea may decrease the risk of cancer. The chemopreventive effect of green tea polyphenols (GTP) has been demonstrated through the inhibition of cell proliferation and angiogenesis in cell culture and animal models of breast cancer. Metastasis of breast cancer is the major reason for the high mortality of breast cancer patients and is directly linked to the invasive behavior of breast cancer cells. Cancer metastasis consists of several interdependent processes including cancer cell adhesion, cancer cell migration, and invasion ... Read More »
» Published in Nutr Cancer. 2005;52(1):66-73.

14. Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells.
Match Strength: 8.344

Epidemiological studies have suggested that consumption of green tea may decrease the risk of a variety of cancers. In addition, mushroom Ganoderma lucidum has been used for the promotion of health, longevity and treatment of cancer in traditional Chinese medicine. In the present study we show that extract from green tea (GTE) increased the anticancer effect of G. lucidum extract (GLE) on cell proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of breast cancer cells. This effect was mediated by the down-regulation of expression of oncogene c ... Read More »
» Published in Int J Oncol. 2007 Apr;30(4):963-9.

15. Green tea and the prevention of breast cancer: a case-control study in southeast China.
Match Strength: 8.317

Breast cancer is the most common malignancy in women worldwide. Tea has anticarcinogenic effects against breast cancer in experimental studies. However, epidemiologic evidence that tea protects against breast cancer has been inconsistent. A case-control study was conducted in southeast China between 2004 and 2005. The incidence cases were 1, 009 female patients aged 20-87 years with histologically confirmed breast cancer. The 1, 009 age-matched controls were healthy women randomly recruited from breast disease clinics. Information on duration, frequency, quantity, preparation, and type of tea ... Read More »
» Published in Carcinogenesis. 2006 Dec 20;

16. No association between green tea and prostate cancer risk in Japanese men: the Ohsaki Cohort Study.
Match Strength: 8.270

In a prospective study of 19,561 Japanese men, green-tea intake was not associated with a lower risk of prostate cancer (110 cases), the multivariate hazard ratio for men drinking > or =5 cups compared with <1 cup per day being 0.85 (95% confidence interval 0.50-1.43, trend P = 0.81). Publication Types: Comparative Study, Research Support, Non-U.S. Gov ... Read More »
» Published in Br J Cancer. 2006 Aug 7;95(3):371-3. Epub 2006 Jun 27.

17. Inhibition of mammary tumorigenesis in the C3(1)/SV40 mouse model by green tea.
Match Strength: 8.262

Previous studies show inhibitory effects of green tea in chemically induced mammary tumors or human tumor explants, but not in spontaneous tumor models that are more representative of human breast cancer. The C3(1)/SV40 mouse model is particularly suited for breast cancer prevention studies because it produces spontaneous ductal adenocarcinomas and a predictable time course for mammary tumorigenesis through a multistage progression similar to that occurring in humans. We therefore used this model to test the chemoprotective effects of green tea. Administration of 0.5% Polyphenon E (Poly E) (a ... Read More »
» Published in Breast Cancer Res Treat. 2007 May 5;

18. Green tea and stomach cancer--a short review of prospective studies.
Match Strength: 8.240

BACKGROUND: In Japan, green tea has been drunk for a long time. Because it can be drunk casually, many people love drinking it. If such green tea has an effect to prevent stomach cancer, it will be a very convenient way to prevent the disease. METHODS: To examine the association between green tea consumption and the risk of stomach cancer, past epidemiologic studies including JACC Study were reviewed. RESULTS: Among eight case-control studies, five showed risk reduction with a statistically significant difference, and two studies showed risk reduction without a statistically significant ... Read More »
» Published in J Epidemiol. 2005 Jun;15 Suppl 2:S109-12.

19. A comparison of the emission efficiency of four common green fluorescence dyes after internalization into cancer cells.
Match Strength: 8.202

In vivo optical imaging to enhance the detection of cancer during endoscopy or surgery requires a targeted fluorescent probe with high emission efficiency and high signal-to-background ratio. One strategy to accurately detect cancers is to have the fluorophore internalize within the cancer cells permitting nonbound fluorophores to be washed away or absorbed. The choice of fluorophores for this task must be carefully considered. For depth of penetration, near-infrared probes are ordinarily preferred but suffer from relatively low quantum efficiency. Although green fluorescent protein has been ... Read More »
» Published in Bioconjug Chem. 2006 Nov-Dec;17(6):1426-31.

20. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study.
Match Strength: 8.073

CONTEXT: Green tea polyphenols have been extensively studied as cardiovascular disease and cancer chemopreventive agents in vitro and in animal studies. However, the effects of green tea consumption in humans remain unclear. OBJECTIVE: To investigate the associations between green tea consumption and all-cause and cause-specific mortality. DESIGN, SETTING, AND PARTICIPANTS: The Ohsaki National Health Insurance Cohort Study, a population-based, prospective cohort study initiated in 1994 among 40,530 Japanese adults aged 40 to 79 years without history of stroke, coronary heart disease, or cancer ... Read More »
» Published in JAMA. 2006 Sep 13;296(10):1255-65. Comment in: JAMA. 2007 Jan 24;297(4):360; author reply 360-1.

21. Catechin-vanilloid synergies with potential clinical applications in cancer.
Match Strength: 8.045

A cancer-specific cell surface protein, tNOX, has been identified as a target for low-dose cell killing (apoptosis) of cancer cells by green tea catechins and Capsicum vanilloid combinations. This protein is uniquely associated with all forms of cancer and is absent from normal cells and tissues. Its activity is correlated with cancer growth. When blocked, cancer cells fail to enlarge after division and eventually die. Among the most potent and effective inhibitors of tNOX are naturally occurring polyphenols exemplified by the principal green tea catechin (-)-epigallocatechin gallate (EGCg) ... Read More »
» Published in Rejuvenation Res. 2006 Spring;9(1):45-55.

22. Green tea and skin
Match Strength: 7.946

OBJECTIVE: To discuss the current knowledge of polyphenolic compounds present in green tea as anti-inflammatory, antioxidant, and anticarcinogenic in skin. DATA SOURCES: References identified from bibliographies of pertinent articles, including our work in related fields. STUDY SELECTION AND DATA EXTRACTION: Articles were selected based on the use of green tea or its polyphenolic constituents for prevention against inflammation and cancer in the skin. Also discussed is the possible use of green tea to treat various inflammatory dermatoses. DATA SYNTHESIS: The polyphenolic compounds from green ... Read More »
» Published in Arch Dermatol. 2000 Aug;136(8):989-94. Comment in: Arch Dermatol. 2000 Aug;136(8):1051. Arch Dermatol. 2001 May;137(5):664.

23. Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis.
Match Strength: 7.796

Tea, one of the most widely consumed beverages worldwide, has been shown to have anti-cancer activity in various cancers including colon cancer. It has been demonstrated that overexpression of the inducible isoform of cyclooxygenase (COX-2) occurs during colon tumorigenesis and inhibition of COX-2 by non-steroidal anti-inflammatory drugs (NSAIDs) is chemopreventive. To determine whether the anti-cancer effect associated with green tea impacted COX-2 expression levels, human colorectal cancer cell lines HT-29 and HCA-7, were treated with (-)-epigallocatechin-3-gallate (EGCG), the most abundant ... Read More »
» Published in Mol Carcinog. 2006 May;45(5):309-19.

24. Vegetable intake and pancreatic cancer risk: the multiethnic cohort study.
Match Strength: 7.694

Investigators studying associations between vegetable intake and pancreatic cancer risk have reported inconsistent findings to date. To further explore these associations, the authors analyzed data on 183,522 participants enrolled in the Hawaii-Los Angeles Multiethnic Cohort Study in 1993-1996. Intakes of total vegetables, light green, dark green, yellow-orange, and cruciferous vegetables, tomato products, and legumes were estimated from a quantitative food frequency questionnaire. After an average of 8.3 years of follow-up, 529 pancreatic cancer cases were identified. Multivariate-adjusted ... Read More »
» Published in Am J Epidemiol. 2007 Jan 15;165(2):138-47. Epub 2006 Oct 26.

25. Medicinal benefits of green tea: part II. review of anticancer properties.
Match Strength: 7.670

Currently there is wide interest in the medicinal benefits of green tea (Camellia sinensis). Tea is one of the most widely consumed beverages in the world, and extracts of tea leaves are also sold as dietary supplements. Green tea extracts contain a unique set of catechins that possess biologic activity in antioxidant, antiangiogenesis, and antiproliferative assays that are potentially relevant to the prevention and treatment of various forms of cancer. With the increasing interest in the health properties of tea and a significant rise in their scientific investigation, it is the aim of this ... Read More »
» Published in J Altern Complement Med. 2005 Aug;11(4):639-52.

26. Green vegetable drink consumption protects peripheral lymphocytes DNA damage in Korean smokers.
Match Strength: 7.595

Smoking increases indices of free radical-mediated damage of DNA which are potential underlying processes in the pathogenesis of many diseases. In this study, we evaluated whether 8 weeks of green vegetable drink (Angelica keiskei based juice) supplementation to smokers can be protective against lymphocytic DNA damage. Twenty smokers were given 240 ml of commercially available green vegetable drink every day for 8 weeks. The DNA damage was determined using single cell gel electrophoresis (COMET assay) and the damage was quantified by measuring tail length (TL), tail moment (TM), and percent ... Read More »
» Published in Biofactors. 2004;22(1-4):245-7.

27. Beneficial effects of green tea--a review.
Match Strength: 7.584

Tea is the most consumed drink in the world after water. Green tea is a 'non-fermented' tea, and contains more catechins, than black tea or oolong tea. Catechins are in vitro and in vivo strong antioxidants. In addition, its content of certain minerals and vitamins increases the antioxidant potential of this type of tea. Since ancient times, green tea has been considered by the traditional Chinese medicine as a healthful beverage. Recent human studies suggest that green tea may contribute to a reduction in the risk of cardiovascular disease and some forms of cancer, as well as to the promotion ... Read More »
» Published in J Am Coll Nutr. 2006 Apr;25(2):79-99.

28. Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies.
Match Strength: 7.527

Experimental studies have shown that tea and tea polyphenols have anti-carcinogenic properties against breast cancer. A number of epidemiologic studies, both case-control and cohort in design, have examined the possible association between tea intake and breast cancer development in humans. This meta-analysis included 13 papers which examined populations in eight countries and provided data on consumption of either green tea or black tea, or both in relation to breast cancer risk. Summary odds ratios (ORs) for highest versus non/lowest tea consumption level were calculated based on fixed and ... Read More »
» Published in Carcinogenesis. 2006 Jul;27(7):1310-5. Epub 2005 Nov 25.

29. Tea and lycopene protect against prostate cancer.
Match Strength: 7.478

Prostate cancer is the most common male cancer in developed countries and is increasing in the developing world. Its long latency and geographical variation suggest the possibility of prevention or postponement of onset by dietary modification. To investigate the possible joint effect of lycopene and green tea on prostate cancer risk, a case-control study was conducted in Hangzhou, China, with 130 prostate cancer patients and 274 hospital controls. Information on tea and dietary intakes, and possible confounders was collected using a structured questionnaire. The risk of prostate cancer for ... Read More »
» Published in Asia Pac J Clin Nutr. 2007;16 Suppl 1:453-7.

30. Possible mechanisms of the cancer-preventive activities of green tea.
Match Strength: 7.446

The cancer-preventive activities of tea and some tea constituents, such as caffeine and (-)-epigallocatechin-3-gallate (EGCG), have been demonstrated in animal models. The mechanisms of action of the tea constituents have been extensively investigated, but the mechanisms for the cancer-preventive activity of tea are not clearly understood. This chapter discusses some of the reported studies on the green tea polyphenol, EGCG, and the major issues in the interpretation of these data. Among the different activities of EGCG observed in cell culture systems, we need to select the physiologically ... Read More »
» Published in Mol Nutr Food Res. 2006 Feb;50(2):170-5.

31. A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins.
Match Strength: 7.437

Bladder cancer is the fourth most common cancer in men and ninth most common in women. It has a protracted course of progression and is thus an ideal candidate for chemoprevention strategies and trials. This study was conducted to evaluate the chemopreventive/antiproliferative potential of (-)-epigallocatechin gallate (EGCG, the major phytochemical in green tea) against bladder cancer and its mechanism of action. Using the T24 human bladder cancer cell line, we found that EGCG treatment caused dose- and time-dependent inhibition of cellular proliferation and cell viability, and induced ... Read More »
» Published in Biochem Biophys Res Commun. 2007 Jan 9;

32. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.
Match Strength: 7.366

Cell signaling pathways, responsible for maintaining a balance between cell proliferation and death, have emerged as rational targets for the management of cancer. Emerging data amassed from various laboratories around the world suggests that green tea, particularly its major polyphenolic constituent (-)-epigallocatechin-3-gallate (EGCG), possesses remarkable cancer chemopreventive and therapeutic potential against various cancer sites in animal tumor bioassay systems and in some human epidemiologic studies. EGCG has been shown to modulate multiple signal transduction pathways in a fashion ... Read More »
» Published in Cancer Res. 2006 Mar 1;66(5):2500-5.

33. Medicinal Benefits of Green Tea: Part I. Review of Noncancer Health Benefits
Match Strength: 7.328

Tea, in the form of green or black tea, is one of the most widely consumed beverages in the world. Extracts of tea leaves also are sold as dietary supplements. However, with the increasing interest in the health properties of tea and a significant rise in scientific investigation, this review covers recent findings on the medicinal properties and noncancer health benefits of both green and black tea. In Part II, a review of anticancer properties of green tea extracts is presented. Green tea contains a unique set of catechins that possess biological activity in antioxidant, anti-angiogenesis, ... Read More »
» Published in J Altern Complement Med. 2005 Jun;11(3):521-8.

34. Fluorescence navigation with indocyanine green for detecting sentinel lymph nodes in breast cancer.
Match Strength: 7.309

BACKGROUND: Sentinel lymph node biopsy using a vital dye is a convenient and safe method to assess lymph node status in breast cancer. However, intensive training is necessary to obtain a satisfactory detection rate and to avoid false-negative results. This paper presents a novel method using indocyanine green fluorescence imaging to detect sentinel lymph nodes. METHODS: Fluorescence images were obtained using a charge coupled device camera with a cut filter as the detector, and light emitting diodes at 760 nm as the light source. When indocyanine green was injected around the areola, ... Read More »
» Published in Breast Cancer. 2005;12(3):211-5.

35. Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies.
Match Strength: 7.286

Experimental studies have supported tea as a chemopreventive agent for colorectal cancer. No quantitative summary of the epidemiologic evidence on tea and colorectal cancer risk has ever been performed. The current meta-analysis included 25 papers conducted in 11 countries across three continents (North America, Asia and Europe). Summary odds ratios (ORs) for highest versus non/lowest tea consumption levels were calculated based on fixed and random effects models. The meta-regression and stratified methods were used to examine heterogeneity across studies. For green tea, the combined results ... Read More »
» Published in Carcinogenesis. 2006 Jul;27(7):1301-9. Epub 2006 Apr 25.

36. Intraoperative localization of lymph node metastases with a replication-competent herpes simplex virus.
Match Strength: 7.230

OBJECTIVES: Lymph node status is the most important prognostic factor determining recurrence and survival in patients with mesothelioma and other thoracic malignancies. Accurate localization of lymph node metastases is therefore necessary to improve selection of resectable and curable patients for surgical intervention. This study investigates the potential to identify lymph node metastases intraoperatively by using herpes-guided cancer cell-specific expression of green fluorescent protein. METHODS: After infection with NV1066, a herpes simplex virus carrying green fluorescent protein ... Read More »
» Published in J Thorac Cardiovasc Surg. 2006 Nov;132(5):1179-88.

37. The relationship between access and quality of urban green space with population physical activity.
Match Strength: 7.217

OBJECTIVES: This study examined the association between access to quality urban green space and levels of physical activity. STUDY DESIGN: A cross-sectional examination of the relationship between access to quality urban green space and level of recreational physical activity in 4950 middle-aged (40-70 years) respondents from the European Prospective Investigation into Cancer and Nutrition (EPIC), who resided in Norwich, UK. METHODS: Using geographic information systems (GIS), three measures of access to open green space were calculated based on distance only, distance and size of green space ... Read More »
» Published in Public Health. 2006 Dec;120(12):1127-32. Epub 2006 Oct 25.

38. A Review of the Health Effects of Green Tea Catechins in In Vivo Animal Models
Match Strength: 7.192

There is good evidence from in vitro studies that green tea catechins have a role in protection against degenerative diseases. However, the concentrations used in vitro are often higher than those found in animal or human plasma, and so in vivo evidence is required to demonstrate any protective effect of catechins. This article summarizes the most interesting in vivo animal studies on the protective effects of green tea catechins against biomarkers for cancer, cardiovascular disease, and other degenerative diseases. Generally, most studies using animal models show that consumption of green tea ... Read More »
» Published in J Nutr. 2004 Dec;134(12 Suppl):3431S-3440S.

39. Tea and circulating estrogen levels in postmenopausal Chinese women in Singapore.
Match Strength: 7.168

The role of tea in the etiology of breast cancer is controversial. We recently provided the first set of human evidence that breast cancer risk is significantly inversely associated with tea intake, largely confined to intake of green tea. Since black tea and green tea possess comparable levels of the total tea polyphenols that possess antioxidative activities, reasons for the paradoxical effects of green tea and black tea on breast cancer protection are not apparent. Some limited evidence suggests that green tea may have downregulatory effects on circulating sex-steroid hormones, whereas ... Read More »
» Published in Carcinogenesis. 2005 May;26(5):976-80. Epub 2005 Jan 20.

40. Physiological activity of irradiated green tea polyphenol on the human skin.
Match Strength: 7.164

Physiological activity of irradiated green tea polyphenol on the human skin was investigated for further industrial application. The green tea polyphenol was separated and irradiated at 40 kGy by y-ray. For an anti-wrinkle effect, the collagenase inhibition effect was higher in the irradiated sample (65.3%) than that of the non-irradiated control (56.8%) at 200 ppm of the concentration (p < 0.05). Collagen biosynthesis rates using a human fibroblast were 19.4% and 16.3% in the irradiated and the non-irradiated polyphenols, respectively. The tyrosinase inhibition effect, which is related to ... Read More »
» Published in Am J Chin Med. 2005;33(4):535-46.

41. Effect of green tea in the prevention and reversal of fasting-induced intestinal mucosal damage.
Match Strength: 6.997

OBJECTIVE: Epidemiologic studies have suggested that high consumption of green tea protects against the development of chronic active gastritis and decreases the risk of stomach cancer. The effect of green tea on the intestinal mucosa was not studied previously, so we examined the effects of green tea on the intestinal mucosa of fasting rats in a controlled experimental setting. METHODS: Two sets of experiments were performed. In the recovery set, rats were fasted for 3 d, after which they were allowed free access to water, black tea, green tea, or vitamin E for 7 d. On day 8, the animals were ... Read More »
» Published in Nutrition. 2003 Jun;19(6):536-40.

42. Suppression of human cervical cancer cell lines Hela and DoTc2 4510 by a mixture of lysine, proline, ascorbic acid, and green tea extract.
Match Strength: 6.987

Cervical cancer, the second most common cancer in women, once metastasized, leads to poor prognosis. We investigated the antitumor effect of a nutrient mixture (NM) containing lysine, proline, arginine, ascorbic acid, and green tea extract on human cervical cancer cells Hela (CCL-2) and DoTc2 4510 by measuring cell proliferation (MTT assay), modulation of matrix metalloproteinases (MMP)-2 and MMP-9) expression (gelatinase zymography), and cancer cell invasive potential (Matrigel). NM showed significant antiproliferative effect on CCL-2 and DoTc2 4510 cancer cells. The NM inhibited CCL-2 ... Read More »
» Published in Int J Gynecol Cancer. 2006 May-Jun;16(3):1241-7.

43. Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer.
Match Strength: 6.977

Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast or prostate cancer. Extensive in vitro investigations using both hormone responsive and non-responsive cell lines have shown that EGCG induces apoptosis and alters the expression of cell cycle regulatory proteins that are critical for cell survival and apoptosis. This review will highlight the important in ... Read More »
» Published in Life Sci. 2006 Nov 17;79(25):2329-36. Epub 2006 Aug 5.

44. Case-control study of diet and other risk factors for gastric cancer in Hawaii (United States).
Match Strength: 6.938

OBJECTIVE: To investigate the association of diet and other factors with gastric adenocarcinoma of the distal stomach. METHODS: Three hundred cases and 446 population-based controls were interviewed with a quantitative, food frequency questionnaire, which listed over 250 foods. The questionnaire also included information on smoking history, alcohol intake, education, medical history, medication use, and a family history of cancer. RESULTS: Cigarette smoking, family history of gastric cancer and personal history of gastric ulcer were positively associated with gastric cancer, while education ... Read More »
» Published in Cancer Causes Control. 2003 Aug;14(6):547-58.

45. Polyphenols from green tea and pomegranate for prevention of prostate cancer.
Match Strength: 6.923

Prostate cancer (PCa) is the most common non-cutaneous cancer diagnosed in North America with similar trends in many Western countries. Geographic, epidemiological and laboratory studies suggest a role for dietary constituents in the etiology as well as prevention of PCa. The rising incidence of PCa in several countries appears to be coincidental with adoption of western lifestyle. Increase in the incidence of PCa has also been found in Asian populations migrating to the west. These facts give numerous leads to explore testable PCa prevention strategies. There is growing evidence in support of ... Read More »
» Published in Free Radic Res. 2006 Oct;40(10):1095-104.

46. Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives.
Match Strength: 6.922

The compound (-)-epigallocatechin-3-gallate (EGCG) is the major catechin found in green tea [Camellia sinensis L. Ktze. (Theaceae)]. This polyphenolic compound and several related catechins are believed to be responsible for the health benefits associated with the consumption of green tea. The potential health benefits ascribed to green tea and EGCG include antioxidant effects, cancer chemoprevention, improving cardiovascular health, enhancing weight loss, protecting the skin from the damage caused by ionizing radiation, and others. The compound EGCG has been shown to regulate dozens of ... Read More »
» Published in Phytochemistry. 2006 Sep;67(17):1849-55. Epub 2006 Jul 31.

47. Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells.
Match Strength: 6.894

Green tea extract and its major component (-)-epigallocatechin-3-gallate (EGCG) exhibit antiangiogenic activities in various experimental tumor models. A growing body of evidence has established that hypoxia-inducible factor-1alpha (HIF-1alpha) and its downstream target, vascular endothelial growth factor (VEGF), play a critical role in tumor angiogenesis. In this study, we investigated the effect of green tea extract and EGCG on HIF-1alpha and VEGF expression in human cervical carcinoma (HeLa) and hepatoma (HepG2) cells. Our results showed that green tea extract and EGCG significantly ... Read More »
» Published in Mol Cancer Ther. 2006 May;5(5):1227-38.

48. Fruit and vegetable consumption and incidence of gastric cancer: a prospective study.
Match Strength: 6.881

BACKGROUND: Whether fruit and vegetable consumption may confer protection from gastric cancer remains controversial. METHODS: We prospectively investigated the association between consumption of fruits and vegetables and the incidence of gastric cancer among participants from two population-based cohort studies: 36,664 women in the Swedish Mammography Cohort and 45,338 men in the Cohort of Swedish Men. Participants completed a food-frequency questionnaire in 1997 and were followed up for cancer incidence through June 2005. Cox proportional hazards models were used to estimate multivariate ... Read More »
» Published in Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1998-2001.

49. Modulatory efficacy of green tea polyphenols on glycoconjugates and immunological markers in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis-A therapeutic approach.
Match Strength: 6.859

Green tea polyphenols (GTP) has been used as a chemopreventive agent world wide against chemically induced cancer. The present study is aimed to understand the therapeutic action of GTP on glycoconjugates and immunological markers in 4-Nitroquinoline 1-oxide (4-NQO)-induced oral cancer over a period of 30 days at 200mg/kg, p.o., Oral cancer was induced by painting 4-NQO for 8 weeks followed by administration of GTP after 22 weeks, for 30 days. Glycoconjugates such as hexose, hexosamine, sialicacid, fucose and mucoprotein were analysed. Expression of glycoconjugates was examined through ... Read More »
» Published in Chem Biol Interact. 2006 Aug 25;162(2):149-56. Epub 2006 Jun 12.

50. In vivo photoacoustic flow cytometry for monitoring of circulating single cancer cells and contrast agents.
Match Strength: 6.834

A new photoacoustic flow cytometry was developed for real-time detection of circulating cells, nanoparticles, and contrast agents in vivo. Its capability, integrated with photothermal and optical clearing methods, was demonstrated using a near-infrared tunable laser to characterize the in vivo kinetics of Indocyanine Green alone and single cancer cells labeled with gold nanorods and Indocyanine Green in the vasculature of the mouse ear. In vivo applications are discussed, including selective nanophotothermolysis of metastatic squamous cells, label-free detection of melanoma cells, study of ... Read More »
» Published in Opt Lett. 2006 Dec 15;31(24):3623-5.

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