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1. Should diabetic patients be asked to test their blood glucose 90 to 120 minutes after the beginning of their meals?
Match Strength: 3.890

There are three distinct objectives in reducing the post-prandial blood glucose peaks: 1st to reduce the risk of foetal macrosomia in pregnancy, 2nd to reduce cardiovascular morbi-mortality, 3rd to lower the HbA1c. With 6-7 glycaemic controls per day and fractionning their meals, motivated women with gestational diabetes reach this goal. But there is no data today directly proving that post-prandial glycaemia is specifically related to the development of micro and macrovascular complications. So to reduce the cardiovascular risk, there are more arguments in favour of lowering HbA1c or ... Read More »
» Published in Diabetes Metab. 2006 Sep;32(4):377-81.

2. Delivery of local anaesthetic via a sternal catheter to reduce the pain caused by sternal fractures: first case series using the new technique.
Match Strength: 3.538

Sternal fractures cause considerable pain, and a proportion of patients require admission for analgesia. Local anaesthetic techniques have been used to reduce the pain from chest wall injuries and may reduce complications from these injuries. The use of a local anaesthetic delivered via a sternal catheter over a fractured sternum has been described in a patient whose pain was inadequately controlled with opiates. This technique was recently offered to patients in the emergency department at the Royal Devon and Exeter Hospital, Exeter, UK, and the experiences of patients and doctors are ... Read More »
» Published in Emerg Med J. 2006 Oct;23(10):791-3.

3. The impact of severe exacerbations on quality of life and the clinical course of chronic obstructive pulmonary disease.
Match Strength: 3.164

Severe exacerbations of chronic obstructive pulmonary disease (COPD) are morbid events with slow recovery periods. They consume substantial healthcare resources, and they may cause a more rapid reduction in lung function over time. Quality of life (QOL) deteriorates in patients who experience exacerbations, and the more frequent the exacerbations, the more rapid the decline in QOL. Hospitalizations due to exacerbations account for up to 70% of the cost of medical care for patients with COPD. Patients with more severe COPD have more hospitalizations compared with those with less severe disease. ... Read More »
» Published in Am J Med. 2006 Oct;119(10 Suppl 1):38-45.

4. Pneumococcal conjugate vaccines: emerging clinical information and its implications.
Match Strength: 3.150

Since 2000, when the first pneumococcal conjugate vaccine was introduced into routine use in the USA, it has had a substantial impact on invasive pneumococcal disease both in the immunized and nonimmunized population. It has also been shown to reduce pneumonia and otitis in young children and has reduced antibiotic nonsusceptible pneumococcal infections. In the USA, three primary doses and a booster dose are recommended (a so-called '3 + 1 schedule'). Some countries have or will soon introduce routine immunization with fewer doses, with either two primary doses and a booster dose ('2 + 1 ... Read More »
» Published in Expert Rev Vaccines. 2006 Aug;5(4):553-64.

5. A wire-cutting clamp designed to reduce complications during sternotomy closure.
Match Strength: 3.111

PURPOSE: Sternal wire placement frequently results in glove disruption, wound contamination and personnel skin puncture. The described cutting clamp was developed to simplify sternotomy closure and reduce complications. DESCRIPTION: Informed consent was obtained from 103 patients who underwent a variety of common cardiac surgical procedures. In each instance, once the cardiac portion of the procedure was completed, the median sternotomy was closed using standard sternal wires and the described cutting clamps. A single set of clamps was repeatedly re-sterilized and used for all cases. ... Read More »
» Published in Ann Thorac Surg. 2006 Oct;82(4):1494-6.

6. Children's health and mercury exposure.
Match Strength: 3.090

The reason why mercury is dangerous is that once released into the environment it cannot be removed and is rapidly transformed by microorganisms into organic compounds that tend to bioaccumulate and biomagnify in animals. The principal organic compound is methylmercury (MeHg). The primary route of exposure to MeHg for humans is consumption of fish. The safe dose (reference dose, RfD) of MeHg that can be consumed without neurotoxicological consequences is 0.1 microg per kg b.w./day. According to available data, the whole population of certain European countries or people who consume large ... Read More »
» Published in Acta Paediatr. 2006 Oct;95:36-44.

7. Evaluation and comparative analysis of a technique for laparoscopic ovariectomy in rhesus macaques (Macaca mulatta).
Match Strength: 2.774

Surgical ovariectomy is commonly performed to support studies involving the rhesus macaque (Macaca mulatta). Traditionally, these procedures have been performed via laparotomy. We developed a laparoscopic approach to reduce surgical pain, decrease convalescence times, and reduce the total number of animals necessary to obtain valuable scientific data in studies requiring repeated intra-abdominal access in conjunction with ovariectomy. We used our new technique to perform laparoscopic ovariectomy on 8 adult female rhesus macaques; 2 additional animals underwent ovariectomy via laparotomy; data ... Read More »
» Published in J Am Assoc Lab Anim Sci. 2006 Sep;45(5):74-8.

8. Tight control of type 1 diabetes: recommendations for patients.
Match Strength: 2.741

Tight control of blood glucose levels and risk factors for cardiovascular disease (e.g., hypertension, hypercholesterolemia) can substantially reduce the incidence of microvascular and macrovascular complications from type 1 diabetes. Physicians play an important role in helping patients make essential lifestyle changes to reduce the risk of these complications. Key recommendations that family physicians can give patients to optimize their outcomes include: take control of daily decisions regarding your health, focus on preventing and controlling risk factors for cardiovascular disease, ... Read More »
» Published in Am Fam Physician. 2006 Sep 15;74(6):971-8.

9. Comparative investigation of N,N'-bis-(dithiocarboxy)piperazine and diethyldithiocarbamate as precipitants for Ni(II) in simulated wastewater.
Match Strength: 2.667

The performances of a coordination polymerization precipitant, N,N'-bis-(dithiocarboxy)piperazine (BDP) were compared with the widely used heavy metal precipitant, diethyldithiocarbamate (DDTC), through the treatment of three kinds of nickel-containing wastewaters, NiSO(4), nickel citrate (NiCA) and Ni(2+)-dye. Results indicated that both BDP and DDTC at their stiochiometric doses could reduce 50.00mgl(-1) free nickel(II) to lower than 1.0mgl(-1) (discharge limit of nickel ions in China) and 10% precipitants doses increase could treat NiCA containing 50.00mgl(-1) Ni(2+) to meet the discharge ... Read More »
» Published in J Hazard Mater. 2006 Aug 22;

10. A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement.
Match Strength: 2.626

OBJECTIVES: This was a pilot, phase 2a study to assess methodological feasibility and the safety and efficacy of donepezil in preventing postoperative delirium after elective total hip replacement surgery in older people without pre-existing dementia. The hypothesis was that donepezil would reduce the incidence of postoperative delirium. METHODS: A double blind, placebo controlled, parallel group randomized trial was undertaken. Patients were block randomized pre-operatively to receive placebo or donepezil 5 mg immediately following surgery and every 24 h thereafter for a further three days. ... Read More »
» Published in Int J Geriatr Psychiatry. 2006 Sep 27;

11. The effectiveness of passive stretching in children with cerebral palsy.
Match Strength: 2.550

Passive stretching is widely used for individuals with spasticity in a belief that tightness or contracture of soft tissues can be corrected and lengthened. Evidence for the efficacy of passive stretching on individuals with spasticity is limited. The aim of this review was to evaluate the evidence on the effectiveness of passive stretching in children with spastic cerebral palsy. Seven studies were selected according to the selection criteria and scored against the Physiotherapy Evidence Database scale. Effect size and 95% confidence intervals were calculated for comparison. There was limited ... Read More »
» Published in Dev Med Child Neurol. 2006 Oct;48(10):855-62.

12. Prevention of anti-inflammatory drug-induced gastrointestinal damage: benefits and risks of therapeutic strategies.
Match Strength: 2.528

Patients who take non-steroidal anti-inflammatory drugs (NSAIDs) may develop serious gastrointestinal (GI) side effects in both the upper and lower GI tract. Those at risk should be considered for prevention with misoprostol, proton pump inhibitor (PPI) or COX-2 selective inhibitor (coxib) therapy. A coxib or an NSAID+PPI combination is considered to have comparable GI safety profiles, but evidence from direct comparison is limited. PPIs are effective in the prevention of upper GI events in endoscopy trials and in a few, small, outcome trials in patients at risk. Coxibs have been evaluated in ... Read More »
» Published in Ann Med. 2006;38(6):415-28.

13. Aprotinin improves cerebral protection: evidence from a survival porcine model.
Match Strength: 2.510

OBJECTIVE: Aprotinin is a serine protease inhibitor used during cardiac surgery to reduce blood loss and preserve platelet function. It has also been shown to reduce leukocyte activation during and after cardiopulmonary bypass. The goal of the study was to test the hypothesis that aprotinin could reduce cerebral injury after low-flow cardiopulmonary bypass and deep hypothermic circulatory arrest. METHODS: Sixteen piglets (mean weight, 13.6 +/- 1.3 kg) were randomly assigned to receive aprotinin or placebo (8 animals per group) before a 120-minute period of deep hypothermic circulatory arrest ... Read More »
» Published in J Thorac Cardiovasc Surg. 2006 Oct;132(4):948-53.

14. Efficacy of suppository analgesia in postabortion pain reduction.
Match Strength: 2.469

PURPOSE: Termination of pregnancy is a painful procedure. Currently, there are no sufficient data regarding the best mode to reduce this pain. The aim of the study was to evaluate postabortion pain levels and to examine the analgesic effect of three different generic types of suppositories provided at the end of the surgical procedure prior to awakening from general anesthesia. METHOD: Two hundred seventeen women were randomly assigned to four groups: indomethacin (100 mg), paracetamol (1000 mg), tramadol (100 mg), and control group with no suppository treatment. Pain levels were evaluated by ... Read More »
» Published in Contraception. 2006 Oct;74(4):345-8. Epub 2006 May 15.

15. Creating alliances to improve cancer prevention and detection among urban medically underserved minority groups: the East Harlem Partnership for Cancer Awareness.
Match Strength: 2.462

The East Harlem Partnership for Cancer Awareness (EHPCA) was formed in 1999 to reduce disparities in cancer screening and prevention among medically underserved minorities residing in a large urban community (East Harlem, New York City) by increasing awareness of cancer risk, prevention, and treatment, and promoting greater participation in breast, cervical, colorectal, and prostate cancer screening and early detection. The Partnership augments a 20-year collaboration between an academic medical center, a public hospital, and 2 community health centers. Needs assessments were conducted to ... Read More »
» Published in Cancer. 2006 Oct 15;107(8 Suppl):2043-51.

16. Dislocation of Primary Total Hip Arthroplasty with 36 and 40 mm Femoral Heads.
Match Strength: 2.460

Some authors suggest the use of larger (36 and 40 mm) femoral heads against highly cross-linked polyethylene acetabular liners will reduce the prevalence of early dislocation after primary total hip arthroplasty (THA). We prospectively followed 61 consecutive patients at high risk for dislocation to determine the prevalence of early dislocation after primary THA with 36 and 40 mm femoral heads. We established specific indications for the use of these larger heads in primary arthroplasty. There were 65 hips in 61 patients with a minimum followup of 1 year (mean 2 years, range 1-4 years). There ... Read More »
» Published in Clin Orthop Relat Res. 2006 Sep 21;

17. ESC study group of sports cardiology position paper on adverse cardiovascular effects of doping in athletes.
Match Strength: 2.397

The use of doping substances and methods is extensive not only among elite athletes, but also among amateur and recreational athletes. Many types of drugs are used by athletes to enhance performance, to reduce anxiety, to increase muscle mass, to reduce weight or to mask the use of other drugs during testing. However, the abuse of doping substances and methods has been associated with the occurrence of numerous health side-effects. The adverse effects depend on the type of the consumed drug, as well as the amount and duration of intake and the sensitivity of the body, since there is a large ... Read More »
» Published in Eur J Cardiovasc Prev Rehabil. 2006 Oct;13(5):687-94.

18. The Great Lakes Regional Stroke Network experience.
Match Strength: 2.330

Stroke is a leading cause of disability and the third leading cause of death among adults in the United States and in the Great Lakes states of Illinois, Indiana, Michigan, Minnesota, Ohio, and Wisconsin. The Great Lakes Regional Stroke Network was created to enhance collaboration and coordination among the Great Lakes states to reduce the burden of stroke and stroke-related disparities associated with race, sex, and geography. Three priorities were identified for reducing the effects of stroke in the Great Lakes region: 1) build epidemiologic capacity to improve stroke prevention and control ... Read More »
» Published in Prev Chronic Dis. 2006 Oct;3(4):A128. Epub 2006 Sep 15.

19. OC12 Combination of IVF Strategies to Reduce Porcine Polyspermic Fertilization: Straw IVF System and Short Gamete Coincubation Time.
Match Strength: 2.314

This study was conducted to evaluate the combined effect of a short period of gamete coincubation and a new in vitro fertilization (IVF) system in straw (Li et al., 2003; Biol. Reprod. 69: 1580) to attempt to reduce polyspermic penetration. A total of 723 in vitro matured oocytes were inseminated with thawed spermatozoa. Various sperm concentrations (20 000, 30 000, 40 000, and 50 000 sperm/oocyte) and two coincubation times (6 h and 10 min) were used for straw-IVF and compared to control group (1000 sperm/ovocito, in microdrop). The oocytes from 10 min group were washed in mTBM medium to ... Read More »
» Published in Reprod Domest Anim. 2006 Oct;41 Suppl 2:105.

20. Direct volatilization of naphthalene to the atmosphere at a phytoremediation site.
Match Strength: 2.302

Phytoremediation systems are known to reduce groundwater contamination by at least three major mechanisms: plant uptake, phytovolatilization, and enhanced rhizosphere bioremediation. The potential for such systems to enhance a fourth remediation pathway--direct surface volatilization of contaminants through the subsurface and into the atmosphere-has not yet been investigated in the field. A vertical flux chamber was used to measure direct surface volatilization of naphthalene over nine months at a creosote-contaminated site in Oneida, Tennessee, where a phytoremediation system of poplar trees ... Read More »
» Published in Environ Sci Technol. 2006 Sep 1;40(17):5560-6.

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