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Peer Reviewed Scientific Research Reports.
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1. Treatment of cereal products with a tailored preparation of trichoderma enzymes increases the amount of soluble dietary fiber.
Match Strength: 4.520
Nutritionists recommend increasing the intake of soluble dietary fiber (SDF), which is very low in most cereal-based products. Conversion of insoluble DF (IDF) into SDF can be achieved by chemical treatments, but this affects the sensorial properties of the products. In this study, the possibility of getting a substantial increase of SDF from cereal products using a tailored preparation of Trichoderma enzymes is reported. Enzymes were produced cultivating Trichoderma using durum wheat fiber (DWF) and barley spent grain (BSG) as unique carbon sources. Many Trichoderma strains were screened, and ... Read More »
» Published in J Agric Food Chem. 2006 Oct 4;54(20):7863-9.
2. First encounters--deployment of defence-related natural products by plants.
Match Strength: 4.519
Plant-derived natural products have important functions in ecological interactions. In some cases these compounds are deployed to sites of pathogen challenge by vesicle-mediated trafficking. Polar vesicle trafficking of natural products, proteins and other, as yet uncharacterized, cargo is emerging as a common theme in investigations of diverse disease resistance mechanisms in plants. Root-derived natural products can have marked effects on interactions between plants and soilborne organisms, for example by serving as signals for initiation of symbioses with rhizobia and mycorrhizal fungi. ... Read More »
» Published in New Phytol. 2006;172(2):193-207.
3. Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products.
Match Strength: 4.486
The bactericide triclosan is commonly used in e.g. plastics, textiles and health care products. In vitro studies on rat and human biological systems indicate that triclosan might exert adverse effects in humans. Triclosan has previously been found in human plasma and milk, but neither the primary source of human exposure nor the efficiency of triclosan transfer to human milk is known. In this study, plasma and milk were sampled from 36 mothers and analyzed for triclosan. Scrutinization of the women's personal care products revealed that nine of the mothers used toothpaste, deodorant or soap ... Read More »
» Published in Sci Total Environ. 2006 Dec 15;372(1):87-93. Epub 2006 Sep 26.
4. Update on tissue-engineered biological dressings.
Match Strength: 3.962
Tissue-engineered biological dressings offer promise in the treatment of burns, chronic ulcers, donor site and other surgical wounds, and a variety of blistering and desquamating dermatologic conditions. For example, the prevalence of diabetic foot ulcers ranges from 4.4% to 10.5% of diabetics, resulting in 82,000 lower extremity amputations annually; venous leg ulcers affect 0.18% to 1.35% of the population; and pressure ulcers are found in 5.0% to 8.8% of institutionalized patients and 14.8% of patients in acute care facilities. Despite the large number of potential beneficiaries, cellular ... Read More »
» Published in Tissue Eng. 2006 Sep;12(9):2407-24.
5. Comparison between therapeutic antitoxin F(ab)2 fractionated with ammonium sulfate and caprylic acid.
Match Strength: 3.844
To date, animal derived therapeutic antibodies represent the best and only choice source of antitoxins, especially in developing countries. Furthermore, this industry needs to develop a production protocol to achieve safer products. Recently, several laboratories changed their production protocol from ammonium sulfate (AS) protocol to caprylic acid (CA) fractionation. Our results showed that using the CA protocol leads to improvement in the product quality, as assessed by the albumin and protein content decrease (from 4.75 to 3.54 g/dL and 0.64 to 0.18 g/dL, respectively), which yielded a ... Read More »
» Published in J Immunoassay Immunochem. 2006;27(4):319-29.
6. Detection of sildenafil analogues in herbal products for erectile dysfunction.
Match Strength: 3.794
Sildenafil, the active ingredient in Viagra (Pfizer), is a prescription medicine used for erectile dysfunction. Compounds with chemical structures similar to that of sildenafil were isolated and purified during the analysis of some herbal products marketed for treatment of erectile dysfunction. Structural elucidation using liquid chromatography-diode array detection, infrared spectroscopy, liquid chromatography-tandem mass spectrometry, and nuclear magnetic resonance spectroscopy confirmed that the compounds were homosildenafil, hydroxyhomosildenafil, and acetildenafil. The implications of ... Read More »
» Published in J Toxicol Environ Health A. 2006 Nov;69(21):1951-8.
7. Studies on the mechanism of action of prekinamycin, a member of the diazoparaquinone family of natural products: evidence for both sp2 radical and orthoquinonemethide intermediates.
Match Strength: 3.698
The putative reductive activation chemistry of the diazoparaquinone antibiotics was modeled with Bu(3)Sn-H and prekinamycin dimethyl ether along with prekinamycin itself. Reaction in various combinations of aromatic solvents, with and without the nucleophile benzylmercaptan present, led to isolation of both radical-trapping arene adducts and nucleophilic capture benzyl thioether products. On the basis of these product distribution studies, the intermediacies of, first, a cyclopentenyl radical and, next, an orthoquinonemethide electrophile are postulated. Publication Types: Research Support, N ... Read More »
» Published in J Am Chem Soc. 2006 Sep 27;128(38):12562-73.
8. Sourdough products for convenient use in baking.
Match Strength: 3.639
Sourdough fermentations require a specific knowledge on the effects of process parameters, raw materials and micro-organisms in order to obtain a specific, reproducible sourdough and bread quality. This knowledge is not necessarily available in bakeries. Sourdough starter cultures, either active sourdoughs (Reinzuchtsauerteig) or freeze-dried micro-organisms are used to start sourdough fermentation with the required micro-flora. As sourdough fermentation is a labour-intensive and a time-consuming process, a growing demand for convenient products arised early. First organic acids (lactic acid, ... Read More »
» Published in Food Microbiol. 2007 Apr;24(2):161-4. Epub 2006 Sep 8.
9. An experimental and kinetic modeling study of the reaction of CHF3 with methane.
Match Strength: 3.616
The gas-phase reaction of CHF3 with CH4 has been studied experimentally and computationally. The motivation behind the study is that reaction of CHF3 with CH4 provides a possible route for synthesis of CH2=CF2 (C2H2F2). Experiments are carried out in a plug flow, isothermal alpha-alumina reactor at atmospheric pressure over the temperature range of 973-1173 K. To assist in understanding the reaction mechanism and the role of the reactor material involved in the reaction of CHF3 with CH4, the reaction of CHF3 with CH4, pyrolysis of CH4, and pyrolysis of CHCIF2 have been studied in the presence ... Read More »
» Published in Environ Sci Technol. 2006 Sep 15;40(18):5778-85.
10. Amelogenin gene splice products A+4 and A-4 implanted in soft tissue determine the reorientation of CD45-positive cells to an osteo-chondrogenic lineage.
Match Strength: 3.591
Several molecules such as bone morphogenetic protein-7, bone sialoprotein (BSP), or amelogenin gene splice products (A+4 or A-4) have been shown to induce reparative dentin formation in a rat model. However, at the moment, the origin and the mechanism of differentiation of the pulp cells stimulated by the bioactive molecules remain poorly understood. The present investigation was undertaken to validate an ectopic oral mucosal mouse model to evaluate the effects of amelogenin gene splice product implantation in a non-mineralizing tissue. Agarose beads, alone or coated with amelogenin gene ... Read More »
» Published in J Biomed Mater Res A. 2006 Dec 15;79(4):1015-22.
11. Synthesis and reactivity of 6,7-dihydrogeranylazides: reagents for primary azide incorporation into peptides and subsequent staudinger ligation.
Match Strength: 3.583
Protein farnesyltransferase (PFTase) catalyzes the attachment of a geranylazide moiety to a peptide substrate, N-dansyl-GCVIA. Because geranylazide is actually a mixture of isomeric, interconverting primary and secondary azides, incorporation of this isoprenoid into peptides can potentially result in a corresponding mixture of prenylated peptides. Here, we first examined the reactivity of geranyl azide in a model Staudinger reaction and determined that a mixture of products is formed. We then describe the synthesis of 6,7-dihydrogeranylazide diphosphate and demonstrate that this compound ... Read More »
» Published in Chem Biol Drug Des. 2006 Aug;68(2):85-96.
12. Decolonization of the skin of the patient and surgeon.
Match Strength: 3.564
Objective: To review the evidence regarding antisepsis and decolonization of the skin of the patient and surgeon for the prevention of surgical site infection (SSI). Data Sources: General bibliographic and specialist computer databases, along with manual searching of reference lists of primary and review articles, were used to search for relevant peer-reviewed citations Results: Antisepsis of the surgical site and of the hands of the surgeon is a mainstay in the prevention of SSI. Waterless and scrubless alcohol-based products are an alternative to traditional antiseptic scrubs. Chlorhexidine ... Read More »
» Published in Surg Infect (Larchmt). 2006;7 Suppl 3:s3-s15.
13. A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study.
Match Strength: 3.517
The development of inhibitory antibodies to factor VIII is a serious complication of hemophilia. FEIBA (factor VIII inhibitor-bypassing activity), an activated prothrombin complex concentrate (aPCC), and NovoSeven, recombinant factor VIIa (rFVIIa), are used as hemostatic bypassing agents in treating patients with inhibitors. The FENOC study was designed to test equivalence of the products in the treatment of ankle, knee, and elbow joint bleeding. A prospective, open-label, randomized, crossover, equivalency design was used. The parameters of interest were the percentage of patients who ... Read More »
» Published in Blood. 2007 Jan 15;109(2):546-51. Epub 2006 Sep 21.
14. Primary mechanism of the thermal decomposition of tricyclodecane.
Match Strength: 3.477
To better understand the thermal decomposition of polycyclanes, the pyrolysis of tricyclodecane has been studied in a jet-stirred reactor at temperatures from 848 to 933 K, for residence times between 0.5 and 6 s and at atmospheric pressure, corresponding to a conversion between 0.01% and 25%. The main products of the reaction are hydrogen, methane, ethylene, ethane, propene, 1,3-cyclopentadiene, cyclopentene, benzene, 1,5-hexadiene, toluene, and 3-cyclopentylcyclopentene. A primary mechanism containing all the possible initiation steps, including those involving diradicals, as well as ... Read More »
» Published in J Phys Chem A Mol Spectrosc Kinet Environ Gen Theory. 2006 Oct 5;110(39):11298-314.
15. Quality assurance, information tracking, and consumer labeling.
Match Strength: 3.462
Reducing marine-based public health risk requires strict control of several attributes of seafood products, often including location and conditions of catch or aquaculture, processing, and handling throughout the supply chain. Buyers likely will also be interested in other attributes of these products such as eco-friendliness or taste. Development of markets for improved safety, as well as for other quality attributes, requires an effective certification and tracking of these attributes as well as their communication to buyers. Several challenges must be met if labeling, particularly consumer ... Read More »
» Published in Mar Pollut Bull. 2006;53(10-12):650-6. Epub 2006 Sep 25.
16. The sensitivity and specificity of red-starch paper for the detection of saliva.
Match Strength: 3.317
The detection of saliva in forensic casework is extremely important in many types of cases. This study describes a relatively sensitive method, based on a red dye bound to starch, for the detection of amylase. The sensitivity and specificity of the method has been examined by testing over 50 household products, various body fluids and five laboratory chemicals. This study demonstrated for the first time that positive results can be obtained from certain washing powders as well as other household products. As well as detecting amylase in saliva, positive Red-Starch results were obtained from ... Read More »
» Published in Sci Justice. 2006 Apr-Jun;46(2):97-105.
17. Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins.
Match Strength: 3.279
The primate TRIM5 proteins constitute a class of restriction factors that prevent host cell infection by retroviruses from different species. The TRIM5 proteins act early after virion entry and prevent viral reverse transcription products from accumulating. We recently found that proteasome inhibitors altered the rhesus monkey TRIM5alpha restriction of human immunodeficiency virus type 1 (HIV-1), allowing reverse transcription products to accumulate even though viral infection remained blocked. To assess whether sensitivity to proteasome inhibitors was a common feature of primate TRIM5 ... Read More »
» Published in J Virol. 2006 Oct;80(19):9754-60.
18. FDA's critical path initiative: a perspective on contributions of biostatistics.
Match Strength: 3.257
This article describes the motivation for, description of, and the objectives and plans for the FDA's initiative that was introduced in March of 2004 by way of a report titled 'Innovation or Stagnation?--Challenge and Opportunity on the Critical Path to New Medical Products'. The FDA initiative is very much an outreach effort and a wake-up call to many constituencies to contribute and partner to improve the product development process and thereby to contribute to the success rate of new products that will benefit the public. We discuss in general terms where some of the opportunities and ... Read More »
» Published in Biom J. 2006 Aug;48(4):559-64. Comment in: Biom J. 2006 Aug;48(4):586-90; discussion 613-22., Biom J. 2006 Aug;48(4):591-7; discussion 613-22., Biom J. 2006 Aug;48(4):598-603; discussion 613-22., Biom J. 2006 Aug;48(4):604-8; discussion 613-22., Biom J. 2
19. Small molecule oxidation products trigger disease-associated protein misfolding.
Match Strength: 3.229
Oxidative stress and inflammation are risk factors for both the development of alpha-synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, and Alzheimer's disease, the two most common neurodegenerative disorders. These diseases are associated with the neurotoxic deposition of misassembled alpha-synuclein and amyloid-beta (Abeta) peptides, respectively. Both occur sporadically, that is, without detectable disease-related mutations, in the vast majority of cases. Small molecule oxidation products, especially secosterols derived from cholesterol and 4-hydroxynonenal ... Read More »
» Published in Acc Chem Res. 2006 Sep;39(9):611-9.
20. Kinetic and mechanistic study of the gas-phase reactions of a series of vinyl ethers with the nitrate radical.
Match Strength: 3.179
NO(3) oxidation of methyl, ethyl, propyl, and butyl vinyl ethers has been studied under tropospheric conditions (atmospheric pressure and T = 293 +/- 3 K) in the LISA indoor simulation chamber. NO(3) was produced inside the reactor by thermal decomposition of N(2)O(5) previously added to the air-VOC mixture, and concentrations were monitored using FTIR spectrometry. All the kinetic experiments were carried out by relative rate technique using isoprene as reference compound, leading to the rate constants k(1) = (7.2 +/- 1.5) x 10(-13), k(2) = (13.1 +/- 2.7) x 10(-13), k(3) = (13.3 +/- 3.0) x 10 ... Read More »
» Published in J Phys Chem A Mol Spectrosc Kinet Environ Gen Theory. 2006 Sep 28;110(38):11074-81.
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