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1. Capillary electrophoresis monitors enhancement in subcellular reactive oxygen species production upon treatment with doxorubicin.
Match Strength: 3.886

This study investigated the role of doxorubicin (DOX) accumulation in reactive oxygen species (ROS) production detected in individually electrophoresed organelles, including mitochondria, acidic organelles, and peroxisomes. While bulk measurements of ROS production in cells and organelles are not capable of discriminating between the effects of preparative procedures on measured ROS production, capillary electrophoresis with dual laser-induced detection of individual organelles demonstrated a difference in the measured ROS production as a result of various preparative procedures. Using this ... Read More »
» Published in Chem Res Toxicol. 2006 Sep;19(9):1151-9.

2. The effect of progesterone on oxytocin-stimulated intracellular mobilization of Ca2+ and prostaglandin E2 and F2alpha secretion from porcine myometrial cells.
Match Strength: 3.227

Our past studies have shown that porcine myometrium produce prostaglandins (PG) during luteolysis and early pregnancy and that oxytocin (OT) and its receptor (OTr) support myometrial secretion of prostaglandins E2 and F2alpha (PGE2 and PGF2alpha) during luteolysis. This study investigates the role of intracellular Ca2+ [Ca2+]i as a mediator of OT effects on PG secretion from isolated myometrial cells in the presence or absence of progesterone (P4). Basal [Ca2+]i was similar in myometrial cells from cyclic and pregnant pigs (days 14-16). OT (10(-7)M) increased [Ca2+]i in myometrial cells of ... Read More »
» Published in Prostaglandins Other Lipid Mediat. 2006 Oct;81(1-2):37-44. Epub 2006 Aug 1.

3. Emerging fermentation technologies: development of novel sourdoughs.
Match Strength: 2.900

The increasing knowledge of sourdough fermentation generates new opportunities for its use in the bakery field. New fermentation technologies emerged through in depth sourdough research. Dextrans are extracellular bacterial polysaccharides produced mainly by lactic acid bacteria (LAB). These bacteria convert sucrose thanks to an inducible enzyme called dextransucrase into dextran and fructose. The structure of dextran depends on the producing micro-organism and on culture conditions. Depending on its structure, dextran has specific properties which lead to several industrial applications in ... Read More »
» Published in Food Microbiol. 2007 Apr;24(2):155-60.

4. Neurobiology of sleep.
Match Strength: 2.755

The central nervous system undergoes several dynamic changes during sleep, which are coordinated by the pons, basal forebrain areas, and other subcortical structures and are mediated by three major neurotransmitters-norepinephrine, serotonin, and acetylcholine. The neuronal populations that produce these neuromodulators constitute the central representation of the sympathetic and parasympathetic subdivisions of the autonomic nervous system. The locus coeruleus (noradrenergic) and the raphe nucleus (serotoninergic) are most active during waking and become progressively less active in the ... Read More »
» Published in Metabolism. 2006 Oct;55(10 Suppl 2):S2-6.

5. Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice.
Match Strength: 2.743

NC/Nga (NC) mice are known to develop dermatitis resembling atopic dermatitis (AD) in conventional (Conv) conditions, but not in specific pathogen-free (SPF) conditions. We reported that the ability of skin prostaglandin D(2) (PGD(2)) production, which might be the endogenous inhibitor of itching, was attenuated in skin-lesioned Conv-NC mice. We examined the age-related change in scratching, dermatitis symptoms, and skin PGs of SPF- and Conv-NC mice. In Conv-NC, PGD(2) increased at 7 weeks, at which scratching counts increased, but dermatitis did not develop. PGE(2), PGI(2) and PGF(2alpha) ... Read More »
» Published in Exp Dermatol. 2006 Nov;15(11):875-82.

6. Expression of bacterial biphenyl-chlorobiphenyl dioxygenase genes in tobacco plants.
Match Strength: 2.669

Optimized plant-microbe bioremediation processes in which the plant initiates the metabolism of xenobiotics and releases the metabolites in the rhizosphere to be further degraded by the rhizobacteria is a promising alternative to restore contaminated sites in situ. However, such processes require that plants produce the metabolites that bacteria can readily oxidize. The biphenyl dioxygenase is the first enzyme of the bacterial catabolic pathway involved in the degradation of polychlorinated biphenyls. This enzyme consists of three components: the two sub-unit oxygenase (BphAE) containing a ... Read More »
» Published in Biotechnol Bioeng. 2006 Sep 27;

7. The dry plant extract of common bean seed (Phaseoli vulgari pericarpium) does not have an affect on postprandial glycemia in healthy human subject.
Match Strength: 2.580

The aim of present study was to assess the effects and safety of a dry Phaseoli vulgari pericarpium (PVP) extract on postprandial glycemia in healthy participants. A randomized crossover experiment where participants received either PVP extract or placebo. Chemical compounds in dry extract were assessed by established methods. Eighteen healthy participants (9 male and 9 female) aged 29+/-4,8 years, body mass index (BMI) 23+/-3,7 kg/m(2) were recruited among students and staff at the Faculty of Pharmacy, University of Belgrade. All participants were able to follow the study protocol without ... Read More »
» Published in Bosn J Basic Med Sci. 2006 Aug;6(3):28-33.

8. A novel immune-to-CNS communication pathway: Cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus.
Match Strength: 2.523

Pain is enhanced in response to elevations of proinflammatory cytokines in spinal cerebrospinal fluid (CSF), following either intrathecal injection of these cytokines or intrathecal immune challenge with HIV-1 gp120 that induces cytokine release. Spinal cord glia have been assumed to be the source of endogenous proinflammatory cytokines that enhance pain. However, assuming that spinal cord glia are the sole source of CSF cytokines may be an underestimate, as the cellular composition of the meninges surrounding the spinal cord CSF space includes several cell types known to produce ... Read More »
» Published in Brain Behav Immun. 2006 Sep 19;

9. Virtual histology and color flow intravascular ultrasound in peripheral interventions.
Match Strength: 2.470

The quality and interpretation of intravascular ultrasound (IVUS) imaging has been revolutionized in recent years by two new and major advances: virtual histology and color flow IVUS. Virtual histology intravascular ultrasound (VHIVUS) is a catheter-based technology where IVUS is generated from the transducer on the catheter tip and the reflected signals from the artery wall produce a color-coded map of the arterial disease. Different histological constituents of the plaque produce different reflected signals and these are assigned different colors (dark green, fibrous; yellow/green, ... Read More »
» Published in Semin Vasc Surg. 2006 Sep;19(3):155-62.

10. Balancing framework densification with charged, halogen-bonded-pi-conjugated linkages: [PPh4]2{[E-TTF-I2][Re6Se8(CN)6]} versus [PPh4]2[EDT-TTF-I]2{[EDT-TTF-I][Re6Se8(CN)6]}.
Match Strength: 2.456

The ionic character of a set of two redox linkages and strong, directional halogen bonding at the organic-inorganic interface compromise to produce two materials sharing a common two-dimensional net, eventually extended in a third dimension, although two of the six symmetrical halogen bond acceptors ultimately remain uninvolved as a result of charge densification. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Chem Commun (Camb). 2006 Jul 21;(27):2878-80.

11. Molecular analysis of successful cell line selection in transfected GS-NS0 myeloma cells.
Match Strength: 2.423

The production of recombinant proteins from mammalian cells is now an essential part of biotechnology. However, despite this importance, the detailed characteristics of good producing cell lines remain largely unknown. The industrially important GS-NS0 mammalian expression system is able to produce large amounts of protein from relatively few copies of recombinant genes. This makes GS-NS0 cell lines ideal candidates to study the consequence of recombinant plasmid transfection in mammalian cells. This study investigated the molecular features of a panel of 17 randomly chosen GS-NS0 cell lines ... Read More »
» Published in Biotechnol Bioeng. 2007 Feb 1;96(2):337-48.

12. A hydrogen-bonded heterodimer of 1-(4-hexyloxyphenyl)pyridin-4(1H)-one with 4-cyanobenzoic acid.
Match Strength: 2.338

The two components of the title heterodimer, C17H21NO2.C8H5NO2, are linked end-to-end via O-H...O(=C) and C-H...O(=C) hydrogen-bond interactions. Additional lateral C-H...O interactions link the dimers in a side-by-side fashion to produce wide infinite molecular ribbons. Adjacent ribbons are interconnected via pi-pi stacking and C-H...pi(arene) interactions. This structure represents the first evidence of robust hydrogen-bond formation between the moieties of pyridin-4(1H)-one and benzoic acid. Publication Types: Research Support, U.S. Gov't, Non-P.H.S ... Read More »
» Published in Acta Crystallogr C. 2006 Oct;62(Pt 10):o596-8. Epub 2006 Sep 12.

13. Biological tooth replacement.
Match Strength: 2.309

Teeth develop from a series of reciprocal interactions that take place between epithelium and mesenchyme during development of the mouth that begin early in mammalian embryogenesis. The molecular control of key processes in tooth development such as initiation, morphogenesis and cytodifferentiation are being increasingly better understood, to the point where this information can be used as the basis for approaches to produce biological replacement teeth (BioTeeth). This review outlines the current approaches, ideas and progress towards the production of BioTeeth that could form an alternative ... Read More »
» Published in J Anat. 2006 Oct;209(4):503-9.

14. Recombinant antibodies: from the laboratory to the clinic.
Match Strength: 2.260

The development of recombinant antibodies has facilitated the exploitation of the Ab-Ag interaction specificity for targeted therapies. A fully human antibody, with custom integrated designs, can be obtained in one-third the time, compared to development of antibodies by hybridoma technology. Recombinant antibodies can be tailored for specific applications, "armed" with cytotoxic agents in a controllable fashion, and used for extracellular and intracellular targeting. Multitargeted and combination therapies are rapidly evolving for the treatment of cancer. Antibody therapeutics, costly to ... Read More »
» Published in Cancer Biother Radiopharm. 2006 Aug;21(4):285-304.

15. Milestones leading to the genetic engineering of baculoviruses as expression vector systems and viral pesticides.
Match Strength: 2.237

The baculovirus expression vector system (BEVS) is widely established as a highly useful and effective eukaryotic expression system. Thousands of soluble and membrane proteins that, in general, are correctly folded, modified, sorted and assembled to produce highly authentic recombinant proteins have been cloned and expressed. This historical chronology and perspective will focus on the original, peer-reviewed discoveries that were pioneering and seminal to the development of the BEVS and that provided the basis for subsequent and more recent developments and applications. Publication Types: ... Read More »
» Published in Adv Virus Res. 2006;68:3-73.

16. Multipotent adult progenitor cell lines originating from the peripheral blood of green fluorescent protein transgenic swine.
Match Strength: 2.233

Multipotent self-renewing stem cell lines have been established using peripheral blood mononuclear cells from adult green fluorescent protein transgenic swine. These cells proliferate as nonadherent spheroids in primordial-specific culture media and readily differentiate into angiogenic, osteogenic, adipogenic, and neurogenic phenotypes when cultured under the appropriate conditions. These cells are designated peripheral blood-derived multipotent adult progenitor cells (PBD-MAPCs). When differentiated in endothelial-specific media, these cells exhibit a cobblestone morphology and express von ... Read More »
» Published in Stem Cells Dev. 2006 Aug;15(4):507-22.

17. Duplication, divergence and formation of novel protein topologies.
Match Strength: 2.222

The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work explored one possible underlying mechanism called permutation-by-duplication, which produces special forms of motif rearrangements called circular permutations. Permutation-by-duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence. (c) 2006 Wiley Periodicals, ... Read More »
» Published in Bioessays. 2006 Oct;28(10):973-8.

18. Transgenesis using nuclear transfer in goats.
Match Strength: 2.179

Nuclear transfer (NT) using transgenic donor cells is an efficient means for generation of transgenic founder goats, especially in regard to the number of animals required to produce a transgenic founder expressing the protein of interest. Vectors can be designed for organ-specific expression and secretion of recombinant proteins within the target tissue. Furthermore, donor cells can be selected for gender, genetically modified to introduce the transgene of interest and screened for incorporation of the transgene into the genome before use in NT. This chapter describes methods for production ... Read More »
» Published in Methods Mol Biol. 2006;348:213-26.

19. Elevated Eocene atmospheric CO2 and its subsequent decline.
Match Strength: 2.175

Quantification of the atmospheric concentration of CO2 ([CO2]atm) during warm periods of Earth's history is important because burning of fossil fuels may produce future [CO2]atm approaching 1000 parts per million by volume (ppm). The early Eocene (~56 to 49 million years ago) had the highest prolonged global temperatures of the past 65 million years. High Eocene [CO2]atm is established from sodium carbonate minerals formed in saline lakes and preserved in the Green River Formation, western United States. Coprecipitation of nahcolite (NaHCO3) and halite (NaCl) from surface waters in contact ... Read More »
» Published in Science. 2006 Sep 29;313(5795):1928.

20. Nonpharmacologic treatment of erectile dysfunction.
Match Strength: 2.156

Nonpharmacologic treatment for erectile dysfunction (ED) includes sex therapy, the use of vacuum erection devices, penile prosthesis implantation, and penile vascular surgery. Sex therapy is indicated for psychogenic ED and is at times a useful adjunct for other treatments in men with mixed psychogenic and organic ED. Vacuum erection devices produce usable erections in over 90% of patients; however, patient and partner acceptability is an issue. Three-piece inflatable penile prostheses create flaccidity and an erection that comes close to that which occurs naturally. Penile vascular surgery ... Read More »
» Published in Rev Urol. 2002;4 Suppl 3:S9-S16.

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