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Peer Reviewed Scientific Research Reports.
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1. Parkinson's disease: background, diagnosis, and initial management.
Match Strength: 9.357
Parkinson's disease is a common neurodegenerative disorder associated with aging. After essential tremor, it is the most common movement disorder of the elderly. Parkinson's disease is the most common disabling movement disorder. This article reviews the major clinical features, differential diagnosis, approach to diagnosis, and initial management of Parkinson's disease. Publication Types: Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., ... Read More »
» Published in Clin Geriatr Med. 2006 Nov;22(4):735-51, v.
2. Cognitive, affective, and psychiatric features of Parkinson's disease.
Match Strength: 8.950
Nonmotor symptoms, including cognitive deterioration and dementia, depression and apathy, and psychosis, are common in Parkinson's disease. Their presence is associated with a tremendous burden for the patient and family members. This article reviews the pathophysiololgy, risks, impact, major features, diagnosis, and treatment of these symptoms in Parkinson's disease. Publication Types: Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, ... Read More »
» Published in Clin Geriatr Med. 2006 Nov;22(4):773-96, v-vi.
3. Kinase activity of mutant LRRK2 mediates neuronal toxicity.
Match Strength: 8.666
Mutations in the the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson disease and some cases of sporadic Parkinson disease. Here we found that LRRK2 kinase activity was regulated by GTP via the intrinsic GTPase Roc domain, and alterations of LRRK2 protein that reduced kinase activity of mutant LRRK2 correspondingly reduced neuronal toxicity. These data elucidate the pathogenesis of LRRK2-linked Parkinson disease, potentially illuminate mechanisms of sporadic Parkinson disease and suggest therapeutic targets. Publication Types: Comparative Study, Research Support, N ... Read More »
» Published in Nat Neurosci. 2006 Oct;9(10):1231-3. Epub 2006 Sep 17.
4. Parkinson's disease due to the R1441G mutation in Dardarin: a founder effect in the Basques.
Match Strength: 8.252
The recent discovery of mutations in Dardarin (LRRK2) have been related to the appearance of Parkinson's disease in several families. Notably, one single mutation in this gene (R1441G) not only appeared in familial, but also in apparently sporadic Parkinson disease (PD) patients of Basque descent. A clinical population was ascertained, and subjects were classified into Basque and non-Basque descent according to their known ancestry. The R1441G mutation was assayed using an allele-specific polymerase chain reaction, and several single nucleotide polymorphisms surrounding this mutation were ... Read More »
» Published in Mov Disord. 2006 Nov;21(11):1954-9.
5. Life goals of patients with Parkinson's disease: A pilot study on correlations with mood and cognitive functions.
Match Strength: 7.816
OBJECTIVE: To identify the life goals of people with Parkinson's disease, to assess whether patients felt that these goals were 'on track', and to assess the relation of these life goals to neuropsychologic and mood function. DESIGN: Cross-sectional descriptive study with an age-matched control group. SETTING: Outpatient Movement Disorders Clinics Veterans Hospital. SUBJECTS: Twenty-two patients with mid-stage Parkinson's disease and 22 age-matched controls. MEASURES: Rivermead Life Goals Inventory, neuropsychological and mood scales. RESULTS: People with Parkinson's disease were less likely ... Read More »
» Published in Clin Rehabil. 2006 Sep;20(9):818-26.
6. A specific survival response in dopamine neurons at most risk in Parkinson's disease.
Match Strength: 7.526
The specific expression of fibroblast growth factor 20 (FGF-20) in the adult substantia nigra and the association between FGF-20 mutations and Parkinson's disease provoked exploration of the function of this growth factor. We show by gain- and loss-of-function in vitro experiments that FGF-20 promotes survival and stimulates dopamine (DA) release in a calbindin-negative subset of cells that are preferentially lost in Parkinson's disease. FGF-20 selectively activates tyrosine hydroxylase in calbindin-negative neurons. In the adult substantia nigra, calbindin-negative neurons specifically ... Read More »
» Published in J Neurosci. 2006 Sep 20;26(38):9750-60.
7. NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach.
Match Strength: 7.443
The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Mov Disord. 2006 Nov;21(11):1960-3.
8. Medical management of advanced Parkinson's disease.
Match Strength: 7.156
The management of advancing Parkinson's disease (PD) is a daunting task, complicated by dynamic medication responses, side effects, and treatment-refractory symptoms in an aging patient population. The motor and nonmotor complications of advancing PD are reviewed, and practical treatment strategies are provided. Careful assessment in the context of the known natural history of advancing PD and rational treatment choices can create significant improvement in the lives of patients who have advancing PD. Publication Types: ... Read More »
» Published in Clin Geriatr Med. 2006 Nov;22(4):753-72, v.
9. Individualized assessment of quality of life in idiopathic Parkinson's disease.
Match Strength: 6.822
The purpose of this study was to assess quality of life (QoL) of patients with idiopathic Parkinson's disease (IPD). The Parkinson's Disease Questionnaire (PDQ-39) was compared with an individualized QoL tool: the Schedule for Evaluation of Individual Quality of Life Direct Weighting (SEIQoL-DW). One hundred twenty-three patients underwent interviews using these tools, together with the Mini Mental State examination, Beck Depression Inventory, a qualitative pain assessment, and the Palliative Care Assessment tool (for symptoms). The SEIQoL-DW was well tolerated and demonstrated that QoL not ... Read More »
» Published in Mov Disord. 2006 Nov;21(11):1929-34.
10. Ubiquitin-protein ligase parkin and its role in the development of Parkinson's disease.
Match Strength: 6.307
Parkin is a protein encoded by the corresponding parkin gene. It exhibits ubiquitin-protein ligase activity. In this review, we analyze domain structure, substrate specificity, subcellular localization of parkin, and regulation of its activity. Then we discuss data on the effects of various mutations in the parkin gene on structure and functions of this protein and results obtained with parkin knock-out animals. Better understanding of parkin biochemistry, its compartmentalization, functions, and altered functions would help the development of new approaches for the treatment of both inherited ... Read More »
» Published in Biochemistry (Mosc). 2006 Aug;71(8):851-60.
11. Mutations in DJ-1 are rare in familial Parkinson disease.
Match Strength: 6.271
Mutations in DJ-1 (PARK7) are one cause of early-onset autosomal-recessive parkinsonism. We screened for DJ-1 mutations in 93 affected individuals from the 64 multiplex Parkinson disease (PD) families in our sample that had the highest family-specific multipoint LOD scores at the DJ-1 locus. In addition to sequencing all coding exons for alterations, we used multiplex ligation-dependent probe amplification (MLPA) to examine the genomic copy number of DJ-1 exons. A known polymorphism (R98Q) was found in five PD subjects, once as a homozygote and in the other four cases as heterozygotes. No ... Read More »
» Published in Neurosci Lett. 2006 Nov 20;408(3):209-13. Epub 2006 Sep 25.
12. Therapeutic effects of differentiated bone marrow stromal cell transplantation on rat models of Parkinson's disease.
Match Strength: 5.688
This study was to explore curative effect of bone marrow stromal cells (BMSCs) differentiated into nestin-positive cells transplantation on rat Parkinson's disease (PD) model. The PD rats were selected and allocated randomly into three groups. BMSCs with differentiation, BMSCs without differentiation and physiological saline were injected into right striatum of PD rat. The rotation test and immunofluorescence double staining were done. Frequency of rotation was significantly less in differentiated or non-differentiated BMSCs groups than that in normal saline group. Brdu/GFAP- and Brdu/NSE ... Read More »
» Published in Parkinsonism Relat Disord. 2007 Feb;13(1):44-9. Epub 2006 Sep 26.
13. A common cognitive profile in elderly fallers and in patients with Parkinson's disease: the prominence of impaired executive function and attention.
Match Strength: 5.550
The present study examined the cognitive profile of elderly fallers relative to healthy elderly controls and patients with Parkinson's disease (PD), a positive-control group, using a computerized battery. Fallers performed more poorly than controls on executive function, attention, and motor skills, but performed comparably on memory, information processing and the Mini-Mental State Examination. A similar profile was evident for PD patients. However, unlike PD patients, fallers were abnormally inconsistent in their reaction times. These findings indicate that elderly fallers may have a unique ... Read More »
» Published in Exp Aging Res. 2006 Oct-Dec;32(4):411-29.
14. Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging.
Match Strength: 5.444
OBJECTIVE: The objective of this study was to investigate cross-sectional and longitudinal white matter hyperintensity (WMH) changes in older subjects with clinically diagnosed dementia. METHODS: Fluid-attenuated inversion recovery images were acquired one year apart in subjects with dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), Alzheimer disease (AD), and also healthy elderly comparison subjects. WMH volume was quantified using an automated technique. RESULTS: Baseline WMH (as a percent of brain volume) was significantly greater compared with healthy subjects (N=33, ... Read More »
» Published in Am J Geriatr Psychiatry. 2006 Oct;14(10):842-9.
15. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.
Match Strength: 5.129
The molecules underlying neuron loss in Parkinson's disease (PD) are essentially unknown, and current therapies focus on diminishing symptoms rather than preventing neuron death. We identified RTP801 as a gene whose transcripts were highly induced in a cellular model of PD in which death of neuronal catecholaminergic PC12 cells was triggered by the PD mimetic 6-OHDA. Here, we find that RTP801 protein is also induced in this and additional cellular and animal PD models. To assess the relevance of these observations to PD, we used immunohistochemistry to compare RTP801 expression in postmortem ... Read More »
» Published in J Neurosci. 2006 Sep 27;26(39):9996-10005.
16. Impact of Parkinson's disease on continence after radical prostatectomy.
Match Strength: 5.098
OBJECTIVES: It is widely believed that men with idiopathic Parkinson's disease (PD) should not undergo prostate surgery because of the prohibitively high risk of incontinence. However, the data supporting this conclusion were based on cohorts undergoing prostate surgery for voiding dysfunction, not for cancer control. Because both prostate cancer and PD are predominantly diseases of the elderly, it is likely that some men are concurrently diagnosed with both disorders who would otherwise be good candidates for radical prostatectomy (RP). However, the urinary outcomes in men with PD undergoing ... Read More »
» Published in Urology. 2006 Sep;68(3):575-7. Epub 2006 Sep 18.
17. Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.
Match Strength: 4.960
Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic neuron depletion; ALS, a disease of motor neuron death; and Alzheimer's, a disease of plaques and tangles. Although these disorders differ in important ways, they also have common pathogenic features, including inflammation, genetic mutations, inappropriate protein aggregates (e.g., Lewy bodies, amyloid plaques), and biochemical defects leading to apoptosis, such as oxidative stress and mitochondrial dysfunction. In most disorders, it remains uncertain whether inflammation and ... Read More »
» Published in J Neuroimmunol. 2006 Jul;176(1-2):198-215.
18. Resting state oscillatory brain dynamics in Parkinson's disease: an MEG study.
Match Strength: 4.940
OBJECTIVE: The pathophysiological mechanisms of cognitive dysfunction and dementia in Parkinson's disease (PD) are still poorly understood. Altered resting state oscillatory brain activity may reflect underlying neuropathological changes. The present study using magneto encephalography (MEG) was set up to study differences in the pattern of resting state oscillatory brain activity in groups of demented and non-demented PD patients and healthy, elderly controls. METHODS: The pattern of MEG background oscillatory activity was studied in 13 demented PD patients, 13 non-demented PD patients and 13 ... Read More »
» Published in Clin Neurophysiol. 2006 Nov;117(11):2521-31. Epub 2006 Sep 25.
19. Small molecule oxidation products trigger disease-associated protein misfolding.
Match Strength: 4.889
Oxidative stress and inflammation are risk factors for both the development of alpha-synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, and Alzheimer's disease, the two most common neurodegenerative disorders. These diseases are associated with the neurotoxic deposition of misassembled alpha-synuclein and amyloid-beta (Abeta) peptides, respectively. Both occur sporadically, that is, without detectable disease-related mutations, in the vast majority of cases. Small molecule oxidation products, especially secosterols derived from cholesterol and 4-hydroxynonenal ... Read More »
» Published in Acc Chem Res. 2006 Sep;39(9):611-9.
20. Parkinson's disease genetic mutations increase cell susceptibility to stress: Mutant alpha-synuclein enhances H(2)O(2)- and Sin-1-induced cell death.
Match Strength: 4.849
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. alpha-Synuclein is a major component of Lewy bodies in sporadic PD, and genetic alterations in alpha-synuclein cause autosomal-dominant hereditary PD. The pathogenesis of PD remains incompletely understood, but it appears to involve both genetic susceptibility and environmental factors. Here we investigated the effect of alpha-synuclein expression on cell susceptibility to proteasome inhibition, oxidative and nitrative stresses ... Read More »
» Published in Neurobiol Aging. 2006 Sep 13;
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