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Peer Reviewed Scientific Research Reports.
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1. Antiviral activity of CHO-SS cell-derived human omega interferon and other human interferons against HCV RNA replicons and related viruses.
Match Strength: 9.200
The fully glycosylated human omega interferon produced from CHO-SS cells (glycosylated IFN-omega) has been shown to be well-tolerated in man and to induce a sustained virologic response in patients infected with hepatitis C virus (HCV). We examined the antiviral activity of glycosylated IFN-omega and various human IFNs (IFN-alpha, -beta, -gamma and non-glycosylated bacterial (Escherichia coli) recombinant IFN-omega (non-glycosylated IFN-omega)) against HCV RNA replicons and several viruses related to HCV. Since none of the IFNs displayed cytotoxicity we compared their activities based on the ... Read More »
» Published in Antiviral Res. 2007 Feb;73(2):118-25. Epub 2006 Sep 11.
2. Glycerol-derived ester oligomers from cork suberin.
Match Strength: 8.732
The cork suberin polyester was partially depolymerized by a methanolysis reaction catalyzed by calcium hydroxide. The methanolisate was analysed by ESI-MS/MS in the form of [M+Li](+) adduct-ions. This reaction solubilized a mixture of monomers and oligomers, including a set of glycerol-derived dimeric and trimeric esters. Four types of glycerol esters were identified: monoacylglycerols of alpha,omega-diacids, of omega-hydroxyacids and of monoacids; diglycerol diesters of alpha,omega-diacids; diacylglycerols of alpha,omega-diacids; monoacylglycerols of linear dimeric esters of alpha,omega ... Read More »
» Published in Chem Phys Lipids. 2006 Oct;144(1):96-107. Epub 2006 Aug 8.
3. Nanomechanical force measurements of gliadin protein interactions.
Match Strength: 8.392
The strength and nature of interactions between monomeric gliadin proteins involving alpha-alpha, omega-omega, and alpha-omega interactions in 0.01M acetic acid, and the effect of urea has been investigated. It was shown by means of nanomechanical force measurements that the stretching events in the separation curve after adhesive phenomena originated from proteins. These stretching events displayed different responses of the alpha- and omega-gliadins to urea. While 2M urea caused the more globular alpha-gliadins to unfold, the beta-turn-rich omega-gliadins remained fairly stable even in 8M ... Read More »
» Published in Biopolymers. 2006 Dec 15;83(6):658-67.
4. Inhibition by mercuric chloride of aquaporin-1 in the parietal sheep peritoneum: an electrophysiologic study.
Match Strength: 5.115
The peritoneal mesothelium is a barrier to ion transport in peritoneal dialysis. In this study, we used Ussing-chamber experiments to investigate the effect of HgCl2, an aquaporin-1 inhibitor, on the transmesothelial electrical resistance (RTM) of isolated sheep parietal peritoneum. Peritoneal samples from the diaphragm of adult sheep were isolated immediately after the death of the animal and were transferred within 30 minutes to the laboratory in a cooled Krebs-Ringer bicarbonate solution (4 degrees C, pH 7.5) bubbled with 95% O(2)/5% CO2. A planar sheet of the parietal peritoneum was ... Read More »
» Published in Adv Perit Dial. 2006;22:7-10.
5. Chloroplasts as a nitric oxide cellular source. Effect of reactive nitrogen species on chloroplastic lipids and proteins.
Match Strength: 3.900
Nitric oxide (NO) generation by soybean (Glycine max var. ADM 4800) chloroplasts was studied as an endogenous product assessed by the electron paramagnetic resonance spin-trapping technique. Nitrite and l-arginine (Arg) are substrates for enzymatic activities considered to be the possible sources of NO in plants. Soybean chloroplasts showed a NO production of 3.2 +/- 0.2 nmol min(-1) mg(-1) protein in the presence of 1 mm NaNO(2). Inhibition of photosynthetic electron flow by 3-(3,4-dichlorophenyl)-1,1-dimethyl urea resulted in a lower rate (1.21 +/- 0.04 nmol min(-1) mg(-1) protein) of NO ... Read More »
» Published in Plant Physiol. 2006 Nov;142(3):1246-55. Epub 2006 Sep 15.
6. Dynamics of paramagnetic agents by off-resonance rotating frame technique.
Match Strength: 3.689
Off-resonance rotating frame technique offers a novel tool to explore the dynamics of paramagnetic agents at high magnetic fields (B0 > 3T). Based on the effect of paramagnetic relaxation enhancement in the off-resonance rotating frame, a new method is described here for determining the dynamics of paramagnetic ion chelates from the residual z-magnetizations of water protons. In this method, the dynamics of the chelates are identified by the difference magnetization profiles, which are the subtraction of the residual z-magnetization as a function of frequency offset obtained at two sets of ... Read More »
» Published in J Magn Reson. 2006 Dec;183(2):213-27. Epub 2006 Sep 18.
7. Improved results for the excited states of nitric oxide, including the B/C avoided crossing.
Match Strength: 3.166
The potential energy surfaces of ten electronic states of nitric oxide (NO) have been reexamined computationally, with state energies calculated using ab initio multireference methods. Our wave function expansions of 10x10(6) configurations improve upon the results of de Vivie and Peyerimhoff [J. Chem. Phys. 89, 3028 (1988)], who obtained excellent results from expansions of 16 000 configurations in 1988. We present results for the adiabatic properties r(e), B(e), T(e), and omega(e), demonstrating standard errors of 0.012 A, 0.026 cm(-1), 620 cm(-1), and 41 cm(-1), respectively. Vertical ... Read More »
» Published in J Chem Phys. 2006 Sep 14;125(10):104311.
8. Specialization of the specialized in features of external human brain morphology.
Match Strength: 2.824
Recent studies have shown brain differences between professional musicians and non-musicians with respect to size, asymmetry or gray matter density of specific cerebral regions. Here we demonstrate: (1) that anatomical differences in the motor cortex can already be detected by coarse visual inspection; and (2) that within musicians, even a discrimination of instruments with different manual dominance is possible on a gross anatomical scale. Multiple raters, blinded for subject identity and hemisphere, investigated within-musician differences in the Omega Sign (OS), an anatomical landmark of ... Read More »
» Published in Eur J Neurosci. 2006 Sep;24(6):1832-4.
9. A novel neuroprotective agent with antioxidant and nitric oxide synthase inhibitory action.
Match Strength: 2.743
N(alpha)-vanillyl-N(omega)-nitroarginine (N - 1) that combines the active functions of natural antioxidant and nitric oxide synthase inhibitor was developed for its neuroprotective properties. N - 1 exhibited protective effects against hydrogen peroxide-induced cell damage and the inhibitory effect on nitric oxide 'NO' production induced by calcium ionophore in NG 108-15 cells. N - 1 inhibited the constitutive NOS isolated from rat cerebellar in a greater extent than constitutive NOS from human endothelial cells. Low binding energy (-10.2 kcal/mol) obtained from docking N - 1 to nNOS supported ... Read More »
» Published in Free Radic Res. 2006 Jul;40(7):685-95.
10. Amino-terminal dimerization of peptides on the solid support. Synthesis and biological activity of the immunosuppressive HLA-DR fragments linked by poly(ethylene glycol)s.
Match Strength: 2.704
The nonapeptide fragment of the HLA-DR molecule, located in the exposed loop of the beta chain (164-172) and having the sequence VPRSGEVYT, suppresses the immune response. On the basis of the three-dimensional structure of the HLA-DR superdimer, we designed new dimeric analogs in which the VPRSGEVYT peptides are linked through their N-termini by poly(ethylene glycol) linkers of different lengths and are able to mimic the dimeric nature of the immunosuppressive fragments of HLA class II molecules. The analogs were synthesized using standard solid-phase peptide synthesis protocols. The ... Read More »
» Published in Bioconjug Chem. 2006 Sep-Oct;17(5):1116-24.
11. Nutrient intake and risk of non-Hodgkin's lymphoma.
Match Strength: 2.639
The mechanisms through which diet may influence the development of non-Hodgkin's lymphoma (NHL) are unclear but can be better understood by examining associations between nutrient consumption and NHL risk. Between 2000 and 2002, 591 NHL cases and 460 population-based controls in Sweden completed a semiquantitative food frequency questionnaire. Unconditional logistic regression was performed to estimate odds ratios and 95% confidence intervals for associations with nutrient intake; all statistical tests were two sided. Dietary intake of most macronutrients was not associated with risk of NHL or ... Read More »
» Published in Am J Epidemiol. 2006 Dec 15;164(12):1222-32. Epub 2006 Sep 27.
12. Aging associated with mild dyslipidemia reveals that COX-2 preserves dilation despite endothelial dysfunction.
Match Strength: 2.593
The endothelial function declines with age, and dyslipidemia (DL) has been shown to hasten this process by favoring the generation of reactive oxygen species (ROS). Cyclooxygenase-2 (COX-2) can be induced by ROS, but its contribution to the regulation of the endothelial function is unknown. Since COX-2 inhibitors may be deleterious to the cardiovascular system, we hypothesized that DL leads to ROS-dependent endothelial damage and a protective upregulation of COX-2. Dilations to acetylcholine (ACh) of renal arteries isolated from 3-, 6-, and 12-mo-old wild-type (WT) and DL mice expressing the ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H451-8. Epub 2006 Sep 15.
13. Activation of protein kinase a improves vascular endothelial dysfunction.
Match Strength: 2.421
The study has been designed to investigate the effect of 8-Br-cAMP, an activator of protein kinase A (PKA), in diabetes mellitus- and hyperhomocysteinemia-induced vascular endothelial dysfunction. Streptozotocin (55 mg kg-1, i.v.) and methionine (1.7% w/w, p.o., 4 weeks) were administered to rats to produce diabetes mellitus (serum glucose >200 mg dL-1) and hyperhomocysteinemia (serum homocysteine >10 microM), respectively. Vascular endothelial dysfunction was assessed using isolated aortic ring preparation, electron microscopy of thoracic aorta, and serum concentration of nitrite ... Read More »
» Published in Endothelium. 2006 Jul-Aug;13(4):267-77.
14. Radiofrequency ablation of osteoid osteoma: initial results with a bipolar ablation device.
Match Strength: 2.387
PURPOSE: To report the initial results with percutaneous radiofrequency (RF) ablation of osteoid osteomas with a bipolar ablation device. MATERIALS AND METHODS: Twelve patients (seven male patients and five female patients; mean age, 17.3 years; age range, 6-36 y) with clinically and radiologically suspected osteoid osteoma were treated with computed tomography-guided percutaneous bipolar RF ablation. The procedure was performed with the patients under general anesthesia. After localization of the nidus, an 11-gauge hollow drill was introduced into the nidus through a 9-F introducer sheath. A ... Read More »
» Published in J Vasc Interv Radiol. 2006 Sep;17(9):1465-70.
15. Diminished FAD binding in the Y459H and V492E Antley-Bixler syndrome mutants of human cytochrome P450 reductase.
Match Strength: 2.360
Numerous mutations/polymorphisms of the POR gene, encoding NADPH:cytochrome P450 oxidoreductase (CYPOR), have been described in patients with Antley-Bixler syndrome (ABS), presenting with craniofacial dysmorphogenesis, and/or disordered steroidogenesis, exhibiting ambiguous genitalia. CYPOR is the obligate electron donor to 51 microsomal cytochromes P450 that catalyze critical steroidogenic and xenobiotic reactions, and to two heme oxygenase isoforms, among other redox partners. To address the molecular basis of CYPOR dysfunction in ABS patients, the soluble catalytic domain of human CYPOR was ... Read More »
» Published in J Biol Chem. 2006 Nov 24;281(47):35975-82. Epub 2006 Sep 24.
16. Omega-3 fatty acids and rodent behavior.
Match Strength: 2.273
This paper reviews the role of the n-3 fatty acids in the regulation of cognitive functions, locomotor and exploratory activity and emotional status in rodents. There are disparate data on the performance of n-3 fatty acid deficient animals in the open field test and elevated plus maze. Results obtained in our laboratory indicated slower habituation to the open field in deficient mice, which affects total locomotor and exploratory parameters. We also observed no change in plus maze performance of deficient mice under low-stress but elevated anxiety under high-stress conditions. There is some ... Read More »
» Published in Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):271-89. Epub 2006 Sep 14.
17. A reevaluation of the effects of stimulation of the dorsal motor nucleus of the vagus on gastric motility in the rat.
Match Strength: 2.229
Our primary purpose was to characterize vagal pathways controlling gastric motility by microinjecting l-glutamate into the dorsal motor nucleus of the vagus (DMV) in the rat. An intragastric balloon was used to monitor motility. In 39 out of 43 experiments, microinjection of l-glutamate into different areas of the DMV rostral to calamus scriptorius (CS) resulted in vagally mediated excitatory effects on motility. We observed little evidence for inhibitory effects, even with intravenous atropine or with activation of gastric muscle muscarinic receptors by intravenous bethanechol. Inhibition of ... Read More »
» Published in Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R291-307. Epub 2006 Sep 21.
18. Gate dielectric chemical structure--organic field-effect transistor performance correlations for electron, hole, and ambipolar organic semiconductors.
Match Strength: 2.204
This study describes a general approach for probing semiconductor-dielectric interfacial chemistry effects on organic field-effect transistor performance parameters using bilayer gate dielectrics. Organic semiconductors exhibiting p-/n-type or ambipolar majority charge transport are grown on six different bilayer dielectric structures consisting of various spin-coated polymers/HMDS on 300 nm SiO(2)/p(+)-Si, and are characterized by AFM, SEM, and WAXRD, followed by transistor electrical characterization. In the case of air-sensitive (generally high LUMO energy) n-type semiconductors, dielectric ... Read More »
» Published in J Am Chem Soc. 2006 Oct 4;128(39):12851-69.
19. Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma.
Match Strength: 2.152
Peptides play important roles in cell regulation and signaling in many tissues and are regulated by peptidases, most of which are highly expressed in the kidney. Several peptide convertases have a function in different tumor stages, and some have been clearly characterized as diagnostic and prognostic markers for solid tumors, including renal cancer; however, little is known about their in vivo role in kidney tumors. The present study compares the activity of a range of peptidases in human tumor samples and nontumor tissue obtained from clear cell renal cell carcinoma (CCRCC) patients. To ... Read More »
» Published in Am J Physiol Renal Physiol. 2007 Feb;292(2):F780-8. Epub 2006 Sep 19.
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