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Peer Reviewed Scientific Research Reports.
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1. Obesity, waist-hip ratio and hunter-gatherers.
Match Strength: 6.207
Obesity is a rapidly growing global problem. It is not simply the result of eating too much, and not all types of obesity have the same significance. Obesity is in part genetic, and one particularly important genetic type of obesity is the tendency to 'truncal obesity',-that is, a raised waist-to-hip ratio. Such obesity is powerfully associated not only with a tendency to diabetes, but also to cardiovascular disease, ('Syndrome X'). Interestingly, this is the type of obesity seen in every hunter-gatherer (HG) population around the globe. Such people are intolerant of carbohydrate, especially ... Read More »
» Published in BJOG. 2006 Oct;113(10):1110-6.
2. Genetics of obesity and the prediction of risk for health.
Match Strength: 5.965
Obesity has always existed in human populations, but until very recently was comparatively rare. The availability of abundant, energy-rich processed foods in the last few decades has, however, resulted in a sharp rise in the prevalence of obesity in westernized countries. Although it is the obesogenic environment that has resulted in this major healthcare problem, it is acting by revealing a sub-population with a pre-existing genetic predisposition to excess adiposity. There is substantial evidence for the heritability of obesity, and research in both rare and common forms of obesity has ... Read More »
» Published in Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R124-30.
3. Maternal obesity in pregnancy: Is it time for meaningful research to inform preventive and management strategies?
Match Strength: 5.807
The growing epidemic of obesity in our society has become a major public health issue, with serious social and psychological consequences in addition to the physical health implications. Obesity has reached epidemic proportions globally with a similar rise in prevalence among women in the reproductive age group. This has critical consequences for fetal and maternal health in the antepartum, intrapartum and postpartum periods. The aims of this study were to summarise the implications of maternal obesity on maternal, fetal and neonatal health and to recommend good practice guidelines on the ... Read More »
» Published in BJOG. 2006 Oct;113(10):1134-40.
4. Thiazolidinediones, insulin resistance and obesity: Finding a balance.
Match Strength: 5.549
The clinical efficacy of currently available thiazolidinediones (TZDs) in improving glycaemic control and ameliorating several risk factors for cardiovascular disease (linked to their insulin-sensitising actions as well as direct vascular effects) is well established. Treatment-associated weight gain, however, which has been identified as a class effect of the TZDs, is seen in a number of patients. The magnitude of weight gain correlates in part with improved metabolic control, i.e. better responders are more prone to increases in body weight. The cardiovascular risk associated with obesity ... Read More »
» Published in Int J Clin Pract. 2006 Oct;60(10):1272-80.
5. Prenatal Programming of Childhood Overweight and Obesity.
Match Strength: 5.384
Objective: To review the scientific evidence for prenatal programming of childhood overweight and obesity, and discuss its implications for MCH research, practice, and policy. Methods: A systematic review of observational studies examining the relationship between prenatal exposures and childhood overweight and obesity was conducted using MOOSE guidelines. The review included literature posted on PubMed and MDConsult and published between January 1975 and December 2005. Prenatal exposures to maternal diabetes, malnutrition, and cigarette smoking were examined, and primary study outcome was ... Read More »
» Published in Matern Child Health J. 2006 Sep 28;
6. Dietetics students possess negative attitudes toward obesity similar to nondietetics students.
Match Strength: 5.180
This study explored attitudes toward obesity between dietetics and nondietetics majors at Ohio University and their relationship with dietary intake and body composition. A convenience sample comprised of 76 female dietetics (n=38) and nondietetics (n=38) majors was assessed for attitudes toward obesity using a validated Fat Phobia Scale. Dietary intake and percent body fat were measured using a food frequency questionnaire and air displacement plethysmography, respectively. Results show that both groups were well matched with respect to age, weight, and percent body fat. The two groups were ... Read More »
» Published in J Am Diet Assoc. 2006 Oct;106(10):1678-82.
7. Obesity distribution and reproductive hormone levels in women: a report from the NHLBI-sponsored WISE Study.
Match Strength: 5.169
PURPOSE: Relationships between body weight and disease are not straightforward. Central obesity appears to be a relatively greater cardiovascular risk factor than generalized obesity. The purpose of this study was to evaluate body mass index (BMI) and waist circumference and the association of obesity distribution with blood estrogen levels (estradiol, bioavailable estradiol, and estrone). METHODS: The study cohort consisted of 207 postmenopausal women enrolled in the Women's Ischemia Syndrome Evaluation (WISE) undergoing angiography for evaluation of suspected ischemia. RESULTS: Both BMI and ... Read More »
» Published in J Womens Health (Larchmt). 2006 Sep;15(7):836-42.
8. Clinical aspects of obesity in the gynecological endocrinologicaly practice.
Match Strength: 5.100
Obesity is epidemic of 21st century, its visceral form is associated with increased risk for type 2 diabetes, cardiovascular disease, hypertension and increased mortality due to consequences of the disease. This type of obesity is a common diagnostic and therapeutic problem in gynecological practice. This especially concerns polycystic ovary disease, in which this type of obesity with its metabolic consequences is one of the important factors in etiology and additionally may lead to remote metabolic and cardiovascular problems. Another group of women in which this type of obesity plays an ... Read More »
» Published in Maturitas. 2007 Feb 20;56(2):113-21. Epub 2006 Sep 12.
9. Obesity in bipolar disorder and major depressive disorder: results from a national community health survey on mental health and well-being.
Match Strength: 4.987
OBJECTIVE: We aimed to ascertain the prevalence of obesity in individuals with a mood disorder (MD) (that is, bipolar disorder or major depressive disorder), compared with the general population. We further aimed to examine the likelihood of an association between obesity and MD, while controlling for the influence of sociodemographic variables. METHOD: The analysis was based on data from Statistics Canada's Canadian Community Health Survey: Mental Health and Well-Being (CCHS 1.2), conducted in 2002. The sample (n = 36 984; > or = aged 15 years) was drawn from the Canadian household ... Read More »
» Published in Can J Psychiatry. 2006 Apr;51(5):274-80.
10. Obesity--a growing issue.
Match Strength: 4.960
OBJECTIVES: This article, based on longitudinal data, follows a sample of people who were aged 20 to 56 in 1994/95 to determine the percentage who made the transition from normal to overweight, or from overweight to obese by 2002/03. Characteristics that increased the chances of overweight people becoming obese are examined. DATA SOURCES: The data are from five cycles of the National Population Health Survey, 1994/95 through 2002/03. ANALYTICAL TECHNIQUES: Cox proportional hazards modelling was used to identify variables associated with an increased or decreased risk of becoming obese; 1,937 ... Read More »
» Published in Health Rep. 2006 Aug;17(3):43-50.
11. Linkage and association between CA repeat polymorphism of the TNFR2 gene and obesity phenotypes in two independent Caucasian populations.
Match Strength: 4.943
Previously, our group has reported a suggestive linkage evidence of 1p36 with body mass index (BMI) (LOD = 2.09). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is an excellent positional and functional candidate gene for obesity. In this study, we have investigated the linkage and association between the TNFR2 gene and obesity phenotypes in two large independent samples, using the quantitative transmission disequilibrium tests (QTDT). The first group was made up of 1,836 individuals from 79 multi-generation pedigrees. The second group was a randomly ascertained set of 636 individuals ... Read More »
» Published in Yi Chuan Xue Bao. 2006 Sep;33(9):775-81.
12. Self-reported prevalence of obesity among 20,329 adults from large territories of Greece, Serbia and Turkey.
Match Strength: 4.899
The aim of this study was to investigate the prevalence of overweight, obesity and body mass index (BMI) distribution in people living in large territories of Greece, Serbia and Turkey. A cross-sectional multi-national epidemiological survey was designed on the basis of self-reported information on height and weight using the formula kg/m(2). Overall, 20,329 individuals, aged 20-68 yrs, 8,973 males and 11,356 females, participated in the study. Of these, 4,032 were selected from northern Greece, 10,069 from southwest Turkey and 6,228 from central Serbia. More specifically, participants from ... Read More »
» Published in Hormones (Athens). 2003 Jan-Mar;2(1):49-54.
13. Overweight and obesity among children and youth.
Match Strength: 4.782
OBJECTIVES: This article describes the prevalence of overweight and obesity among Canadian children and youth aged 2 to 17, based on direct measurements of their height and weight. Data from 1978/79 and 2004 are compared, and trends by sex and age groups are presented. DATA SOURCES: Data based on direct measurements are from the 2004 Canadian Community Health Survey (CCHS): Nutrition. Other information is from the 1978/79 Canada Health Survey and the 1999-2002 National Health and Nutrition Examination Survey, conducted in the US. ANALYTICAL TECHNIQUES: The estimated prevalence of overweight ... Read More »
» Published in Health Rep. 2006 Aug;17(3):27-42.
14. Birth weight and risk of type 2 diabetes, abdominal obesity and hypertension among Chinese adults.
Match Strength: 4.749
OBJECTIVE: To investigate the association between birth weight and risk of type 2 diabetes, abdominal obesity and hypertension among Chinese adults. RESEARCH METHODS AND PROCEDURES: Nine hundred and seventy-three individuals from a population-based cross-sectional survey for the prevalence of type 2 diabetes conducted in Shanghai in 2002 were enrolled and followed up to 2004 with yearly examination. Birth weight was classified into four categories: <2500, 2500-2999, 3000-3499 and >or=3500 g. RESULTS: In this study, there were 373 males and 600 females, with a mean age of 46.2+/-9.9 years ... Read More »
» Published in Eur J Endocrinol. 2006 Oct;155(4):601-7.
15. The obesity epidemic: current and future pharmacological treatments.
Match Strength: 4.717
The unabated rise in the prevalence of obesity is a challenge for global health care systems. Efforts to reverse this trend by dietary or behavioral counseling have not been successful, which has stimulated efforts to find a role for pharmacotherapy. Currently only a small number of antiobesity drugs are approved for long-term use and only a few compounds are in clinical development. Despite recent progress in the understanding of the regulation of energy balance, drug discovery has been less productive than expected. In the present review, the clinically available antiobesity agents are ... Read More »
» Published in Annu Rev Pharmacol Toxicol. 2007;47:565-92.
16. Midlife obesity and long-term risk of nursing home admission.
Match Strength: 4.702
OBJECTIVE: Obesity is a growing problem among middle-aged individuals. We investigated whether obesity in middle-aged individuals influences the need for future nursing home care and whether the risk of nursing home admission associated with obesity is greater in whites than in blacks. RESEARCH METHODS AND PROCEDURES: The study population (N = 8804) consisted of long-term members of the Kaiser Permanente Medical Care Plan ages 75 to 85 years in 1995 who had completed a standardized, multiphasic health checkup while in their 50s. The multiphasic health checkup examinations were performed as ... Read More »
» Published in Obesity (Silver Spring). 2006 Aug;14(8):1472-8.
17. A new approach to assessing the health benefit from obesity interventions in children and adolescents: the assessing cost-effectiveness in obesity project.
Match Strength: 4.668
OBJECTIVE: To report on a new modelling approach developed for the assessing cost-effectiveness in obesity (ACE-Obesity) project and the likely population health benefit and strength of evidence for 13 potential obesity prevention interventions in children and adolescents in Australia. METHODS: We used the best available evidence, including evidence from non-traditional epidemiological study designs, to determine the health benefits as body mass index (BMI) units saved and disability-adjusted life years (DALYs) saved. We developed new methods to model the impact of behaviours on BMI post ... Read More »
» Published in Int J Obes (Lond). 2006 Oct;30(10):1463-75.
18. Oxyntomodulin : a novel potential treatment for obesity.
Match Strength: 4.618
The prevalence of obesity is increasing rapidly and the associated morbidity and mortality has led to an urgent need for potential therapeutic targets to reduce appetite and food intake. Gut hormones released after eating that coordinate digestive activity and promote satiety are novel potential treatments for obesity. Oxyntomodulin is a gut hormone that is produced by the L cells in the small intestine and reduces food intake. It is timely to review some of the original literature on oxyntomodulin, to evaluate what is already known about the peptide, and also to set the recent findings on its ... Read More »
» Published in Treat Endocrinol. 2006;5(5):265-72.
19. Both obesity and lack of physical activity are associated with a less favorable health-related quality of life in Hong Kong Chinese.
Match Strength: 4.598
PURPOSE: To investigate the relationships among obesity, physical activity and quality of life (QOL) in Hong Kong Chinese adults. METHODS: A cross-sectional study involving 876 subjects (32.9% men and 67.1% women, mean age: 34.8 +/- 7.9 years) from a nonmanual working population. The Medical Outcome Study Short Form 36 (SF-36, Chinese version) was used for health-related QOL. Level of physical activity was assessed with self-reported questionnaire. Obesity was defined as body mass index > or = 25 kg/m2. RESULTS: 31% of men and 9% of women were obese (overall 16.0%). Obese subjects had lower ... Read More »
» Published in Am J Health Promot. 2006 Sep-Oct;21(1):49-52.
20. Childhood obesity: strategies for prevention.
Match Strength: 4.534
The incidence of overweight children aged between 6 and 11 years has more than doubled while the incidence for adolescents from age 12 to 19 has tripled between 1980 and 2000. The prevalence is highest among minorities and children belonging to low socioeconomic classes. Because overweight children tend to become obese adults, the future economic burden on the American healthcare system will be significant. This article examines the prevalence of the problem, highlights research and best practice models, and reviews policy trends related to childhood obesity ... Read More »
» Published in Fam Community Health. 2006 Oct-Dec;29(4):288-98.
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