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Peer Reviewed Scientific Research Reports.
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1. Biomimetic synthesis of marine sponge metabolite spiculoic acid A and establishment of the absolute configuration of the natural product.
Match Strength: 5.019
The synthesis of spiculoic acid A (1) using a biomimetic Diels-Alder reaction is described; comparison of the specific rotation of the natural and synthetic material revealed that the enantiomer of the natural product has been synthesized. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Chem Commun (Camb). 2006 Jul 21;(27):2863-5.
2. The application of reproductive technologies to natural populations of red deer.
Match Strength: 4.491
Over the past decade, there has been increasing interest in the application of reproductive technology to the conservation and management of natural populations of deer. The application of assisted reproduction technologies within natural population of deer is in its infancy. However, its future potential is enormous, particularly in relation to genetic management or conservation. This paper reviews the present state of such technologies for a wild subspecies of red deer, the Iberian red deer (Cervus elaphus hispanicus), by discussing the major components of oestrous synchronization, semen ... Read More »
» Published in Reprod Domest Anim. 2006 Oct;41 Suppl 2:93-102.
3. First encounters--deployment of defence-related natural products by plants.
Match Strength: 4.427
Plant-derived natural products have important functions in ecological interactions. In some cases these compounds are deployed to sites of pathogen challenge by vesicle-mediated trafficking. Polar vesicle trafficking of natural products, proteins and other, as yet uncharacterized, cargo is emerging as a common theme in investigations of diverse disease resistance mechanisms in plants. Root-derived natural products can have marked effects on interactions between plants and soilborne organisms, for example by serving as signals for initiation of symbioses with rhizobia and mycorrhizal fungi. ... Read More »
» Published in New Phytol. 2006;172(2):193-207.
4. Natural IgM antibodies: from parias to parvenus.
Match Strength: 4.366
Over the years, natural IgM antibodies were considered as the parias among the immune competent molecules. Their characteristic properties, like low affinity, cross-reactivity and pentameric structure, were assessed as difficult and nebulous. Today, mainly based on the persistent work of a few researchers and the key discoveries on innate immunity, natural IgM antibodies are "back on stage". Their important role in the immune response against invasive particles, modified self-components and altered cells is accepted. All the so far negatively judged features have to be seen in a different ... Read More »
» Published in Histol Histopathol. 2006 Dec;21(12):1355-66.
5. Using DNA microarrays to study natural variation.
Match Strength: 4.365
The emerging field of genomics examines the relationship between genetic and phenotypic variation by describing and analyzing patterns of natural variation on a genome-wide scale. In this endeavor, an important tool is the use of microarrays, which enable simultaneous screening of thousands of assays. Microarrays were originally designed for the detection of differences between samples and are thus ideally suited to high-throughput studies of natural variation. Novel microarray platforms enable the high throughput survey of variation at multiple levels, including DNA sequences, gene expression ... Read More »
» Published in Curr Opin Genet Dev. 2006 Dec;16(6):553-8. Epub 2006 Sep 27.
6. Luteal hormonal profile of oocyte donors stimulated with a GnRH antagonist compared with natural cycles.
Match Strength: 4.243
The effect of gonadotrophin-releasing hormone (GnRH) antagonist treatment on luteal phase hormonal profile has not yet been fully investigated. Cycle characteristics of 23 fertile donors stimulated with recombinant FSH and the GnRH antagonist, ganirelix 0.25, for IVF and receiving no kind of luteal supplementation were compared with control, natural cycles. Luteal luteinizing hormone (LH) serum concentrations as well area under the curve (AUC) for LH were significantly higher in natural cycles. In addition, luteal phase length was longer in natural cycles compared with donor cycles. ... Read More »
» Published in Reprod Biomed Online. 2006 Sep;13(3):326-30.
7. Knowledge, attitude and practice of natural family planning methods in a population with poor utilisation of modern contraceptives.
Match Strength: 4.014
Sub-Saharan Africa has one of the highest fertility rates in the world, which is further promoted by the low utilisation of modern contraceptive methods. Yet, many communities claim to have traditional methods of family planning that pre-date the introduction of modern contraceptives, implying that contraception is a culturally acceptable norm. It was therefore postulated that the study population would have a high level of awareness and practice of natural methods of family planning. We aimed to obtain an insight into the extent and correctness of knowledge about natural family planning ... Read More »
» Published in J Obstet Gynaecol. 2006 Aug;26(6):555-60.
8. Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury.
Match Strength: 3.831
Reperfusion of ischemic tissues elicits an acute inflammatory response involving serum complement, which is activated by circulating natural IgM specific to self-Ags exposed by ischemia. Recent reports demonstrating a role for the lectin pathway raise a question regarding the initial events in complement activation. To dissect the individual roles of natural IgM and lectin in activation of complement, mice bearing genetic deficiency in early complement, IgM, or mannan-binding lectin were characterized in a mesenteric model of ischemia reperfusion injury. The results reveal that IgM binds ... Read More »
» Published in J Immunol. 2006 Oct 1;177(7):4727-34.
9. Natural selection on Erysimum mediohispanicum flower shape: insights into the evolution of zygomorphy.
Match Strength: 3.665
Paleontological and phylogenetic studies have shown that floral zygomorphy (bilateral symmetry) has evolved independently in several plant groups from actinomorphic (radially symmetric) ancestors as a consequence of strong selection exerted by specialized pollinators. Most studies focused on unraveling the developmental genetics of flower symmetry, but little is known about the adaptive significance of intraspecific flower shape variation under natural conditions. We provide the first evidence for natural selection favoring zygomorphy in a wild population of Erysimum mediohispanicum ... Read More »
» Published in Am Nat. 2006 Oct;168(4):531-45. Epub 2006 Aug 29.
10. Natural killer cells: from bench to cancer therapy.
Match Strength: 3.631
Natural killer (NK) cells are effectors of the innate immune system that play an important role in host response against viruses and tumour cells through the production of cytokines and direct cytolytic activity. There has been limited success reported from clinical trials in cancer patients treated with activated NK cells. Over the last decade, a better understanding of the biology of NK cells, NK cell receptors and the role of interleukin-15 has led to the development of new strategies using NK cells as immunotherapy for cancer treatment in the transplant and non-transplant settings. ... Read More »
» Published in Expert Opin Biol Ther. 2006 Oct;6(10):967-70.
11. Man-caused uranium contamination of biosphere objects in the territory of Kyrgyzstan.
Match Strength: 3.572
The paper presents data on uranium content in water, soils and plants in the territories of the largest uranium geochemical provinces of Kyrgyzstan where uranium mining and production complexes functioned and operated until the 1960s. The migration of uranium and its contamination of the biosphere are discussed. The paper provides recommendations on using natural phytomeliorants that would discriminate uranium, fix the ground, reduce the risk of mudflows formation and the degree of uranium contamination of the territory, and also facilitate the recovery of the disturbed natural mountainous ... Read More »
» Published in J Environ Sci Health A Tox Hazard Subst Environ Eng. 2006;41(11):2665-82.
12. Soluble Mn(III) in suboxic zones.
Match Strength: 3.438
Soluble manganese(III) [Mn(III)] has been thought to disproportionate to soluble Mn(II) and particulate Mn(IV)O2 in natural waters, although it persists as complexes in laboratory solutions. We report that, in the Black Sea, soluble Mn(III) concentrations were as high as 5 micromolar and constituted up to 100% of the total dissolved Mn pool. Depth profiles indicated that soluble Mn(III) was produced at the top of the suboxic zone by Mn(II) oxidation and at the bottom of the suboxic zone by Mn(IV)O2 reduction, then stabilized in each case by unknown natural ligands. We also found micromolar ... Read More »
» Published in Science. 2006 Sep 29;313(5795):1955-7. Comment in: Science. 2006 Sep 29;313(5795):1896-7.
13. Artificial insemination increases the probability of a male calf in dairy and beef cattle.
Match Strength: 3.322
The objective of this study was to determine if natural mating affected secondary sex ratio. Data consisting of 642,401 calving records from the Irish national database, during the years 2002-2005, were used in the analysis. Factors affecting the logit of the probability of a male calf being born were determined using multiple regression generalised estimating equations with sire of the calf included as a repeated effect. Month of the year at calving, sex of the previous calf born within dam, breed of service sire, parity of dam and type of mating (i.e., natural or artificial insemination) ... Read More »
» Published in Theriogenology. 2007 Jan 15;67(2):346-52. Epub 2006 Sep 18.
14. NK and NKT cells in the rat dental pulp tissues.
Match Strength: 3.301
OBJECTIVE: The objective of this study was to elucidate the presence of natural killer (NK) and natural killer T (NKT) cells in rat dental pulp. STUDY DESIGN: Male Wistar rats (n = 10) were used. The presence of NK and NKT cells in the coronal and root pulps of the lower first molars was detected immunohistochemically. RESULTS: Infiltration of NK and NKT cells into the normal pulp was observed, and most of these cells were located in the coronal pulp rather than in the root pulp. The population of NKT cells in the pulp was only small compared to the population of NK cells. CONCLUSION: NK and ... Read More »
» Published in Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Oct;102(4):558-63. Epub 2006 Jun 27.
15. A novel modelling approach for evaluating the preindustrial natural carrying capacity of human population in Iceland.
Match Strength: 3.287
The pre-industrial natural carrying capacity is believed to have limited the human population in Iceland to a maximum of fifty to sixty thousand inhabitants. Since AD 1800 the Icelandic population has gradually grown up to nearly 300 thousand in 2005. In this paper a simple approach is used to evaluate the potential population size that the pre-industrial Icelandic environment could possibly sustain. A dynamic model was constructed that simulates the population size according to potential biological production available for livestock. Biological production was determined by the extent of the ... Read More »
» Published in Sci Total Environ. 2006 Dec 15;372(1):109-19. Epub 2006 Sep 18.
16. Chewing the fat on natural killer T cell development.
Match Strength: 3.267
Natural killer T cells (NKT cells) are selected in the thymus by self-glycolipid antigens presented by CD1d molecules. It is currently thought that one specific component of the lysosomal processing pathway, which leads to the production of isoglobotrihexosylceramide (iGb3), is essential for normal NKT cell development. New evidence now shows that NKT cell development can be disrupted by a diverse range of mutations that interfere with different elements of the lysosomal processing and degradation of glycolipids. This suggests that lysosomal storage diseases (LSDs) in general, rather than one ... Read More »
» Published in J Exp Med. 2006 Oct 2;203(10):2229-32. Epub 2006 Sep 25. Comment on: J Exp Med. 2006 Oct 2;203(10):2293-303.
17. Comparison of mice born after intracytoplasmic sperm injection with in vitro fertilization and natural mating.
Match Strength: 3.243
The procedures of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are routinely used in modern medicine to overcome infertility and, in animal husbandry, to propagate lines with compromised fertility. However, there remains concern that manual selection and injection of whole sperm into oocytes could contribute to pre- and postnatal developmental defects. To address this, we have used gene expression profiling and immunophenotyping to characterize offspring generated by these procedures. We used gametes from glutathione peroxidase 1 knockout (Gpx1-/-) mice as a ... Read More »
» Published in Mol Reprod Dev. 2007 Apr;74(4):512-9.
18. Serum antibody decay in adults following natural respiratory syncytial virus infection.
Match Strength: 3.216
Serum antibody decay following RSV infection in adults was examined to evaluate the durability of the immune response. Twenty subjects with RSV infection and 10 subjects who remained RSV uninfected had blood samples obtained over 16-25 months analyzed by microneutralization assay and enzyme immunoassay. The mean titers of infected subjects rose approximately eightfold post-infection. The mean rate of antibody decline was -0.20 log 2 titer per month which led to a > or =fourfold drop in titer in 75% of subjects at 1 year. In contrast, titers of uninfected subjects were relatively stable. The ... Read More »
» Published in J Med Virol. 2006 Nov;78(11):1493-7.
19. Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue.
Match Strength: 3.203
The 3D structure of a complex formed by the acidic fibroblast growth factor (FGF-1) and a specifically designed synthetic heparin hexasaccharide has been determined by NMR spectroscopy. This hexasaccharide can substitute natural heparins in FGF-1 mitogenesis assays, in spite of not inducing any apparent dimerization of the growth factor. The use of this well defined synthetic heparin analogue has allowed us to perform a detailed NMR structural analysis of the heparin-FGF interaction, overcoming the limitations of NMR to deal with the high molecular mass and heterogeneity of the FGF-1 oligomers ... Read More »
» Published in FEBS J. 2006 Oct;273(20):4716-27. Epub 2006 Sep 21.
20. Reciprocal regulation between natural killer cells and autoreactive T cells.
Match Strength: 3.148
The initiation and the progression of autoimmune diseases stem from complex interactions that involve cells of both the innate and the adaptive immune system. As we discuss here, natural killer (NK) cells, which are components of the innate immune system, can inhibit or promote the activation of autoreactive T cells during the initiation of autoimmunity. After they have been activated, autoreactive T cells contribute to the homeostatic contraction of NK-cell populations. The dynamic interaction between NK cells and autoreactive T cells might indicate the transition from the innate immune ... Read More »
» Published in Nat Rev Immunol. 2006 Oct;6(10):751-60.
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