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More Diet Supplements Recommended by Level1diet.com

<< Read Our List of the Most Important Supplements



An explanded list of recommended diet supplements by Level1diet.com. These nutritional aids can help reduce inflammation, lose weight, reverse insulin resistance, and improve symptoms of major degenerative diseases.


1. Pharmaceutical Grade Fish Oil: How Much? -- Research supports taking about 2-1/2 grams (2,500mg) of total EPA and DHA every day. To calculate how may capsules that takes, simply add the mg of EPA to the DHA shown on the label of your fish oil bottle, per capsule. Inexpensive fish oils like the Natrol or Nature's Way brands usually contain about 180mg EPA and 120mg DHA, totaling 300mg. You would need about 9 of those capsules to get at least 2,500mg daily of total EPA/DHA. Higher quality fish oils like Dr Sears' or Carlson Labs' brands may require only 4 or 5 capsules per day, but they are more expensive. Read the label of the fish oil you buy to see how many to take.

TIP: When taking large amounts of Fish Oil with several grams of EPA/DHA, you are advised to also take Borage Oil at the same time. This is due to the fish oil reducing the amount of DGLA being generated. This is probably due to the EPA competing with GLA for utilization of the involved enzymes. Taking Borage Oil simultaneously each time you take Fish Oil will compensate for this problem. 25

WARNING: It is absolutely essential that you avoid eating omega-6 poly-unsaturated vegetable oils such as corn oil, peanut oil, safflower oil, soybean oil, and most other frying, cooking and salad oils, used in fried or processed foods, and most common salad dressings. Merely adding fish oil to your diet will not help you, unless you simultaneously cut out the omega-6 oils almost entirely. Omega-6 poly-unsaturated vegetable oils compete with omega-3 fish or flax oils for digestive enzymes. Furthermore, high levels of omega-6 oils block conversion of EPA into anti-inflammatory prostaglandin series-3. Additionally, omega-6 oils accelerate the "burning" or storage of EPA into body fat deposits as triglycerides. Try to replace omega-6 oils with omega-3 oils, to get the ratio of 6 to 3 oils to be equal in your diet -- 1:1 or at worst 2:1. Today's average American eats about 20 or 30 times as much omega-6 as omega-3. This results in a chronic level of excessive prostaglandin series-2, and therefore chronic sub-clinical inflammation. 34 Fish Oil Health Benefits -- Fish Oil contains high amounts of two essential nutrients the body does not make very well for itself, EPA and DHA. These are extremely important, because they are converted into series-3 prostaglandins - PGE3. These PGE3's are powerful anti-inflammatory agents in your body. If these are not working for you, you develop chronic or persistent inflammation, which leads to major diseases. Chronic, low-level inflammation may progress into obesity, heart disease, cancer, diabetes and many other diseases. Some young or very healthy people, could possibly make EPA and DHA, if they ate enough Omega-3 oils from some plants such as Flax Seed, Perilla, Walnuts, and a few others. Of course, most people do not eat enough of those oils. But there is another problem... University of Iowa Scientists(1) have recently discovered that a needed digestive enzyme to convert Omega-3 vegetable oils into EPA/DHA may be deficient in some people. This genetic enzyme deficiency is now known to be due to an inherited poorly functioning gene that controls the body's ability to make the vital delta-6 desaturase - D6D digestive enzyme.(1,2,3) So some people don't make enough D6D. And, for many if not most other Americans, the functionality of their existing D6D is chemically blocked by their diet or lifestyle factors; alcohol, smoking, pollution, exposure to chemicals, high fats in the diet, existing high levels of insulin, high chronic inflammation levels, and so on. This means most Americans may not be able to make enough EPA and DHA to maintain health, even if they ate the right vegetable oils (which they don't do anyway). The easy way to fix this problem is to change your diet, improve your lifestyle, and take fish oil supplements that already contain the EPA you need without requiring you to have lots of working D6D. When people add fish oil into a good diet, amazing things happen: They lose weight, lower their triglycerides, improve risks for cancers, heart disease and diabetes. Taking the proper amount of high quality fish oil every day may be the most important single thing you can do to improve your health.

Click to See Studies
From Peer Reviewed Scientific Journals
Supplements Proven to Increase Series-1 & 3 Anti-Inflammation Prostaglandins
weight loss diet supplements
weight loss diet supplementsFish Oil, EPA 24-25,34-35
weight loss diet supplementsBorage Oil, GLA 26-33
weight loss diet supplementsSesame Seed Lignans 41
weight loss diet supplements
Supplements Proven to Block Pro-Inflammation Cytokines
weight loss diet supplements
weight loss diet supplementsGreen Tea 4-9
weight loss diet supplementsMagnesium 10-12
weight loss diet supplementsN-Acetyl-Cysteine 36-38
weight loss diet supplementsNettle Leaf Extract 39-40
weight loss diet supplementsVitamins K1, K2 42
weight loss diet supplementsBromelain, Pineapple 13
weight loss diet supplementsPomegranate Extract 14
weight loss diet supplementsSAMe 15
weight loss diet supplementsBrown Tea 16
weight loss diet supplementsPapaya Seed Extract 17
weight loss diet supplementsMilk Thistle 18
weight loss diet supplementsIndian Celery Seed 19
weight loss diet supplementsGreen-Lipped Mussel 20
weight loss diet supplementsTurmeric, Curcumin 21
weight loss diet supplementsGolden Seal 22
weight loss diet supplementsAspirin 23
weight loss diet supplementsAcetaminophen 23


2. GLA Gamma Linolenic Acid (from Borage Oil), with Sesame Seed Lignans -- The main active ingredient is GLA or Gamma Linolenic Acid. This is an Omega-6 oil that acts like an Omega-3 oil in many beneficial ways. In perfectly healthy people, the body converts some Omega-6 oils into GLA using the D6D enzyme discussed above under Fish Oil, then into DGLA and from there into PGE1 series-1 prostaglandins. Like the PGE3's from EPA in Fish Oil, these new PGE1's fight inflammation in your body. So, we want lots of PGE1, which means we need to get D6D to work for us, or we need to take GLA Borage Oil, which already has GLA without needing D6D. The plants will make our GLA for us if we take Borage Oil or another source of GLA. Like with Fish Oil above, if we take the needed nutrient we want, we don't have to worry so much about D6D delta-6 desaturase not working for us. GLA also requires a few more nutrients to be converted into PGE1, but those are more common in most people. We won't worry about them here. Sources: The best sources of GLA are Borage Oil, Black Currant Oil and Evening Primrose Oil. Borage Oil contains just a bit more GLA than does Black Currant Oil, and almost 2-1/2 times as much GLA as Evening Primrose Oil. How Much to Take? Take at least 2 large 1,200mg capsules of Borage Oil per day, one in the morning and evening. Ensure that each capsule contains at least 245mg of the GLA active ingredient. A small amount of Vitamin-E should also be listed on the label to prevent possible oxidation of the vital fatty acid ingredients during storage. Very sick, obese or people with high levels of C-Reactive Protein should consider taking up to double the regular daily dose of GLA.

3. Green Tea Drinks, and Green Tea Extracts -- Green teas contain extremely powerful phyto-nutrients that have been profoundly researched around the world for many years. This herb may be the most important single herbal supplement that you can add to your daily regimen. Green tea moderates blood glucose, and improves blood lipids and cholesterol significantly. Green tea suppresses inflammatory cytokines that are active in stimulating the growth of cancerous tumors. It also enables the return to normal rates of programmed cell death or turnover, so that cancerous growths can die normally instead of out-living YOU. Green tea is very helpful in reducing the growth of inflammation of the heart and circulatory system, so that the building of arterial plaques slow down. It is helpful in prevention of thrombosis, renal failure, influenza management, cirrhosis management, and in the detoxification of the liver after exposure to chemicals or radiation. Green tea should be taken throughout the day for maximum protective benefit. How Much per Day? Consider drinking 6 to 8 cups of fresh green tea. Use caffeine free types if you have heart disease or high blood pressure. If you want even more Green Tea benefits, you may wish to add 2 or 3 more concentrated and standardized Green Tea Extract capsules in your morning and evening supplementation program.

4. Magnesium -- Magnesium has been shown to be deficient by many studies. Some report that as many as 80% of modern Americans are lacking optimum levels of magnesium to maintain excellent health. This deficiency is associated with many inflammatory and insulin resistant conditions and major diseases. (4) They include diabetes, heart disease, hypertension, migraine and cluster headaches, and many more. Magnesium is especially important for glucose metabolism. More Information

For decades, scientists have searched for the hidden link between diabetes mellitus, heart disease, high blood pressure, high cholesterol and high blood clotting factors (high fibrinogen). Many researchers now believe that magnesium plays a central role in uniting many of these associated insulin resistant diseases. Supplements of magnesium are recommended for diabetics, hypertensives, and similar people who have metabolic syndrome x.

WEIGHT LOSS DIETERS AND MAGNESIUM
If you are already deficient in magnesium (like most over weight people are according to research), and then go on a calorie restricted diet, you are very likely to become even more deficient in magnesium, which can make your insulin resistance much worse, which will increase your glucose and average insulin levels throughout the day. These processes further reduce your ability to maintain magnesium in your tissues, and further reduce your ability to use it to process glucose and insulin -- a chain-reaction of reduced magnesium functionality, lower metabolism and lower resting energy expenditure. This will make it very, very difficult to lose weight. Dieters are strongly recommended to consider supplementing with magnesium. (5)

How Much Magnesium Should You Take per Day? Our review of the research supports suggested supplementation of magnesium, totaling about 400mg in divided doses, 200mg morning and 200mg evening. This supplementary dose should be taken in addition to eating high magnesium foods, such as more vegetables, whole grains, legumes, and nuts. Bigger people, people who perform stressful exercise more than average, or people who are supplementing calcium for bone loss, or diabetics and other people with high levels of inflammation, should consider a larger 600mg daily dose - 300mg in the morning and 300mg in the evening.

Safety Issues -- Taking the recommended supplements above should not be a problem for most people. Very high levels of magnesium can cause diarrhea(6) and general gastrointestinal distress, as well as interfere with calcium absorption and bone metabolism. Since research reports no advantages to higher doses of magnesium than the 600mg daily dose, you should not take more than this, unless specifically instructed by a health care professional. Medical experts suggest that people with kidney disease should not take supplemental magnesium. As always, we suggest you inform your doctor or health professional before adding any supplement to your diet. You may want to print this page to take to your medical professional, in case they are not familiar with current research on magnesium.





5. Soluble and Insoluble Fiber -- Fiber is powerfully associated with reductions in total cholesterol, since it is the only was your body has of disposing of cholesterol once it has been created. One of the most enjoyable ways to eat more fiber is to eat 2 apples or pears per day. They combine fiber with many other nutrients and taste great! Other good types of fiber to supplement include: Flax Seed Meal, Rice Bran, Orange Pulp and Peel, Grapefruit Pectin, Lemon Peel, Milk Thistle, Psylium Seed, Acacia, Oat Bran, Wheat Bran, and other seed and bran type fibers. How Much per Day? Research supports increasing your total intake of fiber to between 25 and 30 grams per day from all sources. You should take your fiber with the highest fatty meal of the day, but not with fish oil, borage oil GLA, or CLA (see below). You should take those supplements at least an hour before taking fiber.

6. CLA - Conjugated Linoleic Acid with Guarana and Sesame Seed Lignans -- When taken properly without other foods, CLA has been found to block the addition of new fats into existing adipose cells. Recent research has shown that people who took supplements of CLA were able to decrease the total fat or adipose tissue mass significantly (size of cells). However, when these people also supplemented with Guarana at the same time, the total number of fat cells actually decreased by up to 50%. This is an amazing result, and well worthy of your investment in adding a few extra pills to your daily regimen. How Much to Take per Day? Studied results were achieved with only 4-5 grams or capsules of the CLA with Guarana per day. Sesame Seed Lignans have been shown to help prevent the oxidation of CLA, whereas they simultaneously encourage oxidation or burning of fats in the liver. Sesame Lignans further enhance the effect of taking CLA and Guarana. NOTE: It is essential that CLA should be taken at mid-morning, on an empty stomach. If taken when there is food in the stomach, your digestive enzymes may break down the CLA into its basic parts before it can reach the intestines where it does its work. Look for a product with all 3 ingredients, or buy them separately and take them at the same time.



Take at least 200mg Natural Vitamin-E GAMMA Tocopherol per day. The gamma version of Vitamin-E has been shown to be at least twice as effective as the alpha type in fighting platelet aggregation, blood clots, and plaques. We recommend the highly purified, high quality natural Gamma E Tocopherol with Sesame Lignans made by the Life Extension Foundation. Take the D-Tocopherol Gamma Vitamin-E, not the DL- type. The D- type is more easily assimilated by the body. The primary purpose of supplementing with vitamin E is to suppress damaging free radicals. Scientific studies have identified the gamma-tocopherol form of vitamin E as being critical to human health.* Research shows that sesame lignans increase gamma-tocopherol levels in the body while reducing free radical damage.126 In response to these findings, Life Extension has reformulated the popular Gamma E Tocopherol supplement to replace tocotrienols with sesame lignans. The LEF Gamma Vit-E Tocopherol formula provides more gamma-tocopherol than the previous version, and it is fortified with standardized sesame lignans to augment the antioxidant effects of gamma-tocopherol.*

Scientific Research Supporting Vitamin-E Gamma Tocopherol Supplementation -- (1) Read over 660 scientific studies reported at Pubmed.org (the web page of the National Library of Medicine, National Institutes of Health, NIH) reporting research involving Gamma Tocopherol Vitamin-E. (2) Read over 110 scientific studies at Pubmed.org about Gamma Tocopherol Vitamin-E and Cancer. (3) Read over 15 scientific studies at Pubmed.org about Gamma Tocopherol Vitamin-E and Diabetes. (4) Read over 50 scientific reports at Pubmed.org about Gamma Tocopherol Vitamin-E and Cardiovascular Disease. (5) Read how Gamma vs. Alpha Vitamin-E reduces the body's tendency for blood clotting and circulatory blockages due to platelet aggregation or "stickiness" of particles in the blood, at "Differential effects of {alpha}- and {gamma}-tocopherol on low-density lipoprotein oxidation, super-oxide activity, platelet aggregation and arterial thrombogenesis", The Journal of the American College of Cardiology, 1999, Vol. 34, No. 4. (6) Vitamin-E (studied at a dose of 600mg per day) also improves your body's ability to handle starches and sugars, especially if you have high blood pressure or hypertension - read this important research at "Effects of Vitamin E and Glutathione on Glucose Metabolism - Role of Magnesium", Hypertension, Journal of the American Heart Association, 1999, Vol. 34;1002-1006.

Take at least 800mg of Vitamin-E ALPHA Tocopherol per day. We recommend the high quality, and very low priced Nature Made Natural Vitamin E d-Alpha, 400 IU (100 Softgels), shown to the right. Natural Vitamin E is recommended as part of a daily regimen for heart health, women's and men's health, longevity, prenatal care, memory, and fitness. Vitamin E is an antioxidant that fights against damaging natural substances known as free radicals. It is incorporated into the fat-based tissues of the body, such as the heart, fat-carrier molecules like LDL ("bad" cholesterol), and our cell membranes, where it acts to stabilize these structures and protect them from free radical attack. Vitamin E also protects our cells from compounds such as lead, mercury, and other heavy metals. Vitamin E complements vitamin C in its function; therefore, it's recommended to take the two vitamins together. There are several natural compounds, called tocopherols, that demonstrate vitamin E activity, but the natural form of vitamin E (d-Alpha Tocopherol) is the most common and potent form, and is best absorbed by the body. This natural vitamin E is the most active compound in terms of antioxidant activity. The alpha version of Vitamin-E also reduces the effects of atherosclerosis and blood clotting. Take the D-Tocopherol Alpha Vitamin-E, not the DL- type. The D- type is more easily assimilated by the body.*

Scientific Research Supporting Vitamin-E Alpha Tocopherol Supplementation -- (1) Long term supplementation of the diet with Alpha Tocopherol Vitamin-E has been shown to be associated with decreased risk of bladder cancer (the fourth most common cancer) in men and women: American Journal of Epidemiology, "Vitamin C and Vitamin E Supplement Use and Bladder Cancer Mortality in a Large Cohort of US Men and Women", 2002, Volume 156, Number 11, Pages 1002-1010. The study was reported by Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA. That important study followed the health of 991,522 US adults for 16 years in the Cancer Prevention Study II (CPS-II), from 1982 to 1998. (2) Vitamin-E has also been shown to reduce the risk of Coronary Heart Disease, and taking higher daily doses tends to reduce the risk more: "Vitamin E Consumption and the Risk of Coronary Heart Disease in Men", The New England Journal of Medicine, Volume 328:1450-1456, May 20, 1993, Number 20. This scientific study followed 39,910 U.S. male health professionals 40 to 75 years of age for four years. Vitamin-E supplementation was associated with a lower risk for heart disease in current smokers and non-smokers and never-smoked participants alike, while Beta-Carotene (the natural Vitamin-A precursor supplement) was associated with a lower risk of heart disease only in smokers and previous smokers. (3) For yet another detailed discussion of the relative value of the two main kinds of Vitamin-E, Gamma vs. Alpha D-Tocopherol, see the report above from The Journal of The American College of Cardiology, 1999.

Take at least 300mg per day of Alpha lipoic Acid (ALA). Even higher doses of up to 1.5 grams (1,500mg) per day or more have been used by many physicians to treat active Type-2 Diabetes and Cardiovascular Disease in their patients. The combination of Vitamin-E and Alpha lipoic Acid has been shown to significantly improve heart performance and reduce lipid oxidation when added to diets. Alpha Lipoic Acid (ALA) is a powerful antioxidant that helps protect the body from oxidative damage related to aging and exercise. ALA is capable of regenerating several other antioxidants to their active states, including vitamin C, vitamin E, glutathione, and coenzyme Q-10. ALA also has several potential benefits for people with diabetes. It enhances glucose uptake in type 2 (non-insulin-dependent) diabetes, inhibits glycosylation (the abnormal attachment of sugar to protein), and has been used to improve diabetic nerve damage and reduce associated pain. Most studies have used intravenous alpha lipoic acid, but oral supplementation has nonetheless proved partially helpful in treating at least one form of diabetic neuropathy (using 800 mg per day). Preliminary evidence also indicates that 150 mg of alpha lipoic acid, taken daily for one month, improves visual function in people with glaucoma. The Natrol product linked to the right uses no yeast, wheat, corn, milk, egg, soy, glutens, artificial colors or flavors, added sugar, starch, or preservatives.

Scientific Research Supporting Alpha Lipoic Acid Supplementation -- (1) Read over 220 scientific studies reported at Pubmed.org (the web page of the National Library of Medicine, National Institutes of Health, NIH) reporting research about Alpha Lipoic Acid and Diabetes. (2) If you have Diabetes, you should consider taking Alpha Lipoic Acid to prevent, control and possibly reverse diabetic neuropathy in your feet and hands* - a condition that is the number one cause of amputation in the U.S. Read over 90 scientific studies reported at Pubmed.org reporting research about Alpha Lipoic Acid and Diabetic Neuropathy. (3) Read how Alpha lipoic Acid works with Vitamin-E in this scientific article "Improved cardiac performance after ischemia in aged rats supplemented with vitamin E and alpha -lipoic acid", American Journal of Physiology: Regulatory and Integrative and Comparative Physiology (The American Physiological Society), 2000, 279:R2149-R2155. (4) Read over 130 scientific studies reported at Pubmed.org about Alpha Lipoic Acid and Vitamin-E, working together. (5) Read over 110 scientific studies reported at Pubmed.org about Alpha Lipoic Acid and Vitamin-C, working together.

Take at least 3 grams a day of Borage Oil (our recommended choice) or Evening Primrose Oil. Borage Oil (usually about 24% GLA) contains more than twice as much GLA per capsule as Evening Primrose Oil (usually about 10% GLA). And, when you take Borage Oil, you end up taking less Omega-6 (lenoleic acid) vegetable oils, since that is the remainder of the oil contained in each of the supplements. These are excellent sources of Gamma Lenolenic Acid (GLA). GLA is the immediate precursor to your body's production of Prostaglandin Series 1, which is vital to the body's ability to handle blood lipids, cholesterol and triglycerides. We recommend Borage Oil, but many studies have also supported somewhat larger daily doses of Evening Primrose Oil. Evening Primrose Oil is more common, but Borage Oil is a better GLA source due to the amount per capsule. In many individuals, the needed enzyme Delta-6 Desaturase (D6D) is missing completely due to genetic factors, or significantly less available. In other people, dietary and environmental factors such as high alcohol use, trans-fatty acids from margarines and other foods, animal fats from red meats, milk, cancer, certain infections such as tuberculosis, and so on can reduce the utilization of D6D. If you don't have enough D6D enzyme, you can't ever get enough GLA, and therefore the Omega-6 fats you eat become Arachidonic Acid (AA) instead of GLA. This advances metabolic disease and insulin resistance. As a result, the Lenoleic Omega-6 fats you eat cannot be converted into the "good" prostaglandins that fight inflammation and control cholesterol and obesity. You get obese, develop high blood pressure, high LDL-C cholesterol, high triglycerides, low HDL-C, etc. Some scientists have suggest that a D6D deficiency due to genetic or dietary factors is the cause of most metabolic disease, including diabetes and other insulin resistant diseases. As a result, they recommend supplementation of the diet with direct sources of GLA that do not need D6D for conversion. GLA from Borage Oil or Evening Primrose oil enables the body to produce Prostaglandin series 1, which can help reverse existing or developing metabolic diseases related to insulin resistance.*

Scientific Research Supporting Gamma Lenolenic Acid (GLA) Supplementation -- (1) For a discussion of GLA supplementation and its role in helping control or improve metabolic, insulin resistant or inflammatory disease read this PDF report written by Jur Plesmon in the Hypoglycemic Health Association Newsletter, September, 1996. (2) Read over 45 scientific studies reported at Pubmed.org (the web page of the National Library of Medicine, National Institutes of Health, NIH) reporting research about Gamma Linolenic Acid (GLA) and Inflammation. (3) Read over 200 scientific studies reported at Pubmed.org about Gamma Linolenic Acid (GLA) and Cancer. (4) Read over 60 scientific studies reported at Pubmed.org about Gamma Linolenic Acid (GLA) and Cardiovascular Heart Disease. (5) Read over 90 scientific studies reported at Pubmed.org about Gamma Linolenic Acid (GLA) and Diabetes.

Take at least 500mg per day of Ester Vitamin-C. We recommend Natrol Ester-C with Bioflavonoids, 500 mg (225 Tablets), at only $14.99 per 225 count bottle, shown to the right. Ester-C is a unique form of vitamin C containing naturally occurring metabolites. Its patented manufacturing process neutralizes the pH, making Ester-C gentler on the digestive system than normal vitamin C. Vitamin C's major role is to produce collagen, a protein substance that holds connective tissues together in skin, bone, teeth, and other parts of the body. Vitamin C is also critical for the proper function of the immune system, for manufacturing certain nerve-transmitting substances and hormones, and for the absorption and utilization of other nutrients, such as vitamin E and iron. Vitamin C is also a very important and powerful antioxidant that works in the aqueous (water) environments of the body, such as the lungs and lens of the eye. Its primary antioxidant partners are vitamin E and the carotenes, though it also works with the antioxidant enzymes. Vitamin C regenerates oxidized vitamin E, and restores the antioxidant potential of vitamin E in the body. The Natrol Ester-C product also contains bioflavonoids, with often occur naturally whenever Vitamin-C is encountered in dietary fresh fruits and vegetables. Scientists suggest that bioflavinoids may help Vit-C do its work in the body, or they may perform other important anti-oxidant work in the fight against free radicals. The Natrol Vit-C product linked to the right contains no yeast, wheat, corn, milk, egg, soy, glutens, artificial colors or flavors, or added sugar, starch, or preservatives. Up to 3 grams per day or more is commonly recommended by physicians to fight cardiovascular disease. Vitamins C and E work together to reduce blood platelet aggregation and blood clotting, and in the reduction of oxidized LDL cholesterol, which is associated with improved cardiac and circulatory health.*

Scientific Research Supporting Vitamin-C Supplementation -- There is overwhelming support in the scientific literature that supports supplementation of the diet with Vitamin-C, with some cautions and limitations, as with any dietary advice.* (1) Read over 2,600 scientific studies reported at Pubmed.org (the web page of the National Library of Medicine, National Institutes of Health, NIH) reporting research involving Vitamin-C and Cancer. (2) Read over 2,400 scientific studies reported at Pubmed.org reporting research on Vitamin-C and Cardiovascular Heart Disease. (3) Read over 180 scientific studies reported at Pubmed.org reporting research on Vitamin-C and Hypercholesterolemia (High Cholesterol). (4) Read over 400 scientific studies reported at Pubmed.org reporting research on Vitamin-C and Atherosclerosis. (5) Read over 310 scientific studies reported at Pubmed.org reporting research on Vitamin-C and Hypertension (High Blood Pressure). (6) Read over 710 scientific studies reported at Pubmed.org reporting research on Vitamin-C and Diabetes. (7) Read over 140 scientific studies reported at Pubmed.org reporting research on Vitamin-C and Stroke. (8) Read over 350 scientific studies reported at Pubmed.org reporting research on Vitamin-C and Inflammation. (9) Read how Vitamins C and E work to improve your blood circulation in this report at "Vitamins C and E Prolong Time to Arterial Thrombosis in Rats", Journal of Nutrition, 129: 109-112, 1999. (10) Then read a helpful report about anti-oxidants and aging at "Oxidants, antioxidants, and the degenerative diseases of aging", Proceedings of the National Academy of Sciences, 1993, Vol 90, 7915-7922.



<< Read Our List of the Most Important Supplements



References
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  2. "Identification of a fatty acid {Delta}6-desaturase deficiency in human skin fibroblasts", Journal of Lipid Research, Vol. 42, 501-508, April, 2001.
  3. "Suspected faulty essential fatty acid metabolism in Sjogren-Larsson syndrome", Pediatric Research, Vol 16, 45-49, 1982.
  4. "Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver", Biomedical Research (Tokyo, Japan) 2005 Oct;26(5):187-92.
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  13. "Bromelain (pineapple extract) as a Treatment for Osteoarthritis: a Review of Clinical Studies", Evidence Based Complementary and Alternative Medicine, 2004 December; 1(3): 251-257.
  14. "Punica granatum L. (pomegranate fruit) extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro", The Journal of Nutrition, 2005 Sep;135(9):2096-102.
  15. "S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial", BMC Musculoskeletal Disorders, February 26, 2004; 5: 6.
  16. "Tannic Acid Is an Inhibitor of CXCL12 (SDF-1{alpha})/CXCR4 with Antiangiogenic Activity", Clinical Cancer Research Vol. 9, 3115-3123, August 2003.
  17. "Possible immunomodulatory actions of Carica papaya seed extract", Clinical Hemorheology and Microcirculation 2003;29(3-4):219-29.
  18. "Silymarin (milk thistle extract) and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (Review)", International Journal of Oncology, 2005 Jan;26(1):169-76.
  19. "Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products" (Indian Celery Seed & New Zealand Green-Lipped Mussel), Inflammopharmacology. 2003;11(4):453-64.
  20. "Systematic review of a marine nutriceutical supplement in clinical trials for arthritis: the effectiveness of the New Zealand green-lipped mussel Perna canaliculus", Clinical Rheumatology, 2005 Oct 12;:1-10.
  21. "Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers", Molecular Pharmacology, Vol. 61, Issue 3, 554-561, March 2002.
  22. "Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6" (Goldenseal), Cancer Letters, 2000 Sep 29;158(1):35-41.
  23. "Modulators of prostaglandin E2 synthesis in human amnion" (Aspirin, Acetaminophen), Journal of the Society Gynecologic Investigation, 1994 Apr-Jun;1(2):131-4.
  24. "Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea" (Fish Oil EPA/DHA), Journal of Ocular Pharmacology, 1993 Winter;9(4):365-72.
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  26. "Importance of Dietary Gamma-Linolenic Acid in Human Health and Nutrition" (Sources of GLA: Borage Oil, Black Currant Oil, Evening Primrose Oil), The Journal of Nutrition, Vol. 128 No. 9 September 1998, pp. 1411-1414.
  27. "Evening primrose oil and borage oil in rheumatologic conditions" (Sources of GLA), American Journal of Clinical Nutrition, Vol. 71, No. 1, 352S-356s, January 2000.
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  29. "Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes" (Borage Oil GLA), Journal of Clinical Immunology, 2002 Mar;22(2):83-91.
  30. "Diabetic neuropathy: pathogenesis and therapy" (Borage Oil, Source of GLA), The American Journal of Medicine, 1999 Aug 30;107(2B):17S-26S.
  31. "Dietary Supplementation with gamma -Linolenic Acid Alters Fatty Acid Content and Eicosanoid Production in Healthy Humans" (Borage Oil, Source of GLA), The Journal of Nutrition, Vol. 127 No. 8 August 1997, pp. 1435-1444.
  32. "Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multi-center Trial Group" (Borage Oil, Source of GLA), Diabetes Care. 1993 Jan;16(1):8-15.
  33. "The effect of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial" (Borage Oil, Source of GLA), Diabetic Medicine: A Journal of the British Diabetic Association, 1990 May;7(4):319-23.
  34. "Differential effects of prostaglandin derived from w-6 and w-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion" (Fish Oil, Source of EPA/DHA), Proceedings of the National Academy of Sciences of the United States of America, 2003 February 18; 100(4): 1751-1756.
  35. "Cellular interactions between n-6 and n-3 fatty acids: a mass analysis of fatty acid elongation/desaturation, distribution among complex lipids, and conversion to eicosanoids" (Role of Enzymes and Other Factors in Lipid Metabolism of Omega-3 vs. Omega-6 Fatty Acids), Journal of Lipid Research, 1992 Oct;33(10):1431-40.
  36. "Trans, trans-2,4-decadienal, a product found in cooking oil fumes, induces cell proliferation and cytokine production due to reactive oxygen species in human bronchial epithelial cells" (Protective role of N-Acetylcysteine NAC), Toxicological Sciences, 2005 Oct;87(2):337-43. Epub 2005 Jul 13.
  37. "Five Cysteine-Containing Compounds Delay Diabetic Deterioration in Balb/cA Mice" (Protective role of N-Acetyl-Cysteine NAC), The American Society for Nutritional Sciences J. Nutr. 134:3245-3249, December 2004.
  38. "N-acetylcysteine and alpha-tocopherol reverse the inflammatory response in activated rat Kupffer cells" (Protective role of N-Acetyl-Cysteine NAC), The Journal of Immunology, 1997 Jun 1;158(11):5418-23.
  39. "Cytokine secretion in whole blood of healthy subjects following oral administration of Urtica dioica L. plant extract" (Reduction of TNF-alpha and IL-6 by Nettle Leaf Extract, in German with English Abstract), Arzneimittelforschung. 1996 Sep;46(9):906-10.
  40. "Ameliorative effect of IDS 30, a stinging nettle leaf extract, on chronic colitis" (Reduction of Tumor Necrosis Factor-alpha by Nettle Leaf Extract and the extension of long-term remission from inflammatory bowel disease), International Journal of Colorectal Disease, 2005 Jan;20(1):9-17. Epub 2004 Aug 25.
  41. "Effects of sesamin and capsaicin on the mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes" (Sesame Seed Lignans - Sesamin - reduced activity of delta5 desaturase enzyme), Journal of Nutritional Science Vitaminology (Tokyo). 2003 Dec;49(6):442-6.
  42. "Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compounds", Cytokine. 1995 Apr;7(3):287-90.




* All information on Level1Diet.com is for educational purposes only. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Before changing your diet, or adding supplements to your diet, or beginning an exercise program, everyone should consult a qualified and licensed health practitioner; a physician, dietician or similar professional.



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Replace omega-6 vegetable oils with omega-9 olive oil... Eat oily fish like tuna, sardines, anchovy, salmon, herring... Beans, lentils, peas add fiber... Nine or more 3-ounce servings of fruits or vegetables per day...