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1. Modeling chronic glycemic exposure variables as correlates and predictors of microvascular complications of diabetes.
Match Strength: 7.113

OBJECTIVE: The degree to which chronic glycemic exposure (CGE) (fasting plasma glucose [FPG], HbA1c [A1C], duration of diabetes, age at onset of diabetes, or combinations of these) is associated with or predicts the severity of microvessel complications is unsettled. Specifically, we test whether combinations of components correlate and predict complications better than individual components. RESEARCH DESIGN AND METHODS: Correlations and predictions of CGE and complications were assessed in the Rochester Diabetic Neuropathy Study, a population-based, cross-sectional, and longitudinal ... Read More »
» Published in Diabetes Care. 2006 Oct;29(10):2282-8.

2. Comparison of orlistat treatment and placebo in obese type 2 diabetic patients.
Match Strength: 6.742

AIM: To evaluate the effects of 1-year treatment with orlistat compared with placebo on different inflammatory parameters in type 2 obese diabetic patients. MATERIALS AND METHODS: Two hundred and fifty-four type 2 diabetic patients were randomized to take orlistat 120 mg three times a day or placebo for 12 months. We evaluated at baseline and after 3, 6, 9 and 12 months: leptin, tumor necrosis factor (TNF)-alpha, adiponectin (ADN), vaspin and high-sensitivity C-reactive protein (HS-CRP), body weight, waist circumference, body mass index (BMI), lipid profile, glycemic profile, fasting plasma ... Read More »
» Published in Expert Opin Pharmacother. 2010 Aug;11(12):1971-82.

3. Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients.
Match Strength: 6.325

Our study wants to evaluate the effects of one year treatment with orlistat plus L-carnitine compared to orlistat alone on body weight, glycemic and lipid control, and insulin resistance state in type 2 diabetic patients. Two hundred and fifty-eight patients with uncontrolled type 2 diabetes mellitus (T2DM) [glycated hemoglobin (HbA(1c)) > 8.0%] in therapy with different oral hypoglycemic agents or insulin were enrolled in this study and randomised to take orlistat 120 mg three times a day plus L-carnitine 2 g one time a day or orlistat 120 mg three times a day. We evaluated at baseline, and ... Read More »
» Published in Endocr J. 2010 Sep 29;57(9):777-86. Epub 2010 Jul 30.

4. ET-Kyoto ductal injection and density-adjusted purification combined with potent anti-inflammatory strategy facilitated single-donor islet transplantation: case reports.
Match Strength: 5.123

BACKGROUND: The necessity to use multiple donors for achieving insulin independence in clinical islet transplantation is still a major issue. We have developed a modified islet isolation method for non-heart-beating donors (Kyoto method) to significantly increase islet yield. In this study, we further modified the method for brain-dead donors and in addition, introduced a potent anti-inflammatory strategy aiming for single-donor islet transplantation. MATERIALS AND METHODS: Two islet isolations used pancreatic ductal preservation with the modified Kyoto solution and a density-adjusted ... Read More »
» Published in Transplant Proc. 2010 Jul-Aug;42(6):2159-61.

5. Oxidizing and reducing responses of granulocytes from type 2 diabetic patients.
Match Strength: 5.059

Oxidizing/reducing response by granulocytes and a potential correlation between reactive oxygen species generation and triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein, body mass index, fasting plasma glucose, glycemic control (hemoglobin A(1c)), or duration of diabetes were examined in type 2 diabetic patients and in healthy subjects. An increase in both oxidizing and reducing responses was observed in cells from diabetic patients relative to normoglycemic individuals. The increase in oxidizing response was nearly 2-fold higher, whereas the antioxidant ... Read More »
» Published in Metabolism. 2006 Oct;55(10):1426-8.

6. Low-density lipoproteins are more electronegatively charged in type 1 than in type 2 diabetes mellitus.
Match Strength: 3.976

Multifactorial etiology is involved in premature atherosclerosis related to diabetes. Most of the mechanisms that are responsible for the etiology in diabetes have remained unsolved so far. Type 1 diabetes is associated with a favorable lipid pattern and with microangiopathy, which is not true for type 2 diabetes, which is related to dyslipidemia and macroangiopathy. The aim of this work was to evaluate the degree of LDL modification related to the types of diabetes. The question is whether the LDL could be differently modified since the pathogenesis of type 1 and type 2 diabetes is different. ... Read More »
» Published in Lipids. 2006 Jun;41(6):529-33.

7. Nutritional influences on inflammation and type 2 diabetes risk.
Match Strength: 3.931

There is a clear role for inflammation in the development of type 2 diabetes and its associated co-morbidities. Circulating inflammatory markers such as C-reactive protein, sialic acid, and interleukin- 6 are all significant independent predictors of disease. A number of nutritional components are hypothesized to modulate inflammation, and hence impact on disease risk. The most extensively studied nutrients are the long-chain n-3 polyunsaturated fatty acids. However, evidence is also emerging with respect to whole grain or low glycemic index foods and antioxidant vitamins. Obesity, resulting ... Read More »
» Published in Diabetes Technol Ther. 2006 Feb;8(1):45-54.

8. Diet and inflammation.
Match Strength: 3.795

The emerging role of chronic inflammation in the major degenerative diseases of modern society has stimulated research into the influence of nutrition and dietary patterns on inflammatory indices. Most human studies have correlated analyses of habitual dietary intake as determined by a food frequency questionnaire or 24-hour recall with systemic markers of inflammation like high-sensitivity C-reactive protein (HS-CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-a). An occasional study also includes nutrition analysis of blood components. There have been several controlled ... Read More »
» Published in Nutr Clin Pract. 2010 Dec;25(6):634-40.

9. Hormonal and metabolic responses to acute ghrelin administration in patients with bulimia nervosa.
Match Strength: 3.647

Ghrelin is generally influenced by energy balance status and is inversely associated with body mass index (BMI), being reduced in simple obesity, notable exception being Prader Willi syndrome, and elevated in several conditions of undernutrition, including anorexia nervosa (AN). Interestingly, ghrelin levels have also been found elevated in patients with bulimia nervosa (BN) in spite of normal BMI. In humans, intravenous (iv) ghrelin administration induces endocrine (increase in GH, PRL, ACTH and cortisol) and metabolic (increase in glucose and decrease in insulin) effects as well as an ... Read More »
» Published in Psychoneuroendocrinology. 2005 Jul;30(6):534-40.

10. Decrement of postprandial insulin secretion determines the progressive nature of type-2 diabetes.
Match Strength: 3.564

OBJECTIVE: Type-2 diabetes is a progressive disease. However, little is known about whether decreased fasting or postprandial pancreatic beta-cell responsiveness is more prominent with increased duration of diabetes. The aim of this study was to evaluate the relationship between insulin secretion both during fasting and 2 h postprandial, and the duration of diabetes in type-2 diabetic patients. DESIGN: Cross-sectional clinical investigation. METHODS: We conducted a meal tolerance test in 1466 type-2 diabetic patients and calculated fasting (M0) and postprandial (M1) beta-cell responsiveness. ... Read More »
» Published in Eur J Endocrinol. 2006 Oct;155(4):615-22.

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* All information on is for educational purposes only. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Before changing your diet, or adding supplements to your diet, or beginning an exercise program, everyone should consult a qualified and licensed health practitioner; a physician, dietician or similar professional.

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