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Peer Reviewed Scientific Research Reports.
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1. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53.
Match Strength: 6.087
The in vitro relationship between human p53 DNA binding domain (p53 DBD) and FA was investigated. We found that saturated and monounsaturated long-chain FA inhibited the double-stranded DNA (dsDNA) binding activity of p53 DBD. The strongest inhibitors of saturated and unsaturated FA were docosanoic acid (22:0) and cis-12-heneicosenoic acid (21:1n-9), respectively. n-Octadecane, trans-unsaturated FA, and FAME had no influence on the binding activity of p53 DBD, showing that the FA structures such as one or no double bond of cis configuration, hydrocarbon chain of length C20 to C22, and free ... Read More »
» Published in Lipids. 2006 Jun;41(6):521-7.
2. Comparison of seasonal dynamics of the essential PUFA contents in benthic invertebrates and grayling Thymallus arcticus in the Yenisei river.
Match Strength: 5.501
Seasonal dynamics of contents of essential polyunsaturated fatty acids (PUFA) in dominant groups of benthic invertebrates: gammarids (Gammaridae, Amphipoda), oligochaetes (Oligochaeta), chironomid larvae (Chironomidae, Diptera) and caddisfly larvae (Trichoptera), and dominant benthivorous fish, Siberian grayling Thymallus arcticus, have been studied in ecosystem of the large Siberian river. During the year of the study most benthic invertebrate taxa showed significant variations in the contents of both C-18 and long chain C-20-22 PUFAs. In contrast, the fish, which consumed the zoobenthos, had ... Read More »
» Published in Comp Biochem Physiol B Biochem Mol Biol. 2006 Nov-Dec;145(3-4):278-87. Epub 2006 Aug 7.
3. Quorum signal molecules as biosurfactants affecting swarming in Rhizobium etli.
Match Strength: 5.489
Swarming motility is suggested to be a social phenomenon that enables groups of bacteria to coordinately and rapidly move atop solid surfaces. This multicellular behavior, during which the apparently organized bacterial populations are embedded in an extracellular slime layer, has previously been linked with biofilm formation and virulence. Many population density-controlled activities involve the activation of complex signaling pathways using small diffusible molecules, also known as autoinducers. In Gram-negative bacteria, quorum sensing (QS) is achieved primarily by means of N ... Read More »
» Published in Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14965-70. Epub 2006 Sep 21.
4. Very long-chain fatty acid-containing lipids rather than sphingolipids per se are required for raft association and stable surface transport of newly synthesized plasma membrane ATPase in yeast.
Match Strength: 5.067
The proton-pumping H+-ATPase, Pma1p, is an abundant and very long lived polytopic protein of the yeast plasma membrane. Pma1p constitutes a major cargo of the secretory pathway and thus serves as a model to study plasma membrane biogenesis. Pma1p associates with detergent-resistant membrane domains (lipid "rafts") already in the ER, and a lack of raft association correlates with mistargeting of the protein to the vacuole, where it is degraded. We are analyzing the role of specific lipids in membrane domain formation and have previously shown that surface transport of Pma1p is independent of ... Read More »
» Published in J Biol Chem. 2006 Nov 10;281(45):34135-45. Epub 2006 Sep 15.
5. Yeast sphingolipids do not need to contain very long chain fatty acids.
Match Strength: 4.914
Synthesis of VLCFAs (very long chain fatty acids) and biosynthesis of DHS (dihydrosphingosine) both are of vital importance for Saccharomyces cerevisiae. The bulk of VLCFAs and DHS are used for ceramide synthesis by the Lag1p (longevity-assurance gene 1)/Lac1p (longevity-assurance gene cognate 1)/Lip1p (Lag1p/Lac1p interacting protein) ceramide synthase. LAG1 and LAC1 are redundant but LIP1 is essential. Here we show that 4Delta (lag1Deltalac1Deltaypc1Deltaydc1Delta) cells devoid of all known endogenous ceramide synthesis pathways are unviable but can be rescued by the expression of Lass5, a ... Read More »
» Published in Biochem J. 2007 Jan 1;401(1):205-16.
6. Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs.
Match Strength: 4.374
The sodium-calcium exchanger (NCX) is a critical mediator of calcium homeostasis. In the heart, NCX1 predominantly operates in forward mode to extrude Ca(2+); however, reverse-mode NCX1 activity during ischemia/reperfusion (IR) contributes to Ca(2+) loading and electrical and contractile dysfunction. IR injury has also been associated with altered fat metabolism and accumulation of long-chain acyl CoA esters. Here, we show that acyl CoAs are novel, endogenous activators of reverse-mode NCX1 activity, exhibiting chain length and saturation dependence, with longer chain saturated acyl moieties ... Read More »
» Published in EMBO J. 2006 Oct 4;25(19):4605-14. Epub 2006 Sep 14.
7. Propagating structural perturbation inside bacteriorhodopsin: crystal structures of the M state and the D96A and T46V mutants.
Match Strength: 3.920
The X-ray diffraction structure of the non-illuminated D96A bacteriorhodopsin mutant reveals structural changes as far away as 15 A from residue 96, at the retinal, Trp-182, Ala-215, and waters 501, 402, and 401. The Asp-to-Ala side-chain replacement breaks its hydrogen bond with Thr-46, and the resulting separation of the cytoplasmic ends of helices B and C is communicated to the retinal region through a chain of covalent and hydrogen bonds. The unexpected long-range consequences of the D96A mutation include breaking the hydrogen bond between O of Ala-215 and water 501 and the formation of a ... Read More »
» Published in Biochemistry. 2006 Oct 3;45(39):12003-10.
8. Endothelin-1 decreases CD36 protein expression in vascular smooth muscle cells.
Match Strength: 3.846
Recent studies have shown that CD36 plays important roles as a major scavenger receptor for oxidized low-density lipoproteins and as a crucial transporter for long-chain fatty acids. CD36 deficiency might be associated with insulin resistance and abnormal dynamics of long-chain fatty acids. Endothelin-1 (ET-1), which is synthesized and secreted by vascular endothelial cells, is the most potent endogenous vasoconstrictor known and also stimulates the proliferation of vascular smooth muscle cells (VSMCs) and thus is believed to play an important role in the development of various circulatory ... Read More »
» Published in Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E648-52. Epub 2006 Sep 19.
9. Biodegradation of short-chain n-alkanes in oil sands tailings under methanogenic conditions.
Match Strength: 3.824
The biodegradation of a mixture of low molecular weight n-alkanes (C6, C7, C8, and C10) was assessed under methanogenic conditions using mature fine tailings (MFT) produced by the oil sands industry in Alberta, Canada. Microorganisms present in the MFT mineralized the added n-alkane mixture, producing 16.2 (+/- 0.3) or 20.5 (+/- 0.1) mmol of methane in the headspace of microcosms spiked with 0.2% or 0.5% w/v n-alkanes, respectively, during 29 weeks of incubation. The spiked n-alkanes biodegraded in the sequence C10 > C8 > C7 > C6. Degradation of 100% C10, 97% C8, 74% C7, and 44% C6 ... Read More »
» Published in Environ Sci Technol. 2006 Sep 1;40(17):5459-64.
10. Effects of higher dietary protein intake on energy balance and metabolic control in children with long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) or trifunctional protein (TFP) deficiency.
Match Strength: 3.764
The incidence of overweight and obesity is increasing among children with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) or mitochondrial trifunctional (TFP) deficiency. Traditional treatment includes fasting avoidance and consumption of a low-fat, high-carbohydrate diet. A diet higher in protein and lower in carbohydrate may help to lower total energy intake while maintaining good metabolic control. To determine the short-term safety and efficacy of a high protein diet, subjects were admitted to the General Clinical Research Center and fed an ad-libitum high-protein diet and a high ... Read More »
» Published in Mol Genet Metab. 2007 Jan;90(1):64-9. Epub 2006 Sep 22.
11. The multifunctional beta-oxidation enzyme is required for full symptom development by the biotrophic maize pathogen Ustilago maydis.
Match Strength: 3.725
The transition from yeast-like to filamentous growth in the biotrophic fungal phytopathogen Ustilago maydis is a crucial event for pathogenesis. Previously, we showed that fatty acids induce filamentation in U. maydis and that the resulting hyphal cells resemble the infectious filaments observed in planta. To explore the potential metabolic role of lipids in the morphological transition and in pathogenic development in host tissue, we deleted the mfe2 gene encoding the multifunctional enzyme that catalyzes the second and third reactions in beta-oxidation of fatty acids in peroxisomes. The ... Read More »
» Published in Eukaryot Cell. 2006 Dec;5(12):2047-61. Epub 2006 Sep 22.
12. A survival study and prognostic factors analysis on acute promyelocytic leukemia at a single center.
Match Strength: 3.434
This study was aimed to investigate the factors influencing long-term survival on patients with acute promyelocytic leukemia. Here, we present a single center retrospective study with long-term follow-up to explore the prognostic factors and a rationale of the using of ATRA, chemotherapy and As(2)O(3) in the treatment of newly diagnosed APL patients. In total, 222 patients, 184 achieved complete remission (CR) with the CR rate of 82.88% and 22 patients died during early induction therapy with the early-death-rate of 10%. Total 171 newly diagnosed APL patients entering CR were retrospectively ... Read More »
» Published in Leuk Res. 2006 Sep 26;
13. Gelatin hydrogels cross-linked with bis(vinylsulfonyl)methane (BVSM): 1. The chemical networks.
Match Strength: 3.408
This paper deals with chemical gelation of gelatin in the presence of a cross-linker, bis(vinylsulfonyl)methane (BVSM), which is able to create covalent C-N bonds with amine groups. The investigation is performed at 40 degrees C, where no triple helices are present. Gelatin is in random coil conformation. The influence of various parameters (gelatin concentration, cross-linker concentration, and pH (number of reacting sites along the gelatin chain)) was examined. Gel formation was followed by rheological and thermodynamic measurements (microcalorimetry) versus time (kinetic measurements). ... Read More »
» Published in Langmuir. 2006 Sep 26;22(20):8509-15.
14. Adriamycin-induced oxidative mitochondrial cardiotoxicity.
Match Strength: 3.403
The anticancer agent Adriamycin (ADR) has long been recognized to induce a dose-limiting cardiotoxicity. Numerous studies have attempted to characterize and elucidate the mechanism(s) behind its cardiotoxic effect. Despite a wealth of data covering a wide-range of effects mediated by the drug, the definitive mechanism remains a matter of debate. However, there is consensus that this toxicity is related to the induction of reactive oxygen species (ROS). Induction of ROS in the heart by ADR occurs via redox cycling of the drug at complex I of the electron transport chain. Many studies support ... Read More »
» Published in Cell Biol Toxicol. 2007 Jan;23(1):15-25. Epub 2006 Sep 28.
15. Extrinsic whitening effects of sodium hexametaphosphate--a review including a dentifrice with stabilized stannous fluoride.
Match Strength: 3.393
The number of tooth whitening products available to patients has grown dramatically during recent years. While peroxide is the primary agent found in products that bleach and remove intrinsic sources of discoloration, various ingredients are incorporated in formulations to remove and inhibit extrinsic sources of tooth discoloration, ie, tooth stain. Recently, an advanced antitartar ingredient with extrinsic-stain-inhibiting benefits was introduced: sodium hexametaphosphate. This long-chain condensed phosphate, also known as polypyrophosphate, chemically removes existing stains and provides ... Read More »
» Published in Compend Contin Educ Dent. 2005 Sep;26(9 Suppl 1):47-53.
16. Phytochemical constituents from Salsola tetrandra.
Match Strength: 3.246
The new norisoprenoid 3beta-hydroxy-5alpha,6alpha-epoxy-beta-ionone-2alpha-O-beta-d-glucopyranoside (1) and the long-chain hydroxy fatty acids 9,12,13-trihydroxyoctadeca-10(E),15(Z)-dienoic acid (2) and 9,12,13-trihydroxyoctadeca-10(E)-dienoic acid (3) were isolated from Salsola tetrandra aerial parts, together with 3,4,5-trimethoxyphenyl-beta-d-glucopyranoside (4), 9-hydroxylinaloyl glucoside (5), taxiphyllin (6), trans-N-feruloyltyramine (7), and S-(-)-trans-N-feruloyloctopamine (8). Their structures were elucidated by extensive spectroscopic analysis and chemical methods. Compounds 6 and 8 ... Read More »
» Published in J Nat Prod. 2006 Sep;69(9):1366-9.
17. Relationships between molecular structure and physical properties in bent-core mesogens.
Match Strength: 3.015
New five-ring bent-core mesogens that possess only ester connecting groups between the aromatic rings and different lateral substituents at the central phenyl ring are presented. The mesophases have been assigned by polarizing microscopy, differential scanning calorimetry, X-ray diffraction and electro-optical measurements. It is shown that the mesophase behaviour depends strongly on the position of the lateral substituents. Compounds, which are derived from 4-cyano-, 4-chloro- and 4,6-dichloro-resorcinol, show polymorphism variants where polar phases (SmAP, SmCP) occur together with nematic ... Read More »
» Published in Philos Transact A Math Phys Eng Sci. 2006 Oct 15;364(1847):2657-79.
18. Redesign of human carbonic anhydrase II for increased esterase activity and specificity towards esters with long acyl chains.
Match Strength: 3.003
The effect of modulating the shape and the size of the hydrophobic pocket on the esterase activity and specificity of human carbonic anhydrase II (HCAII) for esters with different acyl chain lengths was investigated. Following an initial screen of 7 HCAII variants with alanine substitutions in positions 121, 143 and 198, detailed kinetic measurements were performed on HCAII and the variants V121A, V143A and V121A/V143A. For some variants, an increased size of the hydrophobic pocket resulted in increased activities and specificities for longer substrates. For V121A/V143A, the rate of hydrolysis ... Read More »
» Published in Biochim Biophys Acta. 2006 Oct;1764(10):1601-6. Epub 2006 Aug 17.
19. Generation of aroma compounds in sourdough: effects of stress exposure and lactobacilli-yeasts interactions.
Match Strength: 2.911
The effects of the interaction between Saccharomyces cerevisiae LBS and Lactobacillus sanfranciscensis LSCE1 and of their responses to acid, oxidative or osmotic stress on alcohol and aroma production were assessed. The exposure of S. cerevisiae LBS and L. sanfranciscensis LSCE1 cells to oxidative, acid or osmotic sub-lethal stress gave rise to a common or specific responses. Gamma-decalactone, 2(5H)-furanones and aldehydes were overproduced by LAB following oxidative stress. The acid stress induced both in yeasts and LAB, as well as in their co-cultures, a relevant accumulation of isovaleric ... Read More »
» Published in Food Microbiol. 2007 Apr;24(2):139-48.
20. Two isoforms of GABA(A) receptor beta2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia.
Match Strength: 2.748
Single nucleotide polymorphisms in type A gamma-aminobutyric acid (GABA(A)) receptor beta2 subunit gene (GABRB2) were found to be associated with schizophrenia in Chinese, German, Japanese and Portuguese. To explore potential functional consequences of these DNA sequence polymorphisms, this study examined the expression and electrophysiological properties of two alternatively spliced products of GABRB2 along with genotypical disease association analysis. Real-time quantitative polymerase chain reaction, performed with a cohort of 31 schizophrenics and 31 controls of US population, showed 21.7% ... Read More »
» Published in Mol Psychiatry. 2006 Dec;11(12):1092-105. Epub 2006 Sep 19.
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