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Peer Reviewed Scientific Research Reports.
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1. Large fasciocutaneous perforator based V-Y advancement flap for large post-mastectomy wound reconstruction--our experience with three cases.
Match Strength: 3.924
Old and frail patients with advance breast malignancy require mastectomy which often results in large defects requiring soft tissue cover. We present three cases of large fasciocutaneous perforator based V-Y advancement flaps for reconstruction of large post-mastectomy wounds in older patients with large tumours. This technique reduces the morbidity of patients who have severe co-existing morbidity factor in addition to the advance breast disease. Publication Types: Case ... Read More »
» Published in J Plast Reconstr Aesthet Surg. 2006;59(10):1073-5. Epub 2006 May 11.
2. Treatment of refractory vernal ulcers with large-diameter bandage contact lenses.
Match Strength: 3.232
PURPOSE: To report two cases of refractory vernal ulcers in which the fitting of a large-diameter (22 mm) hydrogel (Contaflex T75) bandage contact lens (BCL) ameliorated the signs and symptoms of the condition. METHODS: Two patients with refractory vernal ulcers are described. Mechanisms of the effect of a large-diameter lens across the ocular surface are discussed in this condition. RESULTS: The first patient is a 10-year-old boy who had been treated unsuccessfully for a left vernal corneal ulcer with topical prednisolone 0.5% and olopatadine. The vernal ulcer resolved 2 weeks after the ... Read More »
» Published in Eye Contact Lens. 2006 Sep;32(5):245-7.
3. Visions for novel biophysical elucidations of extracellular matrix networks.
Match Strength: 2.909
The extracellular matrix consists of multifunctional molecules, which are composed of a large numbers of different domains. Clearly these domains and even the entire molecules do not function independently as isolated species, but interact with each other in large networks. In many cases specific regions of the networks may be considered as molecular machines in which the different molecules are arranged in highly defined spatial structures and act in a dynamic, concerted fashion. At present most structural information is limited to single molecules, and dynamics have been measured mainly for ... Read More »
» Published in Int J Biochem Cell Biol. 2007;39(2):311-8. Epub 2006 Aug 18.
4. Are GC-rich isochores vanishing in mammals?
Match Strength: 2.889
Several studies of nucleotide substitution patterns in mammalian species suggested that GC-rich isochores might be vanishing in mammalian genomes. However, the number of genes and the number of genomes included in these studies might not have given a reliable broad view of the trend in GC change in mammals. It is therefore worth exploiting this issue with a broader coverage of mammalian genomes using a reliable approach, the maximum likelihood approach. We have applied two maximum likelihood methods to infer the ancestral GC contents of 176 mammalian genes from representative eutherian species ... Read More »
» Published in Gene. 2006 Dec 30;385:50-6. Epub 2006 Aug 5.
5. Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: A study of 18 cases.
Match Strength: 2.803
The most common type of primary testicular lymphoma is diffuse large B-cell type, which has the potential for aggressive clinical behavior. Diffuse large B-cell lymphoma can be further subclassified into two major prognostic categories: germinal center B-cell-like and nongerminal center B-cell-like. Such distinction is made possible using the immunohistochemical expression of CD10, Bcl-6 and MUM1. The aim of this study was to stratify primary testicular lymphoma of the diffuse large B-cell type according to this scheme. Immunohistochemical stains for CD10, Bcl-6 and MUM1 were performed on 18 ... Read More »
» Published in Mod Pathol. 2006 Dec;19(12):1521-7. Epub 2006 Sep 22.
6. Anaplastic large-cell non-Hodgkin's lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer-a case report.
Match Strength: 2.770
Primary, as well as secondary, lymphomas of the breast are rare diseases and might, in some cases, be misdiagnosed as breast cancer on routine hematoxylin/eosin stainings. We report a case of an anaplastic large cell lymphoma in a 72-year-old woman with a history of breast cancer treated with breast-ablative surgery and a subsequent silicon implant 32 years ago. Clinically, she presented with an ulceration of the skin, which had developed within a few months. On conventional histology, the tumor cells were mimicking poorly differentiated invasive ductal carcinoma with a prominent leukocytic ... Read More »
» Published in Virchows Arch. 2006 Nov;449(5):561-4. Epub 2006 Sep 16.
7. The Escherichia coli GTPase CgtAE is involved in late steps of large ribosome assembly.
Match Strength: 2.767
The bacterial ribosome is an extremely complicated macromolecular complex the in vivo biogenesis of which is poorly understood. Although several bona fide assembly factors have been identified, their precise functions and temporal relationships are not clearly defined. Here we describe the involvement of an Escherichia coli GTPase, CgtA(E), in late steps of large ribosomal subunit biogenesis. CgtA(E) belongs to the Obg/CgtA GTPase subfamily, whose highly conserved members are predominantly involved in ribosome function. Mutations in CgtA(E) cause both polysome and rRNA processing defects; ... Read More »
» Published in J Bacteriol. 2006 Oct;188(19):6757-70.
8. Large-scale correlation of DNA accession numbers to the cDNAs in the FANTOM full-length mouse cDNA clone set.
Match Strength: 2.755
Oligonucleotide-based microarrays, such as GeneChip, are widely used to determine the large-scale gene expression profiles. However, GeneChip only provides information on the identity of the molecules, and the investigator must obtain each cDNA clone for further analyses. In this study, we devised a program which enables us to correlate a large number of DNA accession numbers to the FANTOM (functional annotation of the mouse) full-length mouse cDNA clone set, and made a correlative table between mouse GeneChip clones and FANTOM clones. This allows easy identification of the corresponding ... Read More »
» Published in Keio J Med. 2006 Sep;55(3):107-10.
9. A large splenic cyst mimicking diabetic gastroparesis.
Match Strength: 2.718
Splenic cysts are rare, many of which are asymptomatic and incidental finding. We report an interesting case of a large incidental splenic cyst in a young diabetic patient who presented with diabetic ketoacidosis and mimicking gastroparesis. The differential diagnosis and management of splenic cysts is discussed ... Read More »
» Published in Int J Clin Pract. 2006 Oct;60(10):1317-8.
10. Identifying genes underlying skin pigmentation differences among human populations.
Match Strength: 2.699
Skin pigmentation is a human phenotype that varies greatly among human populations and it has long been speculated that this variation is adaptive. We therefore expect the genes that contribute to these large differences in phenotype to show large allele frequency differences among populations and to possibly harbor signatures of positive selection. To identify the loci that likely contribute to among-population human skin pigmentation differences, we measured allele frequency differentiation among Europeans, Chinese and Africans for 24 human pigmentation genes from 2 publicly available, large ... Read More »
» Published in Hum Genet. 2007 Jan;120(5):613-21. Epub 2006 Sep 15.
11. A simple method for the production of plasmid DNA in bioreactors.
Match Strength: 2.627
The need for large quantities of purified plasmid DNA has increased as the applications of DNA vaccines continue to expand. This chapter describes a simple, scaleable procedure based on the fed-batch cultivation of various Escherichia coli clones, which can be easily implemented and scaled-up to large bioreactors. Although some clones may require minor modifications to the feeding strategy, in general, this procedure, implemented as described, is likely to support the production of milligram to gram quantities of plasmid DNA. Publication Types: ... Read More »
» Published in Methods Mol Med. 2006;127:295-309.
12. Health care for children and youth in the United States: annual report on patterns of coverage, utilization, quality, and expenditures by a county level of urban influence.
Match Strength: 2.624
OBJECTIVE: To examine child and hospital demographics and children's health care coverage, use, expenditures, and quality by a county-level measure of urban influence. METHODS: Two national health care databases serve as the sources of data for this report: the 2002 Medical Expenditure Panel Survey (MEPS) and the 2002 Nationwide Inpatient Sample (NIS) and State Inpatient Databases (SID) from the Healthcare Cost and Utilization Project (HCUP). In both data sets, county urbanicity is defined by use of a collapsed version of the 2003 Urban Influence Codes, to distinguish among children residing ... Read More »
» Published in Ambul Pediatr. 2006 Sep-Oct;6(5):241-64.
13. Monomorphic Epstein-Barr virus (EBV)-associated large B-cell posttransplant lymphoproliferative disorder presenting as a tongue ulcer in a pancreatic transplant patient.
Match Strength: 2.593
Posttransplant lymphoproliferative disorders are a group of lymphoid proliferations and lymphomas that develop as a consequence of immunosuppression in recipients of solid organ or bone marrow allografts. We describe an unusual oral presentation of posttransplant Epstein-Barr virus-associated diffuse large B-cell lymphoma in a 45-year-old woman after pancreatic transplant. Publication Types: Case ... Read More »
» Published in Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Oct;102(4):e24-8. Epub 2006 Jul 27.
14. Ginkgo nut intoxication in a 2-year-old male.
Match Strength: 2.516
This report describes a case of ginkgo nut intoxication in a 2-year-old male. The patient presented with vomiting and afebrile convulsion 4 hours after eating a large number of roasted gingko nuts. There was a large volume of ginkgo nuts in his vomited matter, and on admission the concentrations of 4-O-methoxypyridoxine in his serum and urine were elevated. The patient was diagnosed as having ginkgo nut intoxication, and diazepam and pyridoxal phosphate were administered intravenously. After the treatment, his symptoms were resolved. The neurotoxicity of ginkgo nuts should be recognized by ... Read More »
» Published in Pediatr Neurol. 2006 Oct;35(4):275-6.
15. Healing of large midline wounds in infants: unlike in adults, does conservative approach give better results? Two case reports and review of the literature.
Match Strength: 2.488
The case of two infants with large midline wounds, one with an omphalocele and the other with a lumbosacral wound secondary to ruptured meningocele, is reported wherein the advantages of leaving such wounds in infants to heal spontaneously over surgical intervention are shown. In this report, the cases are discussed and the literature is reviewed. It is concluded that the midline wounds in infants yield better results if left to heal spontaneously. Publication Types: Case ... Read More »
» Published in Int Wound J. 2006 Sep;3(3):248-50.
16. In situ Raman spectroscopic study of the dissociation of methane hydrate at high pressure.
Match Strength: 2.433
The dissociation of methane hydrate at high pressure is studied by in situ Raman spectroscopy in a diamond-anvil cell. As for the Raman spectrum of sI methane hydrate, the v(1) band of CH(4) is split into two peaks v'(1) and v''(1), indicating the partitioning of CH(4) between the large (5(12)6(2)) and small (5(12)) cavities, respectively. With increasing temperature, the intensity ratio of Iv'(1)/Iv''(1) decreases obviously, and the d(Iv'(1)/Iv''(1))/dT is -0.079 K(-1). Additionally, the v(1) band of the dissolved CH(4) is close to v''(1) of the CH(4) molecule engaged in the small 5(12) ... Read More »
» Published in Appl Spectrosc. 2006 Sep;60(9):985-8.
17. Clearcut: a fast implementation of relaxed neighbor joining.
Match Strength: 2.432
SUMMARY: Clearcut is an open source implementation for the relaxed neighbor joining (RNJ) algorithm. While traditional neighbor joining (NJ) remains a popular method for distance-based phylogenetic tree reconstruction, it suffers from a O(N(3)) time complexity, where N represents the number of taxa in the input. Due to this steep asymptotic time complexity, NJ cannot reasonably handle very large datasets. In contrast, RNJ realizes a typical-case time complexity on the order of N(2)logN without any significant qualitative difference in output. RNJ is particularly useful when inferring a very ... Read More »
» Published in Bioinformatics. 2006 Nov 15;22(22):2823-4. Epub 2006 Sep 18.
18. Sensitivity of computerized neuropsychological screening in depressed university students.
Match Strength: 2.380
This study examined the sensitivity of a computerized neuropsychological screening (ImPACT) to the cognitive effects of depression in a sample of 20 students with suspected depression and 20 healthy university students matched for gender, age, and education. Students with depression had slower reaction times (p < .02; d = .82, large effect) and processing speeds (p < .03; d = .77, large effect). The brevity and sensitivity of ImPACT to the cognitive effects of depression warrants further research with psychiatric populations. Publication Types: Comparative Study, Research Support, Non-U ... Read More »
» Published in Clin Neuropsychol. 2006 Dec;20(4):695-701.
19. An RNA ligase-mediated method for the efficient creation of large, synthetic RNAs.
Match Strength: 2.376
RNA ligation has been a powerful tool for incorporation of cross-linkers and nonnatural nucleotides into internal positions of RNA molecules. The most widely used method for template-directed RNA ligation uses DNA ligase and a DNA splint. While this method has been used successfully for many years, it suffers from a number of drawbacks, principally, slow and inefficient product formation and slow product release, resulting in a requirement for large quantities of enzyme. We describe an alternative technique catalyzed by T4 RNA ligase instead of DNA ligase. Using a splint design that allows the ... Read More »
» Published in RNA. 2006 Nov;12(11):2014-9. Epub 2006 Sep 18.
20. Butterfly cartilage graft inlay tympanoplasty for large perforations.
Match Strength: 2.339
OBJECTIVE: Butterfly graft inlay tympanoplasty is a well-established technique for the repair of small perforations. However, the efficacy of the technique for medium and large tympanic membrane perforations remains unknown. STUDY DESIGN: Retrospective case series. METHODS: Postauricular tympanoplasty and tympanomastoidectomy using a large butterfly cartilage inlay graft (>4 mm diameter to total drum replacement) were analyzed in 90 pediatric patients (99 ears). RESULTS: Patient ages ranged from 2 to 20 years; mean follow-up duration was 27.6 months. Successful closure occurred in 92% of ... Read More »
» Published in Laryngoscope. 2006 Oct;116(10):1813-6.
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