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Joint Pain
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1. Denervation of the painful temporomandibular joint.
Match Strength: 8.016

The successful management of temporomandibular joint (TMJ) pain remains elusive. Often the initial relief of pain is complicated by recurrence of the symptoms. This time frame suggests that the pain may be related to neuromas of the nerves that innervate the TMJ. In 2003, an anatomic description of the innervation of the TMJ suggested that denervation of this joint might be the appropriate treatment for pain resistant to traditional forms of therapy. In January, 2005, this approach was used to treat recalcitrant left TMJ pain in a 21-year-old woman with congenital hearing loss who had ... Read More »
» Published in J Craniofac Surg. 2006 Sep;17(5):828-32.

2. A quantitative approach to measure joint pain in experimental osteoarthritis--evidence of a role for nitric oxide.
Match Strength: 7.821

OBJECTIVES: To describe a method to study joint pain in experimental osteoarthritis (OA) and to study nitric oxide (NO) participation in experimental OA. DESIGN: Rats were subjected to anterior cruciate ligament transection (ACLT) (OA group) of the right knee and evaluated during 28 days. A sham group was false operated and a naive group received no manipulation. Joint pain was measured by recording the time the right hind paw fails to touch the surface while walking. Cell influx (CI) and nitrite levels were measured in joint exudates. Expression of inducible NO synthase (iNOS) in synovia was ... Read More »
» Published in Osteoarthritis Cartilage. 2006 Aug;14(8):769-76. Epub 2006 Mar 31.

3. Pressure application measurement (PAM): a novel behavioural technique for measuring hypersensitivity in a rat model of joint pain.
Match Strength: 7.666

Chronic joint pain affects physical well being and can lead to severe psychological and social problems, therefore successful long-term management is highly sought-after. No current behavioural measures of pain used in pre-clinical models mimic the clinical dolorimeter, which provides an objective measure of joint hypersensitivity. In this study we aim to use a novel behavioural readout alongside an established measure to mimic the multifactorial measurements taken in the clinic. Using the pressure application measurement (PAM) device a gradually increasing squeeze was applied across the knee ... Read More »
» Published in J Neurosci Methods. 2007 Jun 15;163(1):67-75. Epub 2007 Feb 20.

4. Septic arthritis of the manubriosternal joint.
Match Strength: 7.661

Pyarthrosis of the manubriosternal joint is exceedingly rare. Its rarity defies an early diagnosis, and other causes of chest pain would normally be ruled out first. We describe a patient with a short history of chest pain, pyrexia, and raised inflammatory markers. A destroyed manubriosternal joint with a large abscess was found during surgical exploration. This case illustrates an unusually rapid development of septic arthritis involving a fibrocartilaginous joint in an otherwise healthy young man. Nine other cases have been described in the literature and are reviewed. Early diagnosis ... Read More »
» Published in Ann Thorac Surg. 2007 Mar;83(3):1190-4.

5. Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain.
Match Strength: 7.625

The origin of pain in osteoarthritis is poorly understood, but it is generally thought to arise from inflammation within the innervated structures of the joint, such as the synovium, capsule and bone. We investigated the role of nerve growth factor (NGF) in pain development in murine OA, and the analgesic efficacy of the soluble NGF receptor, TrkAD5. OA was induced in mice by destabilisation of the medial meniscus and pain was assessed by measuring hind-limb weight distribution. RNA was extracted from joints, and NGF and TNF expressions were quantified. The effect of tumour necrosis factor ... Read More »
» Published in Pain. 2010 May;149(2):386-92. Epub 2010 Mar 29.

6. Cervical facet joint injections in the neck and shoulder pain.
Match Strength: 7.613

The effects from cervical facet joint injections in those patients who have been complaining cervical zygapophyseal joint pain were compared. The patients were diagnosed originally as myofascial pain syndrome (MPS), cervical herniated nucleus pulposus (HNP), and whiplash-associated disorders (WAD). Patients with the zygapophyseal joints pain of C5-6 and C6-7 were classified by their pain origin as MPS, HNP, and WAD. All patients had been undergone cervical zygapophyseal joints injections with the mixture of lidocaine and triamcinolone unilaterally or bilaterally through the posterior approach ... Read More »
» Published in J Korean Med Sci. 2005 Aug;20(4):659-62.

7. Therapeutic efficacy of facet joint blocks.
Match Strength: 7.577

OBJECTIVE: The objective of our study was to investigate outcome predictors of short- and medium-term therapeutic efficacy of facet joint blocks. MATERIALS AND METHODS: Forty-two patients with chronic lower back pain who were undergoing facet joint blocks at one (n = 29) or two (n = 13) levels were analyzed. All patients underwent MRI or CT of the lumbar spine within 5 months before the facet joint blocks. The facet joint blocks were performed under fluoroscopic guidance. A small amount (< 0.3 mL) of iodinated contrast agent, 0.5 mL of local anesthetics and 0.5 mL of steroids, were injected. ... Read More »
» Published in AJR Am J Roentgenol. 2006 May;186(5):1228-33.

8. The longitudinal effectiveness of lateral atlantoaxial intra-articular steroid injection in the treatment of cervicogenic headache.
Match Strength: 7.457

OBJECTIVE: The most accepted mechanism of cervicogenic headache is referred pain from cervical structures innervated by the upper three cervical spinal nerves. The lateral atlantoaxial joint is not an uncommon cause of cervicogenic headache. In this retrospective study, we examined the effect of lateral atlantoaxial intra-articular steroid injection in managing 32 patients with cervicogenic headache who have a clinical picture suggestive of atlantoaxial joint pain. DESIGN AND SETTING: The data were collected retrospectively by reviewing the patient's medical records and pain questionnaires. ... Read More »
» Published in Pain Med. 2007 Mar;8(2):184-8.

9. Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice.
Match Strength: 7.397

OBJECTIVE: To investigate the role of proteinase-activated receptor 4 (PAR-4) in mediating joint inflammation and pain in mice. METHODS: Knee joint blood flow, edema, and pain sensitivity (as induced by thermal and mechanical stimuli) were assessed in C57BL/6 mice following intraarticular injection of either the selective PAR-4 agonist AYPGKF-NH(2) or the inactive control peptide YAPGKF-NH(2). The mechanism of action of AYPGKF-NH(2) was examined by pretreatment of each mouse with either the PAR-4 antagonist pepducin P4pal-10 or the bradykinin antagonist HOE 140. Finally, the role of PAR-4 in ... Read More »
» Published in Arthritis Rheum. 2009 Mar;60(3):728-37.

10. Nonsteroidal anti-inflammatory drugs: are they safe after joint arthroplasty for early pain?
Match Strength: 7.287

A significant proportion of patients will experience moderate to severe pain after hip or knee replacement surgery. Multimodal pain control regimens have been developed to address this issue. These regimens may include the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Concern over excessive bleeding in the perioperative period, especially in joint arthroplasty patients receiving anticoagulation therapy, generally prohibits the use of nonspecific NSAIDs. Cyclooxygenase-2 inhibitors, a class of NSAIDs, are not believed to increase the risk of bleeding and may be useful in this population ... Read More »
» Published in Instr Course Lect. 2007;56:133-7.

11. The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study.
Match Strength: 7.267

INTRODUCTION: Despite recent advances in anti-inflammatory therapy, rheumatoid arthritis (RA) patients continue to rate pain as a priority. The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sleep, psychiatric distress and pain sensitivity in RA. METHODS: Fifty-nine female RA patients completed questionnaires and underwent pressure pain threshold testing to assess hyperalgesia/allodynia at joint and non-joint sites. Blood samples were taken to measure C-reactive ... Read More »
» Published in Arthritis Res Ther. 2009;11(5):R160. Epub 2009 Oct 29.

12. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain.
Match Strength: 7.093

Between 40% and 60% of Americans use complementary and alternative medicine to manage medical conditions, prevent disease, and promote health and well-being. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been used to treat joint pain associated with several inflammatory conditions. We conducted a meta-analysis of 17 randomized, controlled trials assessing the pain relieving effects of omega-3 PUFAs in patients with rheumatoid arthritis or joint pain secondary to inflammatory bowel disease and dysmenorrhea. Meta-analysis was conducted with Cochrane Review Manager 4.2.8. for six ... Read More »
» Published in Pain. 2007 May;129(1-2):210-23. Epub 2007 Mar 1.

13. Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis.
Match Strength: 7.082

Pain and cachexia are two of the most debilitating aspects of rheumatoid arthritis. Despite that, the mechanisms by which they are mediated are not well understood. We provide evidence that nerve growth factor (NGF), a secreted regulatory protein that controls neuronal survival during development, is a key mediator of pain and weight loss in auto-immune arthritis. Function blocking antibodies to NGF completely reverse established pain in rats with fully developed arthritis despite continuing joint destruction and inflammation. Likewise, these antibodies reverse weight loss while not having any ... Read More »
» Published in Pain. 2005 Jul;116(1-2):8-16.

14. The use of surface electromyography as a tool in differentiating temporomandibular disorders from neck disorders.
Match Strength: 7.037

The aim of this study was to assess the electromyographic characteristics of the masticatory muscles (masseter and temporalis) of patients with either "temporomandibular joint disorder" or "neck pain". Surface electromyography of the right and left masseter and temporalis muscles was performed during maximum teeth clenching in 38 patients aged 21-67 years who had either (a) temporomandibular joint disorder (24 patients); (b) "neck pain" (13 patients). Ninety-five control, healthy subjects were also examined. During clenching, standardized total muscle activities (electromyographic potentials ... Read More »
» Published in Man Ther. 2006 Sep 12;

15. Absence of the medial sesamoid bone associated with metatarsophalangeal pain.
Match Strength: 6.994

Pain at the first metatarsophalangeal (MTP) joint can result from inflammation, chondromalacia, flexor hallucis brevis tendinitis, osteochondritis dessecans, fracture of a sesamoid bone, avascular necrosis of sesamoids, inflamed bursae, intractable keratoses, infection, sesamoiditis, gout arthropathy, and rheumatoid arthritis. Congenital absence of a sesamoid bone is extremely rare. We present a 17-year-old male patient with pain at the plantar aspect of the right MTP joint associated with congenital absence of the medial sesamoid. There was tenderness and the range of motion was minimally ... Read More »
» Published in Clin Anat. 2006 Oct;19(7):634-9.

16. Celecoxib in the treatment of haemophilic synovitis, target joints, and pain in adults and children with haemophilia.
Match Strength: 6.970

Joint haemorrhage and subsequent haemophilic arthropathy are significant complications of haemophilia. The pathophysiology involves inflammation and angiogenesis. Cyclo-oxygenase 2 (COX-2) inhibitors have anti-inflammatory, anti-angiogenic and analgesic properties yet do not affect platelet function in the manner of traditional non-steroidal anti-inflammatory drugs. We have previously reported the successful use of rofecoxib in the management of haemophilic arthropathy and currently report our use of celecoxib. A retrospective chart review was conducted of all patients with haemophilia A or B ... Read More »
» Published in Haemophilia. 2006 Sep;12(5):514-7.

17. Systemic therapies for joint disease in horses.
Match Strength: 6.712

Systemic therapies for joint disease may be prescribed when a single joint is involved or when multiple sites are affected. The precise therapeutic regimen recommended depends on the duration,cause, and site(s) of injury and is often an adjunct to intra-articular or supportive therapies. If the clinical signs of joint disease are acute and moderate in severity, nonsteroidal anti-inflammatory drugs are often administered to alleviate pain and inflammation. When aiming for more of a generalized maintenance or chondro-protective regimen, an alternative medication, such as hyaluronan,polysulfated ... Read More »
» Published in Vet Clin North Am Equine Pract. 2005 Dec;21(3):547-57, v.

18. Development and pharmacological characterization of a rat model of osteoarthritis pain.
Match Strength: 6.712

Osteoarthritis (OA) is an age-related joint disease characterized by degeneration of articular cartilage and is associated with chronic pain. Although several experimental models of OA have been employed to investigate the underlying etiologies of the disease, there has been relatively little investigation into development of animal models of OA to study the pain associated with the condition. In the present study, we investigated OA induced by injection of either iodoacetate or papain into the knee joint of rats, and assessed the joint degeneration with radiographic analyses and measured pain ... Read More »
» Published in Pain. 2005 Apr;114(3):339-46. Epub 2004 Dec 19.

19. Hyperbaric oxygen treatment is comparable to acetylsalicylic acid treatment in an animal model of arthritis.
Match Strength: 6.641

Approximately 1 in 5 adults in the United States are affected by the pain, disability, and decreased quality of life associated with arthritis. The primary focus of treatment is on reducing joint inflammation and pain through a variety of pharmacotherapies, each of which is associated with various side effects. Hyperbaric oxygen therapy is an alternative treatment that has been recommended to treat a variety of inflammatory diseases, ranging from chronic brain injury to exercise induced muscle soreness. The purpose of this set of experiments was to explore the effect of hyperbaric oxygen ... Read More »
» Published in J Pain. 2007 Dec;8(12):924-30. Epub 2007 Aug 9.

20. Radiofrequency denervation with or without addition of pentoxifylline or methylprednisolone for chronic lumbar zygapophysial joint pain.
Match Strength: 6.637

Radiofrequency neurolysis of lumbar medial branch is currently the only proven way to treat patients with chronic lumbar zygapophysial joint pain, however, in some patients it can cause transient postoperative pain due to an inflammation caused by trauma of the electrode insertion and the thermal lesion around the target nerves. The aim of this study was to assess the effectiveness of intraoperative injection of methylprednisolone or pentoxifylline in comparison with placebo (saline) to prevent this process. 45 consecutive patients seen by one physician at one pain management clinic were ... Read More »
» Published in Pharmacol Rep. 2005 Jul-Aug;57(4):475-80.

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