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Inflammatory
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1. Targeted delivery of anti-inflammatory agents to tumors.
Match Strength: 0.259

Inflammation is considered a hallmark of cancer. The chronic inflammatory process is driven by the interaction of cells, proteins, cytokines, transcription factors, and lipid mediators within the tumor microenvironment giving rise to complex pro-inflammatory cascades. These can be inhibited by a variety of different anti-inflammatory compounds, like non-steroidal anti-inflammatory drugs, glucocorticoids, anti-inflammatory biologicals, phytotherapeutics (mainly polyphenols), and drugs with pleiotropic anti-inflammatory effects. In general, it appears that the anti-tumor activity of these ... Read More »
» Published in Curr Pharm Des. 2009;15(16):1825-43.

2. Lipoxin analogs: novel anti-inflammatory mediators.
Match Strength: 0.258

Most pharmacological anti-inflammatory agents are designed to inhibit the enzymes or receptors that are directly involved in mediating inflammation. In contrast, lipoxin analogs utilize an entirely different anti-inflammatory paradigm, namely that of activating the endogenous anti-inflammatory signaling pathways by which inflammation is normally resolved. Specifically, synthetic stable analogs of the endogenous anti-inflammatory eicosanoid lipoxin A4 (LXA4) have been shown to mimic the anti-inflammatory actions of LXA4 in a variety of inflammation models and display desirable pharmacological ... Read More »
» Published in Curr Opin Investig Drugs. 2005 Nov;6(11):1112-5.

3. Successful preoperative treatment of pediatric bladder inflammatory myofibroblastic tumor with anti-inflammatory therapy.
Match Strength: 0.250

Inflammatory myofibroblastic tumors are rare, locally invasive tumors that can involve the genitourinary tract. Therapy has consisted primarily of surgery, and anecdotal experience using both chemotherapy and radiotherapy, which have yielded unimpressive results. We report the first case of a bladder inflammatory myofibroblastic tumor that responded to an anti-inflammatory regimen (prednisone and Cox-2 inhibitor) before surgical extirpation ... Read More »
» Published in Urology. 2007 Aug;70(2):372.e13-5.

4. Tuning inflammation with anti-inflammatory neuropeptides.
Match Strength: 0.249

The immune system is confronted with the daunting task of defending the organism against invading pathogens while at the same time remaining self-tolerant to the body's own constituents and preserving its integrity. The loss of immune tolerance stemming from an unbalance in pro-inflammatory factors versus anti-inflammatory cytokines, or of autoreactive/inflammatory T helper 1 cells versus regulatory/suppressive T cells, results in the breakdown of immune homeostasis and the subsidiary appearance of exacerbated inflammatory and autoimmune diseases. Some neuropeptides have been shown to have ... Read More »
» Published in Expert Opin Biol Ther. 2007 Apr;7(4):461-78.

5. Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases.
Match Strength: 0.249

Discoveries in the first few years of the 21st century have led to an understanding of important interactions between the nervous system and the inflammatory response at the molecular level, most notably the acetylcholine (ACh)-triggered, alpha7-nicotinic acetylcholine receptor (alpha7nAChR)-dependent nicotinic anti-inflammatory pathway. Studies using the alpha7nAChR agonist, nicotine, for the treatment of mucosal inflammation have been undertaken but the efficacy of nicotine as a treatment for inflammatory bowel diseases remains debatable. Further understanding of the nicotinic anti ... Read More »
» Published in World J Gastroenterol. 2006 Dec 14;12(46):7451-9.

6. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation.
Match Strength: 0.249

Immunoglobulin G (IgG) mediates pro- and anti-inflammatory activities through the engagement of its Fc fragment (Fc) with distinct Fcg receptors (FcgRs). One class of Fc-FcgR interactions generates pro-inflammatory effects of immune complexes and cytotoxic antibodies. In contrast, therapeutic intravenous gamma globulin and its Fc fragments are anti-inflammatory. We show here that these distinct properties of the IgG Fc result from differential sialylation of the Fc core polysaccharide. IgG acquires anti-inflammatory properties upon Fc sialylation, which is reduced upon the induction of an ... Read More »
» Published in Science. 2006 Aug 4;313(5787):670-3.

7. Cyclooxygenase enzymes and their products in the carrageenan-induced pleurisy in rats.
Match Strength: 0.246

Rodent models of inflammation have helped in our understanding of the inflammatory process and also for the screening of compounds with anti-inflammatory potential. Although they do not represent a particular inflammatory disease in humans, cavity models of inflammation in rodents are easy to induce and to quantify the inflammatory reaction as well as to harvest the inflammatory exudates for cytological, biochemical and molecular biological analysis. Of these models, the carrageenan-induced pleurisy model has been extensively used to study the role of the cyclooxygenase (COX) enzymes and the ... Read More »
» Published in Methods Mol Biol. 2010;644:201-5.

8. Nitric oxide as a regulator of inflammatory processes.
Match Strength: 0.244

Nitric oxide (NO) plays an important role in mediating many aspects of inflammatory responses. NO is an effector molecule of cellular injury, and can act as an anti-oxidant. It can modulate the release of various inflammatory mediators from a wide range of cells participating in inflammatory responses (e.g., leukocytes, macrophages, mast cells, endothelial cells, and platelets). It can modulate blood flow, adhesion of leukocytes to the vascular endothelium and the activity of numerous enzymes, all of which can have an impact on inflammatory responses. In recent years, NO-releasing drugs have ... Read More »
» Published in Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:5-9. Epub 2005 Jun 14.

9. Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
Match Strength: 0.243

This work describes the synthesis and anti-inflammatory properties of a pentadienone derivative, HB2. The treatment with HB2 produced anti-oedematogenic, anti-inflammatory and antinociception without change locomotors performance. Finally, HB2 reduced the nitric oxide and prostaglandin E(2) production on RAW 264.7 cells stimulated with LPS without changing the cell viability. Taken together, our results show, for the first time, that HB2 can modulate the inflammatory response when administered to mice ... Read More »
» Published in Bioorg Med Chem. 2009 Jul 1;17(13):4290-5. Epub 2009 May 18.

10. Radio-immunological mechanisms of anti-inflammatory treatment: is there a way from the past into the future?
Match Strength: 0.243

The anti-inflammatory efficiency of low-dose radiotherapy (LD-RT) for degenerative joint disorders was demonstrated over decades but had no explanation on a cellular or molecular level. As inflammatory diseases are the results of complex and pathologically unbalanced cellular and molecular interactions more recent in-vivo and in-vitro data will be discussed for possible explanation of the mechanism underlying ant-inflammatory LD-RT.2 ... Read More »
» Published in Autoimmunity. 2009 May;42(4):337-9.

11. The systemic inflammatory response syndrome.
Match Strength: 0.242

The systemic inflammatory response syndrome (SIRS) is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components. This review outlines the pathophysiology of SIRS and highlights potential targets for future therapeutic intervention in patients with this complex entity ... Read More »
» Published in Microbes Infect. 2006 Apr;8(5):1382-9. Epub 2006 Mar 23.

12. An inflammatory review of glucocorticoid actions in the CNS.
Match Strength: 0.241

In recent years, the classic view that glucocorticoids, the adrenal steroids secreted during stress, are universally anti-inflammatory has been challenged at a variety of levels. It was first observed that under some circumstances, acute GC exposure could have pro-inflammatory effects on the peripheral immune response. More recently, chronic exposure to GCs has been found to have pro-inflammatory effects on the specialized immune response to injury in the central nervous system. Here we review the evidence that in some cases, glucocorticoids can increase pro-inflammatory cell migration, ... Read More »
» Published in Brain Behav Immun. 2007 Mar;21(3):259-72. Epub 2006 Dec 27.

13. Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents.
Match Strength: 0.239

The synthesis of a new class of 9-(S)-dihydroerythromycin derivatives and their anti-inflammatory activity on in vivo PMA assay are described. Modifying the desosamine sugar on the C-3' amino group, it was possible to differentiate between anti-biotic and anti-inflammatory action. The compounds are completely devoid of anti-microbial effects but their anti-inflammatory properties are enhanced. These results strongly suggest the potential of macrolides as a new class of anti-inflammatory agents ... Read More »
» Published in Bioorg Med Chem Lett. 2006 Nov 15;16(22):5801-4. Epub 2006 Sep 18.

14. Design, synthesis and in vivo activity of 9-(S)-dihydroerythromycin derivatives as potent anti-inflammatory agents.
Match Strength: 0.239

The synthesis of a new class of 9-(S)-dihydroerythromycin derivatives and their anti-inflammatory activity on in vivo PMA assay are described. Modifying the desosamine sugar on the C-3' amino group, it was possible to differentiate between anti-biotic and anti-inflammatory action. The compounds are completely devoid of anti-microbial effects but their anti-inflammatory properties are enhanced. These results strongly suggest the potential of macrolides as a new class of anti-inflammatory agents ... Read More »
» Published in Bioorg Med Chem Lett. 2006 Nov 15;16(22):5801-4. Epub 2006 Sep 18.

15. Inflammatory reaction after sirolimus-eluting stent implant.
Match Strength: 0.239

Sirolimus-eluting stents (SES) are supposed to attenuate cell proliferation and reduce restenosis rate. Histologic finding from coronary artery after SES implant showed fibrosis and inflammatory infiltrate, revealing a chronic inflammatory reaction. Extension of coronary inflammatory reaction after stenting needs clarification. The long-term consequences are unknown ... Read More »
» Published in Ann Thorac Surg. 2005 Nov;80(5):1903-4.

16. Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist.
Match Strength: 0.238

To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components. Thus, ERb-131 is sufficient to alleviate chronic but not acute inflammatory pain states ... Read More »
» Published in Eur J Pharmacol. 2008 Sep 11;592(1-3):158-9. Epub 2008 Jul 4.

17. Anti-inflammatory effects of antidepressants: possibilities for preventives against Alzheimer's disease.
Match Strength: 0.237

Increasing evidence of pro-inflammatory mediator expression in major depressions indicate that inflammatory changes may play a role. If this is true, the efficacy of antidepressants may be partially attributable to suppression of inflammation. Various types of antidepressants can suppress serum and plasma levels of pro-inflammatory mediators in patients with major depression. Therefore they can inhibit the production of pro-inflammatory mediators by immune cells. These include glial cells, which are the main sources and targets of cytokines in the brain. This review summarizes the evidence ... Read More »
» Published in Cent Nerv Syst Agents Med Chem. 2009 Mar;9(1):12-9.

18. Use of herbal preparations in the treatment of oxidant-mediated inflammatory disorders.
Match Strength: 0.237

Complementary and alternative medicine (CAM) use has increased in popularity in recent years and herbal therapy alone is now a billion dollar market. For centuries herbs have been used as food and for medicinal purposes. Various herbs have been identified as possessing anti-inflammatory and antioxidative properties, and they are currently being used to treat inflammatory disorders as well as those caused by reactive oxygen species (ROS). Asthma, Alzheimer's disease, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and atherogenesis are all disorders where inflammation and ROS are ... Read More »
» Published in Complement Ther Med. 2007 Sep;15(3):207-16. Epub 2006 Aug 21.

19. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response.
Match Strength: 0.236

Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation, primarily through a mechanism that selectively blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory agent has, however, not met expectations. Nevertheless, the signaling pathway used by the IL-10 receptor to generate the anti-inflammatory response is ... Read More »
» Published in Curr Opin Pharmacol. 2006 Aug;6(4):379-86. Epub 2006 May 18.

20. Anti-inflammatory activity profile of JANEX-1 in preclinical animal models.
Match Strength: 0.236

We examined the biologic activity of the rationally designed JAK3 inhibitor, JANEX-1, in several cellular and animal models of inflammation. Notably, JANEX-1 exhibited potent anti-inflammatory activity in each of these preclinical models, including mouse models of peritonitis, colitis, cellulitis, and systemic inflammatory response syndrome. Therefore, JANEX-1 may prove useful as a broad-spectrum anti-inflammatory agent. The present study may provide the basis for new and effective treatment as well as prevention programs for inflammatory disorders ... Read More »
» Published in Bioorg Med Chem. 2008 Feb 1;16(3):1287-98. Epub 2007 Oct 24.

 << Prev 20  Showing results 1 to 20 of 23,061 Next 20 >>




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