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Peer Reviewed Scientific Research Reports.
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1. Cytokine and anti-cytokine therapies for psoriasis and atopic dermatitis.
Match Strength: 3.415
Since the discovery of cytokines as key mediators in inflammation, targeting the cytokine network has represented a promising therapeutic approach. Psoriasis and atopic dermatitis, as T cell-mediated diseases with a strong cytokine component and a high unmet medical need, have moved into the focus of experimental therapies. Whereas pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha are overexpressed in both diseases, a type 1 cytokine pattern predominates in psoriasis and a type 2 cytokine pattern is of pathophysiological importance at least in the initial stages of atopic ... Read More »
» Published in BioDrugs. 2006;20(2):93-103.
2. Cytokine signal regulation and autoimmune disorders.
Match Strength: 3.201
Understanding of biological activities of cytokines and exquisite mechanism to regulate their functions has facilitated the therapeutic concept to restore the disequilibrium between pro-inflammatory cytokines and anti-inflammatory cytokines or cytokine inhibitors in some autoimmune inflammatory diseases such as rheumatoid arthritis (RA) and Crohn's disease. The application of molecular biology techniques to design monoclonal antibodies, soluble receptors, or receptor antagonists as therapeutic biologic agents made it possible to regulate the cytokine signals for the treatment of the diseases ... Read More »
» Published in Autoimmunity. 2005 Aug;38(5):359-67.
3. Leukocyte, plasma, and organ-associated cytokine profiles in an animal model of acute inflammation.
Match Strength: 3.193
Systemic administered lipopolysaccharide (LPS) induces a cytokine response in peripheral blood without correlations with cytokine content at the organ level. We hypothesised (1) that cytokine mRNA expression in peripheral blood mononuclear cells (PBMCs) preceded the plasma cytokine increase during endotoxaemia and (2) that statins as anti-inflammatory agents modified the LPS-induced cytokine responses. 30 pigs were randomised into 3 groups: placebo (I) or atorvastatin 80 mg (II) for 21 days, followed by LPS-infusion on day 22, or controls (III). LPS was infused at increasing concentrations (2 ... Read More »
» Published in APMIS. 2008 May;116(5):352-60.
4. Cytokines and anti-cytokines as therapeutics--an update.
Match Strength: 3.169
Cytokines which comprise of a family of proteins--interleukins, lymphokines, monokines, interferons, and chemokines, are important components of the immune system. They act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune response. Their physiologic role in inflammation and pathologic role in systemic inflammatory states are now well recognized. An imbalance in cytokine production or cytokine receptor expression and/or dysregulation of a cytokine process contributes to various pathological disorders. Research is progressing rapidly in the ... Read More »
» Published in Eur J Pharmacol. 2008 Jan 28;579(1-3):1-12. Epub 2007 Oct 25.
5. Cytokine signaling modules in inflammatory responses.
Match Strength: 3.156
Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively regulates all cell types involved in the initiation, propagation, and resolution of inflammation. Here, we focus on Jak-Stat signaling in three major cell types involved in inflammatory responses: T cells, neutrophils, and macrophages. We summarize how the Jak-Stat pathways in these cells are negatively regulated by the Suppressor of cytokine signaling (Socs) proteins. We emphasize that common Jak-Stat-Socs signaling modules can have diverse developmental, pro- and anti-inflammatory outcomes depending on ... Read More »
» Published in Immunity. 2008 Apr;28(4):477-87.
6. Differences in the inflammatory plasma cytokine response following two elite female soccer games separated by a 72-h recovery.
Match Strength: 3.096
We investigated changes in a large battery of pro- and anti-inflammatory cytokines in elite female soccer players following two 90-min games separated by a 72-h active or passive recovery. Blood samples were taken from 10 players before, within 15-20 min, 21, 45 and 69 h after the first game and within 15-20 min after the second game. The leukocyte count was analyzed, together with several plasma pro- and anti-inflammatory cytokines, using a multiplex bead array system. After the first and second game, the total leukocytes and neutrophils increased significantly. Likewise, increases (P<0.05) ... Read More »
» Published in Scand J Med Sci Sports. 2010 Oct;20(5):740-7. doi: 10.1111/j.1600-0838.2009.00989.x.
7. General nature of the STAT3-activated anti-inflammatory response.
Match Strength: 3.073
Although many cytokine receptors generate their signals via the STAT3 pathway, the IL-10R appears unique in promoting a potent anti-inflammatory response (AIR) via STAT3 to antagonize proinflammatory signals that activate the innate immune response. We found that heterologous cytokine receptor systems that activate STAT3 but are naturally refractory (the IL-22R), or engineered to be refractory (the IL-6, leptin, and erythropoietin receptors), to suppressor of cytokine signaling-3-mediated inhibition activate an AIR indistinguishable from IL-10. We conclude that the AIR is a generic cytokine ... Read More »
» Published in J Immunol. 2006 Dec 1;177(11):7880-8.
8. Cytokine and anti-cytokine therapy for asthma.
Match Strength: 3.051
Cytokines play a critical role in the pathogenesis of asthma. Asthma resolution may depend on the correction of dysregulated cytokine expression, which is a characteristic feature of this chronic inflammatory disease. It is, therefore, not surprising that attempts have been made to either block cytokines present at elevated levels or to substitute cytokines that are insufficiently expressed in asthma. In this article, the results of these studies are discussed, and the obtained insights regarding asthma pathogenesis and new treatment options are summarized ... Read More »
» Published in Curr Allergy Asthma Rep. 2006 Mar;6(2):117-21.
9. Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes.
Match Strength: 3.033
We have previously shown that both chloroquine and paracetamol (acetaminophen) have antipyretic activity during treatment of acute uncomplicated Plasmodium falciparum malaria in children 1-4 years old. Here, we studied if this effect was accompanied by changes in plasma cytokine levels. The 104 children were treated with either chloroquine or sulfadoxine/pyrimethamine (SP) alone, SP+chloroquine or SP+paracetamol for 4 days. Cytokine levels were determined days 0, 2 and 3, body temperature every sixth hour until 72h and parasitemia once daily for 4 days. At admission, body temperature ... Read More »
» Published in Acta Trop. 2006 Aug;99(1):75-82. Epub 2006 Sep 8.
10. HDL and electronegative LDL exchange anti- and pro-inflammatory properties.
Match Strength: 3.026
Electronegative LDL [LDL(-)] is a minor modified LDL subfraction present in blood with inflammatory effects. One of the antiatherogenic properties of HDL is the inhibition of the deleterious effects of in vitro modified LDL. However, the effect of HDL on the inflammatory activity of LDL(-) isolated from plasma is unknown. We aimed to assess the putative protective role of HDL against the cytokine released induced in monocytes by LDL(-). Our results showed that LDL(-) cytokine release was inhibited when LDL(-) was coincubated with HDL and human monocytes and also when LDL(-) was preincubated ... Read More »
» Published in J Lipid Res. 2010 Oct;51(10):2947-56. Epub 2010 Jul 20.
11. IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells.
Match Strength: 3.017
Interleukin 12 (IL 12) p35/p40 is a heterodimeric cytokine which plays a critical role in inflammation, immunity and tissue proliferation, and also plays a relevant function in T helper (Th) cell polarization and Th1 T-cell differentiation. IL-12 family members, IL-12p70, IL-23, IL-27 and IL-35, play an important role in influencing helper T-cell differentiation. EBV-induced gene 3 can be associated with the p35 subunit of IL-12 to form the EBI3/p35 heterodimer, also called IL-35. It has been shown that IL-35 has biological activity and able to expand CD4+CD25+ Treg cells, suppress the ... Read More »
» Published in J Biol Regul Homeost Agents. 2010 Apr-Jun;24(2):131-5.
12. Association of cytokine gene polymorphisms and the release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone.
Match Strength: 3.013
Immunosuppressive drugs are widely used in the therapy of autoimmune disorders to suppress autoreactive T cells. The immune system is regulated by the release of cytokines. Cytokine are potent immunomodulatory molecules that act as mediators of inflammation and the immune response. Primarily secreted by T cell and macrophages, they influence cellular activation, differentiation, and function. Cytokine production is under genetic control. This is evidenced by the identification of polymorphism in cytokine gene regulatory regions that correlate with intra-individual variations in actual cytokine ... Read More »
» Published in Int Immunopharmacol. 2006 Mar;6(3):351-7. Epub 2005 Sep 6.
13. Effect of cardiopulmonary bypass on cytokine network and myocardial cytokine production.
Match Strength: 3.010
BACKGROUND: In addition to the well-investigated proinflammatory cytokine expression, there is an ever increasing interest in the field of anti-inflammatory response to cardiopulmonary bypass (CPB). Evidence suggests that myocardium serves as an important source of cytokines during reperfusion and application of CPB. The effect of coronary artery bypass graft (CABG) without CPB on myocardial cytokine production has not as yet been investigated. HYPOTHESIS: Cardiopulmonary bypass can cause long-term disturbance in pro- and anti-inflammatory cytokine balance, which may impede a patient's ... Read More »
» Published in Clin Cardiol. 2006 Jul;29(7):311-5.
14. Redirection of cytokine production by lymphocytes from women with pre-term delivery by dydrogesterone.
Match Strength: 3.006
PROBLEM: To study the ability of dydrogesterone to modulate the production of pro-inflammatory and anti-inflammatory cytokines by lymphocytes from women undergoing pre-term delivery (PTD). METHOD OF STUDY: Peripheral blood mononuclear cells (PBMC) from 18 subjects undergoing PTD were stimulated with the mitogen phytohemagglutinin in the presence and absence of progesterone and dydrogesterone. The levels of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-4, and IL-10 in culture supernatants were then estimated by enzyme-linked immunoabsorbant assay. Cytokine ... Read More »
» Published in Am J Reprod Immunol. 2007 Jul;58(1):31-8.
15. Patents in targets and drugs for unbalanced cytokine and chemokine network mediated disorders.
Match Strength: 2.964
A wide range of pathologies are affected by unbalanced cytokine production namely autoimmune, metabolic and infectious diseases. The intrinsic regulation of the pathways involved are very complex, as they include incomplete described intracellular signaling pathways and the pleiotropic cytokine balance within the inflammatory mediators network. Tumor necrosis factor-alpha (TNFalpha) is considered a key cytokine for the development of diverse pathologies. A wide range of strategies was developed to treat syndromes, including administration of anti-inflammatory cytokines and blockade of main ... Read More »
» Published in Recent Pat Inflamm Allergy Drug Discov. 2007;1(3):176-82.
16. Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes.
Match Strength: 2.961
IL-27 is a heterodimeric cytokine bridging innate and adaptive immunity by playing a role in the activation of naive T cells and in development of Th1 cells. Additionally, recent evidence supports a role for IL-27 in the activation of monocytic cells. Both pro-inflammatory and anti-inflammatory activities have been attributed to IL-27; however, the role played by IL-27 in the activation of human monocytic cells in terms of cytokine production has not been well described. Our results show that IL-27 is a strong inducer of proinflammatory cytokine and chemokine expression, including enhancement ... Read More »
» Published in J Biol Chem. 2010 Aug 6;285(32):24404-11. Epub 2010 Jun 2.
17. MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis.
Match Strength: 2.950
Macrophage migration inhibitory factor (MIF) is well established as a key cytokine in immuno-inflammatory diseases such as rheumatoid arthritis. Inflammation is now also recognized as having a crucial role in atherosclerosis, and recent evidence indicates that MIF could also be important in this disease. Here, we review the role of MIF in rheumatoid arthritis and atherosclerosis, discuss the ways in which MIF and its relationship with glucocorticoids could link these diseases, and consider the potential of MIF as a new therapeutic target for small-molecule and antibody-based anti-cytokine ... Read More »
» Published in Nat Rev Drug Discov. 2006 May;5(5):399-410.
18. Vascular IL-10: a protective role in preeclampsia.
Match Strength: 2.926
IL-10 is a pregnancy compatible cytokine that plays a vital role in maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the maternal-fetal interface. Recent evidence now suggests that IL-10 is a potent vascular cytokine that can blunt hypertension and inflammation-mediated vascular dysfunction. Thus, a re-evaluation of IL-10 as a cytokine supporting endovascular interactions and angiogenesis as well as blunting hypoxic-injury and preeclampsia-like features is warranted. In this review, we highlight these novel functions of IL-10 and propose that its immune-modulating ... Read More »
» Published in J Reprod Immunol. 2011 Mar;88(2):165-9. Epub 2011 Feb 18.
19. Peritonitis in childhood: clinical relevance of cytokines in the peritoneal exudate.
Match Strength: 2.925
BACKGROUND: The aim of the study was to assess pro-inflammatory cytokine (tumor necrosis factor alpha [TNF-alpha], interleukin 6 [IL-6]) and anti-inflammatory cytokine (interleukin 10 [IL-10]) responses in children with peritonitis secondary to hollow viscus perforation, and to evaluate the influence of peritoneal microbial status on cytokine expression and morbidity. METHODS: The peritoneal fluid of 13 children with perforated appendicitis was examined with qualitative analysis of bacteria, and measurement of cytokine levels, which were compared to cytokine plasma levels, over a five-day ... Read More »
» Published in Eur J Pediatr Surg. 2006 Apr;16(2):94-9.
20. Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor.
Match Strength: 2.910
Cytokines are small protein molecules that facilitate communication between cells of the immune system and other tissues. Their messenger function elicits responses in other cells, ranging from DNA binding and tissue remodeling to coordinating the local cellular response to inflammation. The magnitude of the cytokine response is regulated closely, because an over- or underabundance of cytokine activity can impair organ function and cause shock and tissue injury. Counterregulatory molecular and humoral mechanisms protect the host from cytokine excess, including the pituitary-adrenal ... Read More »
» Published in Ann N Y Acad Sci. 2005 Dec;1062:209-19.
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