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Peer Reviewed Scientific Research Reports.
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1. Dampening inflammation.
Match Strength: 1.235
This series of reviews addresses mechanisms whereby inflammation can be reduced, turned off or perhaps prevented, both in the context of natural dampening processes as well as possible approaches to anti-inflammatory therapy. Underlying the central issue is the implication that inflammation is indeed something inherently bad that needs to be dampened. Although this is certainly often the case and it can be argued that most human disease processes include some element of inflammation, nevertheless, inflammation is also natural, beneficial and, indeed, essential. This balance and its possible ... Read More »
» Published in Nat Immunol. 2005 Dec;6(12):1179-81.
2. Cannabinoids for the treatment of inflammation.
Match Strength: 1.214
Cannabinoids are effective at suppressing immune and inflammation functions in leukocytes in vitro, and in animal models of acute inflammation, such as the mouse hind paw, ear and air pouch models, as well as gastrointestinal, pulmonary, myocardial, vascular, periodontal, neural, hepatic, pancreatic and arthritic inflammation models. The non-psychoactive cannabinoid receptor CB2 is emerging as a critical target for cannabinoid regulation of inflammation, and thus CB2-selective agonists are undergoing intense investigation and research. This review discusses the evidence for cannabinoid ... Read More »
» Published in Curr Opin Investig Drugs. 2007 May;8(5):373-84.
3. Dietary polyphenols, inflammation, and cancer.
Match Strength: 1.202
A considerable amount of evidence indicates that tumorigenesis is associated with inflammation. Nuclear factor-kappa B (NF-kappa B), a master regulator of infection and inflammation, has been identified as a key modulator in which inflammation could develop into cancer. Dietary polyphenols have been shown to have anti-inflammatory and anticancer activity partially through inhibition of NF-kappa B activation. This review summarizes the effect of polyphenols on inflammation and cancer; avenanthramides, a unique polyphenol from oats, are especially focused ... Read More »
» Published in Nutr Cancer. 2009;61(6):807-10.
4. Cancer and inflammation: implications for pharmacology and therapeutics.
Match Strength: 1.175
Smoldering, nonresolving inflammation is a component of the tumor microenvironment. The linkage between inflammation and cancer, first perceived in the nineteenth century, is now part of an accepted paradigm of carcinogenesis ... Read More »
» Published in Clin Pharmacol Ther. 2010 Apr;87(4):401-6. Epub 2010 Mar 3.
5. Inflammation and genes.
Match Strength: 1.149
Inflammation is a protective immune response to infection, trauma, or injury; however, only a subset of patients develops inflammation, suggesting other contributing factors involved, such as the environment and genes. Inflammation-associated genes involving those with pro- and anti-inflammatory effect should be properly balanced and regulated; the protein products of these genes ultimately determine the outcome of inflammation. Apart from gene mutations, gene polymorphisms related to some inflammatory markers also appear to correlate with the incidence and/or outcome of serious inflammatory ... Read More »
» Published in Acta Medica (Hradec Kralove). 2007;50(1):17-21.
6. Inflammation in juvenile idiopathic arthritis.
Match Strength: 1.113
Inflammation evolved to aid in the clearance of microorganisms. In pediatric arthritides, the inflammation persists and causes damage to the joint. The contribution of the innate immune system to inflammation is significant and can be exploited therapeutically. Although cells of the adaptive immune system such as T cells and B cells participate in the disease process, many of the features of arthritis are directly attributable to inflammatory mediators. Recent advances in the understanding of these processes have led to dramatic improvements in treatment ... Read More »
» Published in Pediatr Clin North Am. 2005 Apr;52(2):335-57, v.
7. What's new in CF airway inflammation: an update.
Match Strength: 1.109
Neutrophilic airway inflammation is a characteristic feature of cystic fibrosis (CF) lung disease and present in most patients with pulmonary manifestations of the disease. Here we discuss the ongoing controversy whether the CFTR mutation itself causes a pro-inflammatory milieu in the airways or whether inflammation is always secondary to infection. Since the presence of inflammation has been shown to be a risk factor for subsequent lung function decline, noninvasive tests to monitor airway inflammation are urgently needed. Induced sputum is currently being assessed as a clinical and research ... Read More »
» Published in Paediatr Respir Rev. 2006;7 Suppl 1:S70-2. Epub 2006 Jun 5.
8. Inflammation and cancer: a failure of resolution?
Match Strength: 1.109
There are clear links between chronic inflammation and cancer; strong epidemiological and genetic evidence indicates that inflammation can drive tumour progression, and more-recent evidence indicates that the disruption of endogenous anti-inflammatory mechanisms in mice can lead to tumour development. The resolution of inflammation is an active coordinated process that requires the production of anti-inflammatory mediators, the termination of proinflammatory signalling pathways and the appropriate clearance or migration of inflammatory cells. Disruption of any of these processes can lead to ... Read More »
» Published in Trends Pharmacol Sci. 2007 Apr;28(4):162-5. Epub 2007 Feb 28.
9. Triamcinolone acetonide injection for persistent atypical idiopathic orbital inflammation.
Match Strength: 1.103
PURPOSE: To report a patient with atypical idiopathic orbital inflammation who was successfully treated with intra-orbital injections of triamcinolone acetonide. METHODS: Interventional case report and literature review. MAIN OUTCOME MEASURES: Resolution of orbital inflammation. RESULTS: A 71-year-old female with right orbital mass and conjunctival inflammation underwent orbital biopsy that was consistent with the diagnosis of atypical idiopathic orbital inflammation. Inflammation has deteriorated despite oral steroids. The patient underwent two additional orbital biopsies that confirmed the ... Read More »
» Published in Orbit. 2009;28(6):401-3.
10. Patenting on new topical anti-inflammatory drug.
Match Strength: 1.094
Inflammation is a group of important pathological disorders in medicine. The main classical hallmarks for inflammation are pain, swelling and heat. Basically, there are two main groups of anti-inflammation drug, the steroid anti-inflammation drug and non steroid anti-inflammation drug, which is widely called NSAIDS. At present, there are many new anti-inflammatory drugs. Those new anti-inflammatory drugs are developed expecting for the better pharmacological reaction. In this article, the author will briefly review on the patents on new topical anti-inflammatory drug ... Read More »
» Published in Recent Pat Inflamm Allergy Drug Discov. 2008;2(2):102-4.
11. Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice.
Match Strength: 1.091
We have shown earlier that H(2)S acts as a mediator of inflammation. In this study, we have investigated the involvement of substance P and neurogenic inflammation in H(2)S-induced lung inflammation. Intraperitoneal administration of NaHS (1-10 mg/kg), an H(2)S donor, to mice caused a significant increase in circulating levels of substance P in a dose-dependent manner. H(2)S alone could also cause lung inflammation, as evidenced by a significant increase in lung myeloperoxidase activity and histological evidence of lung injury. The maximum effect of H(2)S on substance P levels and on lung ... Read More »
» Published in Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L896-904. Epub 2006 Jun 23.
12. Novel insights into the aetiology and pathophysiology of increased airway inflammation during COPD exacerbations.
Match Strength: 1.091
Airway inflammation increases during acute exacerbations of COPD. Extrinsic factors, such as airway infections, increased air pollution, and intrinsic factors, such as increased oxidative stress and altered immunity may contribute to this increase. The evidence for this and the potential mechanisms by which various aetiological agents increase inflammation during COPD exacerbations is reviewed. The pathophysiologic consequences of increased airway inflammation during COPD exacerbations are also discussed. This review aims to establish a cause and effect relationship between etiological factors ... Read More »
» Published in Respir Res. 2006 May 22;7:80.
13. The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications.
Match Strength: 1.090
Inflammation and coagulation are closely linked interdependent processes. Under physiologic conditions, the tissue microcirculation functions in anticoagulant and anti-inflammatory fashions. However, when inflammation occurs, coagulation is also set in motion and actively participates in enhancing inflammation. Recently, novel and unexpected roles of hemostasis in the humoral and cellular components of innate immunity have been described. In particular, the protein C system, besides its well-recognized role in anticoagulation, plays a crucial role in inflammation. Indeed, the protein C system ... Read More »
» Published in Blood. 2010 Feb 11;115(6):1121-30. Epub 2009 Dec 17.
14. The resolution of inflammation and cancer.
Match Strength: 1.080
Inflammation has long been thought to contribute to the development of cancer; however there is also clear evidence that the immune system can recognize and eliminate cancer cells. Current research suggests that cancer-associated inflammation has a dual role in tumor progression; inflammatory mediators promote the malignant activity of cancer cells by acting as growth factors and also stimulate angiogenesis, however, cancer-associated inflammation is also linked with immune-suppression that allows cancer cells to evade detection by the immune system. In this review we will discuss the dual ... Read More »
» Published in Cytokine Growth Factor Rev. 2010 Feb;21(1):61-5. Epub 2009 Dec 22.
15. Inflammation in preterm and term labour and delivery.
Match Strength: 1.079
Inflammation has been implicated in the mechanisms responsible for preterm and term parturition, as well as fetal injury. Out of all of the suspected causes of preterm labour and delivery, infection and/or inflammation is the only pathological process for which both a firm causal link with preterm birth has been established and a molecular pathophysiology defined. Inflammation has also been implicated in the mechanism of spontaneous parturition at term. Most cases of histopathological inflammation and histological chorioamnionitis, both in preterm and term labour, are sub-clinical in nature. ... Read More »
» Published in Semin Fetal Neonatal Med. 2006 Oct;11(5):317-26. Epub 2006 Jul 12.
16. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics.
Match Strength: 1.067
Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood disorders, Alzheimer's disease, diabetes, and cancer. Involvement in such disparate conditions stems from the widespread influences of GSK3 on many cellular functions, with this review focusing on its regulation of inflammatory processes. GSK3 promotes the production of ... Read More »
» Published in Neurochem Res. 2007 Apr-May;32(4-5):577-95. Epub 2006 Aug 30.
17. Effects of inhaled therapy on biomarkers of systemic inflammation in stable chronic obstructive pulmonary disease.
Match Strength: 1.063
In chronic obstructive pulmonary disease (COPD) airways inflammation is associated in more advanced stages with systemic inflammation. COPD-associated systemic inflammation syndrome is defined currently with rather non-specific biomarkers such as C-reactive protein (CRP) but there are also other 'organ-specific' biomarkers such as surfactant protein-D which are still not well characterized but might represent more appropriate and reliable alternatives to the non-specific biomarkers. Inhaled therapies are the mainstay in stable COPD and they were demonstrated to reduce airway inflammation and ... Read More »
» Published in Biomarkers. 2010 Mar;15(2):97-103.
18. Nonresolving inflammation.
Match Strength: 1.062
Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an inherent risk because inflammation can damage tissue and necrosis can provoke inflammation. Nonetheless, multiple mechanisms normally ensure resolution. Cells like macrophages switch phenotypes, secreted molecules like reactive oxygen intermediates switch impact from pro- to anti-inflammatory, and additional mediators of resolution arise, including proteins, lipids, and gasses. Aside from persistence of initiating stimuli, nonresolution may result from deficiencies in these mechanisms when an ... Read More »
» Published in Cell. 2010 Mar 19;140(6):871-82.
19. Multiple sclerosis: is there neurodegeneration independent from inflammation?
Match Strength: 1.060
Clinical and magnetic resonance imaging studies in multiple sclerosis have recently suggested that neurodegenerative events may take place in multiple sclerosis brains, which occur independently from inflammation. Here we summarize the results from recent pathological studies, which show, that inflammation is invariably present at all stages and in all forms of the disease. However, the patterns of inflammation differ between different disease stages. This may in part explain, why anti-inflammatory or immunosuppressive treatments fail in progressive multiple sclerosis ... Read More »
» Published in J Neurol Sci. 2007 Aug 15;259(1-2):3-6. Epub 2007 Mar 23.
20. Inflammation, aging, and cancer vaccines.
Match Strength: 1.057
Immunosenescence is characterized by a series of changes of immune pathways, including a chronic state of low-grade inflammation. Mounting evidence from experimental and clinical studies suggests that persistent inflammation increases the risk of cancer and the progression of the disease. Cancer vaccination, which came into view in the last years as the most intriguing means of activating an immune response capable of effectively hampering the progression of the preclinical stages of a tumour, has been shown to be less effective in older age than in young adults. Available evidence on the use ... Read More »
» Published in Biogerontology. 2010 Oct;11(5):615-26. Epub 2010 May 9.
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