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Peer Reviewed Scientific Research Reports.
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1. Fenofibrate improves age-related endothelial dysfunction in rat resistance arteries.
Match Strength: 4.101
This study was designed to test the hypothesis that fenofibrate, the peroxisome proliferator-activated receptor alpha (PPARalpha) activator, improves age-related endothelial dysfunction in small mesenteric arteries (SMA). Adult and aged rats were treated with fenofibrate and then endothelium-dependent relaxations of SMA; expressions of endothelial NO synthase (eNOS), cyclo-oxygenase (COX-1 and COX-2) and superoxide dismutases (SOD) (Cu/Zn SOD, Mn SOD and EC SOD) proteins and release of TXB(2) and 6-keto-PGF(1alpha) were assessed. Fenofibrate improved endothelium-dependent vasodilatation of ... Read More »
» Published in Atherosclerosis. 2006 Sep 15;
2. Intravenous iron alone for the treatment of anemia in patients with chronic heart failure.
Match Strength: 3.009
OBJECTIVES: This study was undertaken to assess the hematologic, clinical, and biochemical response to intravenous iron in patients with chronic heart failure (CHF) and anemia. BACKGROUND: Anemia is common in patients with CHF and is associated with higher morbidity and mortality. The combination of erythropoietin (EPO) and iron increases hemoglobin (Hb) and improves symptoms and exercise capacity in anemic CHF patients. It is not known whether intravenous iron alone is an effective treatment for anemia associated with CHF. METHODS: Sixteen anemic patients (Hb < or =12 g/dl) with stable CHF ... Read More »
» Published in J Am Coll Cardiol. 2006 Sep 19;48(6):1225-7. Epub 2006 Aug 28.
3. More extensive nodal dissection improves survival for stages I to III of colon cancer: a population-based study.
Match Strength: 3.003
OBJECTIVE: To determine whether analyzing more lymph nodes in colon cancer specimens improves survival. SUMMARY BACKGROUND DATA: Increasing the number of lymph nodes analyzed has been reported to correlate with improved survival in patients with node-negative colon cancer. METHODS: The Surveillance, Epidemiology, and End Results database was queried for all patients undergoing resection for histologically confirmed colon cancer between the years 1988 and 2000. Patients were excluded for distant metastases or if an unknown number of nodes was sampled. The number of nodes sampled was categorized ... Read More »
» Published in Ann Surg. 2006 Oct;244(4):602-10.
4. Aprotinin improves cerebral protection: evidence from a survival porcine model.
Match Strength: 2.937
OBJECTIVE: Aprotinin is a serine protease inhibitor used during cardiac surgery to reduce blood loss and preserve platelet function. It has also been shown to reduce leukocyte activation during and after cardiopulmonary bypass. The goal of the study was to test the hypothesis that aprotinin could reduce cerebral injury after low-flow cardiopulmonary bypass and deep hypothermic circulatory arrest. METHODS: Sixteen piglets (mean weight, 13.6 +/- 1.3 kg) were randomly assigned to receive aprotinin or placebo (8 animals per group) before a 120-minute period of deep hypothermic circulatory arrest ... Read More »
» Published in J Thorac Cardiovasc Surg. 2006 Oct;132(4):948-53.
5. Enhanced external counterpulsation treatment improves arterial wall properties and wave reflection characteristics in patients with refractory angina.
Match Strength: 2.746
OBJECTIVES: To determine if arterial properties and wave reflection characteristics are favorably altered after enhanced external counterpulsation (EECP) treatment in patients with refractory angina. BACKGROUND: Early return of reflected waves from the lower body, resulting from increased arterial stiffness, augments central aortic pressure and increases left ventricular (LV) afterload and myocardial oxygen demand. EECP acutely enhances coronary perfusion (supply) and reduces LV afterload (demand). However, the mechanisms responsible for the sustained beneficial effects of EECP treatment are ... Read More »
» Published in J Am Coll Cardiol. 2006 Sep 19;48(6):1208-14. Epub 2006 Aug 28. Comment in: J Am Coll Cardiol. 2006 Sep 19;48(6):1215-6.
6. Peritoneal lavage with activated protein C alters compartmentalized coagulation and fibrinolysis and improves survival in polymicrobial peritonitis.
Match Strength: 2.706
OBJECTIVE: During peritonitis, intra-abdominal fibrin entraps bacteria and hampers their elimination. Systemic administration of anticoagulant activated protein C improves survival in patients with severe sepsis, but its precise mode of action is unclear. This study in polymicrobial peritonitis assessed the effects of local activated protein C administration in peritoneal lavage fluid on coagulation, fibrinolysis, and survival. DESIGN: Prospective, randomized study. SETTING: University-based research laboratory. SUBJECTS: C57BL/6 mice. INTERVENTIONS: Twenty-four hours after induction of ... Read More »
» Published in Crit Care Med. 2006 Nov;34(11):2799-805.
7. Design, synthesis, and evaluation of enhanced DNA binding new lipopolythioureas.
Match Strength: 2.595
Nonviral gene delivery is limited to a large extent by the cationic nature of most of the chemical vector. We have shown that lipopolythioureas interact with DNA. However, lipopolythioureas were not very efficient at transfecting cells, probably due to reduced interaction between the noncationic synthetic lipid and the cell membrane. Here, we report that liposomes made from a new thiourea lipid, DPPC, and a lipid bearing an RGD ligand allowed very efficient entry of the lipopolythioureas into integrin alpha(v)beta(3) expressing cells. In addition, we show that a stable interaction between DNA ... Read More »
» Published in Bioconjug Chem. 2006 Sep-Oct;17(5):1200-8.
8. NMR in the SPINE Structural Proteomics project.
Match Strength: 2.435
This paper describes the developments, role and contributions of the NMR spectroscopy groups in the Structural Proteomics In Europe (SPINE) consortium. Focusing on the development of high-throughput (HTP) pipelines for NMR structure determinations of proteins, all aspects from sample preparation, data acquisition, data processing, data analysis to structure determination have been improved with respect to sensitivity, automation, speed, robustness and validation. Specific highlights are protonless (13)C-direct detection methods and inferential structure determinations (ISD). In addition to ... Read More »
» Published in Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1150-61. Epub 2006 Sep 19.
9. Postoperative radiotherapy for squamous cell carcinoma of the head and neck.
Match Strength: 2.433
This review discusses the role of postoperative radiotherapy (RT) for patients with squamous cell carcinoma of the head and neck. Patients with unfavorable pathologic features have a high-risk of local-regional recurrence and a decreased likelihood of survival after surgery alone. Postoperative RT reduces the risk of local-regional failure and probably improves survival. Patients who are at high risk for recurrence may benefit from more aggressive altered fractionation schedules to decrease the overall time from surgery to the completion of RT. Adjuvant cisplatin-based chemotherapy also ... Read More »
» Published in Clin Med Res. 2006 Sep;4(3):200-8.
10. Effects of inspiratory muscle training on exercise responses in normoxia and hypoxia.
Match Strength: 2.364
The purpose of this study was to determine the effects of inspiratory muscle training (IMT) on exercise in hypoxia (H) and normoxia (N). A 4-week IMT program was implemented with 12 healthy subjects using an inspiratory muscle trainer set at either 15% (C; n=5) or 50% (IMT; n=7) maximal inspiratory mouth pressure (PI(max)). Two treadmill tests (85% V O(2max)) to exhaustion and measures of diaphragm thickness (T(di)) and function were completed before and after training in H and N. Significant increases of 8-12% and 24.5+/-3.1% in T(di) and PI(max), respectively, were seen in the IMT group. ... Read More »
» Published in Respir Physiol Neurobiol. 2006 Sep 20;
11. Treatment with edaravone improves the survival rate in renal warm ischemia-reperfusion injury using rat model.
Match Strength: 2.330
Renal ischemia-reperfusion (I/R) injury during renal transplantation is a significant cause of renal dysfunction. The pathological role of free radicals in this process is a major concern. We investigated the effect of a free radical scavenger, edaravone (MCI-186), in renal I/R injury. Male Lewis rats (270 to 320 g) were used for the model. The right kidney was harvested and left renal artery and vein were clamped as laparotomy. The kidney was reperfused after 90 minutes of ischemia. Edaravone (10 mg/kg) was delivered intravenously before ischemia and after reperfusion to prevent the ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2199-200.
12. Peptide length-based prediction of peptide-MHC class II binding.
Match Strength: 2.311
MOTIVATION: Algorithms for predicting peptide-MHC class II binding are typically similar, if not identical, to methods for predicting peptide-MHC class I binding despite known differences between the two scenarios. We investigate whether representing one of these differences, the greater range of peptide lengths binding MHC class II, improves the performance of these algorithms. RESULTS: A non-linear relationship between peptide length and peptide-MHC class II binding affinity was identified in the data available for several MHC class II alleles. Peptide length was incorporated into existing ... Read More »
» Published in Bioinformatics. 2006 Nov 15;22(22):2761-7. Epub 2006 Sep 25.
13. Application of predictive biosimulation within pharmaceutical clinical development: examples of significance for translational medicine and clinical trial design.
Match Strength: 2.309
The challenge of accurately predicting human clinical outcome based on preclinical data has led to a high failure rate of compounds in human clinical trials. A series of methods are described by which biosimulation can address these challenges and guide the design and evaluation of experimental and clinical protocols. Early compound development often proceeds on the basis of preclinical data from animal models. The systematic evaluation possible in a simulation can assist in the critical step of translating the preclinical outcomes to human physiology. Later in the process, clinical trials ... Read More »
» Published in Syst Biol (Stevenage). 2005 Dec;152(4):214-20.
14. The rationale for screening and surveillance of Barrett's metaplasia.
Match Strength: 2.269
Oesophageal adenocarcinoma is a rare cancer; however, it is the most rapidly increasing cancer in the western world. Barrett's oesophagus is the only recognised precursor and is associated with the majority of cases of adenocarcinoma. The role of screening and surveillance in patients with Barrett's oesophagus remains controversial. There is insufficient evidence to show that screening improves survival and is cost-effective. Indirect evidence suggests that patients diagnosed with cancer while undergoing surveillance endoscopy are diagnosed at an earlier stage and have an improved survival. ... Read More »
» Published in Best Pract Res Clin Gastroenterol. 2006;20(5):829-42.
15. Higher intracoronary attenuation improves diagnostic accuracy in MDCT coronary angiography.
Match Strength: 2.223
OBJECTIVE: The purpose of this study was to investigate whether the amount of intracoronary attenuation influences the diagnostic accuracy of MDCT coronary angiography in the detection of clinically significant stenosis. MATERIALS AND METHODS: One hundred twenty patients in sinus rhythm with suspected coronary artery disease who underwent MDCT of the heart and conventional coronary angiography were retrospectively selected. The population was divided into two groups depending on median (326 H) coronary vascular enhancement (i.e., low attenuation and high attenuation). The diagnostic accuracy ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):W430-3.
16. Impact of ovarian endometrioma on assisted reproduction outcomes.
Match Strength: 2.212
The effects of ovarian endometrioma on fertility outcomes with IVF and embryo transfer have been causally related to poor outcomes. The objective of this meta-analysis was to evaluate the ovarian reserve and ovarian responsiveness to ovarian stimulation and assisted reproduction outcomes in patients with ovarian endometrioma. The odds for clinical pregnancy were not affected significantly in patients with ovarian endometrioma compared with controls, with an overall odds ratio of 1.07 from three studies [95% CI: (0.63, 1.81), P = 0.79]. The overall pregnancy rate was similar with an estimated ... Read More »
» Published in Reprod Biomed Online. 2006 Sep;13(3):349-60.
17. Imaging by sensitized oxygenations of photochromic anthracene films: examination of effects that improve performance and reversibility.
Match Strength: 2.189
The aliphatic anthracene compound 1 and the oligomeric anthracene 2 were synthesized. Thin films of 1 and 2 mixed with the sensitizers tetraphenylporphyrin (TPP) and methylene blue (MB) were irradiated with visible light in air. Upon formation of singlet oxygen, the anthracene units were converted quantitatively to the corresponding endoperoxides. Heating of the irradiated samples afforded the parent anthracenes with high yields. Here, we demonstrate that the kinetics and reversibility of this reaction strongly depend on the microenvironment of the anthracene groups in the two compounds. The ... Read More »
» Published in Chemistry. 2006 Dec 13;12(36):9276-83.
18. Electron energy filtering significantly improves amplitude contrast of frozen-hydrated protein at 300kV.
Match Strength: 2.162
The amplitude contrast of frozen-hydrated biological samples was measured using the bacterial flagellar filament embedded in vitreous ice at an accelerating voltage of 300kV. From the mean radial amplitude spectra of overfocused images, amplitude contrast was estimated to be 6.9+/-1.9% and 2.7+/-1.0% of the whole contrast at the low spatial frequency range with and without energy filtering, respectively, and that of the carbon film to be 9.5+/-2.0% and 5.8+/-1.8%. Energy filtering effectively doubled the signal-to-noise ratio in the images of frozen-hydrated filaments, and substantially ... Read More »
» Published in J Struct Biol. 2006 Dec;156(3):524-36. Epub 2006 Aug 15.
19. Association of the pre-B cell receptor (BCR) expression level with the quality of pre-BII cell differentiation reveals hierarchical pre-BCR function.
Match Strength: 2.161
The expression of a pre-B cell receptor (pre-BCR) is required for allelic exclusion and pre-BII cell differentiation. V(H)12 microH chains are unusual in that they form pre-BCRs and mediate allelic exclusion, but most cannot drive pre-BII cell differentiation. To explain this paradox, we examined pre-BCR functions and pre-BII cell differentiation in mice expressing microH chain transgenes encoding a B cell-permissible V(H)12 microH chain (designated 10/G4(6-1)), and a non-permissible V(H)12 microH chain (designated 8/G0). Compared with 10/G4 pre-BCRs, 8/G0 pre-BCRs are expressed at low levels ... Read More »
» Published in Mol Immunol. 2007 Mar;44(7):1765-74. Epub 2006 Sep 27.
20. Effect of weight loss and nutritional intervention on arterial stiffness in type 2 diabetes.
Match Strength: 2.135
OBJECTIVE: There is increased stiffness of the large central arteries in type 2 diabetic patients, and obesity is a risk factor. However, the effect of intentional weight loss on arterial stiffness is uncertain, and the purpose of the current study was to assess this effect. RESEARCH DESIGN AND METHODS: Arterial stiffness was assessed by measuring aortic pulse wave velocity (aPWV) at baseline and at completion of a 1-year weight loss intervention. Metabolic control of type 2 diabetes was also appraised. RESULTS: Mean weight loss at 1 year in 38 volunteers with type 2 diabetes was 7.8%. There ... Read More »
» Published in Diabetes Care. 2006 Oct;29(10):2218-22.
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