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Peer Reviewed Scientific Research Reports.
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1. The epidemiology of acute urinary retention in benign prostatic hyperplasia.
Match Strength: 2.158
One of the most important events in the natural history of BPH is acute urinary retention (AUR). Better estimates of AUR incidence are now available from both population-based studies and placebo control groups (patients diagnosed with BPH). Several strong risk factors for AUR have been identified by analytical epidemiology, the most important being serum PSA levels. When counseling patients with BPH who are considering watchful waiting, clinicians should also take into account prostate volume, maximum flow rate, and symptom severity ... Read More »
» Published in Rev Urol. 2001 Fall;3(4):187-92.
2. Behavior change and health-related interventions for heterosexual risk reduction among drug users.
Match Strength: 2.108
Prevention of heterosexual transmission of HIV between and from drug users is important for controlling the local and global HIV heterosexual epidemic. Sex risk reduction interventions and health-related interventions are important for reducing the sex risk behaviors of drug users. Sex risk reduction interventions address individual-level, peer-level, and structural-level determinants of risk reduction. Health-related interventions include HIV counseling and testing, prevention and treatment of sexually transmitted diseases, and delivery of highly active antiretroviral therapy. It is important ... Read More »
» Published in Subst Use Misuse. 2006;41(10-12):1349-78.
3. Models of genetic susceptibility to breast cancer.
Match Strength: 2.095
One of the most important risk factors for breast cancer is family history of the disease, indicating that genetic factors are important determinants of breast cancer risk. A number of breast cancer susceptibility genes have been identified, the most important being BRCA1 and BRCA2. However, it is estimated that all the currently known breast cancer susceptibility genes accounts for less than 25% of the familial aggregation of breast cancer. In this paper, we review the evidence for other breast cancer susceptibility genes arising from twin studies, pedigree analysis and studies of phenotypes ... Read More »
» Published in Oncogene. 2006 Sep 25;25(43):5898-905.
4. Functional mapping and single chain construction of the anti-cytokeratin 8 monoclonal antibody TS1.
Match Strength: 2.086
The anti-cytokeratin (CK) 8 monoclonal antibody (mab) TS1 has been shown to efficiently bind to CK8 expressed in carcinomas in vivo. The anti-idiotypic antibody of TS1, alphaTS1, can be used to regulate the tumor:non-tumor ratio of TS1 by clearing non-tumor binding TS1 from the circulation. If the interaction of TS1 to CK8 and alphaTS1 is fully understood, mutations can be used to improve the tumor:non-tumor ratio. A scFv was made of the mab TS1 and residues earlier identified by Erlandsson et al. as important for the interaction with both its antigen CK8 and its anti-idiotype alphaTS1, were ... Read More »
» Published in Mol Immunol. 2007 Feb;44(6):1075-84. Epub 2006 Sep 20.
5. Therapeutic targeting of cytokines.
Match Strength: 2.067
Over recent years, with many advances in understanding the pathological processes that underlie many inflammatory conditions, it has become clear that targeting cytokines has proven to be highly effective therapeutically. The second International Cytokine symposium, held recently in Manchester UK, has provided an important forum for bringing basic and clinical scientists together to discuss many aspects of cytokine medicine from the laboratory to the clinic. In this article, we provide an overview of the main issues raised from this important conference and set the scene for more detailed ... Read More »
» Published in Cytokine. 2006 Aug;35(3-4):217-9. Epub 2006 Sep 26.
6. Redox regulation of human thioredoxin network.
Match Strength: 2.000
Oxidative stresses are largely mediated by intracellular protein oxidations by reactive oxygen species (ROS). Host cells are equipped with antioxidants that scavenge ROS. The cellular reduction/oxidation (redox) balance is maintained by ROS and antioxidants. Accumulating evidence suggests that the redox balance plays an important role in cellular signaling through the redox modification of cysteine residues in various important components of the signal transduction pathway. Thioredoxin (TRX) is a small protein playing important roles in cellular responses, including cell growth, cell cycle, ... Read More »
» Published in Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1881-90.
7. Honing the in silico toolkit for detecting protein disorder.
Match Strength: 1.989
Not all proteins form well defined three-dimensional structures in their native states. Some amino-acid sequences appear to strongly favour the disordered state, whereas some can apparently transition between disordered and ordered states under the influence of changes in the biological environment, thereby playing an important role in processes such as signalling. Although important biologically, for the structural biologist disordered regions of proteins can be disastrous even preventing successful structure determination. The accurate prediction of disorder is therefore important, not least ... Read More »
» Published in Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1260-6. Epub 2006 Sep 19.
8. Role of bacterial superantigens in atopic dermatitis : implications for future therapeutic strategies.
Match Strength: 1.980
The role of staphylococcal superantigens in the pathophysiology of atopic dermatitis (AD) has been the focus of intense interest during the past decade. Although the increased prevalence of Staphylococcus aureus and its bacterial toxins in AD skin is well established, exploitation of the known mechanisms of superantigens in this disease for the development of novel therapies remains an active area of research. With the emergence of multi-drug resistant S. aureus, the need for a better understanding of the pathophysiology of bacterial superantigens in AD has become increasingly important. This ... Read More »
» Published in Am J Clin Dermatol. 2006;7(5):273-9.
9. Protein modification in aging: an update.
Match Strength: 1.971
Post-translational modifications of proteins are an important biologic tool for the production of various protein species from a single gene, which may vary in conformation, function, biologic half-life and complex formation with other proteins. The present minireview summarizes a few selected research observations important for the role of post-translational modifications in biologic aging and age-related diseases, including farnesylation, methylglyoxal-derivatization, transglutaminase pathways and the formation of 3-nitrotyrosine and 2-oxo-histidine in vivo. Publication Types: Research ... Read More »
» Published in Exp Gerontol. 2006 Sep;41(9):807-12. Epub 2006 Sep 26.
10. Update on public health surveillance in emergency departments.
Match Strength: 1.952
The development of public health surveillance systems based on ED visits, in conjunction with other health and non-health-related data, is an important step to better understanding the health needs of the US population. There are multiple steps to develop a functional organization, and these actions require the support and involvement of many different partners. The ability to (1) analyze data; (2) distribute results; and (3) influence policy, funding, and patients' behavior are important outgrowths of these activities. This chapter discusses the opportunities and obstacles related to public ... Read More »
» Published in Emerg Med Clin North Am. 2006 Nov;24(4):1035-52.
11. Responsiveness and minimal important differences for patient reported outcomes.
Match Strength: 1.943
Patient reported outcomes provide the patient's perspective on the effectiveness of treatment. The draft Food and Drug Administration guidance on patient reported outcomes for labeling and promotional claims raises a number of method and measurement issues that require further clarification, including methods of determining responsiveness and minimal important differences. For clinical trials, instruments need to be based on a clear conceptual framework, have evidence supporting content validity and acceptable psychometric qualities. The measures must also have evidence documenting ... Read More »
» Published in Health Qual Life Outcomes. 2006 Sep 27;4:70.
12. Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease.
Match Strength: 1.898
OBJECTIVE: Familial cold autoinflammatory syndrome (FCAS) is a rare, hereditary disorder characterized by cold-induced inflammation. We describe the successful longterm treatment of a patient with FCAS with anakinra, an interleukin 1 receptor antagonist (IL-1Ra). The remarkable response of FCAS and associated Raynaud's disease in this patient suggests that IL-1 is an important mediator of these inflammatory diseases. Our report supports increasing evidence that anakinra plays an important role in the treatment of select chronic inflammatory diseases ... Read More »
» Published in J Rheumatol. 2006 Oct;33(10):2085-7. Epub 2006 Sep 15.
13. Phosphorylation and dephosphorylation of human myristoyltransferase type 1.
Match Strength: 1.868
N-Myristoyltransferase (NMT) is an essential eukaryotic enzyme that catalyzes the co-translational and (or) post-translational transfer of myristate to the amino terminal glycine residue of a number of important proteins, especially the non-receptor tyrosine kinases whose activity is important for tumorigenesis. Human NMT was found to be phosphorylated by non-receptor tyrosine kinase family members of Lyn, Fyn, and Lck and dephosphorylated by the Ca2+/calmodulin-dependent protein phosphatase, calcineurin. In this review, we discuss the cross-talk that exists between NMT and their N ... Read More »
» Published in Can J Physiol Pharmacol. 2006 Jul;84(7):707-12.
14. High-pressure studies of pharmaceutical compounds and energetic materials.
Match Strength: 1.824
The effects of high pressure on pharmaceutical compounds and energetic materials can have important implications for both the properties and performance of these important classes of material. Pharmaceutical compounds are frequently subjected to pressure during processing and formulation, causing interconversion between solid forms that may affect properties such as solubility and bio-availability. Energetic materials experience extremes of both pressure and temperature under conditions of detonation and deflagration, causing changes in properties such as sensitivity to shock and chemical ... Read More »
» Published in Chem Soc Rev. 2006 Oct;35(10):932-42. Epub 2006 Aug 8.
15. Clinical aspects of obesity in the gynecological endocrinologicaly practice.
Match Strength: 1.799
Obesity is epidemic of 21st century, its visceral form is associated with increased risk for type 2 diabetes, cardiovascular disease, hypertension and increased mortality due to consequences of the disease. This type of obesity is a common diagnostic and therapeutic problem in gynecological practice. This especially concerns polycystic ovary disease, in which this type of obesity with its metabolic consequences is one of the important factors in etiology and additionally may lead to remote metabolic and cardiovascular problems. Another group of women in which this type of obesity plays an ... Read More »
» Published in Maturitas. 2007 Feb 20;56(2):113-21. Epub 2006 Sep 12.
16. The role of respiratory viruses in the pathogenesis of pediatric asthma.
Match Strength: 1.798
The role of respiratory viral infection in the development of asthma remains unclear. A number of factors play crucial roles, including the type of virus, the severity of the disease, the time of the infection, and, most important, the host predisposition. On the other hand, there is little doubt that a strong association exists between viral respiratory infections and induction of wheezing illnesses and asthma exacerbations. The underlying mechanisms, although not fully clarified, are likely to be multifactorial, involving inflammation of the bronchial mucosa, which interacts under certain ... Read More »
» Published in Pediatr Ann. 2006 Sep;35(9):637-42.
17. Religion and alcohol in the U.S. National Alcohol Survey: How important is religion for abstention and drinking?
Match Strength: 1.793
OBJECTIVE: This paper examines the relative importance of three religion variables (religious preference, religiosity, and alcohol proscription) and eight demographic variables (gender, ethnicity, education, income, marital status, age, region, and employment status) as statistical predictors of drinking versus abstention and moderate versus heavy drinking. METHOD: Data from 7370 telephone interviews from the 2000 National Alcohol Survey are analyzed using bivariate cross-tabulations and multiple logistic regression. RESULTS: When analyzed by religious preference groups, the NAS showed diverse ... Read More »
» Published in Drug Alcohol Depend. 2006 Sep 18;
18. Imaging of the pituitary and sella turcica.
Match Strength: 1.786
The pituitary gland is housed in the sella turcica and has vital endocrinologic functions. It lies in close proximity to numerous vital structures, including the optic chiasm, sphenoid sinus, cavernous sinus and hypothalamus. An understanding of the function, anatomy and embryology of the pituitary gland and its surrounding structures is vital to understanding its normal appearance, as well as in evaluating the broad spectrum of pathology that can involve the pituitary gland. Imaging of pathology in the sellar region, including pituitary adenomas, meningiomas, craniopharyngiomas and aneurysms, ... Read More »
» Published in Expert Rev Anticancer Ther. 2006 Sep;6 Suppl 9:S15-22.
19. Sex differences in dieting trends, eating habits, and nutrition beliefs of a group of midwestern college students.
Match Strength: 1.780
The influence of sex on dietary trends, eating habits, and nutrition self-assessment and beliefs of a group of college students at a large Midwestern university was investigated. A questionnaire was completed by 105 male and 181 female undergraduate students. Men had significantly higher (P<0.0001) height, weight, and body mass index values. Significantly higher percentages of women than men had tried a low-fat diet (P=0.0075) and a low-carbohydrate diet (P=0.0285). Significantly lower percentages of women than men had never tried a diet (P=0.0173). Significantly higher percentages of women ... Read More »
» Published in J Am Diet Assoc. 2006 Oct;106(10):1673-7.
20. Overactive bladder: The importance of new guidance.
Match Strength: 1.767
Overactive bladder (OAB) affects an estimated 49 million people in Europe, but only a minority receive appropriate treatment. Others are bothered by unacceptable levels of symptoms that severely impair their quality of life and represent a significant financial burden to themselves and to their healthcare providers. Recently updated guidelines from the International Consultation on Incontinence (ICI) and the European Association of Urology (EAU) take account of important new developments in the management of bladder problems in both primary and secondary care. However, local implementation of ... Read More »
» Published in Int J Clin Pract. 2006 Oct;60(10):1263-71.
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