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Peer Reviewed Scientific Research Reports.
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1. High plasma concentration of remnant lipoprotein cholesterol in obese children and adolescents.
Match Strength: 5.852
OBJECTIVE: Remnant lipoproteins (RLPs) are the products of the lipolytic degradation of triglyceride-rich lipoproteins produced by the liver and intestine. Recent studies have demonstrated that RLPs are correlated with cardiovascular risk. We assessed the relationship between obesity and RLP and evaluated the factors related to RLP in children and adolescents. RESEARCH DESIGN AND METHODS: We measured BMI, waist circumference, blood pressure, body fat mass, total abdominal fat, visceral and subcutaneous fat areas, fasting glucose, insulin, total cholesterol, triglycerides, LDL cholesterol, HDL ... Read More »
» Published in Diabetes Care. 2006 Oct;29(10):2305-10.
2. Pravastatin in vivo reduces mononuclear cell migration through endothelial monolayers.
Match Strength: 5.275
The objective was to evaluate pravastatin modulation on peripheral blood mononuclear cell (PBMC) migration across endothelial monolayers. Eleven hypercholesterolaemic patients were treated with pravastatin 20 mg/day. At baseline (T0), after 40 days (T40) and after 6 months (T 6 months) of treatment total serum cholesterol, low-density lipoprotein (LDL), high-density lipoprotein, triglycerides, C-reactive protein, as well as tumour necrosis factor-alpha (TNF-alpha) and metalloproteinases-9 plasma levels were evaluated. At the same time points the effect of pravastatin on migration of PBMCs ... Read More »
» Published in Neurol Sci. 2006 Sep;27(4):261-5.
3. Relative iron "overload" in offspring of patients with type 2 diabetes mellitus: a new component in the conundrum of insulin resistance syndrome?
Match Strength: 4.666
There are a few reports suggesting that subtle disturbances of iron metabolism are frequently found in patients with type 2 diabetes (DM2), but it is not known if these disturbances precede or accompany the diabetic state. We investigated the serum iron indices in 41 offspring of DM2 parents (group I) with normal glucose tolerance, and in 49 offspring whose parents had no history of DM2 and were matched for sex, age, body mass index (BMI), waist to hip ratio (WHR) and blood pressure (group II). Serum iron, ferritin, total iron binding capacity (TIBC), transferrin saturation, serum ... Read More »
» Published in Hormones (Athens). 2003 Jul-Sep;2(3):161-8.
4. Beneficial effects of coconut water feeding on lipid metabolism in cholesterol-fed rats.
Match Strength: 4.497
The purpose of this study was to determine the effect of coconut water feeding in cholesterol-fed rats. Male albino rats were fed tender coconut water and mature coconut water at a dose level of 4 mL/100 g of body weight. Cholesterol feeding caused a marked increase in total cholesterol, very low-density lipoprotein (VLDL) + low-density lipoprotein (LDL) cholesterol, and triglycerides in serum. Administration of coconut water counteracts the increase in total cholesterol, VLDL + LDL cholesterol, and triglycerides, while high-density lipoprotein cholesterol was higher. Lipid levels in the ... Read More »
» Published in J Med Food. 2006 Fall;9(3):400-7.
5. Relationship between lipid abnormalities and insulin resistance in Japanese school children.
Match Strength: 3.485
OBJECTIVE: Dyslipidemia and insulin resistance (IR) are risk factors for coronary heart disease (CHD) in adults. To help prevent the development of CHD, it may be useful to understand the relationship between lipid abnormalities and IR during childhood. METHODS AND RESULTS: IR was assessed by the homeostasis model approximation index. We studied 1175 Japanese school children (642 boys and 533 girls), aged between 7 and 12 years. Obesity was defined by the body mass index standard deviation score (BMISD) (obese: BMISD > or = 2.0). BMISD was most significantly associated with IR in nonobese ... Read More »
» Published in Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2781-6. Epub 2006 Sep 21.
6. Hereditary postprandial hypertriglyceridemic rabbit exhibits insulin resistance and central obesity: a novel model of metabolic syndrome.
Match Strength: 3.194
OBJECTIVE: We have established a hereditary postprandial hypertriglyceridemic (PHT) rabbit. The present study was designed to define whether this rabbit model represents both insulin resistance and central obesity. METHODS AND RESULTS: Body weight, abdominal circumference, visceral fat weight, and glucose tolerance were compared between PHT and Japanese white (JW) rabbit. Plasma levels of triglycerides (TG), total cholesterol (TC), glucose, and insulin were measured before and after feeding. Abdominal circumference of PHT rabbit was larger than that of JW rabbit, with no difference in body ... Read More »
» Published in Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2752-7. Epub 2006 Sep 21.
7. Acute and subacute toxicity of Salvia scutellarioides in mice and rats.
Match Strength: 3.107
The acute and subacute toxicity of the aqueous extract of Salvia scutellarioides (Lamiaceae) was studied in mice and rats. In the acute toxicity test, oral administration of 2g/kg of Salvia scutellarioides produced neither mortality nor changes in behavior or any other physiological activities. In subacute toxicity studies, no mortality was observed when the two doses of 1 or 2g/kgday of aqueous extract of Salvia scutellarioides extract were administered orally for a period of 28 days. In the blood chemistry analysis, no significant changes occurred, including glucose, creatinine, blood urea ... Read More »
» Published in J Ethnopharmacol. 2007 Jan 19;109(2):348-53. Epub 2006 Aug 12.
8. Phospholipid-based microemulsions suitable for use in foods.
Match Strength: 2.805
The preparation of nonaqueous microemulsions using food-acceptable components is reported. The effect of oil on the formation of microemulsions stabilized by lecithin (Epikuron 200) and containing propylene glycol as immiscible solvent was investigated. When the triglycerides were used as oil, three types of phase behavior were noted, namely, a two-phase cloudy region (occurring at low lecithin concentrations), a liquid crystalline (LC) phase (occurring at high surfactant and low oil concentrations), and a clear monophasic microemulsion region. The extent of this clear one-phase region was ... Read More »
» Published in J Agric Food Chem. 2006 Oct 4;54(20):7817-24.
9. Succinic acid monoethyl ester, a novel insulinotropic agent: Effect on lipid composition and lipid peroxidation in streptozotocin-nicotin-amide induced type 2 diabetic rats.
Match Strength: 2.796
Succinic acid monoethyl ester (EMS) is recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. Oxidative stress has been suggested to be a contributory factor in the development and complications of diabetes. In the present study the effect of EMS and Metformin on plasma glucose, insulin, serum and tissue lipid profile, lipoproteins and lipid peroxidation in streptozotocin-nicotinamide induced type 2 diabetic model was investigated. The carboxylic nutrient EMS was administered intraperitonially (8 micromol/g body weight) to streptozotocin ... Read More »
» Published in Mol Cell Biochem. 2006 Sep 28;
10. A pilot study of open label sesame oil in hypertensive diabetics.
Match Strength: 2.656
The objective of this study was to investigate the effect of sesame oil in hypertensive diabetics medicated with atenolol (beta-blocker) and glibenclamide (sulfonylurea). This open label trial with two intervention periods comprised 22 male and 18 female patients, 45-65 years old, with mild to moderate hypertension and diabetes. Sesame oil (Idhayam Gingelly oil, V.V.V. & Sons, Virudhunagar, Tamilnadu, India) was supplied to the patients, who were instructed to use it in place of other cooking oils for 45 days. Blood pressure (BP), anthropometric measurements, plasma glucose, glycated ... Read More »
» Published in J Med Food. 2006 Fall;9(3):408-12.
11. Comparison of anthropometric, metabolic and dietary fatty acids profiles in lean and obese dyslipidaemic Asian Indian male subjects.
Match Strength: 2.210
Objectives:To compare obesity measures, metabolic profiles and dietary fatty acids in lean and obese dyslipideamic Asian Indian male subjects.Design:Cross-sectional.Settings:Asian Indians living in the eastern part of India.Subjects:One hundred and thirty (Group I: lean control, n=50; Group II: lean dyslipidaemic, n=40 and Group III: obese dyslipidaemic, n=40) Asian Indian male subjects (>/=30 years) living in the eastern part of India.Methods:Anthropometric measures namely height, weight, circumferences of waist (WC) and hip, lipids (total cholesterol (TC) and triglycerides (TG)), ... Read More »
» Published in Eur J Clin Nutr. 2006 Sep 27;
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