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Peer Reviewed Scientific Research Reports.
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1. Interactions between oxidative stress and inflammation in salt-sensitive hypertension.
Match Strength: 5.037
The goal of this study was to test the hypothesis that increases in oxidative stress in Dahl S rats on a high-salt diet help to stimulate renal nuclear factor-kappaB (NF-kappaB), renal proinflammatory cytokines, and chemokines, thus contributing to hypertension, renal damage, and dysfunction. We specifically studied whether antioxidant treatment of Dahl S rats on high Na intake would decrease renal inflammation and thus attenuate the hypertensive and adverse renal responses. Sixty-four 7- to 8-wk-old Dahl S or R/Rapp strain rats were maintained for 5 wk on high Na (8%) or high Na + vitamins C ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3388-95. Epub 2007 Oct 5.
2. Intracellular redox state regulation by parthenolide.
Match Strength: 4.971
In the present paper, we report a strong intracellular antioxidant activity of the sesquiterpene lactone parthenolide in the hippocampal HT22 cells. This effect is mediated by an increase of total glutathione at both, low (5 microM) and high (10 microM), concentrations. Parthenolide also increases the activation of the antioxidant/electrophile response element. This effect is the possible mediator of glutathione increase, since the limiting enzyme on its synthesis possesses this response element on its promoter. Finally, we demonstrate that its antioxidant properties do not mediate its ... Read More »
» Published in Biochem Biophys Res Commun. 2005 Jul 1;332(2):321-5.
3. SAR and QSAR of the antioxidant activity of flavonoids.
Match Strength: 4.788
Flavonoids are a group of naturally occurring phytochemicals abundantly present in fruits, vegetables, and beverages such as wine and tea. In the past two decades, flavonoids have gained enormous interest because of their beneficial health effects such as anti-inflammatory, cardio-protective and anticancer activities. These findings have contributed to the dramatic increase in the consumption and use of dietary supplements containing high concentrations of plant flavonoids. The pharmacological effect of flavonoids is mainly due to their antioxidant activity and their inhibition of certain ... Read More »
» Published in Curr Med Chem. 2007;14(7):827-45.
4. Antioxidant and anti-inflammatory effects of Orthosiphon aristatus and its bioactive compounds.
Match Strength: 4.721
Orthosiphon aristatus (Blume) Miq., which can be used as a food ingredient, is grown throughout Southeast Asia and Australia. O. aristatus is frequently used for the treatment of renal inflammation, kidney stones and dysuria. The focus of the current work was to study the antioxidant and anti-inflammatory effects of methanol, ethanol and water extracts from O. aristatus (abbreviated as MEOA, EEOA and WEOA, respectively). The evaluation of antioxidant activity was determined by total phenolics, Trolox equivalent antioxidant capacity (TEAC), oxygen-radical absorbance capacity (ORAC) and cellular ... Read More »
» Published in J Agric Food Chem. 2010 Feb 24;58(4):2150-6.
5. Assessment of polyphenolic compounds, in vitro antioxidant and anti-inflammation properties of Securidaca longepedunculata root barks.
Match Strength: 4.653
The present study was carried out to evaluate the antioxidant activities of the root bark extract of Securidaca longepedunculata. This plant material is commonly used in folk medicine in several parts in the world. The bark extracts of S. longepedunculata were evaluated for their total phenols, flavonoids, anthocyanins, tannins content and total antioxidant capacity. The compounds were identified and quantified both by RP-HPLC and UV spectrophotometer; the antioxidant capacity was assessed by ABTS and DPPH tests and expressed as IC(50). The total phenolic compounds determinate was 9.86mg ... Read More »
» Published in C R Biol. 2010 Sep;333(9):663-9. Epub 2010 Aug 23.
6. Antioxidant micronutrients in major trauma and burns: evidence and practice.
Match Strength: 4.590
There has been a growing interest in micronutrients as a result of their essential role in endogenous antioxidant defense mechanisms and immunity. Critically ill burn and trauma patients are characterized by an increased free radical production, which is proportional to the severity of the injury. In addition, they are at high risk of negative trace element balances, which contribute to the imbalance in endogenous antioxidant capacity and the extension of primary lesions. Although selenium, zinc, and vitamin C and E status are altered in all injured patients, patients with major burns are ... Read More »
» Published in Nutr Clin Pract. 2006 Oct;21(5):438-49.
7. Increased monocyte adhesion-promoting capacity of plasma in end-stage renal disease - response to antioxidant therapy.
Match Strength: 4.577
End-stage renal disease (ESRD) causes accelerated atherosclerosis which is mediated by oxidative stress and inflammation. Activation and infiltration of monocytes represent the critical steps in atherogenesis which is advanced by oxidized LDL and inhibited by HDL. Via its main apolipoprotein (apoA-I) and constituent enzymes (paraoxonase; glutathione peroxidase (GPX), LCAT) HDL exerts potent antioxidant/anti-inflammatory functions. We have found marked reduction of HDL antioxidant/anti-inflammatory and heightened LDL pro-oxidant/pro-inflammatory activities in ESRD patients. Given the ... Read More »
» Published in Clin Nephrol. 2010 Oct;74(4):273-81.
8. Determination of total content of phenolic compounds and their antioxidant activity in vegetables--evaluation of spectrophotometric methods.
Match Strength: 4.560
This research studies in detail the contents of phenolic compounds determined by the Folin-Ciocalteu reagent and the antioxidant activities determined by the TEAC (Trolox equivalent antioxidant capacity), DPPH (using diphenyl-p-picrylhydrazyl radical), and FRAP (ferric reducing antioxidant power) methods, and their correlations for used standards with these methods (catechine, gallic acid, caffeic acid, ferulic acid, Trolox, ascorbic acid, and ferrous sulfate) and extracts from several species of commonly consumed vegetables were studied in detail. The comparison of absolute values of ... Read More »
» Published in J Agric Food Chem. 2006 Feb 8;54(3):607-16.
9. High-density lipoproteins, inflammation and oxidative stress.
Match Strength: 4.509
Plasma levels of HDL (high-density lipoprotein)-cholesterol are strongly and inversely correlated with atherosclerotic cardiovascular disease. Both clinical and epidemiological studies have reported an inverse and independent association between serum HDL-cholesterol levels and CHD (coronary heart disease) risk. The cardioprotective effects of HDLs have been attributed to several mechanisms, including their involvement in the reverse cholesterol transport pathway. HDLs also have antioxidant, anti-inflammatory and antithrombotic properties and promote endothelial repair, all of which are likely ... Read More »
» Published in Clin Sci (Lond). 2009 Jan;116(2):87-98.
10. Characterisation of polyphenols by HPLC-PAD-ESI/MS and antioxidant activity in Equisetum telmateia.
Match Strength: 4.499
The antioxidant activity of an aqueous extract (infusion) and respective ethyl acetate fraction of Equisetum telmateia Ehrh. (Equisetaceae), a plant used in traditional medicine for its anti-inflammatory and diuretic properties, has been evaluated by DPPH, TEAC and TBARS assays. A high and significant antioxidant activity was detected in the ethyl acetate fraction. Analysis of the aqueous extract and the ethyl acetate fraction by HPLC-PAD-ESI/MS allowed the identification of the major phenolic compounds as flavan-3-ol, kaempferol and phenolic acid derivatives. Among the flavan-3-ols, A-type ... Read More »
» Published in Phytochem Anal. 2005 Sep-Oct;16(5):380-7.
11. The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health.
Match Strength: 4.437
The Mediterranean diet is rich in vegetables, cereals, fruit, fish, milk, wine and olive oil and has salutary biological functions. Epidemiological studies have shown a lower incidence of atherosclerosis, cardiovascular diseases and certain kinds of cancer in the Mediterranean area. Olive oil is the main source of fat, and the Mediterranean diet's healthy effects can in particular be attributed not only to the high relationship between unsaturated and saturated fatty acids in olive oil but also to the antioxidant property of its phenolic compounds. The main phenolic compounds, hydroxytyrosol ... Read More »
» Published in Nutr Res Rev. 2005 Jun;18(1):98-112.
12. Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa.
Match Strength: 4.434
Dorstenia barteri and D. convexa extracts and some isolated components of the former were investigated for effectiveness against Trichomonas gallinarum and compared with quercetin and quercitrin. The antioxidant activity of the extracts/compounds was also determined. The minimum lethal concentrations (MLCs) for the extract of D. barteri leaves and twigs at 24 h were found to be 15.625 and 15.625 microg/ml, respectively. However, the MLCs of the leaf and twig extract of D. convexa were 125 and 437.5 microg/ml, respectively. The prenylated and geranylated chalcones were as active as the ... Read More »
» Published in Braz J Med Biol Res. 2005 Jul;38(7):1087-94. Epub 2005 Jul 4.
13. Antioxidant and cytoprotective properties of high-density lipoproteins in vascular cells.
Match Strength: 4.394
Beside their key role in the regulation of cholesterol homeostasis, HDL exhibit antioxidant and anti-inflammatory properties that participate to their general antiatherogenic effect. The purpose of this review is to summarize the recent findings on antioxidant activity and cytoprotective cell signalling elicited by HDL against oxidized LDL and proatherogenic agents in vascular cells. HDL exhibit an antioxidant activity efficient to prevent LDL oxidation, or to inactivate newly formed lipid oxidation products. The antioxidant ability of HDL is due to the apoprotein moiety and to the presence of ... Read More »
» Published in Free Radic Biol Med. 2006 Oct 1;41(7):1031-40. Epub 2006 Jul 12.
14. Effect of resveratrol on high glucose-induced stress in human leukemia K562 cells.
Match Strength: 4.343
Hyperglycemia, a symptom of diabetes mellitus, induces hyperosmotic responses, including apoptosis, in vascular endothelial cells and leukocytes. Hyperosmotic shock elicits a stress response in mammalian cells, often leading to apoptotic cell death. In a previous report, we showed that hyperosmotic shock induced apoptosis in various mammalian cells. Importantly, apoptotic biochemical changes (i.e., caspase-3 activation and DNA fragmentation) were blocked by antioxidant pretreatment during hyperosmotic shock-induced cell death. In the present study, we report that resveratrol, a phytoalexin ... Read More »
» Published in J Cell Biochem. 2005 Apr 15;94(6):1267-79.
15. Safety and antioxidant effects of a modest soy protein intervention in hemodialysis patients.
Match Strength: 4.118
Antioxidant/anti-inflammatory effects of isoflavone-containing soy protein could partly explain why hemodialysis patients in Japan tend to outlive U.S. hemodialysis patients. However, a safety concern is that dialysis patients do not clear isoflavones well. A low-dose intervention with high isoflavone soy protein (25 g protein, four times a week for 4 weeks) was tested in 17 U.S. hemodialysis patients (eight given soy protein, nine given whey protein as a control). Soy protein intake produced no harmful effects based on a typical battery of blood safety tests. Post-treatment isoflavone levels, ... Read More »
» Published in J Med Food. 2006 Fall;9(3):368-72.
16. Biomedicinal implications of high-density lipoprotein: its composition, structure, functions, and clinical applications.
Match Strength: 4.096
High-density lipoprotein (HDL) is a proven biomarker for the monitoring of changes in antioxidant and anti-inflammation capability of body fluids. The beneficial virtues of HDL are highly dependent on its lipids and protein compositions, and their ratios. In normal state, the HDL particle is enriched with lipids and several HDL-associated enzymes, which are responsible for its antioxidant activity. Lower HDL-cholesterol levels (40 mg/dL) have been recognized as an independent risk factor for coronary artery disease, as well as being a known component of metabolic syndrome. Functional and ... Read More »
» Published in BMB Rep. 2009 Jul 31;42(7):393-400.
17. Effects of Grape Pomace Antioxidant Extract on Oxidative Stress and Inflammation in Diet Induced Obese Mice.
Match Strength: 4.027
Norton grape is one of the most important wine grapes in Southern and Midwestern states and generates massive pomace byproducts. The objective of this study is to characterize the antioxidant compounds and activity in Norton grape pomace extract (GPE) and further assess the potential health promoting properties of Norton GPE using an animal disease model. The total phenolic content and anthocyanins in Norton GPE were 475.4 mg of gallic acid equiv/g and 156.9 mg of cyanidin 3-glucoside equiv/g, respectively. Catechin and epicatechin in GPE were 28.6 and 24.5 mg/g, respectively. Other major ... Read More »
» Published in J Agric Food Chem. 2010 Oct 7.
18. Evaluation of anti-inflammatory and antioxidant activities of mixed-ligand Cu(II) complexes of dien and its Schiff dibases with heterocyclic aldehydes and 2-amino-2-thiazoline.
Match Strength: 4.009
A new series of complexes of the type [Cu(dien)(2a-2tzn)Y2] and [Cu(dienXX)(2a-2tzn)Y2] has been tested for anti-inflammatory and antioxidant activity. The tested compounds inhibit significantly the carrageenin induced paw edema (36.4-55.8%) and present important scavenging activities. Although their interaction with the free stable radical DPPH is not high they peroxide anions. Compound 7 is the most potent (55.8%) in the in vivo experiment. Lipophilicity--as RM values and theoretically calculated logP values--has been determined. An attempt to correlate the biological results with their ... Read More »
» Published in Bioorg Med Chem Lett. 2006 Apr 15;16(8):2234-7. Epub 2006 Feb 7.
19. Antioxidative and antiinflammatory potential of different functional drink concepts in vitro.
Match Strength: 4.006
The present study was undertaken to investigate the antioxidative effects of three different functional drink concepts especially designed to improve the body's performance and function and to possess high antioxidant activities. The concepts based on the mixture of various plant ingredients were: (1) eQ - equalize your nutrient balance, brain line [acerola-dragon fruit], (2) eQ - equalize your nutrient balance, beauty line [honey-pepper] and (3) Let's get red [intense]. By using a cell-based test assay, the study investigated the potential of the functional drinks to inactivate reactive ... Read More »
» Published in Phytother Res. 2009 Feb;23(2):165-71.
20. Antioxidant status and stress proteins in the gills of the brown mussel Perna perna exposed to zinc.
Match Strength: 3.950
Zinc, at low levels, has several basic housekeeping functions in metalloenzymes, transcription factors, immunoregulation, growth, and cytoprotection, displaying antioxidant, anti-apoptotic, and anti-inflammatory roles. At high levels, however, the metal can be highly toxic. The aim of this work is to investigate the toxic effect of zinc on antioxidant status and stress proteins in the gills of the brown mussel Perna perna exposed for 48 h to zinc chloride (zinc) at 10, 30 and 100 microM. Glutathione reductase (GR) activity was drastically reduced at 30 and 100 microM zinc. At the lower levels, ... Read More »
» Published in Chem Biol Interact. 2006 Apr 15;160(3):232-40. Epub 2006 Mar 24.
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