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Heart
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1. The value of using the entire New York Heart Association's classification of heart and vascular disease.
Match Strength: 5.320

The New York Heart Association functional classification is commonly used because the value of its determination is generally appreciated. The other four parts of the classification (etiology, anatomy, physiology, and objective assessment) are used less often. The purpose of this paper is to point out the value of using the entire New York Heart Association classification. Publication Types: ... Read More »
» Published in Clin Cardiol. 2006 Sep;29(9):415-7.

2. Heart rate response during exercise predicts survival in adults with congenital heart disease.
Match Strength: 5.304

OBJECTIVES: To assess the prognostic value of heart rate response to exercise in adult congenital heart disease (ACHD) patients. BACKGROUND: An abnormal heart rate response to exercise is related to autonomic dysfunction and may have prognostic implications in ACHD. METHODS: We identified 727 consecutive ACHD patients (mean age [+/- SD] 33 +/- 13 years) with varying diagnoses and without pacemakers. Peak oxygen consumption (peak VO2), resting heart rate, and the increase in heart rate from resting level to peak exercise ("heart rate reserve") were measured. We also quantified the decrease in ... Read More »
» Published in J Am Coll Cardiol. 2006 Sep 19;48(6):1250-6. Epub 2006 Aug 28.

3. Sparing immunosuppression in heart transplant recipients with severe sepsis.
Match Strength: 4.887

This study described an analysis of severe sepsis among heart transplantation recipients who were treated by sparing all immunosuppressants. Sepsis leading to multiple organ failure (MOF) in heart transplantation has a high mortality. This retrospective study of 190 patients who underwent heart transplantation from 1993 to 2004 included 12 who had severe sepsis with MOF who were treated by sparing all immunosuppressants. Half of them survived after sparing all immunosuppressants with intensive endomyocardial biopsy. Only one case needed pulse therapy for an acute rejection episode. The most ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2145-6.

4. Simultaneous heart and kidney transplantation for combined cardiac and renal failure.
Match Strength: 4.456

Simultaneous heart and kidney transplantation (SHKT) is feasible for combined cardiac and renal failure. Herein we reviewed our 10-year experience in SHKT. Six patients underwent SHKT from June 1995 to December 2004. Their ages ranged from 13 to 63 years old with a mean of 45.5 +/- 15.8 years. They were all men except one girl, who was the youngest (aged 13) who suffered from dilated cardiomyopathy with congestive heart failure and chronic renal failure due to systemic lupus erythematosus. Because of aggravating heart failure, she changed from hemodialysis to peritoneal dialysis. Because of ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2135-7.

5. Gene regulatory networks in the evolution and development of the heart.
Match Strength: 4.400

The heart, an ancient organ and the first to form and function during embryogenesis, evolved by the addition of new structures and functions to a primitive pump. Heart development is controlled by an evolutionarily conserved network of transcription factors that connect signaling pathways with genes for muscle growth, patterning, and contractility. During evolution, this ancestral gene network was expanded through gene duplication and co-option of additional networks. Mutations in components of the cardiac gene network cause congenital heart disease, the most common human birth defect. The ... Read More »
» Published in Science. 2006 Sep 29;313(5795):1922-7.

6. Difficulties in maintaining potassium homeostasis in patients with heart failure.
Match Strength: 4.164

Potassium (K) concentration plays a significant role in cell metabolism and membrane excitability. The imbalance of serum potassium is important because it can lead to life-threatening events. Potassium balance may be lost both through the neurohormonal mechanisms involved in cardiovascular diseases and through the drugs used in the treatment of this illness. Avoiding both hypo- and hyperkalemia is beneficial in several cardiovascular diseases, especially heart failure. Electrolyte abnormalities are frequently seen complications in subjects with heart failure. Malignant ventricular arrhythmias ... Read More »
» Published in Clin Cardiol. 2006 Sep;29(9):388-92.

7. New frontiers in the pathology and therapy of heart valve disease: 2006 Society for Cardiovascular Pathology, Distinguished Achievement Award Lecture, United States-Canadian Academy of Pathology, Atlanta, GA, February 12, 2006.
Match Strength: 4.037

This review summarizes several areas relative to the pathology of heart valve disease in which there has been rapid and ongoing evolution, namely, our understanding of: (a) the dynamic functional biology of cardiac valves; and (b) the pathology/pathobiology of valvular heart diseases; (c) new developments in valve repair and substitution using percutaneous approaches; and (d) progress toward the exciting potential of therapeutic valvular tissue engineering and regeneration, including the challenges that will need to be overcome before such therapeutic advances can become clinically useful. ... Read More »
» Published in Cardiovasc Pathol. 2006 Sep-Oct;15(5):271-9.

8. Temperature acclimation modifies sinoatrial pacemaker mechanism of the rainbow trout heart.
Match Strength: 4.033

The hypothesis of pacemaker level origin of thermal compensation in heart rate was tested by recording action potentials (AP) in intact sinoatrial tissue and enzymatically isolated pacemaker cells of rainbow trout acclimated at 4 degrees C (cold) and 18 degrees C (warm). With electrophysiological recordings, the primary pacemaker was located at the base of the sinoatrial valve, where a morphologically distinct ring of tissue comprising myocytes and neural elements was found by histological examination. Intrinsic beating rate of this pacemaker was higher in cold-acclimated (46 +/- 6 APs/min) ... Read More »
» Published in Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R1023-32. Epub 2006 Sep 28.

9. Making or breaking the heart: from lineage determination to morphogenesis.
Match Strength: 4.010

The cues governing cardiac cell-fate decisions, cardiac differentiation, and three-dimensional morphogenesis are rapidly being elucidated. Several themes are emerging that are relevant for childhood and adult heart disease and the growing field of stem cell biology. This review will consider our current understanding of cardiac cell-fate determination and cardiogenesis--largely derived from developmental studies in model organisms and human genetic approaches--and examine future implications for diagnosis, prevention, and treatment of heart disease in the young and old. Publication Types: ... Read More »
» Published in Cell. 2006 Sep 22;126(6):1037-48.

10. Phosphodiesterase 4D and heart failure: a cautionary tale.
Match Strength: 3.978

Stimulation of several G-protein-coupled receptors (GPCRs) promotes intracellular production of cyclic adenosine 3',5'-monophosphate (cAMP) and subsequently activates protein kinase A (PKA). In the heart, beta-adrenergic receptor (beta-AR) stimulation increases contractile performance and heart rate as part of the 'fight-or-flight' stress response. Molecular organisation of PKA-effector association occurs by A kinase anchoring proteins (AKAPs), which target kinase action to specific intracellular sites. Some AKAPs interact directly with specific cAMP-hydrolysing phosphodiesterase (PDE) ... Read More »
» Published in Expert Opin Ther Targets. 2006 Oct;10(5):677-88.

11. Metabolic syndrome as a risk factor for coronary heart disease and stroke: An 11-year prospective cohort in Taiwan community.
Match Strength: 3.788

OBJECTIVE: Patterns of metabolic syndrome among populations in the Asia-Pacific region remain unknown. This study sought to establish the prevalence of metabolic syndrome in Taiwan and the risk of cardiovascular disease imparted by this syndrome. METHODS AND RESULTS: A cohort of 3602 individuals aged 35 years and above from one Taiwan community in 1990-1991 was followed up for a median of 9.0 years (inter-quartile range: 7.9-10.0 years). Women had a higher prevalence rates of age-standardized metabolic syndrome than men (28.9% versus 16.6%) by original NCEP-ATP III criteria, and the rates ... Read More »
» Published in Atherosclerosis. 2006 Sep 13;

12. A pilot investigation of the effect of extremely low frequency pulsed electromagnetic fields on humans' heart rate variability.
Match Strength: 3.765

The question whether pulsed electromagnetic field (PEMF) can affect the heart rhythm is still controversial. This study investigates the effects on the cardiocirculatory system of ELF-PEMFs. It is a follow-up to an investigation made of the possible therapeutic effect ELF-PEMFs, using a commercially available magneto therapeutic unit, had on soft tissue injury repair in humans. Modulation of heart rate (HR) or heart rate variability (HRV) can be detected from changes in periodicity of the R-R interval and/or from changes in the numbers of heart-beat/min (bpm), however, R-R interval analysis ... Read More »
» Published in Bioelectromagnetics. 2007 Jan;28(1):64-8.

13. Pathology of inflammatory native valvular heart disease.
Match Strength: 3.759

Rheumatic disease is an important cause of inflammatory native heart valve disease. However, with increased understanding of the pathoetiology of valve disease and valve injury, it is evident that inflammation may play a role in many valve disorders. We are only beginning to understand these complex processes. With increasing knowledge that many of these processes are active, there may be opportunity for intervention or even prevention ... Read More »
» Published in Cardiovasc Pathol. 2006 Sep-Oct;15(5):243-51.

14. A Large-Scale Analysis of Ion Channel Gene Expression in the Mouse Heart during Perinatal Development.
Match Strength: 3.709

The immature and mature heart differs from each other in terms of its excitability, action potential properties, contractility and relaxation. This includes upregulation of repolarizing K(+) currents, an enhanced inward rectifier K(+) current and changes in Ca(2+), Na(+) and Cl(-) currents. At the molecular level, the developmental regulation of ion channels is scantily described. Using a large-scale real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) assay, we performed a comprehensive analysis of ion channel transcript expression during perinatal development in ... Read More »
» Published in Physiol Genomics. 2006 Sep 19;

15. Radiation dose and long term risk of cardiac pathology following radiotherapy and anthracyclin for a childhood cancer.
Match Strength: 3.702

PURPOSE: To determine the cardiac status in children 15 years (yrs) or more after a solid tumour treatment. PATIENTS AND METHODS: Of the 447 patients, 229 were fully studied and 218 were not. The following cardiac evaluation was proposed to all the 447 consecutive patients: (1) cardiac Doppler US by one of two expert cardiologists; (2) cardiac rhythm and conduction abnormalities including 24-h holter ECG; (3) (131)I-mIBG myocardial scintigraphy; (4) serum brain natriuretic peptide levels at rest; (5) an exercise test with VO(2)max measurement. The radiation dose delivered to 7 points in the ... Read More »
» Published in Radiother Oncol. 2006 Oct;81(1):47-56. Epub 2006 Sep 20.

16. Recent increase of neighborhood socioeconomic effects on ischemic heart disease mortality: a multilevel survival analysis of two large Swedish cohorts.
Match Strength: 3.668

Studies have shown that the decrease in ischemic heart disease mortality over the past decades was paralleled by an increase in socioeconomic disparities. Using two large Swedish cohorts defined in 1986 and 1996, the authors examined whether the effect of neighborhood socioeconomic position on ischemic heart disease mortality strengthened over the period and whether the relative contribution of individual and neighborhood socioeconomic effects changed over time. Multilevel survival models adjusted for individual factors indicated that neighborhood socioeconomic effects on ischemic heart ... Read More »
» Published in Am J Epidemiol. 2007 Jan 1;165(1):22-6. Epub 2006 Sep 14.

17. Smoking-associated factors in myocardial infarction and unstable angina: Do gender differences exist?
Match Strength: 3.667

The aim of this study was to investigate demographic and psychological characteristics associated with smoking in patients with acute coronary syndrome (myocardial infarction or unstable angina). Interviews were conducted with 348 consecutive hospitalized patients with acute coronary syndrome and included questions about demographic characteristics, coffee consumption, heart disease risk perception, economic status, alcohol consumption, depression, anxiety, and stress. Female group multivariate analysis showed that smoking in females was significantly and negatively associated with age, heart ... Read More »
» Published in Addict Behav. 2006 Sep 13;

18. Evaluation of three-dimensional navigator-gated whole heart MR coronary angiography: The importance of systolic imaging in subjects with high heart rates.
Match Strength: 3.620

PURPOSE: To evaluate the influence of heart rate (HR) on magnetic resonance coronary angiography (MRCA) image quality in diastolic and systolic phases. MATERIALS AND METHODS: Twenty-seven healthy volunteers (9 men; 33+/-9 years, HR 53-110bpm), were evaluated with the electrocardiography and three-dimensional navigator-gating MRCA in a 1.5-T MR scanner (Avanto, Siemens) in diastolic and systolic phases (steady-state free precession; TR/TE/flip angle=3.2ms/1.6ms/90 degrees ). The timing of scanning was individually adapted to the cardiac rest periods obtained in the prescanning, by visually ... Read More »
» Published in Eur J Radiol. 2007 Jan;61(1):91-6. Epub 2006 Sep 20.

19. Influence of physiological and subjective arousal on food intake in humans.
Match Strength: 3.509

OBJECTIVES: This study explored the influence of physiologic and subjective arousal on ambient factors of the food environment, such as the eating location, the presence of other people, sound, and time of day and on food intake. It was hypothesized that the influence of environmental stimuli on food intake would be mediated by arousal. METHODS: College students were asked to wear heart rate monitors and to record their food intake in a 7-d diet diary. Subjective arousal (elation and excitement) and aspects of the eating environment were recorded for each meal occasion. RESULTS: Results showed ... Read More »
» Published in Nutrition. 2006 Oct;22(10):996-1004. Epub 2006 Sep 15.

20. Chirality influences the effects of linalool on physiological parameters of stress.
Match Strength: 3.484

The specific physiological responses induced by inhaling R-(-)- as well as S-(+)-linalool in 24 human subjects undergoing experimental stress were investigated in this study. Various physiological parameters of the autonomous nervous system (heart rate, blood pressure, electrodermal activity) as well as the endocrine system (salivary cortisol) were monitored. The study clearly indicated that odorants can modulate salivary cortisol levels, with both linalool enantiomers exerting relaxing effects. Concerning blood pressure and heart rate, S-(+)-linalool acted as an activating agent in contrast ... Read More »
» Published in Planta Med. 2006 Oct;72(13):1188-92. Epub 2006 Sep 18.

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