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Peer Reviewed Scientific Research Reports.
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1. Pathology of inflammatory native valvular heart disease.
Match Strength: 6.628
Rheumatic disease is an important cause of inflammatory native heart valve disease. However, with increased understanding of the pathoetiology of valve disease and valve injury, it is evident that inflammation may play a role in many valve disorders. We are only beginning to understand these complex processes. With increasing knowledge that many of these processes are active, there may be opportunity for intervention or even prevention ... Read More »
» Published in Cardiovasc Pathol. 2006 Sep-Oct;15(5):243-51.
2. Heart rate response during exercise predicts survival in adults with congenital heart disease.
Match Strength: 6.573
OBJECTIVES: To assess the prognostic value of heart rate response to exercise in adult congenital heart disease (ACHD) patients. BACKGROUND: An abnormal heart rate response to exercise is related to autonomic dysfunction and may have prognostic implications in ACHD. METHODS: We identified 727 consecutive ACHD patients (mean age [+/- SD] 33 +/- 13 years) with varying diagnoses and without pacemakers. Peak oxygen consumption (peak VO2), resting heart rate, and the increase in heart rate from resting level to peak exercise ("heart rate reserve") were measured. We also quantified the decrease in ... Read More »
» Published in J Am Coll Cardiol. 2006 Sep 19;48(6):1250-6. Epub 2006 Aug 28.
3. The value of using the entire New York Heart Association's classification of heart and vascular disease.
Match Strength: 6.527
The New York Heart Association functional classification is commonly used because the value of its determination is generally appreciated. The other four parts of the classification (etiology, anatomy, physiology, and objective assessment) are used less often. The purpose of this paper is to point out the value of using the entire New York Heart Association classification. Publication Types: ... Read More »
» Published in Clin Cardiol. 2006 Sep;29(9):415-7.
4. Metabolic syndrome as a risk factor for coronary heart disease and stroke: An 11-year prospective cohort in Taiwan community.
Match Strength: 5.984
OBJECTIVE: Patterns of metabolic syndrome among populations in the Asia-Pacific region remain unknown. This study sought to establish the prevalence of metabolic syndrome in Taiwan and the risk of cardiovascular disease imparted by this syndrome. METHODS AND RESULTS: A cohort of 3602 individuals aged 35 years and above from one Taiwan community in 1990-1991 was followed up for a median of 9.0 years (inter-quartile range: 7.9-10.0 years). Women had a higher prevalence rates of age-standardized metabolic syndrome than men (28.9% versus 16.6%) by original NCEP-ATP III criteria, and the rates ... Read More »
» Published in Atherosclerosis. 2006 Sep 13;
5. New frontiers in the pathology and therapy of heart valve disease: 2006 Society for Cardiovascular Pathology, Distinguished Achievement Award Lecture, United States-Canadian Academy of Pathology, Atlanta, GA, February 12, 2006.
Match Strength: 5.801
This review summarizes several areas relative to the pathology of heart valve disease in which there has been rapid and ongoing evolution, namely, our understanding of: (a) the dynamic functional biology of cardiac valves; and (b) the pathology/pathobiology of valvular heart diseases; (c) new developments in valve repair and substitution using percutaneous approaches; and (d) progress toward the exciting potential of therapeutic valvular tissue engineering and regeneration, including the challenges that will need to be overcome before such therapeutic advances can become clinically useful. ... Read More »
» Published in Cardiovasc Pathol. 2006 Sep-Oct;15(5):271-9.
6. Making or breaking the heart: from lineage determination to morphogenesis.
Match Strength: 5.762
The cues governing cardiac cell-fate decisions, cardiac differentiation, and three-dimensional morphogenesis are rapidly being elucidated. Several themes are emerging that are relevant for childhood and adult heart disease and the growing field of stem cell biology. This review will consider our current understanding of cardiac cell-fate determination and cardiogenesis--largely derived from developmental studies in model organisms and human genetic approaches--and examine future implications for diagnosis, prevention, and treatment of heart disease in the young and old. Publication Types: ... Read More »
» Published in Cell. 2006 Sep 22;126(6):1037-48.
7. Endothelial dysfunction, erectile dysfunction, and coronary heart disease: the pathophysiologic and clinical linkage.
Match Strength: 5.731
Our rapidly expanding knowledge regarding the biology of the endothelial cell and the pathophysiology of coronary heart disease (CHD) and endothelial dysfunction indicates important common factors and overlapping clinical presentations. We are, in effect, presented with a new paradigm-that of varying vascular manifestations of disease linked to the functioning of endothelial cell lining. This article reviews these areas of advancement and addresses their clinical implications regarding erectile dysfunction and CHD, as well as the role of the phosphodiesterase-5 inhibitor sildenafil ... Read More »
» Published in Rev Urol. 2003;5 Suppl 7:S21-7.
8. Recent increase of neighborhood socioeconomic effects on ischemic heart disease mortality: a multilevel survival analysis of two large Swedish cohorts.
Match Strength: 5.655
Studies have shown that the decrease in ischemic heart disease mortality over the past decades was paralleled by an increase in socioeconomic disparities. Using two large Swedish cohorts defined in 1986 and 1996, the authors examined whether the effect of neighborhood socioeconomic position on ischemic heart disease mortality strengthened over the period and whether the relative contribution of individual and neighborhood socioeconomic effects changed over time. Multilevel survival models adjusted for individual factors indicated that neighborhood socioeconomic effects on ischemic heart ... Read More »
» Published in Am J Epidemiol. 2007 Jan 1;165(1):22-6. Epub 2006 Sep 14.
9. Smoking-associated factors in myocardial infarction and unstable angina: Do gender differences exist?
Match Strength: 5.653
The aim of this study was to investigate demographic and psychological characteristics associated with smoking in patients with acute coronary syndrome (myocardial infarction or unstable angina). Interviews were conducted with 348 consecutive hospitalized patients with acute coronary syndrome and included questions about demographic characteristics, coffee consumption, heart disease risk perception, economic status, alcohol consumption, depression, anxiety, and stress. Female group multivariate analysis showed that smoking in females was significantly and negatively associated with age, heart ... Read More »
» Published in Addict Behav. 2006 Sep 13;
10. Gene regulatory networks in the evolution and development of the heart.
Match Strength: 5.398
The heart, an ancient organ and the first to form and function during embryogenesis, evolved by the addition of new structures and functions to a primitive pump. Heart development is controlled by an evolutionarily conserved network of transcription factors that connect signaling pathways with genes for muscle growth, patterning, and contractility. During evolution, this ancestral gene network was expanded through gene duplication and co-option of additional networks. Mutations in components of the cardiac gene network cause congenital heart disease, the most common human birth defect. The ... Read More »
» Published in Science. 2006 Sep 29;313(5795):1922-7.
11. Association of diagnosis of ischaemic heart disease, diabetes mellitus and heart failure with cognitive function in the elderly population.
Match Strength: 5.261
OBJECTIVE: The aim of this study was to describe the association between ischaemic heart disease (IHD), diabetes mellitus (DM) and heart failure (HF) and the prevalence of cognitive impairment. METHODS: In a cross-sectional, community-based study in Karlskrona, Sweden, 1402 participants of the Swedish National Study on Ageing and Care (60-96 y) underwent a medical examination and psychological testing including the Mini Mental State Examination (MMSE). Of these, 58% stated that they were treated for hypertension, IHD, DM or HF, or had ECG abnormalities (positive screen). RESULTS: The ... Read More »
» Published in Eur J Gen Pract. 2006;12(3):114-9.
12. Phosphodiesterase 4D and heart failure: a cautionary tale.
Match Strength: 5.163
Stimulation of several G-protein-coupled receptors (GPCRs) promotes intracellular production of cyclic adenosine 3',5'-monophosphate (cAMP) and subsequently activates protein kinase A (PKA). In the heart, beta-adrenergic receptor (beta-AR) stimulation increases contractile performance and heart rate as part of the 'fight-or-flight' stress response. Molecular organisation of PKA-effector association occurs by A kinase anchoring proteins (AKAPs), which target kinase action to specific intracellular sites. Some AKAPs interact directly with specific cAMP-hydrolysing phosphodiesterase (PDE) ... Read More »
» Published in Expert Opin Ther Targets. 2006 Oct;10(5):677-88.
13. Coronary artery disease in women: the myth still exists.
Match Strength: 4.976
There is a large media effort currently available to increase awareness of coronary artery disease in women. Despite this, there is still a misconception among some people, and unfortunately, some healthcare providers, that heart disease is a man's disease. This article will review some of the information about women and coronary artery disease; a short review of the literature, symptoms, diagnostic tests, and treatment pertinent to women; and the action nurses can take to help educate the public, and other healthcare providers, about this deadly threat. Publication Types: ... Read More »
» Published in Dimens Crit Care Nurs. 2006 Sep-Oct;25(5):209-15.
14. Associations between coronary heart disease, obesity and histological prostate cancer.
Match Strength: 4.962
OBJECTIVE: The present study investigates the possible associations between coronary heart disease and histological prostate carcinoma in autopsy material. MATERIAL AND METHOD: The material of our study, were 116 men between 55 years and 98 years of age, who died in the period of August 2002-January 2005. The initial segment of the aorta and the prostate glands of all cadavers were removed while the initial 30 mm of the left and right coronary arteries and the peripheral zone of the prostate gland underwent pathologic examination. RESULTS: Of all subjects examined 71.8% had pathological ... Read More »
» Published in Int Urol Nephrol. 2006 Sep 28;
15. Intensive statin therapy for treating acute coronary syndromes.
Match Strength: 4.906
The long-term efficacy of statins for the primary and secondary prevention of coronary heart disease is well established; however, until recently, there was little trial-based evidence to support the early clinical benefit of these agents after acute coronary syndromes (ACS). This is particularly important as ACS is characterised by a high rate of recurrent early events in the first 6 months and (traditionally) lipid-lowering therapy was perceived to reduce coronary heart disease risk by lowering the significant risk of elevated cholesterol over many years. This paper reviews the current state ... Read More »
» Published in Expert Opin Investig Drugs. 2006 Oct;15(10):1151-9.
16. Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer.
Match Strength: 4.790
PURPOSE: Androgen deprivation therapy with a gonadotropin-releasing hormone (GnRH) agonist is associated with increased fat mass and insulin resistance in men with prostate cancer, but the risk of obesity-related disease during treatment has not been well studied. We assessed whether androgen deprivation therapy is associated with an increased incidence of diabetes and cardiovascular disease. PATIENTS AND METHODS: Observational study of a population-based cohort of 73,196 fee-for-service Medicare enrollees age 66 years or older who were diagnosed with locoregional prostate cancer during 1992 ... Read More »
» Published in J Clin Oncol. 2006 Sep 20;24(27):4448-56.
17. A comparison of treadmill and arm-leg ergometry exercise testing for assessing exercise capacity in patients with peripheral arterial disease.
Match Strength: 4.727
PURPOSE: To compare the results of treadmill exercise testing (TM) to arm-leg ergometry testing (AL) in patients with peripheral arterial disease (PAD). METHODS: Twelve men and 8 women with PAD (mean age, 62 +/- 10 years) completed a treadmill test and an arm-leg ergometer exercise test. Oxygen uptake, heart rate, rate-pressure product (x10(-3)), ratings of claudication and perceived exertion, and power were measured. RESULTS: Peak oxygen uptake, heart rate, and rate-pressure product were similar between TM and AL. Exercise duration was longer and the peak power higher on the AL than on the TM ... Read More »
» Published in J Cardiopulm Rehabil. 2006 Sep-Oct;26(5):297-303.
18. Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies.
Match Strength: 4.718
The consumption of fruit and vegetables is associated with a reduced rate of coronary heart disease (CHD) in observational cohorts. The purpose of this study was to assess the strength of this association in a meta-analysis. Cohort studies were selected if they reported relative risks (RRs) and 95% CI for coronary heart disease or mortality and if they presented a quantitative assessment of fruit and vegetable intake. The pooled RRs were calculated for each additional portion of fruit and/or vegetables consumed per day, and the linearity of the associations were examined. Nine studies were ... Read More »
» Published in J Nutr. 2006 Oct;136(10):2588-93.
19. Challenges and opportunities in dystrophin-deficient cardiomyopathy gene therapy.
Match Strength: 4.715
The last decade has evidenced unprecedented progress in gene therapy of Duchenne and Becker muscular dystrophy (DMD and BMD) skeletal muscle disease. Cardiomyopathy is a leading cause of morbidity and mortality in both patients and carriers of DMD, BMD and X-linked dilated cardiomyopathy. However, there is little advance in heart gene therapy. The gene, the vector, vector delivery, the target tissue and animal models are five fundamental components in developing an effective gene therapy. Intensive effort has been made in optimizing gene transfer vectors and methods. Systemic and/or local ... Read More »
» Published in Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R253-61.
20. Heart rate variability monitoring in the detection of central nervous system complications in children with enterovirus infection.
Match Strength: 4.661
PURPOSE: Previous studies suggest the possibility of autonomic dysfunction in patients with complicated hand, foot, and mouth disease (HFMD) and herpangina. Heart rate variability (HRV), an index for autonomic nervous system, may be useful to detect disease progression. MATERIALS AND METHODS: From 2001 to 2002, 66 patients (1-9 years old) were enrolled prospectively in either a control (20 patients) or disease (46 patients with HFMD or herpangina) group. The disease group was subdivided into stage I (fever only), stage II (with complications of encephalomyelitis), and stage III (with ... Read More »
» Published in J Crit Care. 2006 Sep;21(3):280-6. Comment in: J Crit Care. 2006 Sep;21(3):286-9.
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