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Peer Reviewed Scientific Research Reports.
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1. Mass screening for prostate cancer in patients with end-stage renal disease: a comparative study.
Match Strength: 3.592
OBJECTIVE: To determine the usefulness of prostate-specific antigen (PSA) screening for prostate cancer in patients with end-stage renal disease (ESRD), as although serum PSA is effective in the early detection of this cancer in the general population, there are few reports of its utility in patients with ESRD. PATIENTS AND METHODS: Blood samples were obtained for PSA screening from April 2002 to September 2003; 1250 men with ESRD aged >50 years were compared with 1007 healthy control men aged >55 years, all in Kumamoto Prefecture, Japan. All men with a serum PSA level of >4.0 ng/mL ... Read More »
» Published in BJU Int. 2006 Oct;98(4):794-7.
2. Passive respiratory mechanics measured during natural sleep in healthy term neonates and infants up to 8 weeks of life.
Match Strength: 3.345
The single occlusion technique (SOT) is a simple and noninvasive technique for measurement of passive respiratory mechanics in infants. Reference values based on measurements of a large population of healthy infants performed outside specialized research laboratories are lacking. The aim of this study was to present reference values for passive respiratory mechanics based on a large population of healthy term neonates and infants measured during natural sleep in routine care. As part of the ongoing Wheezing Illnesses Study Leidsche Rijn (WHISTLER), the compliance (C(rs)) and resistance (R(rs)) ... Read More »
» Published in Pediatr Pulmonol. 2006 Nov;41(11):1058-64.
3. Interaction of negative olfactory stimulation and working memory in schizophrenia patients: development and evaluation of a behavioral neuroimaging task.
Match Strength: 3.309
Negative affect plays a crucial role in the psychopathology of schizophrenia. Although it is known that negative emotion has a strong effect on cognitive performance, this interaction has mainly been studied in healthy volunteers. Hence, working memory was assessed in 24 schizophrenia patients and 24 matched comparison subjects with a 0-back/2-back continuous performance test. Simultaneously, negative emotion was induced by olfactory stimulation. Although subjective ratings confirmed that stimulation with a negative odor was associated with a significant increase in negative affect in patients ... Read More »
» Published in Psychiatry Res. 2006 Nov 15;144(2-3):123-30. Epub 2006 Sep 26.
4. Preliminary study on vestibular-evoked myogenic potential induced by bone-conducted stimuli.
Match Strength: 3.275
OBJECTIVE: To study the relationship between vestibular-evoked myogenic potential evoked by air-conducted stimuli (A-VEMP) and those evoked by bone-conducted stimuli (B-VEMP). STUDY DESIGN: Prospective study. SETTING: University Hospital. PATIENTS: To determine the optimum stimulus conditions for B-VEMP, 40 ears of 20 healthy volunteers were used. To compare results of A-VEMP and B-VEMP, 60 ears of 30 healthy volunteers and 70 ears of 35 patients with unilateral vestibular disorder without conductive hearing loss were used. MAIN OUTCOME MEASURE: A-VEMP and B-VEMP were measured. Both ... Read More »
» Published in Otol Neurotol. 2006 Dec;27(8):1110-4.
5. Change in psychological resources of younger and older cancer patients during chemotherapy.
Match Strength: 3.259
Psychological resources were investigated in 150 recently diagnosed adult cancer patients and in 150 healthy control group members. Before the start of chemotherapy, cancer patients reported higher levels of optimism, purpose in life than their healthy peers, and self-esteem (only younger patients) whereas no between-group differences emerged for internal locus of control. However, the mobilization of psychological resources was limited to younger patients, and varied by item content. Over a 9-month period, most psychological resources of cancer patients showed a small but significant decline, ... Read More »
» Published in Psychooncology. 2006 Sep 29;
6. Multitasking performance of Chinese children with ADHD.
Match Strength: 3.248
The aim of this study was to explore multitasking skills in a Chinese sample of 22 children with attention deficit-hyperactivity disorder (ADHD) compared with 22 healthy controls matched by gender, age, and IQ. All of the participants completed the children's version of the Six Elements Test (C-SET) and neuropsychological tests that captured specific domains of attention, memory, and executive function. Children with ADHD performed significantly worse than the healthy controls in all domains except the number of rules broken in the C-SET. The majority of the C-SET domain scores correlated ... Read More »
» Published in J Int Neuropsychol Soc. 2006 Jul;12(4):575-9.
7. Bispectral index evaluation of the sedative effect of acupuncture in healthy volunteers.
Match Strength: 3.235
Objective. To evaluate the sedative effect of acupuncture in healthy volunteers by means of the BIS monitor. Secondary end-points were the evaluation of subjective sedative sensation induced by acupuncture and possible lasting of the sedative effect post needles removal. Methods. We performed a cross-over, single-blinded study on 10 healthy volunteers to evaluate objective and subjective sedative effect of acupuncture compared to sham acupuncture. We recorded heart rate, pulse-oxymetry, BIS at baseline, during a 20-min. stimulation period, and for the following 20 minutes after needles removal ... Read More »
» Published in J Clin Monit Comput. 2006 Oct;20(5):311-5. Epub 2006 Sep 19.
8. Talking parents, healthy teens: a worksite-based program for parents to promote adolescent sexual health.
Match Strength: 3.195
Parents play an important role in the sexual health of their adolescent children. Based on previous research, formative research, and theories of behavioral change, we developed Talking Parents, Healthy Teens, an intervention designed to help parents improve communication with their adolescent children, promote healthy adolescent sexual development, and reduce adolescent sexual risk behaviors. We conduct the parenting program at worksites to facilitate recruitment and retention of participants. The program consists of 8 weekly 1-hour sessions during the lunch hour. In this article, we review ... Read More »
» Published in Prev Chronic Dis. 2006 Oct;3(4):A126. Epub 2006 Sep 15.
9. Arm constraint and walking in healthy adults.
Match Strength: 3.135
The aim of the present study was to examine the functional adaptations in inter-segmental coordination when constraining one arm in healthy adults during treadmill walking at different velocities. Subjects were instructed to walk on a motorized treadmill at different walking velocities (range: 0.22-1.52m/s) during three experimental conditions, i.e.: (1) no arm constraint, (2) dominant arm constrained, and (3) non-dominant arm constrained. Movements of body segments were recorded with a 3D motion analysis system. A comparison between walking with one arm constrained and normal walking revealed ... Read More »
» Published in Gait Posture. 2006 Sep 21;
10. Predictors of US medical students' prevention counseling practices.
Match Strength: 3.093
OBJECTIVE.: To understand predictors of medical students' prevention counseling practices. METHODS.: We surveyed medical students (n=2316 individuals) in the Class of 2003 at freshman orientation, and again at entrance to wards and senior year in a nationally representative sample of 16 US medical schools (response rate=80.3%). MAIN OUTCOME MEASURES.: Perceived relevance of prevention counseling and seniors' frequency of prevention counseling. RESULTS.: Healthier personal practices (p<0.0001), intention to become a primary care practitioner (p=0.0007), and attending a medical school that ... Read More »
» Published in Prev Med. 2007 Jan;44(1):76-81. Epub 2006 Sep 14.
11. The CD4(+) regulatory T-cells is decreased in adults with latent autoimmune diabetes.
Match Strength: 3.088
The latent autoimmune diabetes in adults (LADA) is a subgroup of type 1 diabetes, which procession of autoimmune destruction of beta-cells was slower than classic type 1 diabetes. To investigate the pathogenesis of LADA, we examined the lymphocyte subsets including the CD4(+)CD25(+) T-cells in 60 LADA patients and 30 patients of type 2 diabetes and 30 healthy individuals by FACS. And we compared the expression of FOXP3 mRNA in CD4(+) T-cell between 10 patients of LADA and 10 matched healthy individuals by real time PCR. The percent of CD4(+)CD25(+) T-cells were higher (11.89+/-4.96% versus 8 ... Read More »
» Published in Diabetes Res Clin Pract. 2006 Sep 25;
12. Anti-calreticulin antibodies in patients with inflammatory bowel disease.
Match Strength: 3.033
PURPOSE: Although the pathogenesis of inflammatory bowel disease (IBD) is unclear, autoimmune processes seem to play roles in IBD because several types of autoantibodies have been found in it. Calreticulin (CRT) is a soluble Ca2+ binding protein which is present in a wide variety of cells. CRT is localized mainly in the endoplasmic reticulum and is often a target for autoantibodies. The aim of this study was to evaluate the clinical significance of anti-CRT antibodies measured by enzyme-linked immunosorbent assay (ELISA) using the sera of patients with ulcerative colitis (UC) and Crohn's ... Read More »
» Published in Fukushima J Med Sci. 2006 Jun;52(1):1-11.
13. Longitudinal changes in food patterns predict changes in weight and body mass index and the effects are greatest in obese women.
Match Strength: 3.017
The prevalence of obesity is increasing in most parts of the world. The objective of this study was to examine whether changes in food patterns were associated with changes in BMI among women over 9 y. Data were from 33,840 women participating in the Swedish Mammography Cohort in 1987 and 1997. Diet was assessed with a FFQ at both time points and 4 food patterns were derived using confirmatory factor analysis (Healthy, Western/Swedish, Alcohol, and Sweets). Our exposure variables were defined as change in factor score for each food pattern from 1987 to 1997. Our outcome variable was defined as ... Read More »
» Published in J Nutr. 2006 Oct;136(10):2580-7.
14. Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus.
Match Strength: 3.008
Patients with type 2 diabetes mellitus have increased risk of cardiovascular disease. Epidemiological studies have shown a correlation between diet and incidence of coronary heart disease. The aim of the study is to determine the effect of a traditional Greek Mediterranean diet on platelet aggregation induced by ADP, arachidonic acid (AA), and especially platelet-activating factor (PAF) on patients with type 2 diabetes mellitus as well as on healthy volunteers. The patients were randomized into two subgroups, A and B. The lipid extracts from traditional Greek Mediterranean-type meals were ... Read More »
» Published in J Med Food. 2006 Fall;9(3):356-62.
15. Pharmacokinetics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults.
Match Strength: 2.985
The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1-compartment model with first-order absorption and first-order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag-time. The model gave an adequate description of adult as well as children data and provided a statistically significant better fit to data than a standard lag-time model. The main difference in the pharmacokinetics between children and adults was the absorption delay. The pharmacokinetic ... Read More »
» Published in J Clin Pharmacol. 2006 Oct;46(10):1204-11.
16. American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity.
Match Strength: 2.979
The American Cancer Society (ACS) publishes Nutrition and Physical Activity Guidelines to serve as a foundation for its communication, policy, and community strategies and ultimately, to affect dietary and physical activity patterns among Americans. These Guidelines, published every 5 years, are developed by a national panel of experts in cancer research, prevention, epidemiology, public health, and policy, and as such, they represent the most current scientific evidence related to dietary and activity patterns and cancer risk. The ACS Guidelines include recommendations for individual choices ... Read More »
» Published in CA Cancer J Clin. 2006 Sep-Oct;56(5):254-81; quiz 313-4. Summary for patients in: CA Cancer J Clin. 2006 Sep-Oct;56(5):310-2.
17. Prevalence of gestrointestinal symptoms in pregnancy.
Match Strength: 2.971
OBJECTIVES: This study is aimed at determining the prevalence of gastrointestinal symptoms among healthy pregnant women attending antenatal clinic at the University of Maiduguri Teaching Hospital. METHODS: Questionnaires were randomly administered to consecutive antenatal clinic attendees until the sample size was reached. RESULTS: Three hundred and seventy pregnant women were interviewed. Heart burns, easy fullness and nausea were the commonest gastrointestinal symptoms in 45%, 40.2% and 39.9% of cases respectively. Primigravidae had significantly more symptoms than multiparae. There were ... Read More »
» Published in Niger J Clin Pract. 2006 Jun;9(1):1-6.
18. Regular heartbeat dynamics are associated with cardiac health.
Match Strength: 2.935
The human heartbeat series is more variable and, hence, more complex in healthy subjects than in congestive heart failure (CHF) patients. However, little is known about the complexity of the heart rate variations on a beat-to-beat basis. We present an analysis based on symbolic dynamics that focuses on the dynamic features of such beat-to-beat variations on a small time scale. The sequence of acceleration and deceleration of eight successive heartbeats is represented by a binary sequence consisting of ones and zeros. The regularity of such binary patterns is quantified using approximate ... Read More »
» Published in Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R368-72. Epub 2006 Sep 14.
19. Pharmacokinetics of an extended release formulation of alprazolam (Xanax XR) in healthy normal adolescent and adult volunteers.
Match Strength: 2.933
The purpose of this study was to estimate pharmacokinetics, safety, and tolerability of single doses of an extended release formulation of alprazolam (Xanax XR) in adolescent and adult healthy volunteers. This was a randomized, open-label, single-dose, 2-period crossover study. Twelve adolescent healthy volunteers (13-17 years) and 12 adult healthy volunteers (20-45 years) received single doses of Xanax XR 1 mg or 3 mg tablets. Blood samples were obtained predose and for 48 hours postdose. Plasma samples were assayed for alprazolam and its two active metabolites alpha-hydroxy-alprazolam and 4 ... Read More »
» Published in Am J Ther. 2006 Sep-Oct;13(5):418-22.
20. Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging.
Match Strength: 2.922
OBJECTIVE: The objective of this study was to investigate cross-sectional and longitudinal white matter hyperintensity (WMH) changes in older subjects with clinically diagnosed dementia. METHODS: Fluid-attenuated inversion recovery images were acquired one year apart in subjects with dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), Alzheimer disease (AD), and also healthy elderly comparison subjects. WMH volume was quantified using an automated technique. RESULTS: Baseline WMH (as a percent of brain volume) was significantly greater compared with healthy subjects (N=33, ... Read More »
» Published in Am J Geriatr Psychiatry. 2006 Oct;14(10):842-9.
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