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1. D-Fructose-L-sorbose interconversions. Access to 5-thio-D-fructose and interaction with the D-fructose transporter, GLUT5.
Match Strength: 10.986

Epimerisation and subsequent functionalization at C-5 of D-fructopyranose derivatives under Mitsunobu and Garegg's conditions provided efficient access to 5-thio-D-fructose (2) as well as to 5-azido-5-deoxy-1,2-O-isopropylidene-beta-D-fructopyranose (19), a known precursor to 2,5-deoxy-2,5-imino-D-mannitol (3). The interaction of 2 with the D-fructose transporter GLUT5, was found to be weaker than that of D-fructose, a result that suggests involvement of the ring oxygen atom in the recognition of D-fructose by GLUT5 ... Read More »
» Published in Carbohydr Res. 2001 Jul 19;333(4):327-34.

2. 1,5-anhydro-D-fructose from D-fructose.
Match Strength: 10.973

1,5-anhydro-D-fructose was efficiently prepared from D-fructose via regiospecific 1,5-anhydro ring formation of 2,3-O-isopropylidene-1-O-methyl(tolyl)sulfonyl-D-fructopyranose and subsequent deprotection ... Read More »
» Published in Carbohydr Res. 2007 Jul 2;342(9):1249-53. Epub 2007 Feb 28.

3. Fructose metabolism by mature boar spermatozoa.
Match Strength: 10.847

In 1945, Mann showed fructose to be the principal sugar in semen. For over half a century the means by which fructose is metabolized by sperm has been assumed to be by an initial phosphorylation catalysed by hexokinase, but this has never been substantiated. In the present study, by comparing the metabolism of glucose and fructose by both whole boar sperm and hypotonically treated cells, it is confirmed that fructose is phosphorylated by hexokinase to produce fructose 6-phosphate. Publication Types: In Vitro, Research Support, Non-U.S. Gov ... Read More »
» Published in Reprod Fertil Dev. 2000;12(7-8):355-9.

4. Fructose malabsorption in Thai adult.
Match Strength: 10.757

Fructose malabsorption has not been well-defined in Thai populations but there has been increasing consumption of fructose-fortified drinks. OBJECTIVES: To assess the incidence of fructose malabsorption and intolerance in Thai normal subjects as well as the facilitating effect of glucose on fructose absorption. METHODS: Twenty-five gram of fructose was ingested by 77 subjects (37 men, 40 women; mean age 26 and 31 y, range 20-50 y and 21-50 y for men and women, respectively). Measurement of breath-H(2) levels after fructose ingestion in each subject up to 2 h was performed. Those who showed ... Read More »
» Published in Asia Pac J Clin Nutr. 2007;16(2):209-12.

5. Metabolism of 13c-Enriched D-Fructose in Hepatocytes from Goto-Kakizaki Rats
Match Strength: 10.686

This study aims at assessing the conversion of exogenous D-[1-13C]fructose, D-[2-13C]fructose or D-[6-13C]-fructose (10 mM) to 13C-enriched and either hydrogenated or deuterated D-glucose, L-lactate and L-alanine released by rat liver cells prepared from Goto-Kakizaki rats and incubated for 120 min in the presence of unlabelled D-glucose (also 10 mM) and D2O. The results of this study are relevant to the relative contribution of fructokinase and hexokinase isoenzyme to the phosphorylation of D-fructose, the capacity of D-glucose to confer to glucokinase positive cooperativity towards D ... Read More »
» Published in Int J Mol Med. 2004 May;13(5):697-703.

6. Regulation of fructose uptake by glucose in Escherichia coli.
Match Strength: 10.524

A mutant, DAI, has been isolated from the Escherichia coli K12, strain K2. 1t, as a colony resistant to 2-deoxyglucose (DG) when growing on fructose but still sensitive to DG when growing on other sugars. The mutation in DAI specifically affects the catabolite inhibition of fructose utilization by glucose and glucose-6-phosphate; the affected gene (designated cif) is located at min 41 on the E. coli linkage map and is highly co-transducible with the genes that specify the uptake of fructose (ptsF) and enzymic conversion of fructose-1-phosphate to fructose-1,6-bisphosphate (fpk) ... Read More »
» Published in J Gen Microbiol. 1975 Sep;90(1):157-68.

7. Fructose-induced insulin resistance and hypertension in rats.
Match Strength: 10.321

To determine if hypertension could be produced in normal rats by feeding them a fructose-enriched diet, Sprague-Dawley rats were fed either normal chow or a diet containing 66% fructose as a percentage of total calories for approximately 2 weeks. At the end of this period systolic blood pressure had increased from 124 +/- 2 to 145 +/- 2 (SEM) mm Hg in the fructose-fed rats, whereas no change occurred in the control group. In addition, hyperinsulinemia and hypertriglyceridemia were associated with hypertension in fructose-fed rats. The addition of clonidine to the drinking water inhibited ... Read More »
» Published in Hypertension. 1987 Nov;10(5):512-6.

8. Comparison of breath testing with fructose and high fructose corn syrups in health and IBS.
Match Strength: 10.221

Although incomplete fructose absorption has been implicated to cause gastrointestinal symptoms, foods containing high fructose corn syrup (HFCS) contain glucose. Glucose increases fructose absorption in healthy subjects. Our hypothesis was that fructose intolerance is less prevalent after HFCS consumption compared to fructose alone in healthy subjects and irritable bowel syndrome (IBS). Breath hydrogen levels and gastrointestinal symptoms were assessed after 40 g of fructose (12% solution) prepared either in water or as HFCS, administered in double-blind randomized order on 2 days in 20 ... Read More »
» Published in Neurogastroenterol Motil. 2008 Jan 22

9. A route for fructose utilization by Escherichia coli involving the fucose regulon.
Match Strength: 10.142

Fructose can be taken up by Escherichia coli via a variety of membrane-spanning proteins that recognize sugars with the 3,4,5-d-arabino-hexose configuration. Here, we describe a mutant that is devoid of those proteins but takes up fructose via the FucP carrier normally used for the transport of alpha-l-fucose; this implies that the fructose is taken up in the alpha- or beta-fructopyranose form. For growth, the assimilated fructose is sequentially phosphorylated by ATP and (i) manno(fructo)kinase, to form fructose 6-phosphate, and (ii) phosphofructokinase, to form fructose 1,6-bisphosphate, ... Read More »
» Published in Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19496-9. Epub 2006 Dec 11.

10. Construction of a new catabolic pathway for D-fructose in Escherichia coli K12 using an L-sorbose-specific enzyme from Klebsiella pneumoniae.
Match Strength: 10.070

Starting with a fruK (formerly fpk) mutant of Escherichia coli K12 lacking D-fructose-1-phosphate kinase (E.C., fructose positive derivatives were isolated after introduction of the cloned gene sorE from Klebsiella pneumoniae coding for an L-sorbose-1-phosphate reductase. The new pathway was shwon to proceed from D-fructose via D-fructose-1-phosphate and D-mannitol-1-phosphate to D-fructose 6-phosphate. It involves a transport system and enzymes encoded in the fru and the mtl operons from E. coli K12 as well as in the sor operon from K. pneumoniae respectively ... Read More »
» Published in Arch Microbiol. 1990;154(2):162-7.

11. Fructose In The Diabetic Diet
Match Strength: 9.971

Fructose is an energy-yielding sweetener coming from different natural sources (fruit, berries, and vegetables) or is added to soft drinks, bakery products, and candies. The current content of fructose in the diabetic diet seems to be within recommendations. Because of the low glycemic index of fructose, fructose may be an alternative as a sweetener for those diabetic patients who like sweet foods but are liable to high postprandial glucose concentrations. In patients with mild non-insulin-dependent diabetes mellitus, fructose may result in lower postprandial glucose and insulin responses than ... Read More »
» Published in Am J Clin Nutr. 1994 Mar;59(3 Suppl):753S-757S.

12. Comparison Between D-[3-3h]- and D-[5-3h]Glucose and Fructose Utilization in Pancreatic Islets from Control and Hereditarily Diabetic Rats
Match Strength: 9.887

The metabolism of D-glucose and/or D-fructose was investigated in pancreatic islets from control rats and hereditarily diabetic GK rats. In the case of both D-glucose and D-fructose metabolism, a preferential alteration of oxidative events was observed in islets from GK rats. The generation of 3HOH from D-[5-3H]glucose (or D-[5-3H]fructose) exceeded that from D-[3-3H]glucose (or D-[3-3H]fructose) in both control and GK rats. This difference, which is possibly attributable to a partial escape from glycolysis of tritiated dihydroxyacetone phosphate, was accentuated whenever the rate of ... Read More »
» Published in Arch Biochem Biophys. 2002 Dec 1;408(1):111-23.

13. Current Issues In Fructose Metabolism
Match Strength: 9.886

The ingestion of fructose, particularly in refined form, has significantly increased in the North American diet over the last two decades. The unique way in which fructose is metabolized has given rise to much research examining whether fructose is advantageous in appetite control, exercise endurance, and disease states such as diabetes. Overall, there is very little evidence that modest amounts of fructose have detrimental effects on carbohydrate and lipid metabolism in nondiabetic or NIDDM subjects or that its use is particularly advantageous compared to that of other sugars. However, ... Read More »
» Published in Annu Rev Nutr. 1991;11:21-39.

14. Doorway mechanism for dissociative electron attachment to fructose.
Match Strength: 9.469

Recently, the three sugars ribose, deoxyribose, and fructose have been shown to undergo dissociative electron attachment at threshold, that is, to fragment upon capture of a zero-energy electron. Here the electron acceptor properties of three fructose isomers are investigated in view of a doorway mechanism. Two key ingredients for a doorway mechanism, a weakly bound state able to support a vibrational Feshbach resonance, and a valence anion more stable than neutral fructose are characterized. Moreover, possible structures for the observed fragment anion (fructose-H2O)- are suggested ... Read More »
» Published in J Chem Phys. 2007 Mar 28;126(12):124301.

15. Is fructose sweeter than glucose for rats?
Match Strength: 9.432

Because it is generally thought that the intensity of the taste of fructose is greater than that of glucose for rats, it seemed surprising when sham-fed rats drank substantially less of a mixture of 6% fructose plus saccharin than of a mixture of 6% glucose plus saccharin. At least 3 different factors contribute to this effect. First, the taste of fructose is less attractive to rats than is the taste of glucose; sham-fed rats strongly preferred glucose over fructose (no saccharin was used in this experiment). The second factor is experience. Rats having substantial previous experience with ... Read More »
» Published in Physiol Behav. 1996 Nov;60(5):1299-306.

16. Diabetes And Fructose Metabolism
Match Strength: 9.418

The clinical aspects of fructose supplementation in the diets of individuals with diabetes should focus on the balance between beneficial effects and possible side effects. Fructose supplementation in diabetes mellitus was advocated before insulin was discovered. Fructose elicits a lower glucose and insulin response in healthy individuals and in individuals with diabetes. The use of fructose as a sweetener in the diets of diabetics has been debated repeatedly. Short-term studies have now shown that substitution of fructose for sucrose in the diets of individuals with diabetes improves glycemic ... Read More »
» Published in Am J Clin Nutr. 1993 Nov;58(5 Suppl):796S-799S.

17. Test for androgen activity at the male reproductive tract in infertile men.
Match Strength: 9.374

A study was conducted to determine the relationship between levels of serum testosterone and corrected seminal fructose levels in men under basal and post-clomiphene stimulation. A prospective controlled study was carried out in 19 selected men attending the andrology laboratory at the Instituto de Investigaciones de la Altura. These subjects were without any evidence of inflammation in the reproduction tract. The men received 100 mg clomiphene citrate daily for 5 days. Serum testosterone, seminal fructose, and corrected fructose levels were measured before and at the end of clomiphene citrate ... Read More »
» Published in Arch Androl. 1994 May-Jun;32(3):235-42.

18. Effects Of Several Simple Sugars On Serum Glucose And Serum Fructose Levels In Normal And Diabetic Subjects
Match Strength: 9.363

Fructose has a reaction constant 7.5 times as high as that of glucose in its nonenzymatic reaction with protein in vitro. The effects of glucose, sucrose and fructose ingestion on serum fructose and glucose levels were studied to evaluate the overall biohazard, i.e., the probability of their altering proteins while circulating in the blood. Normal and diabetic subjects were given either 75 g glucose, 75 g fructose, 75 g sucrose, or 112.5 g fructose after fasting, and their serum levels of sugars were measured at 0, 1, 2 and 3 h. In normal subjects, fructose ingestion produced significantly ... Read More »
» Published in Diabetes Res Clin Pract. 1988 Apr 6;4(4):281-7.

19. Female rats are protected against fructose-induced changes in metabolism and blood pressure.
Match Strength: 9.299

The objective of this study was to determine whether the effects of a fructose diet, which causes hyperinsulinemia, insulin resistance, and hypertension in male rats, are dependent on sex. Blood pressure was measured via the tail-cuff method, and oral glucose tolerance tests were performed to assess insulin sensitivity. Blood pressure in female rats did not differ between fructose-fed and control rats at any time point (126 +/- 5 and 125 +/- 3 mmHg at week 9 for fructose-fed and control rats, respectively) nor was there a difference in any metabolic parameter measured. Furthermore, the ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2002 Dec;283(6):H2478-84.

20. Significance of phosphoglucose isomerase for the shift between heterolactic and mannitol fermentation of fructose by Oenococcus oeni.
Match Strength: 9.282

The bacterium Oenococcus oeni employs the heterolactic fermentation pathway (products lactate, ethanol, CO(2)) during growth on fructose as a substrate, and the mannitol pathway when using fructose as an electron acceptor. In this study, [U-(13)C]glucose, [U-(13)C]fructose, HPLC, NMR spectroscopy, and enzyme analysis were applied to elucidate the use of both pathways by the hexoses. In the presence of glucose or pyruvate, fructose was metabolized either by the mannitol or the phosphoketolase pathways, respectively. Phosphoglucose isomerase, which is required for channeling fructose into the ... Read More »
» Published in Arch Microbiol. 2003 Dec;180(6):465-70. Epub 2003 Nov 8.

21. Reactivity and oxidative potential of fructose and glucose in enkephalin-sugar model systems.
Match Strength: 9.257

The reactions of Leu- and Met-enkephalin (Tyr-Gly-Gly-Phe-Leu/Met) with fructose resulted in the parallel formation of Heyns compounds (N-peptidyl-D: -mannosamine and -D: -glucosamine) and sugar-peptide generated imidazolidinone diastereomers. Glucose showed higher level of reactivity than fructose with respect to the extent of glycated product formation. The presence of fructose in the incubation mixtures makes Met residue more susceptible to oxidation than glucose ... Read More »
» Published in Amino Acids. 2007 Feb 14;

22. Dietary Fructose: Implications For Dysregulation of Energy Homeostasis and Lipid/Carbohydrate Metabolism
Match Strength: 9.222

Fructose intake and the prevalence of obesity have both increased over the past two to three decades. Compared with glucose, the hepatic metabolism of fructose favors lipogenesis, which may contribute to hyperlipidemia and obesity. Fructose does not increase insulin and leptin or suppress ghrelin, which suggests an endocrine mechanism by which it induces a positive energy balance. This review examines the available data on the effects of dietary fructose on energy homeostasis and lipid/carbohydrate metabolism. Recent publications, studies in human subjects, and areas in which additional ... Read More »
» Published in Nutr Rev. 2005 May;63(5):133-57.

23. Fructose-induced hypertension in Wistar-Kyoto rats: interaction with moderately high dietary salt.
Match Strength: 9.218

We investigated the effects of 4% fructose plus moderately high salt (MHS) (4% NaCl) treatment on tissue aldehyde conjugates, platelet cytosolic free calcium ([Ca2+]i), renal morphology, and systolic blood pressure (SBP) in Wistar-Kyoto rats, and whether these effects were reversible (R) after withdrawal of treatment. At age 7 weeks, rats were divided into 4 groups: NS group, given normal salt (NS) diet (0.7% NaCl) for 18 weeks; NS+F(R) group, NS diet and fructose in water for 14 weeks, then 4 weeks fructose withdrawal; MHS+F group, NS diet and fructose for 6 weeks, then MHS diet and fructose ... Read More »
» Published in Can J Physiol Pharmacol. 2007 Mar-Apr;85(3-4):413-21.

24. Transport of D-fructose and its analogues by Trypanosoma brucei.
Match Strength: 9.211

Kinetic parameters for entry of D-fructose into Trypanosoma brucei brucei have been determined. The net uptake of D-fructose was found to be rapid and occurred at a rate which was comparable with that observed for uptake of D-glucose. The Km and Vmax were 3.91 +/- 1.58 mM and 69.1 +/- 7.2 nmol min-1 (mg protein)-1. D-Fructose was metabolized to pyruvate under aerobic conditions and to pyruvate and glycerol under anaerobic conditions in a manner similar to D-glucose. Comparisons of the kinetic parameters for D-fructose transport and metabolism indicated that uptake was rate limiting. Inhibition ... Read More »
» Published in Mol Biochem Parasitol. 1993 Jul;60(1):9-18.

25. Fructose intake increases hyperlipidemia and modifies apolipoprotein expression in apolipoprotein AI-CIII-AIV transgenic mice.
Match Strength: 9.204

Fructose intake has increased steadily during the past two decades. The objective of this study was to determine the effect of fructose intake on lipid metabolism in apolipoprotein (apo) AI-CIII-AIV transgenic (Tg) mice that have severe hypertriglyceridemia and moderate hypercholesterolemia. Tg and control mice were fed for 9 mo a commercial nonpurified diet and had free access to water or 250 g/L fructose solution. In Tg mice, fructose intake increased triglycerides and cholesterol but did not induce insulin resistance. There were no differences in human hepatic apo AI and apo CIII mRNA ... Read More »
» Published in J Nutr. 2002 May;132(5):918-23.

26. Fructose-induced hyperlactemia in hyperosmolar syndromes.
Match Strength: 9.199

Severe hyperlactemia of 8.7, 8.6 and 7.9 mmol/l, respectively, developed in three patients with hyperosmolar syndromes (two hypernatremic, 417 and 415 mosmol/kg H2O; one hyperglycemic 437 mosmol/kg H2O) during rehydration treatment with 5% fructose in water (fructose dosage 0.5 g/kg body wt. per hour). After resolution of the electrolyte disturbances, the infusion of fructose at the same dosage increased the plasma lactate concentration in two of the patients to 4.9 and 4.0 mmol/l, indicating near normalization of hepatic lactate utilization. Thus, in addition to peripheral insulin resistance ... Read More »
» Published in Klin Wochenschr. 1986 Jul 1;64(13):615-8.

27. Thermogenesis in obese women: effect of fructose vs. glucose added to a meal.
Match Strength: 9.170

To assess the effect of a fructose meal on resting energy expenditure (EE), indirect calorimetry was used in 23 women (10 lean and 13 obese) for 30 min before and 6 h after the ingestion of a mixed meal containing 20% protein, 33% fat, and either 75 g glucose or 75 g fructose as carbohydrate source (47%). Expressed as a percentage of the energy content of the meal, the thermogenic response to the fructose meal was significantly greater (10.2 +/- 0.5%) than that of the glucose meal (8.4 +/- 0.4%, P less than 0.01). This difference was still apparent when the lean and obese women were considered ... Read More »
» Published in Am J Physiol. 1992 Apr;262(4 Pt 1):E394-401.

28. Hepatic adaptations to sucrose and fructose.
Match Strength: 9.147

The liver is an important site of postprandial glucose disposal, accounting for the removal of up to 30% of an oral glucose load. The liver is also centrally involved in dietary lipid and amino acid uptake, and the presence of either or both of these nutrients can influence hepatic glucose uptake. The composition of ingested carbohydrate also influences hepatic glucose metabolism. For example, fructose can increase hepatic glucose uptake. In addition, fructose extraction by the liver is exceedingly high, approaching 50% to 70% of fructose delivery. The selective hepatic metabolism of fructose, ... Read More »
» Published in Metabolism. 2005 Sep;54(9):1189-201.

29. Protective effect of fructose 1,6-bisphosphate against carrageenan-induced inflammation
Match Strength: 9.140

Administration of carrageenan (0.5 mg) to the plantar tissue of rats resulted in reversible inflammatory injury. This damage was monitored as changes in foot volume, using a plethysmometer. Administration of fructose 1,6-bisphosphate at different doses, orally or intraperitoneally, prevented the inflammatory action induced by the simultaneous injection of carrageenan in the rat paw. The effect was dose and time dependent. In contrast, fructose or fructose 6-phosphate afforded no significant protection. In order to extend the average half-life of the drug, we prepared liposomes of fructose 1,6 ... Read More »
» Published in Eur J Pharmacol. 1993 Jun 24;237(2-3):251-5.

30. Accumulation of fructose 1,6-bisphosphate in mutant cells of mucoid Pseudomonas aeruginosa as an evidence of phosphofructokinase activity.
Match Strength: 9.139

Phosphoglucose isomerase negative mutant of mucoid Pseudomonas aeruginosa accumulated relatively higher concentration of fructose 1,6-bisphosphate (Fru-1,6-P2) when mannitol induced cells were incubated with this sugar alcohol. Also the toluene-treated cells of fructose 1,6-bisphosphate aldolase negative mutant of this organism produced Fru-1,6-P2 from fructose 6-phosphate in presence of ATP, but not from 6-phosphogluconate. The results together suggested the presence of an ATP-dependent fructose 6-phosphate kinase (EC in mucoid P. aeruginosa ... Read More »
» Published in Arch Microbiol. 1986 May;144(4):405-7.

31. Cardiomyopathy of copper deficiency: effect of vitamin E supplementation.
Match Strength: 9.138

The present study was undertaken to determine whether the intraperitoneal injection of vitamin E to copper-(Cu) deficient rats fed fructose will protect the animals against the severity of Cu deficiency. Cu-deficient and adequate rats were fed a diet containing 62% carbohydrate as fructose. Half the Cu-deficient rats fed fructose were injected daily with vitamin E. Vitamin E treated rats were not protected against the lethal consequences of the interaction between Cu and fructose. These data provide evidence that the cardiomyopathy of Cu deficiency in rats consuming a fructose-based diet ... Read More »
» Published in J Am Coll Nutr. 1992 Jun;11(3):330-3.

32. Synthesis of 1,4-anhydro-D-fructose and 1,4-anhydro-D-tagatose.
Match Strength: 9.119

1,4-Anhydro-D-fructose and 1,4-anhydro-D-tagatose were prepared from 1,2-O-isopropylidene-D-glucofuranose via the common intermediate 3,5,6-tri-O-benzyl-D-glucitol. The title compounds may be interesting anti-oxidants and feature activities akin to their natural pyranoid counterpart, 1,5-anhydro-D-fructose ... Read More »
» Published in Carbohydr Res. 2006 Jul 24;341(10):1737-42. Epub 2006 Apr 5.

33. Biochemical characterization of a fructokinase mutant of Rhizobium meliloti.
Match Strength: 9.101

A double mutant strain (UR3) of Rhizobium meliloti L5-30 was isolated from a phosphoglucose isomerase mutant (UR1) on the basis of its resistance to fructose inhibition when grown on fructose-rich medium. UR3 lacked both phosphoglucose isomerase and fructokinase activity. A mutant strain (UR4) lacking only the fructokinase activity was derived from UR3; it grew on the same carbon sources as the parent strain, but not on fructose, mannitol, or sorbitol. A spontaneous revertant (UR5) of normal growth phenotype contained fructokinase activity. A fructose transport system was found in L5-30, UR4, ... Read More »
» Published in J Bacteriol. 1980 Oct;144(1):12-6.

34. Effect of fructose on phenylephrine-induced glucose output in perfused rat liver.
Match Strength: 9.085

Glucose output induced by phenylephrine in perfused livers of fed rats was decreased by 34% during an infusion of fructose, but was increased by 30% (compared to controls) following cessation of fructose infusion. Corresponding changes in hepatic inorganic phosphate (Pi) were also observed with a 40% decrease and a 48% increase in Pi concentration being measured during and following fructose infusion, respectively. The data suggest that the glycogenolytic response to phenylephrine is dependent on the hepatic Pi concentration. It is also suggested that enhanced hepatic Pi concentrations and ... Read More »
» Published in Horm Metab Res. 1988 Aug;20(8):528-30.

35. Kinetics of Sugar Transport and Phosphorylation Influence Glucose and Fructose Cometabolism by Zymomonas mobilis.
Match Strength: 9.082

The competitive inhibition of fructokinase by glucose has been proposed as the mechanism by which Zymomonas mobilis preferentially consumes glucose from mixtures of glucose and fructose and accumulates fructose when growing on sucrose. In this study, incorporation of radioactive fructose into biomass was used as a measure of fructose catabolism. It was determined that the rate of fructose incorporation by Z. mobilis CP4 was somewhat lower in the presence of an equimolar concentration of glucose but that the inhibition of fructokinase by glucose was not nearly as severe in vivo as was predicted ... Read More »
» Published in Appl Environ Microbiol. 1997 Sep;63(9):3519-3525.

36. Fructose Malabsorption May Be Gender Dependent and Fails to Show Compensation by Colonic Adaptation.
Match Strength: 9.067

Fructose malabsorption is linked to gastrointestinal and other unusual symptoms. Polymers of fructose are also recognized prebiotics. While some prebiotics can self-adapt when consumed regularly (resulting in decreased breath hydrogen and symptoms), we wondered whether self-adaptation occurs with basic fructose. We evaluated 90 subjects (61 females). Each completed a diet questionnaire and underwent a fructose challenge. Breath hydrogen and quantified symptom scores were recorded. Group comparisons for sum of breath hydrogen and total symptom scores were evaluated with the Mann-Whitney U test. ... Read More »
» Published in Dig Dis Sci. 2007 Mar 15;

37. Corrected seminal fructose test.
Match Strength: 9.061

Serum testosterone, seminal fructose, citric acid, and prolactin were measured in 33 men attending an infertility clinic. Seminal samples were assessed for leucocytes using the peroxidase stain technique and were grouped as leucocytospermics or not. Corrected fructose was calculated from actual fructose concentration. The objective of the study was to use the combined measurement of serum levels of testosterone and levels of corrected seminal fructose as a test to determine the presence or absence of an obstructive process by inflammation at the reproductive tract. Seminal fructose and ... Read More »
» Published in Arch Androl. 1994 Jul-Aug;33(1):17-22.

38. Ability of the Normal Human Small Intestine to Absorb Fructose: Evaluation by Breath Testing.
Match Strength: 9.055

BACKGROUND & AIMS: Fructose consumption is increasing, and its malabsorption causes common gastrointestinal symptoms. Because its absorption capacity is poorly understood, there is no standard method of assessing fructose absorption. We performed a dose-response study of fructose absorption in healthy subjects to develop a breath test to distinguish normal from abnormal fructose absorption capacity. METHODS: In a double-blind study, 20 healthy subjects received 10% solutions of 15, 25, and 50 g of fructose and 33% solution of 50-g fructose on 4 separate days at weekly intervals. Breath samples ... Read More »
» Published in Clin Gastroenterol Hepatol. 2007 Jul 9;

39. Reactivity and oxidative potential of fructose and glucose in enkephalin-sugar model systems.
Match Strength: 9.036

The reactions of Leu- and Met-enkephalin (Tyr-Gly-Gly-Phe-Leu/Met) with fructose resulted in the parallel formation of Heyns compounds (N-peptidyl-D-mannosamine and -D-glucosamine) and sugar-peptide generated imidazolidinone diastereomers. Glucose showed higher level of reactivity than fructose with respect to the extent of glycated product formation. The presence of fructose in the incubation mixtures makes Met residue more susceptible to oxidation than glucose. Publication Types:, Research Support, Non-U.S. Gov ... Read More »
» Published in Amino Acids. 2008 Feb;34(2):329-32. Epub 2007 Feb 14.

40. Effect of Anthocyanin-Rich Extract from Black Rice (Oryza sativa L. indica) on Hyperlipidemia and Insulin Resistance in Fructose-Fed Rats.
Match Strength: 9.031

This study was designed to evaluate the effect of an anthocyanin-rich extract from black rice on hyperlipidemia and insulin resistance in fructose-fed rats. Rats fed fructose diet for 4 weeks exhibited significantly higher plasma insulin levels and lower insulin sensitivity than the control rats fed AIN-93G diet. Dietary supplementation with the anthocyanin-rich extract (5 g/kg of high-fructose diet) prevented the development of fructose-induced insulin resistance. After fructose-induced insulin resistance had been established, 4-week treatment with the anthocyanin-rich extract (5 g/kg of high ... Read More »
» Published in Plant Foods Hum Nutr. 2006 Dec 23;

41. Correlation between glucose/fructose discrepancy and hexokinase kinetic properties in different Saccharomyces cerevisiae wine yeast strains.
Match Strength: 9.007

Grape juice contains about equal amounts of glucose and fructose, but wine strains of Saccharomyces cerevisiae ferment glucose slightly faster than fructose, leading to fructose concentrations that exceed glucose concentrations in the fermenting must. A high fructose/glucose ratio may contribute to sluggish and stuck fermentations, a major problem in the global wine industry. We evaluated wine yeast strains with different glucose and fructose consumption rates to show that a lower glucose preference correlates with a higher fructose/glucose phosphorylation ratio in cell extracts and a lower K ... Read More »
» Published in Appl Microbiol Biotechnol. 2008 Jan;77(5):1083-91. Epub 2007 Oct 23.

42. Studies of the mechanism of fructose-induced hypertriglyceridemia in the rat.
Match Strength: 8.990

Carbohydrate-induced hypertriglyceridemia is easily produced in the rat, and fructose has been shown to be particularly potent in this regard. In this study we have compared the effects of feeding rats diets high (66% of total calories) in fructose or glucose on various aspects of carbohydrate and lipid metabolism. The results confirmed previous observations that fructose (456 +/- 276 mg/dl) was more potent (p less than 0.001) in raising plasma TG concentration than was glucose (242 +/- 13 mg/dl), and indicated that the difference in magnitude of hypertriglyceridemia produced by the two ... Read More »
» Published in Metabolism. 1982 Nov;31(11):1077-83.

43. Fructose metabolism in the cerebellum.
Match Strength: 8.977

Under normal physiological conditions, the brain utilizes only a small number of carbon sources for energy. Recently, there is growing molecular and biochemical evidence that other carbon sources, including fructose, may play a role in neuro-energetics. Fructose is the number one commercial sweetener in Western civilization with large amounts of fructose being toxic, yet fructose metabolism remains relatively poorly characterized. Fructose is purportedly metabolized via either of two pathways, the fructose-1-phosphate pathway and/or the fructose-6-phosphate pathway. Many early metabolic ... Read More »
» Published in Cerebellum. 2007;6(2):130-40.

44. Hepatic and renal failure associated with amiodarone infusion in a patient with hereditary fructose intolerance.
Match Strength: 8.963

Hereditary fructose intolerance is a rare inherited metabolic disorder. Although fructose intolerance usually presents in the paediatric age group, individuals can survive into adulthood by self.manipulation of diet. Hospitalisation can become a high.risk environment for these individuals because of loss of control of their strict dietary constraints and the added danger of administration of medications containing fructose, sucrose and sorbitol. We report a case of hereditary fructose intolerance in an adult presenting with hepatic and renal failure associated with an amiodarone infusion and ... Read More »
» Published in Crit Care Resusc. 2002 Jun;4(2):112-5.

45. Hydrogenation of fructose on Ru/C catalysts.
Match Strength: 8.962

The hydrogenation of D-fructose on Ru/C catalysts was studied. Under the conditions applied (1 bar H2, 72 degrees C), the furanose forms of D-fructose react, while the pyranose forms do not. However, all anomers adsorb with comparable strength on the surface. The reaction rate is controlled by product inhibition. The selectivity to D-mannitol can be increased from 47 to 63% by promotion of Pd/C and Pt/C catalysts with Sn ... Read More »
» Published in Carbohydr Res. 2000 Oct 6;328(4):449-57.

46. Vanadate but not tungstate prevents the fructose-induced increase in GLUT5 expression and fructose uptake by neonatal rat intestine.
Match Strength: 8.923

Intermediary signals, precociously enhancing GLUT5 transcription in response to perfusion of its substrate, fructose, in the small intestine of neonatal rats, are not known. Because glucose-6-phosphatase (G6Pase), glucose-6-phosphate translocase (G6PT), and fructose-1,6-bisphosphatase (FBPase) expression increases parallel to or precedes that of GLUT5, we investigated the link between these gluconeogenic genes and GLUT5 by using vanadate or tungstate, potent inhibitors of gluconeogenesis. Small intestinal perfusions of 20-d-old rats were performed with fructose alone, fructose + vanadate or ... Read More »
» Published in J Nutr. 2006 Sep;136(9):2308-13.

47. True corrected seminal fructose level: a better marker of the function of seminal vesicles in infertile men.
Match Strength: 8.910

This study was designed to determine if the value obtained after multiplying motile sperm concentration by seminal fructose concentration, named "true corrected fructose", correlates with sperm motility in asthenozoospermic men. Forty-two male partners in infertile couples were studied. Men were treated with 100 mg daily of clomiphene citrate for 5 days. Blood and semen samples were collected before treatment and 24 h after the end of treatment. Serum testosterone, seminal fructose and sperm motility were measured in each subject. Corrected fructose (log. sperm concentration multiplied by ... Read More »
» Published in Int J Androl. 2001 Oct;24(5):255-60. Comment in: Int J Androl. 2001 Oct;24(5):253-4., Int J Androl. 2002 Aug;25(4):253, author reply 254.

48. Acute Effect Of Fructose On Postprandial Lipaemia In Diabetic And Non-Diabetic Subjects
Match Strength: 8.883

We investigated whether the potentiation of postprandial lipaemia by fructose occurs in both non-diabetic subjects and those with non-insulin-dependent diabetes mellitus. Six non-diabetic and six diabetic subjects were studied on two occasions. They were given a meal containing 1 g fat/kg body weight with, on one occasion, 0.75 g fructose/kg body weight, on the other occasion 0.75 g starch/kg body weight. In both groups, plasma glucose and insulin concentrations rose more after starch than after fructose. At 1-2 h after the meal, plasma non-esterified fatty acid concentrations were suppressed ... Read More »
» Published in Br J Nutr. 1998 Aug;80(2):169-75.

49. In vivo and in vitro 31P magnetic resonance spectroscopic studies of the hepatic response of healthy rats and rats with acute hepatic damage to fructose loading.
Match Strength: 8.865

The hepatic response to a fructose challenge for control rats, and rats subjected to an acute sublethal dose of carbon tetrachloride (CCl4) or bromobenzene (BB), was compared using dynamic in vivo 31P MRS. Fructose loading conditions were used in which control rats showed only a modest increase in hepatic phosphomonoester (PME), and a small decrease in ATP, Pi, and intracellular pH after fructose administration. Both CCl4 and BB-treated rats showed a much greater fructose-induced accumulation of PME than did controls. Trolox C, a free radical scavenger, prevented most of this PME increase. BB ... Read More »
» Published in Magn Reson Med. 1994 May;31(5):469-81. Comment in: Magn Reson Med. 1994 Dec;32(6):801-3.

50. Flavor preferences conditioned by sugars: rats learn to prefer glucose over fructose.
Match Strength: 8.799

The reinforcing effects of glucose and fructose were compared using flavor preference conditioning paradigms. Female rats given access to flavored glucose and flavored fructose solutions developed preferences for the glucose- over the fructose-paired flavor, as well as for unflavored glucose over unflavored fructose. This effect was obtained with 8% and 32% solutions, and with nondeprived and deprived rats. In most cases, the glucose preference was not immediate but appeared only after the rats had one-bottle experience with the two sugars. Female rats also preferred a glucose-paired flavor ... Read More »
» Published in Physiol Behav. 1991 Oct;50(4):815-24.

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