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Peer Reviewed Scientific Research Reports.
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1. The effects of soy extract on the uterus of castrated adult rats.
Match Strength: 6.468
OBJECTIVE: The aim of this study was to evaluate the effects of different doses of a standardized soy extract on the uterus of castrated rats. METHODS: Fifty-six adult castrated female Wistar rats were randomly divided into seven groups (eight animals in each) that received: GI-drug vehicle (propylene glycol); GII-soy extract 10mg/kg per day; GIII-soy extract 50mg/kg per day; GIV-soy extract 100mg/kg per day; GV-soy extract 300mg/kg per day; GVI-soy extract 600mg/kg per day; GVII-conjugated equine estrogens (CEE) 200mug/kg per day. After 21 days of treatment, all animals were sacrificed and ... Read More »
» Published in Maturitas. 2007 Feb 20;56(2):173-183. Epub 2006 Sep 25.
2. Antioxidant and antiaggregatory effects of an extract from Conyza canadensis on blood platelets in vitro.
Match Strength: 6.124
The antioxidative activity of the polysaccharide extract from Conyza canadensis in blood platelets treated with peroxynitrite (ONOO-) was studied. Peroxynitrite as a strong biological oxidant has toxic effects on blood platelets and induces the oxidation of thiols, carbonylation and nitration of platelet proteins and lipid peroxidation. Therefore, the aim of our study was to assess if the natural extract from herbal plant, Conyza Canadensis, may protect platelet proteins against nitrative and oxidative damage induced by ONOO-. In our study we measured oxidative damage of platelet proteins ... Read More »
» Published in Platelets. 2006 Sep;17(6):354-60.
3. Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review.
Match Strength: 5.617
The objective of this review was to evaluate the strength of evidence of effectiveness for Petasites hybridus in the prophylaxis of migraine. Several databases and other sources were searched to identify randomised-controlled trials investigating P. hybridus preparations. Two trials totalling 293 patients (60 and 233 patients) were included in this review. Both trials investigated the proprietary Petasites root extract Petadolex. The trials were described in narrative way, taking into consideration methodological quality scores. Pooling of data was not carried out due to the heterogeneity of ... Read More »
» Published in Phytomedicine. 2006 Nov;13(9-10):743-6. Epub 2006 Sep 20.
4. The dry plant extract of common bean seed (Phaseoli vulgari pericarpium) does not have an affect on postprandial glycemia in healthy human subject.
Match Strength: 5.584
The aim of present study was to assess the effects and safety of a dry Phaseoli vulgari pericarpium (PVP) extract on postprandial glycemia in healthy participants. A randomized crossover experiment where participants received either PVP extract or placebo. Chemical compounds in dry extract were assessed by established methods. Eighteen healthy participants (9 male and 9 female) aged 29+/-4,8 years, body mass index (BMI) 23+/-3,7 kg/m(2) were recruited among students and staff at the Faculty of Pharmacy, University of Belgrade. All participants were able to follow the study protocol without ... Read More »
» Published in Bosn J Basic Med Sci. 2006 Aug;6(3):28-33.
5. Mitochondrial involvement in Atuna racemosa induced toxicity.
Match Strength: 5.581
Our group has developed a system to extract information regarding potential novel pharmaceuticals from historic herbal texts. We have shown that one of the plants identified through this technique has the purported antibacterial properties suggested by the text. Here, the toxicity of this antibacterial extract was examined. Using a Jurkat cell model, a therapeutic window between the minimal inhibitory concentration for Gram-positive bacteria and the dose-dependent toxicity of the Atuna racemosa extract was established. Using cells with a mutated caspase 8, it was shown that the toxicity does ... Read More »
» Published in J Ethnopharmacol. 2007 Jan 19;109(2):304-11. Epub 2006 Aug 8.
6. Assessment of antidiarrhoeal activity of the methanol extract of Xylocarpus granatum bark in mice model.
Match Strength: 5.486
The methanol extract of Xylocarpus granatum bark was studied for its antidiarrhoeal properties in experimental diarrhoea, induced by castor oil and magnesium sulphate in mice. At the doses of 250 and 500mg/kg per oral, the methanol extract showed significant and dose-dependent antidiarrhoeal activity in both models. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to atropine sulphate (5mg/kg; i.m.). The results showed that the extracts of Xylocarpus granatum bark have a significant antidiarrhoeal activity and supports its traditional uses in ... Read More »
» Published in J Ethnopharmacol. 2007 Feb 12;109(3):539-42. Epub 2006 Aug 23.
7. The use of Eucalyptus tereticornis Sm. (Myrtaceae) oil (leaf extract) as a natural larvicidal agent against the malaria vector Anopheles stephensi Liston (Diptera: Culicidae).
Match Strength: 5.056
Secondary metabolites obtained from the indigenous plants with proven mosquito control potential can be used as an alternative to synthetic insecticides under the integrated vector control. The essential oil extract from the forest redgum, Eucalyptus tereticornis Sm. (Myrtaceae) was tested against mature and immature mosquito vector Anopheles stephensi Liston (Diptera) under laboratory condition. The extract showed strong larvicidal, pupicidal and adulticidal activity. The leaf oil extracts showed high bioactivity at high doses. Results obtained from the laboratory experiment showed that the ... Read More »
» Published in Bioresour Technol. 2007 Jul;98(9):1856-1860. Epub 2006 Sep 25.
8. Kinetic distribution of paeoniflorin in cortex of normal and cerebral ischemia-reperfusion rats after intravenous administration of Paeoniae Radix extract.
Match Strength: 5.032
The time course of paeoniflorin in the cortex of normal and cerebral ischemia-reperfusion rats, following intravenous administration of Paeoniae Radix extract at a dose of 60 mg/kg of paeoniflorin, was determined using high-performance liquid chromatographic (HPLC) assay. The results showed that paeoniflorin could penetrate through the blood-brain barrier to reach the cortex, and that the injuries of ischemia-reperfusion could play an important role in pharmacokinetic process of paeoniflorin in the cortex after intravenous administration of Paeoniae Radix extract. The cortex concentrations of ... Read More »
» Published in Biomed Chromatogr. 2006 Dec;20(12):1283-8.
9. Anti-inflammatory and analgesic effects of Spartium junceum L. flower extracts: a preliminary study.
Match Strength: 5.018
Our objective was to study the anti-inflammatory and analgesic activity of extract of Spartium junceum L. flowers. Samples of flowers were collected from wild plants, dried, powdered, and extracted with hexane and methanol. The extracts were evaporated to dryness and then suspended in suitable solvent. They were then tested for anti-inflammatory activity in the carrageenin rat paw edema test and for analgesic activity in the Randall and Selitto mechanical pressure test and in the tail-flick test. Twenty-four hours after treatment, the gastric mucosa of each rat was observed macroscopically. ... Read More »
» Published in J Med Food. 2006 Fall;9(3):386-90.
10. The in-vivo antimalarial activities of Uvaria chamae and Hippocratea africana.
Match Strength: 4.979
The antimalarial activities of ethanolic root extracts of two plants used traditionally as malarial remedies in southern Nigeria, Uvaria chamae (Annonaceae) and Hippocratea africana (Hippocrateaceae), were studied in vivo, in mice infected with Plasmodium berghei berghei. The extract of U. chamae, when given orally at 300-900 mg/kg.day, exhibited significant antimalarial activity against both early and established infections. When established infections were treated, the mean survival time of the mice observed with this extract at 900 mg/kg.day was similar to that seen with the positive ... Read More »
» Published in Ann Trop Med Parasitol. 2006 Oct;100(7):585-90.
11. Intestinal absorption of hawthorn flavonoids--in vitro, in situ and in vivo correlations.
Match Strength: 4.883
Our previous studies identified hyperoside (HP), isoquercitrin (IQ) and epicatechin (EC) to be the major active flavonoid components of the hawthorn phenolic extract from hawthorn fruits demonstrating inhibitory effect on in vitro Cu(+2)-mediated low density lipoproteins oxidation. Among these three hawthorn flavonoids, EC was the only one detectable in plasma after the oral administration of hawthorn phenolic extract to rats. The present study aims to investigate the intestinal absorption mechanisms of these three hawthorn flavonoids by in vitro Caco-2 monolayer model, rat in situ intestinal ... Read More »
» Published in Life Sci. 2006 Nov 25;79(26):2455-62. Epub 2006 Aug 18.
12. Evaluation of transformation growth factor beta(1), interleukin-10, and interferon-gamma in male symptomatic and asymptomatic dogs naturally infected by Leishmania (Leishmania) chagasi.
Match Strength: 4.524
The aims of this study were to evaluate the immunomodulatory role of TGF-beta(1), IL-10, and INF-gamma in spleen and liver extracts and supernatant cultures of white spleen cells from male symptomatic and asymptomatic dogs, naturally infected by Leishmania (Leishmania) chagasi. Thirty dogs from Aracatuba, Sao Paulo, Brazil, an endemic leishmaniosis area, were selected by positive ELISA serological reaction for Leishmania sp. and divided into two groups: asymptomatic (n=15) and symptomatic (n=15) consisting of animals with at least three characteristic signs (fever, dermatitis, lymphoadenopathy ... Read More »
» Published in Vet Parasitol. 2007 Feb 28;143(3-4):267-74. Epub 2006 Sep 18.
13. Spasmolytic and tonic effect of Iberogast((R)) (STW 5) in intestinal smooth muscle.
Match Strength: 4.493
STW 5 (Iberogast((R))) is a fixed combination of nine medicinal plant extracts effective in the treatment of functional dyspepsia and irritable bowel syndrome. The effects of STW 5, a combination of Iberis amara fresh plant extract, and other eight plant extracts as well as single extract components including extracts from Menthae piperitae folium, Matricariae flos and Liquiritiae radix, were assayed in guinea pig ileum with or without stimulation with acetylcholine or histamine, in order to find a possible effect on the contractility of intestinal smooth muscle. STW 5 decreased acetylcholine- ... Read More »
» Published in Phytomedicine. 2006;13 Suppl 1:67-74. Epub 2006 Sep 15.
14. The analgesic effect of Carum copticum extract and morphine on phasic pain in mice.
Match Strength: 4.475
Pain is a universal complaint, which needs further investigations for new pain relieving agents. Carum copticum (L.) Sprague ex Turrill is a plant in Umbelliferae family, which is mentioned to have some therapeutic effects on headache and joint pains in Iranian traditional literature, but there are not enough scientific reports to prove its effects on pain. So, we conducted to design an experimental clinical trial study to assess and compare the analgesic effect of ethanolic extract of Carum copticum fruit with morphine by using a tail-flick analgesiometer device. Our results indicate that the ... Read More »
» Published in J Ethnopharmacol. 2007 Jan 19;109(2):226-8. Epub 2006 Aug 1.
15. Biochemical effects of Nigella sativa L seeds in diabetic rats.
Match Strength: 4.387
Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxidant enzymes like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase in liver and kidney. The results confirm the antidiabetic activity of N. sativa seeds extract and suggest that because of its antioxidant effects its administration may be useful in ... Read More »
» Published in Indian J Exp Biol. 2006 Sep;44(9):745-8.
16. Screening antimicrobial activity of various extracts of Artemisia dracunculus L.
Match Strength: 4.386
The antimicrobial activities of chloroform, acetone and two different concentrations of methanol extracts of Artemisia dracunculus L. were studied. These extracts were tested against nine bacteria and four yeasts strains by the disc diffusion method. The results indicated that the methanol extract of A. dracunculus is more effective against tested microorganisms than chloroform or acetone extracts. The chloroform and acetone extracts were inhibitory only towards Pseudomonas aeruginosa (ATCC 27853). While the methanol extract that was diluted with 10 ml distilled water showed inhibition zones ... Read More »
» Published in Cell Biochem Funct. 2006 Sep 20;
17. In vivo analgesic and anti-inflammatory activities of ursolic acid and oleanoic acid from Miconia albicans (Melastomataceae).
Match Strength: 4.375
The aim of this work was to use in vivo models to evaluate the analgesic and anti-inflammatory activities of ursolic acid (UA) and oleanoic acid (OA), the major compounds isolated as an isomeric mixture from the crude methylene chloride extract of Miconia albicans aerial parts in an attempt to clarify if these compounds are responsible for the analgesic properties displayed by this plant. Ursolic acid inhibited abdominal constriction in a dose-dependent manner, and the result obtained at a content of 40 mg kg(-1) was similar to that produced by administration of acetylsalicylic acid at a ... Read More »
» Published in Z Naturforsch [C]. 2006 Jul-Aug;61(7-8):477-82.
18. Bioassay-guided isolation of antiatherosclerotic phytochemicals from Artocarpus altilis.
Match Strength: 4.254
The cytoprotective effects of various solvent extracts of Artocarpus altilis (Parkinson) Fosberg were evaluated. The cytoprotective effects were determined in human U937 cells incubated with oxidized LDL (OxLDL) using the 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1, 3-benzene disulfonate (WST-1) assay. The results demonstrated that the ethyl acetate extract showed cytoprotective activities. To identify the main cytoprotective components, a bioassay guided isolation of the ethyl acetate extract afforded b-sitosterol (1) and six flavonoids (2-7). Their chemical structures were ... Read More »
» Published in Phytother Res. 2006 Dec;20(12):1052-5.
19. Progress in researches on the pharmaceutical mechanism and clinical application of Ginkgo Biloba extract on various kinds of diseases.
Match Strength: 4.217
Progress made over the pharmaceutical mechanism and clinical application of Ginkgo Biloba extract (GBE) on various kinds of diseases were reviewed in this paper. The effective elements contained in GBE are mainly kinds of Ginkgo flavonoid and Ginkgolide, which have marked protective effects on cardio-cerebral vascular and central nerve systems. In clinical practice, it is applied mostly in treatment of cardio-cerebral vascular diseases. Also it shows apparent effects in the treatment processes of some other diseases as an adjuvant, and therefore, has been gradually accepted by the medical ... Read More »
» Published in Chin J Integr Med. 2006 Sep;12(3):234-9.
20. Acute and subacute toxicity of Salvia scutellarioides in mice and rats.
Match Strength: 4.123
The acute and subacute toxicity of the aqueous extract of Salvia scutellarioides (Lamiaceae) was studied in mice and rats. In the acute toxicity test, oral administration of 2g/kg of Salvia scutellarioides produced neither mortality nor changes in behavior or any other physiological activities. In subacute toxicity studies, no mortality was observed when the two doses of 1 or 2g/kgday of aqueous extract of Salvia scutellarioides extract were administered orally for a period of 28 days. In the blood chemistry analysis, no significant changes occurred, including glucose, creatinine, blood urea ... Read More »
» Published in J Ethnopharmacol. 2007 Jan 19;109(2):348-53. Epub 2006 Aug 12.
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