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Peer Reviewed Scientific Research Reports.
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1. Extra-osseous fat fluid level: a specific sign for osteomyelitis.
Match Strength: 7.269
Osteomyelitis may pose as a diagnostic dilemma on various imaging modalities and may be confused with neoplasms and other pathology. Although a rare finding, extra-osseous fat fluid level, especially when associated with spongy bone destruction, can be considered a specific sign of osteomyelitis. Previously, only two cases of extra-osseous fat fluid level in osteomyelitis have been reported, one on computed tomography (CT) and the other on magnetic resonance imaging (MRI). The former was a case of septic arthritis with intra-articular fat fluid level. A case of osteomyelitis is presented with ... Read More »
» Published in Skeletal Radiol. 2006 Sep 19;
2. The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish.
Match Strength: 5.986
The roles of extra-embryonic tissues in early vertebrate body patterning have been extensively studied, yet we know little about their function during later developmental events. Here, we analyze the function of the zebrafish extra-embryonic yolk syncytial layer (YSL) specific transcription factor, Mtx1, and find that it plays an essential role in myocardial migration. Downregulating the function of Mtx1 in the YSL leads to cardia bifida, a phenotype in which the myocardial cells fail to migrate to the midline. Mtx1 in the extra-embryonic YSL appears to regulate the embryonic expression of ... Read More »
» Published in Development. 2006 Oct;133(20):4063-72.
3. Anti-cyclic citrullinated peptide (CCP) antibodies in patients with long-standing rheumatoid arthritis and their relationship with extra-articular manifestations.
Match Strength: 5.954
OBJECTIVES: To evaluate frequency of anti-cyclic citrullinated peptide antibodies (anti-CCP) in long-standing rheumatoid arthritis (LsRA) patients and their relationship with extra-articular manifestations of rheumatoid arthritis (RA), in addition to comparing frequency of anti-CCP antibodies in early RA (ERA) and LsRA group. DESIGN AND METHODS: One hundred and fifteen consecutive RA patients were included in the study as having LsRA because their disease duration was longer than 3 years. Thirty-nine consecutive patients with RA were included in the study as having ERA (<3 years). Also, 64 ... Read More »
» Published in Clin Biochem. 2006 Oct;39(10):961-5. Epub 2006 Jul 13.
4. Proton transfer reaction-mass spectrometry (PTR-MS) headspace analysis for rapid detection of oxidative alteration of olive oil.
Match Strength: 4.799
Olive oil has been characterized by rapid proton transfer reaction-mass spectrometry (PTR-MS) headspace analysis without any concentration of the volatiles or pretreatment of the samples. Comparison of extra virgin and defective (rancid) samples, as described by a panel of sensory judges, and the monitoring of thermo-oxidation processes are discussed. Multivariate analysis of PTR-MS data has been carried out and cross-validated, providing (i) reliable classification models for extra virgin oil as opposed to defective oil and (ii) calibration models able to predict independently thermo ... Read More »
» Published in J Agric Food Chem. 2006 Oct 4;54(20):7635-40.
5. Measures to improve knowledge and self-care among patients with COPD: A UK general practice audit.
Match Strength: 3.483
The Parchmore Partnership, London, audited 11 evidence-based criteria relating to patient knowledge and COPD morbidity during December 2004 to March 2005 using questionnaires and practice records. 32 patients with moderate to severe COPD participated, and during the project they received information and extra care. Patient knowledge and clinical indicators showed significant improvements ... Read More »
» Published in Prim Care Respir J. 2006 Oct;15(5):307-9. Epub 2006 Sep 14.
6. Estimation of contrast agent concentration in intra- and extra-vascular spaces of brain tissue.
Match Strength: 3.403
This article presents a new method for estimating the leakage of a contrast agent out of a vessel. The proposed method is developed based on tissue homogeneity (TH) model, modified Patlak model, and Monte Carlo simulation. The analytical methods published in the literature estimate the contrast agent leakage by solving the coupled differential equations associated with the TH model under adiabatic conditions. These methods employ unrealistic simplifying assumptions and become intractable in their applications to the vessels that have a non-uniform permeability. Without making any unrealistic ... Read More »
» Published in Math Biosci. 2006 Nov;204(1):102-18. Epub 2006 Aug 4.
7. Progressive familial intrahepatic cholestasis.
Match Strength: 3.209
Progressive familial intrahepatic cholestasis (PFIC) is an important cause of cholestatic liver disease and biliary cirrhosis in pediatric population. Three cases of PFIC are described that were diagnosed on the basis of family history, pruritis, cirrhosis and / or paucity of interlobular bile ducts on liver biopsy and presence of extrahepatic biliary tree on imaging. These patients were initially labeled as suffering from extra-hepatic biliary atresia and neonatal hepatitis. PFIC-1 and 2 could not be differentiated on histological grounds, since these patients presented late and process of ... Read More »
» Published in J Coll Physicians Surg Pak. 2006 Oct;16(10):673-5.
8. Pathogenesis of prion diseases: current status and future outlook.
Match Strength: 2.950
The prion, a conformational variant of a host protein, is the infectious particle responsible for transmissible spongiform encephalopathy (TSE), a fatal neurodegenerative disease of humans and animals. The principal target of prion pathology is the brain, yet most TSEs also display prion replication at extra-cerebral locations, including secondary lymphoid organs and sites of chronic inflammation. Despite significant progress in our understanding of this infectious agent, many fundamental questions relating to the nature of the prion, including the mechanism of replication and the molecular ... Read More »
» Published in Nat Rev Microbiol. 2006 Oct;4(10):765-75.
9. Vitamin D, aging, and the 2005 Dietary Guidelines for Americans.
Match Strength: 2.924
The 2005 Dietary Guidelines for Americans recommend that older adults, people with dark skin, and those exposed to insufficient ultraviolet radiation (i.e., sunlight) consume extra vitamin D from vitamin D-fortified foods and/or supplements. Individuals in these high-risk groups should consume 25 microg (1000 IU) of vitamin D daily to maintain adequate blood concentrations of 25-hydroxyvitamin D, the biomarker for vitamin D status. This review considers recommendations for vitamin D-rich foods and dietary supplements, as well as specific problems with self-prescribing sun exposure or ... Read More »
» Published in Nutr Rev. 2006 Sep;64(9):410-21.
10. Sildenafil in management of persistent pulmonary hypertension of the newborn: report of two cases.
Match Strength: 2.808
Persistent pulmonary hypertension of the newborn (PPHN) was described in 1969 by Gersomy and co-workers as persistent foetal circulation. Supra - systemic pulmonary artery pressures result in right to left shunting of blood through the ductus arteriosus and/or foramen ovale. This results from failure of the normal adaptation to extra uterine life of the foetal heart/lung system. The incidence is estimated at about 0.1-0.2% of live born infants, majority being term or post term. There is no race or gender related predisposition. Management was always difficult before the advent of nitric oxide ... Read More »
» Published in East Afr Med J. 2006 Jun;83(6):337-40.
11. Application of domestic microwave for urgent histopathology reporting: an evaluation.
Match Strength: 2.794
Rapid diagnosis of histopathological material is becoming increasingly desirable. In neuropathology, crush smear preparation and frozen section diagnosis of tissues removed during operative procedures, have remained as essential tools for rapid diagnosis. Microwave technology has been introduced into the field of tissue processing and staining in past decade. Now-a-days even automated microwave assisted rapid tissue processors are available. In our study we have analysed the use of a domestic microwave (cost approximately Rs.5000) for urgent histoprocessing (30 minutes). This could be useful ... Read More »
» Published in Indian J Pathol Microbiol. 2006 Jul;49(3):348-51.
12. Genetics and hormones in testicular descent.
Match Strength: 2.754
Testicular descent is an essential part of normal male sexual development. Any anomaly that disrupts normal testicular descent will be clinically evident as cryptorchidism. Several factors, such as Hoxa-10, epidermal growth factor (EGF), calcitonin gene-related peptide (CGRP), and hormones, especially androgens and insulin-like factor 3 (INSL-3), have been suggested as being regulators of testicular descent. Testicular descent from the lower pole of the kidney into the extra-abdominal scrotal sac is a two-stage process of transabdominal and inguino-scrotal migration. The transabdominal phase ... Read More »
» Published in Hormones (Athens). 2003 Oct-Dec;2(4):211-6.
13. Osteoarthritis, application of physical therapy proceduers.
Match Strength: 2.692
Osteoarthritis (OA) is a group of overlapping disorders, which may have different aetiology but similar biological, morphologic and clinical outcome. In osteoarthritis, process will not encompass the joint cartilage only, but the entire joint, including sub-hondral bone, ligaments, capsule, and sinovial membrane and surrounding muscles. Osteoarthritis is a multi-factor disorder of sinovial joints, which occurs as result of mechanical and biological factors, which destabilise normal hondrocyte function, partitioning of cartilage, extra-cellular matrix and sub-hondral bone. The earliest changes, ... Read More »
» Published in Bosn J Basic Med Sci. 2006 Aug;6(3):84-8.
14. Comparative study on the regeneration of flue-gas desulfurizing agents by using conventional electrodialysis (ED) and bipolar membrane electrodialysis (BMED).
Match Strength: 2.689
Piperazine is an ideal desulfurizing agent but the heat-stable salts formed in desulfurization have caused secondary pollution and waste of resources. In the previous paper, a method was reported to regenerate piperazine by using BMED. To find the variety of that regeneration process, we performed experiments on the regeneration of piperazine by using ED. In comparison, ED has higher piperazine yield and current efficiency, and much lower voltage drop and energy consumption. However, its process cost is higher than that of BMED due to an extra expenditure for the base and its tank and pumps. ... Read More »
» Published in Environ Sci Technol. 2006 Sep 1;40(17):5527-31.
15. Aberrant transcriptional regulation of the MLL fusion partner EEN by AML1-ETO and its implication in leukemogenesis.
Match Strength: 2.553
The EEN (extra eleven nineteen) gene, located on chromosome 19p13, was cloned as a fusion with MLL from a patient with acute myeloid leukemia (AML) with translocation t(11;19)(q23;p13). In this study, we characterized the genomic structure of the EEN gene, including its 5' regulatory region and transcription start site (TSS). We found that Sp1 could bind to the guanine-cytosine (GC)-stretch of the EEN promoter and was critical for the normal EEN expression, whereas the leukemia-associated fusion protein AML1-ETO could aberrantly transactivate the EEN gene through an AML1 binding site. Of note, ... Read More »
» Published in Blood. 2007 Jan 15;109(2):769-77. Epub 2006 Sep 21.
16. Ion permeation through the Na+,K+-ATPase.
Match Strength: 2.433
P-type ATPase pumps generate concentration gradients of cations across membranes in nearly all cells. They provide a polar transmembrane pathway, to which access is strictly controlled by coupled gates that are constrained to open alternately, thereby enabling thermodynamically uphill ion transport (for example, see ref. 1). Here we examine the ion pathway through the Na+,K+-ATPase, a representative P-type pump, after uncoupling its extra- and intracellular gates with the marine toxin palytoxin. We use small hydrophilic thiol-specific reagents as extracellular probes and we monitor their ... Read More »
» Published in Nature. 2006 Sep 28;443(7110):470-4.
17. Treatment of central nervous system metastases: parenchymal, epidural, and leptomeningeal.
Match Strength: 2.390
PURPOSE OF REVIEW: With prolonged survival from systemic therapies in the adjuvant and salvage setting, and because these agents cannot cross the intact blood-brain barrier, central nervous system metastases are becoming a therapeutic challenge in oncology. RECENT FINDINGS: Recent therapeutic achievements include an extended use of surgery and radiosurgery. Although each of these treatment modalities has its own indications, in patients eligible for both treatments the upfront comparison of these two techniques has not been performed yet. Systemic chemotherapies and biotherapies may be ... Read More »
» Published in Curr Opin Oncol. 2006 Nov;18(6):637-43.
18. Simulation of impact test for determining "health" of percutaneous bone anchored implants.
Match Strength: 2.299
There is an ongoing requirement for a clinically relevant, noninvasive technique to monitor the integrity of percutaneous implants used for dental restorations, bone-anchored hearing aids, and to retain extra-oral prostheses (ear, eye, nose, etc). Because of the limitations of conventional diagnostic techniques (CT, MRI), mechanical techniques that measure the dynamic response of the implant-abutment system are being developed. This paper documents a finite element analysis that simulates a transient response to mechanical impact testing using contact elements. The detailed model allows for a ... Read More »
» Published in J Biomech Eng. 2006 Oct;128(5):647-53.
19. A distinct subset of intestinal dendritic cells responds selectively to oral TLR7/8 stimulation.
Match Strength: 2.296
The intestinal innate immune system continually interacts with commensal bacteria, thus oral vaccines should induce extra/alternative activation of DC, potentially through TLR. To examine this we collected intestinal lymph DC (iL-DC) under steady-state conditions and after feeding resiquimod (R-848), a synthetic TLR7/8 ligand, which we showed induces complete emptying of gut DC into lymph. iL-DC are heterogeneous with subset-specific functions. In this study we determined the kinetics of iL-DC subset release, activation and cytokine secretion induced by R-848. We show that L-DC comprise three ... Read More »
» Published in Eur J Immunol. 2006 Oct;36(10):2639-48.
20. Pre-replication assembly of E. coli replisome components.
Match Strength: 2.287
The localization of SeqA, thymidylate synthase, DnaB (helicase) and the DNA polymerase components alpha and tau, has been studied by immunofluorescence microscopy. The origin has been labelled through GFP-LacI bound near oriC. SeqA was located in the cell centre for one replication factory (RF) and at 1/4 and 3/4 positions in pre-divisional cells harbouring two RFs. The transition of central to 1/4 and 3/4 positions of SeqA appeared abrupt. Labelled thymidylate synthetase was found all over the cell, thus not supporting the notion of a dNTP-synthesizing complex exclusively localized near the ... Read More »
» Published in Mol Microbiol. 2006 Nov;62(3):695-708. Epub 2006 Sep 25.
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