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1. Hyperforin: more than an antidepressant bioactive compound?
Match Strength: 1.298

Hyperforin is a lipophilic compound that is present in great amounts in St. John's wort and that has been described as the main responsible for the antidepressant effects of this medicinal plant. In the last few years, evidence has accumulated pointing to other different effects of hyperforin with potential pharmacological interest. They include other neurological effects, effects on inflammation, as well as antibacterial, antitumoral and antiangiogenic effects ... Read More »
» Published in Life Sci. 2006 Jun 6;79(2):105-11. Epub 2006 Jan 24.

2. An overview of steroid use and its potential side-effects.
Match Strength: 1.240

Steroids are prescribed for their physiological and pharmacological effects: they have an antiinflammatory influence and suppress immune responses. However, this can cause side-effects. Assessment for the development of side-effects and advice on avoiding infection and injury are essential aspects of the care of patients taking steroids ... Read More »
» Published in Nurs Times. 2006 Apr 25-May 1;102(17):24-7.

3. Review. Pro- and anti-angiogenesis effects of resveratrol.
Match Strength: 1.211

Resveratrol, a natural polyphenol, has a variety of effects including protection against ischemia-reperfusion injury, and antitumor and chemopreventive action against malignant tumors. In recent years, resveratrol has been found to exert pro-and anti-angiogenic effects, depending on the situation. For example, pro-angiogenic effects are noted in the peri-infarct myocardium, whereas resveratrol inhibits angiogenesis in tumors. In this article, a review of the literature concerning both pro-angiogenic and anti-angiogenic effects of resveratrol and the underlying mechanisms of its effects on ... Read More »
» Published in In Vivo. 2007 Mar-Apr;21(2):365-70.

4. Immunomodulatory effects of statins and autoimmune rheumatic diseases: novel intracellular mechanism involved.
Match Strength: 1.102

Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known as statins, are the most commonly prescribed agents for the treatment of hypercholesterolemia. However, the effects of statins may extend beyond their influences on serum cholesterol levels resulting in cholesterol-independent or pleiotropic effects. Clinical, animal and in vitro studies suggest that statins have additional clinical uses because of their anti-inflammatory and immunomodulatory effects, in part due to their capacity to interfere with the mevalonate pathway and inhibit prenylation of Rho family GTPases ... Read More »
» Published in Int Immunopharmacol. 2006 Dec 5;6(12):1833-46. Epub 2006 Sep 7.

5. Turkish patients with osteoarthritis: their awareness of the side effects of NSAIDs.
Match Strength: 1.097

BACKGROUND/AIMS: The study aim was to determine the awareness of Turkish osteoarthritis patients of the side effects of non-steroidal anti-inflammatory drugs. METHODS: The patients were interviewed by 138 doctors regarding the level of their knowledge of the side effects of non-steroidal anti-inflammatory drugs. RESULTS: A total of 3,755 patients (female/male: 3/1, 35% > 65 years) were included in the study. 35.5% of the patients were aware of side effects of non-steroidal anti-inflammatory drugs. 85.4% and 11.5% were aware of the gastrointestinal and other system-related side effects, ... Read More »
» Published in Turk J Gastroenterol. 2005 Jun;16(2):89-92.

6. Antitumor and antiinflammatory effects of tetrathiotungstate in comparison with tetrathiomolybdate.
Match Strength: 1.054

Tetrathiomolybdate (TM) is an anticopper drug under development for treating Wilson's disease. Its mechanism of action involves forming a tight tripartite complex in the blood with serum albumin and available copper. When available copper levels are lowered in animals with TM, strong antiangiogenic and antitumor effects are observed. Similarly, TM has excellent efficacy in animal models of fibrotic, inflammatory, and autoimmune diseases, and it protects against heart damage from doxorubicin (DXR) and liver damage from acetaminophen, carbon tetrachloride, and concanavalin A. Tetrathiotungstate ... Read More »
» Published in Transl Res. 2007 May;149(5):260-4.

7. Targeting inflammation using selective glucocorticoid receptor modulators.
Match Strength: 1.046

Glucocorticoids have been used since several decades in a variety of diseases in view of their potent anti-inflammatory properties. Nevertheless, the widespread use of glucocorticoids is hampered by the risk of side effects. Because the effects of glucocorticoids are mediated at large through interaction with the glucocorticoid receptor, which results in anti-inflammatory effects as well as side effects, much attention has been given to understanding the molecular regulation. Over the past decade, remarkable progress has been made in the mechanisms mediating glucocorticoid receptor dependent ... Read More »
» Published in Curr Opin Pharmacol. 2010 Aug;10(4):497-504. Epub 2010 May 20.

8. Cyclooxygenase (COX) inhibitors and the intestine.
Match Strength: 1.044

Nonsteroidal anti-inflammatory drugs (NSAIDs) have long been used for the treatment of pain and inflammation because of their inhibitory effects on cyclooxygenase (COX). For almost as long as NSAIDs have been in use, multiple adverse effects have been noted. Assessment of many of these adverse effects have been complicated because of the discovery of multiple splice variants of the cox gene, and a greater array of COX inhibitors, especially the COX-2 selective inhibitors have become available. Some of these adverse effects cannot be readily explained by the effect of these drugs on COX. This ... Read More »
» Published in J Vet Intern Med. 2007 May-Jun;21(3):367-77.

9. Mucosal immunology of geohelminth infections in humans.
Match Strength: 1.038

There is limited data on the human mucosal immune response to geohelminths, but extensive data from experimental animals. Geohelminth infections may modulate mucosal immunity with effects on parasite expulsion or persistence and mucosal inflammation. Geohelminths are considered to have important effects on immunity to mucosal vaccines, infectious disease susceptibility, and anti-inflammatory effects in inflammatory bowel disease and asthma. This review will discuss the findings of studies of human immunity to geohelminths and their potential effects on non-parasite mucosal immune responses. ... Read More »
» Published in Mucosal Immunol. 2009 Jul;2(4):288-99. Epub 2009 Apr 29.

10. Effects of statins beyond lipid lowering: potential for clinical benefits.
Match Strength: 1.037

BACKGROUND: The role of statin drugs in the reduction of serum lipids has been well documented. More recently, evidence suggesting that statins may positively impact many organ systems and disease states independent of lipid reduction has emerged. The term "pleiotropic effects" has been used to refer to these properties. We reviewed the evidence exploring such potential effects. METHODS: A search of the MEDLINE database was conducted for articles published between 1985 to 2005 on the pleiotropic and the lipid-lowering independent effects of statin drugs. The search terms "statin", "HMG-CoA ... Read More »
» Published in Int J Cardiol. 2006 Apr 28;109(1):7-15. Epub 2005 Jul 28.

11. Statins and the endothelium.
Match Strength: 1.034

Statins have been shown to have pleiotropic effects apart from serum lipid-lowering effect in human. One of the major target organs for the effects of statins is the vascular endothelium, which plays an important role in the development of atherosclerosis and angiogenesis. Recent numerous studies have shown that the statins' cholesterol-independent vascular effects appear to involve directly restoring or improving endothelial function by increasing NO production, promoting re-endothelialization after arterial injury, and inhibiting inflammatory responses within the vessel wall that are thought ... Read More »
» Published in Vascul Pharmacol. 2007 Jan;46(1):1-9. Epub 2006 Jun 21.

12. Anti-inflammatory effects of statins: clinical evidence and basic mechanisms.
Match Strength: 1.034

Chronic inflammation is a key feature of vascular disease states such as atherosclerosis. Multiple clinical studies have shown that a class of medications termed statins lower cardiovascular morbidity and mortality. Originally developed to lower serum cholesterol, increasing evidence suggests that these medications have potent anti-inflammatory effects that contribute to their beneficial effects in patients. Here, we discuss the clinical and experimental evidence underlying the anti-inflammatory effects of these agents ... Read More »
» Published in Nat Rev Drug Discov. 2005 Dec;4(12):977-87.

13. Inhaled corticosteroids in COPD: systemic effects of a local therapy?
Match Strength: 1.033

BACKGROUND: There are few data on the effects of inhaled corticosteroids on systemic inflammation in chronic obstructive pulmonary disease (COPD). OBJECTIVE: Evaluation of the systemic anti-inflammatory effects of inhaled corticosteroids alone or in combination with long acting beta2-agonists. METHODS: Analysis of the results of a randomized study assessing the short-term effects of inhaled fluticasone propionate, inhaled fluticasone + salmeterol and placebo on three inflammation biomarkers represented by C-reactive protein, IL-6 and surfactant protein-D. RESULTS/CONCLUSIONS: Inhaled ... Read More »
» Published in Expert Opin Pharmacother. 2008 Dec;9(18):3271-3.

14. Language and action control: the acquisition of action goals in early childhood.
Match Strength: 1.019

This study examined the role of verbal labeling in 4-year-old children's acquisition of action-effect learning. The acquisition of action-effect associations was tested by having children first perform a two-choice key-pressing task in which each key press was followed by an effect (i.e., a particular sound) and then respond to the previously perceived effects under either consistent or inconsistent key-sound mappings. During acquisition, the children overtly described the actions, the effects, both the actions and the effects, or, in a control condition, something irrelevant to the actions ... Read More »
» Published in Psychol Sci. 2006 Sep;17(9):737-41.

15. The anti-inflammatory effects of tetracyclines.
Match Strength: 1.015

Tetracyclines commonly are used in medicine and dentistry because of their efficacy and safety as bacteriostatic antimicrobial agents. As such, tetracyclines function by inhibiting bacterial multiplication and growth. In addition to these effects, tetracyclines have anti-inflammatory properties and have been shown to exhibit several intracellular and extracellular biologic effects that are not related to antibiotic activity. These activities correlate with anti-inflammatory and anticollagenolytic properties. This article will review the anti-inflammatory properties of the tetracyclines and the ... Read More »
» Published in Cutis. 2005 Apr;75(4 Suppl):6-11.

16. Non-genomic glucocorticoid effects to provide the basis for new drug developments.
Match Strength: 1.003

Glucocorticoids act via genomic and non-genomic actions. The genomic glucocorticoid actions are well known and new details on processes of transactivation and transrepression have been reported recently. Here we describe the current knowledge on non-genomic glucocorticoid actions and discuss why these actions are considered to be of therapeutic relevance. It is assumed that rapid non-genomic glucocorticoid effects are mediated by three different mechanisms: (1) physicochemical interactions with cellular membranes (non-specific non-genomic effects); (2) membrane-bound glucocorticoid receptor ... Read More »
» Published in Mol Cell Endocrinol. 2006 Feb 26;246(1-2):142-6. Epub 2006 Jan 18.

17. Is there any difference in the effects of Qi therapy (external Qigong) with and without touching? A pilot study.
Match Strength: 1.003

The aim of this study was to evaluate differences in the effects of Qi therapy without touching or with touching on anxiety, mood, neurohormones, and cellular immune function. Twenty-four healthy male subjects were randomly assigned to either QTN (n = 12) or QTT (n = 12). They received Qi therapy (external Qigong) without touching (QTN) or with touching (QTT). Nonparametric statistical tests revealed no significant differences between the effects of QTN and QTT (all p > .05). Separate Wilcox signed rank tests for each intervention revealed significant effects on anxiety, alertness, depression, ... Read More »
» Published in Int J Neurosci. 2006 Sep;116(9):1055-64.

18. Pleiotropic effects: should statins be considered an essential component in the treatment of dyslipidemia?
Match Strength: 1.002

Cardiovascular disease (CVD) is the leading cause of death in the developed world. Lower risks of morbidity and mortality in trials of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) have changed the conventional wisdom regarding lipid lowering. Since 2001, there have been surprising results concerning the early benefits of statin therapy, which suggest that some benefits may be derived from effects other than those of simply improving dyslipidemias. The earlier than expected CVD benefits from statin trials have led to the theory that statins have effects other than, or ... Read More »
» Published in Curr Atheroscler Rep. 2008 Feb;10(1):45-52.

19. Angiotensin II regulates extraneuronal dopamine uptake in the kidney.
Match Strength: 1.001

BACKGROUND/AIMS: Angiotensin II (ANG II) and dopamine (DA) are both important regulators of sodium and water transport across renal proximal tubules. Previous studies demonstrate that atrial natriuretic factor (ANF) can regulate renal DA uptake and thereby Na(+),K(+)-ATPase activity in the external renal cortex. As ANG II counteracts most of the ANF biological effects, the aim of the present study was to evaluate ANG II effects on renal DA metabolism and identify the receptor involved. METHODS: To determine ANG II effects on renal DA metabolism, we evaluated (3)H-DA uptake in vitro in kidney ... Read More »
» Published in Nephron Physiol. 2006;104(4):136-43. Epub 2006 Sep 22.

20. Multiple biological activities of curcumin: a short review.
Match Strength: 0.998

Turmeric (Curcuma longa rhizomes), commonly used as a spice is well documented for its medicinal properties in Indian and Chinese systems of medicine. It has been widely used for the treatment of several diseases. Epidemiological observations, though inconclusive, are suggestive that turmeric consumption may reduce the risk of some form of cancers and render other protective biological effects in humans. These biological effects of turmeric have been attributed to its constituent curcumin that has been widely studied for its anti-inflammatory, anti-angiogenic, anti-oxidant, wound healing and ... Read More »
» Published in Life Sci. 2006 Mar 27;78(18):2081-7. Epub 2006 Jan 18.

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