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1. Natural polysaccharide carrageenan inhibits toxic effect of gram-negative bacterial endotoxins.
Match Strength: 2.703

The protective effect of polysaccharide carrageenan on the damaging effect of endotoxins of gram-negative bacteria was studied in vivo and in vitro. Carrageenan increased mouse resistance to the toxic effect of LPS. The degree of protection depended on polysaccharide concentration and administration time and route. Pretreatment of donor platelets with carrageenan reduced their aggregation activity caused by cooperative effect of LPS and ADP. Publication Types: In ... Read More »
» Published in Bull Exp Biol Med. 2006 Feb;141(2):230-2.

2. On the effect of pH in aromatic photonitration upon nitrate photolysis.
Match Strength: 2.255

This paper studies the pH effect on the photonitration of catechol, 1-naphthol, naphthalene, and benzene. The pH trend is influenced by the generation of HNO(2) and peroxynitrous acid (HOONO) upon nitrate photolysis. HNO(2) can be involved in a direct and an indirect nitration process. Direct nitration follows the pH distribution of HNO(2) (flexus around 3). Indirect nitration, possibly involving nitrosation+oxidation, would be highest around pH3. HOONO can be involved in electrophilic nitration, where the initial formation rate of the nitroderivatives is proportional to [H(+)], or take part ... Read More »
» Published in Chemosphere. 2007 Jan;66(4):650-6. Epub 2006 Sep 22.

3. Tocopherols and saponins derived from Argania spinosa exert, an antiproliferative effect on human prostate cancer.
Match Strength: 2.117

The aim of our study is to evaluate the antiproliferative effect of tocopherols obtained from alimentary virgin argan oil extracted from the endemic argan tree of Morocco and of saponins extracted from argan press cake on three human prostatic cell lines (DU145, LNCaP, and PC3). The results were compared to 2-methoxyestradiol as antiproliferative drug candidates. Cytotoxicity and antiproliferative effects were investigated after cells' treatment with tocopherols and saponins compared to 2-Methoxyoestradiol as the positive control. Tocopherols and saponins extracted from argan tree and 2 ... Read More »
» Published in Cancer Invest. 2006 Oct;24(6):588-92.

4. Hypoglycaemic effect of Artemisia sphaerocephala Krasch seed polysaccharide in alloxan-induced diabetic rats.
Match Strength: 2.095

The purpose of this study was to examine the hypoglycaemic activity of a new polysaccharide extracted from seed polysaccharide (ASP) was administered orally for 4 weeks and the blood glucose changes were determined in fasted rats. Plasma insulin, cholesterol and triglycerides levels were also determined. The ASP at a dose of 200 mg/kg body weight (bw) produced a significant decrease in blood glucose levels in diabetic rats (P <0.01). In the other hand, the effect of the ASP on the plasma cholesterol were also significant in diabetic rats (P <0.05). Furthermore, there was a significant ... Read More »
» Published in Swiss Med Wkly. 2006 Aug 19;136(33-34):529-32.

5. ATX-S10(Na)-PDT shows more potent effect on collagen metabolism of human normal and scleroderma dermal fibroblasts than ALA-PDT.
Match Strength: 2.090

Recent study revealed that photodynamic therapy (PDT) with a novel photosensitizer (ATX-S10(Na)) shows more potent effects for various skin diseases than ALA-PDT. The effect of ATX-S10(Na)-PDT on dermal fibroblasts is still unknown. Using dermal fibroblasts derived from normal and scleroderma patients, and mouse skin in vivo, we compared the effects of ATX-S10(Na)-PDT and ALA-PDT. Fibroblasts from normal, scleroderma patients or mice skin were treated with ATX-S10(Na)-PDT or ALA-PDT. After the PDT treatments, the expression of matrix metalloproteinases (MMPs) Tissue inhibitors of ... Read More »
» Published in Arch Dermatol Res. 2006 Nov;298(6):257-63. Epub 2006 Sep 15.

6. A literature review: the effects of magnetic field exposure on blood flow and blood vessels in the microvasculature.
Match Strength: 2.073

The effect of magnetic field (MF) exposure on microcirculation and microvasculature is not clear or widely explored. In the limited body of data that exists, there are contradictions as to the effects of MFs on blood perfusion and pressure. Approximately half of the cited studies indicate a vasodilatory effect of MFs; the remaining half indicate that MFs could trigger either vasodilation or vasoconstriction depending on initial vessel tone. Few studies indicate that MFs cause a decrease in perfusion or no effect. There is a further lack of investigation into the cellular effects of MFs on ... Read More »
» Published in Bioelectromagnetics. 2007 Feb;28(2):81-98.

7. Effect of antibodies against serotonin, bovine serum albumin, and complete Freund's adjuvant on mice subjected to acute immobilization stress.
Match Strength: 2.068

Nonspecific immunomodulators (complete Freund's adjuvant and bovine serum albumin) produced an antistress effect on mice during immobilization stress. Immunization with a serotonin-protein conjugate produced no antistress effect ... Read More »
» Published in Bull Exp Biol Med. 2006 Feb;141(2):200-3.

8. Brain dynamic mechanisms of scale effect in visual spatial attention.
Match Strength: 2.066

The dynamic mechanisms of the early event-related potential scale effect of different attentive regions in the brain was studied. The paradigm of this experiment is the precue-target visual search paradigm by event-related potential technique. The results showed that the reaction time was shortened with the reduction of cue scale, a cue to how big the search area would be, and fixed target stimulus, while the amplitudes of P1 and N1 components of event-related potentials increased. These results not only provided the electrophysiological evidences that supported the zoom-lens theory, but also ... Read More »
» Published in Neuroreport. 2006 Oct 23;17(15):1643-7.

9. Language and action control: the acquisition of action goals in early childhood.
Match Strength: 2.047

This study examined the role of verbal labeling in 4-year-old children's acquisition of action-effect learning. The acquisition of action-effect associations was tested by having children first perform a two-choice key-pressing task in which each key press was followed by an effect (i.e., a particular sound) and then respond to the previously perceived effects under either consistent or inconsistent key-sound mappings. During acquisition, the children overtly described the actions, the effects, both the actions and the effects, or, in a control condition, something irrelevant to the actions ... Read More »
» Published in Psychol Sci. 2006 Sep;17(9):737-41.

10. Combined effect of copper and prolonged summer drought on soil Microarthropods in the field.
Match Strength: 2.040

Soil microarthropods experience a large range of natural stressors in their natural environment, e.g. variations in temperature and soil moisture, but also anthropogenic stressors such as soil pollutants. In the present study the combined effect of drought stress and copper pollution on microarthropods was investigated in a field study. We hypothesised that microarthropods in copper polluted soil would be more susceptible to drought than animals in control soil. Surprisingly, the abundance of microarthropods in autumn was positively affected by summer drought and copper pollution did not ... Read More »
» Published in Environ Pollut. 2006 Sep 14;

11. Stimulus and response repetition effects in the detection of sounds: evidence of obligatory retrieval and use of a prior event.
Match Strength: 2.017

Three experiments were performed to examine the extent to which the time required to detect a probe sound is determined by the acoustic characteristics of a preceding prime sound and by the nature of the response made to the prime. The results of Experiment 1 revealed that the effect of frequency repetition was facilitative when a response was made to the occurrence of both the prime and the probe, but was inhibitory when a response was made only to the probe. In contrast, there was no significant effect of location repetition when responses were made to both prime and probe but there was a ... Read More »
» Published in Psychol Res. 2006 Sep 29;

12. Cidofovir administered with radiation displays an antiangiogenic effect mediated by E6 inhibition and subsequent TP53-dependent VEGF repression in HPV18+ cell lines.
Match Strength: 2.017

Therapeutic administration of the antiviral agent cidofovir with radiation markedly enhanced the antitumor effect of ionizing radiation in cells of two HPV18+ human cervical carcinoma cell lines. Although this potent radiosensitizing effect was associated with repression of the viral oncoproteins E6/ E7 and restoration of TP53 as shown previously, additional mechanisms may be involved. In the present study, we investigated the antiangiogenic effect of the combination of cidofovir and radiation in cells of two HPV18+ cervical cancer cell lines, HeLa and ME180, and assessed the molecular ... Read More »
» Published in Radiat Res. 2006 Oct;166(4):600-10.

13. The involvement of the inferior parietal cortex in the numerical Stroop effect and the distance effect in a two-digit number comparison task.
Match Strength: 2.004

The neural mechanism of number representation and processing is currently under extensive investigation. In this functional magnetic resonance imaging study, we designed a number comparison task to examine how people represent and compare two-digit numbers in the brain, and whether they process the decade and unit digits in parallel. We manipulated the decade-unit-digit congruency and numerical distance between the pairs of numbers. We observed both Stroop-like interference and the distance effect in the participants' performance. People responded more slowly to incongruent pairs of numbers ... Read More »
» Published in J Cogn Neurosci. 2006 Sep;18(9):1518-30.

14. Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells.
Match Strength: 1.959

PURPOSE: Panax notoginseng is a commonly used Chinese herb. Although a few studies have found that notoginseng shows anti-tumor effects, the effect of this herb on colorectal cancer cells has not been investigated. 5-Fluorouracil (5-FU) is a chemotherapeutic agent for the treatment of colorectal cancer that interferes with the growth of cancer cells. However, this compound has serious side effects at high doses. In this study, using HCT-116 human colorectal cancer cell line, we investigated the possible synergistic anti-cancer effects between notoginseng flower extract (NGF) and 5-FU on colon ... Read More »
» Published in Cancer Chemother Pharmacol. 2006 Sep 29;

15. Effect of oregano essential oil on chicken lactobacilli and E. coli.
Match Strength: 1.959

The effect of the oregano essential oil (EO) on lactobacilli and E. coli isolated from chicken was showed in the series of in vitro and in vivo experiments. Minimum inhibitory concentrations of amikacin, apramycin, streptomycin, neomycin against E. coli strains increased after oral application of EO. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Folia Microbiol (Praha). 2006;51(4):278-80.

16. 15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line.
Match Strength: 1.950

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin (PG) synthesis enzymes, the cyclooxygenases (COX-1 and 2). It is suggested that these enzymes are not their only targets. We reported that in tumoral TT cell, indomethacin, in vivo and in vitro, decreases proliferation and increases activity of 15-hydroxyprostaglandin-dehydrogenase (15-PGDH), the PG catabolism key enzyme. Here, we show that the COX-1 inhibitors, selective or not, and sulindac sulfone, a non-COX inhibitor, increased 15-PGDH activity and reduced PGE2 levels. This increase was negatively correlated to the ... Read More »
» Published in Prostaglandins Other Lipid Mediat. 2006 Oct;81(1-2):14-30. Epub 2006 Sep 1.

17. Effect of dimephosphon on functional recovery of damaged spinal cord.
Match Strength: 1.934

The effect of endolumbar dimephosphon perfusion in dogs with spinal cord contusion was studied by means of transcranial magnetic stimulation and stimulation electromyography. Treatment with dimephosphon contributed to preservation of conduction function of the spinal cord and decrease in excitability of spinal motoneurons in the perifocal zone ... Read More »
» Published in Bull Exp Biol Med. 2006 Feb;141(2):181-3.

18. Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy.
Match Strength: 1.912

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway can increase vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1alpha (HIF-1alpha) expression. We examined the effect of nelfinavir, an HIV protease inhibitor that inhibits Akt signaling, on VEGF and HIF-1alpha expression and on angiogenesis, tumor oxygenation, and radiosensitization. Nelfinavir decreases VEGF expression under normoxia via the transcription factor Sp1, which regulates the proximal core VEGF promoter. Nelfinavir decreased Sp1 phosphorylation and decreased Sp1 binding to a probe corresponding to the ... Read More »
» Published in Cancer Res. 2006 Sep 15;66(18):9252-9.

19. The effect of nephroureterectomy on glomerular filtration rate.
Match Strength: 1.910

OBJECTIVE: To determine the effect of nephroureterectomy (NU) on the glomerular filtration rate (GFR), and to determine whether the estimated GFR after NU is influenced by age and other factors associated with renal impairment. PATIENTS AND METHODS: We retrospectively identified 131 patients who had had a NU at either of two UK institutions. Their serum creatinine levels were recorded before and after NU, along with comorbidity data, and from this their GFR before and after NU was estimated using the Modification of Diet in Renal Disease Study Group equation. RESULTS: At a median follow-up of ... Read More »
» Published in BJU Int. 2006 Oct;98(4):845-8.

20. Quantifying the treatment effect explained by markers in the presence of measurement error.
Match Strength: 1.905

Surrogate markers or intermediate markers are important in identifying subjects with high risk of a serious disease or for monitoring disease progression of a subject on treatment. Quantifying the proportion of treatment effect (PTE) explained by markers has been studied extensively. Due to reasons such as biological variation, limited machine precision, etc. markers are generally measured with error. The estimated PTE ignoring the measurement error could be biased, which may lead to incorrect conclusions. In this article, we adjust for the measurement error using regression calibration to ... Read More »
» Published in Stat Med. 2006 Sep 15;

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