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1. A case of linear IgA disease occurring in a patient with colonic Crohn's disease.
Match Strength: 2.230

Linear IgA disease has been reported in association with inflammatory bowel disease, in particular ulcerative colitis. We experienced a case of linear IgA disease that occurred simultaneously with colonic Crohn's disease in a 55-year-old woman and rather unusually both skin and bowel disease improved in tandem. We report the presentation, investigations and subsequent improvement of our patient and speculate on possible causes ... Read More »
» Published in Br J Dermatol. 2005 Nov;153(5):1050-2.

2. Mild-to-moderate active luminal Crohn's disease.
Match Strength: 2.195

The management of luminal Crohn's disease, the most common form of initial presentation of the disease, depends on the location and the severity of the disease. Mild-to-moderate disease represents a relatively large proportion of patients with a first flare of luminal disease, which may also be associated with perianal disease. As quality of life of these patients inversely correlates with disease activity, adequate therapy is a central goal of the overall patient management. Treatment options include mainly sulfasalazine, budesonide and systemic steroids, while the role of mesalazine and ... Read More »
» Published in Digestion. 2007;76(2):92-8. Epub 2008 Feb 7.

3. Niemann-pick disease type C and Crohn's disease.
Match Strength: 2.193

A five-year-old girl with Neimann-Pick disease type C subsequently developed Crohn's Disease. This association has only been presented once previously in the literature. This report discusses the options for managing one chronic disease in the presence of another life limiting condition ... Read More »
» Published in Scott Med J. 2005 May;50(2):80-1.

4. A comprehensive guide to patient-focused management strategies for Crohn disease.
Match Strength: 2.102

In Crohn disease, a vigorous inflammatory cascade is caused by the overactivation of helper T-cells in the gastrointestinal system. The results of this inflammation manifest themselves as the symptoms of Crohn disease. This article describes the pathophysiology of Crohn disease as well as multiple pharmacologic and nonpharmacologic interventions that may assist patients with Crohn disease in preventing exacerbations and maintaining longer remissions ... Read More »
» Published in Gastroenterol Nurs. 2007 Mar-Apr;30(2):93-8; quiz 98-100.

5. Pregnancy complicated with Buerger's disease.
Match Strength: 2.067

Buerger's disease is an inflammatory occlusive vascular disorder involving small- and medium-sized arteries in the distal extremities and is usually complicated with thrombophlebitis. Since Buerger's disease develops most frequently in men who smoke, pregnancy complicated with this disease is extremely rare. Only three pregnancies have been reported previously. All cases indicate that Buerger's disease worsens during pregnancy. However, anti-coagulant therapy appeared to be effective in this case. Accordingly, careful observation is mandatory in pregnancies complicated with Buerger's disease ... Read More »
» Published in Int J Gynaecol Obstet. 2006 Jul;94(1):62-6. Epub 2006 Jun 16.

6. Coincidence or causality: celiac and Crohn diseases in a case of Turner syndrome.
Match Strength: 2.056

We describe a 29-year-old woman presenting with chronic diarrhea, growth retardation, and primary amenorrhea who was diagnosed as having celiac disease coexisting with Crohn disease and Turner syndrome. The association of Turner syndrome, inflammatory bowel disease, and celiac disease is reviewed with insights into the genetics of immunologic disorders and possible chromosomal derangements leading to inflammatory bowel disease. To our knowledge, this is the first case of Crohn disease associated with celiac disease and Turner syndrome ... Read More »
» Published in Am J Med Sci. 2005 Apr;329(4):214-6.

7. The genetics of chronic obstructive pulmonary disease.
Match Strength: 2.053

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease caused by the interaction of genetic susceptibility and environmental influences. There is increasing evidence that genes link to disease pathogenesis and heterogeneity by causing variation in protease anti-protease systems, defence against oxidative stress and inflammation. The main methods of genomic research for complex disease traits are described, together with the genes implicated in COPD thus far, their roles in disease causation and the future for this area of investigation ... Read More »
» Published in Respir Res. 2006 Oct 20;7:130.

8. European evidence based consensus on the diagnosis and management of Crohn's disease: current management.
Match Strength: 2.010

This second section of the European Crohn's and Colitis Organisation (ECCO) Consensus on the management of Crohn's disease concerns treatment of active disease, maintenance of medically induced remission, and surgery. The first section on definitions and diagnosis includes the aims and methods of the consensus, as well as sections on diagnosis, pathology, and classification of Crohn's disease. The third section on special situations in Crohn's disease includes postoperative recurrence, fistulating disease, paediatrics, pregnancy, psychosomatics, extraintestinal manifestations, and alternative ... Read More »
» Published in Gut. 2006 Mar;55 Suppl 1:i16-35.

9. Crohn's disease presenting as palatal ulcer.
Match Strength: 2.002

Crohn's disease (CD) in children younger than 5 years of age is termed as early onset inflammatory bowel disease (EO-IBD). We report a 4 yr 6 mo-old child with EO-IBD, who presented with palatal ulcer, an extra intestinal manifestation of Crohn's disease as the dominant feature ... Read More »
» Published in Indian J Pediatr. 2006 Mar;73(3):229-31.

10. Infliximab use in Crohn's disease.
Match Strength: 1.987

Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract. The disease can be quite severe, resulting in hospitalisation, requiring long-term treatment with a variety of medications and frequent surgeries. Infliximab is a chimeric monoclonal antibody directed against tumour necrosis factor, a key cytokine in the inflammatory cascade of many diseases, including Crohn's disease. Numerous studies have shown significant improvement in both clinical and endoscopic luminal and fistulising Crohn's disease with infliximab treatment. The clinical efficacy, indications, safety ... Read More »
» Published in Expert Opin Biol Ther. 2005 Apr;5(4):589-99.

11. Minimal change nephropathy in a 7-year-old boy with Rosai-Dorfman disease.
Match Strength: 1.967

Rosai-Dorfman (R-D) disease is a benign lympho-histiocytosis of the lymphoid system. Immune derangement due to cytokine over-expression (tumor necrosis factor (TNF), interleukin (IL)-1b and IL-6) has been considered the cause of R-D disease. We present a 7-year-old boy with R-D disease who developed minimal change nephropathy (MCN) during the progression of R-D disease. The patient was resistant to oral prednisolone; and the remission of both R-D disease and MCN was achieved with oral cyclophosphamide (2 mg/kg, 12 weeks). MCN, the most common cause of nephrotic syndrome in childhood, is ... Read More »
» Published in J Nephrol. 2006 Mar-Apr;19(2):211-4.

12. Refractory celiac disease: an unusual disease in a Chinese patient.
Match Strength: 1.953

Celiac disease (CD) is an autoimmune disease characterized by mucosal inflammation and villous atrophy of the small bowel upon exposure to ingested gluten. Although common in developed countries, it is extremely rare in the Chinese population. Refractory celiac disease (RCD) is a rare complication of CD with poor prognosis. Patients may die of severe malabsorption or development of enteropathy-associated T-cell lymphoma. We report a case of RCD in a Chinese woman who required steroid therapy in addition to a gluten-free diet to induce disease remission. The possibility of CD in Chinese ... Read More »
» Published in J Dig Dis. 2008 Nov;9(4):238-40.

13. Kikuchi-Fujimoto disease: a case report.
Match Strength: 1.952

Kikuchi-Fujimoto disease is a rare benign cervical lymphadenopathy, which often affects young adult women. Its etiology and pathogenesis are unknown. We present the case of Kikuchi-Fujimoto disease in the Polish population and analyse the difficulties in differentiating this disease from the systemic lupus erythematosus ... Read More »
» Published in Rheumatol Int. 2005 Dec;26(2):179-81. Epub 2005 Jun 10.

14. Polypharmacy and Crohn's disease.
Match Strength: 1.952

BACKGROUND: Polypharmacy has not been defined for Crohn's disease. AIMS: To determine the prevalence of polypharmacy, factors associated with polypharmacy, and consequences of polypharmacy in a Crohn's disease population. METHODS: A review of 291 Crohn's disease patients was performed. Polypharmacy was defined as either minor (two to four medications) or major (> or = 5 medications). Clinical status was evaluated with the Harvey-Bradshaw index of disease activity (HBI) and the short inflammatory bowel disease questionnaire (SIBDQ). RESULTS: Major polypharmacy was identified in 50% of patients. ... Read More »
» Published in Aliment Pharmacol Ther. 2005 May 15;21(10):1211-6.

15. Minor salivary gland inflammation in Devic's disease and longitudinally extensive myelitis.
Match Strength: 1.951

Devic's disease is often considered as a variant of multiple sclerosis (MS). However, evidence suggests that Devic's disease may be distinct from MS. Devic's disease can coexist with connective tissue diseases, particularly Sj�gren's disease, but this association is rare with MS. Diagnosis of Sj�gren's disease in patients with neurological symptoms is often difficult. During early stages of Sj�gren's disease, patients may not fulfill all criteria for Sj�gren's disease. A high percentage of patients with Sj�gren's disease have inflammatory infiltrates in minor salivary glands, and this may be a ... Read More »
» Published in Mult Scler. 2008 Jul;14(6):809-14. Epub 2008 Jun 23.

16. European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
Match Strength: 1.939

This third section of the European Crohn's and Colitis Organisation (ECCO) Consensus on the management of Crohn's disease concerns postoperative recurrence, fistulating disease, paediatrics, pregnancy, psychosomatics, extraintestinal manifestations, and alternative therapy. The first section on definitions and diagnosis reports on the aims and methods of the consensus, as well as sections on diagnosis, pathology, and classification of Crohn's disease. The second section on current management addresses treatment of active disease, maintenance of medically induced remission, and surgery of Crohn ... Read More »
» Published in Gut. 2006 Mar;55 Suppl 1:i36-58.

17. Extra-intestinal manifestations of Crohn's disease.
Match Strength: 1.938

Extra-intestinal manifestations occur in at least 25% of Crohn's disease patients. Some extra-intestinal manifestations, such as erythema nodusum and peripheral arthropathy, will wax and wane in keeping with bowel inflammation. The more severe cutaneous ulcerations, uveitis, and axial arthropathy may precede bowel disease or persist after it subsides. Screening may be appropriate for eye disease and for osteoporosis to prevent complications. Medical management for extra-intestinal manifestations is similar to treatment for the bowel symptoms of Crohn's disease, with corticosteroids the ... Read More »
» Published in Surg Clin North Am. 2007 Jun;87(3):673-80.

18. Pediatric inflammatory bowel disease.
Match Strength: 1.932

Inflammatory bowel disease is an important cause of gastrointestinal pathology in children and adolescents. The incidence of pediatric inflammatory bowel disease is increasing; therefore, it is important for the clinician to be aware of the presentation of this disease in the pediatric population. Laboratory tests, radiology studies, and endoscopic procedures are helpful in diagnosing inflammatory bowel disease and differentiating between Crohn's disease and ulcerative colitis. Once diagnosed, the goal of medical management is to induce remission of disease while minimizing the side effects of ... Read More »
» Published in World J Gastroenterol. 2006 May 28;12(20):3204-12.

19. Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
Match Strength: 1.931

Alzheimer disease is a progressive dementia with unknown etiology that affects a growing number of the aging population. Increased expression of inflammatory mediators in postmortem brains of people with Alzheimer disease has been reported, and epidemiological studies link the use of anti-inflammatory drugs with reduced risk for the disorder. On the initial basis of this kind of evidence, inflammation has been proposed as a possible cause or driving force of Alzheimer disease. If true, this could have important implications for the development of new treatments. Alternatively, inflammation ... Read More »
» Published in Nat Med. 2006 Sep;12(9):1005-15.

20. The development of anti-inflammatory drugs for infectious diseases.
Match Strength: 1.925

Traditionally, disease is thought to result from an insufficient response of the host to infection, leading to increased replication of microorganisms and consequently disease. However, infection may not necessarily lead to disease and disease is not only the result of uncontrolled replication of a microorganism. Indeed, the inflammatory response triggered by certain infections is frequently the cause of tissue damage and death. The present review argues that it is possible to separate mechanisms necessary for the host response to deal with infection from those which cause unwanted ... Read More »
» Published in Discov Med. 2010 Dec;10(55):479-88.

 << Prev 20  Showing results 1 to 20 of 11,896 Next 20 >>




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