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Peer Reviewed Scientific Research Reports.
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1. Greater development of 1,2-dimethylhydrazine-induced colon cancer in a rat model of type 2 diabetes mellitus.
Match Strength: 10.005
Several clinical cohort and case-control studies have suggested a link between diabetes and colon cancer. Otsuka Long-Evans Tokushima Fat (OLETF) rats spontaneously develop type 2 diabetes mellitus and Long-Evans Tokushima Otsuka (LETO) rats are non-diabetic. The relationship between type 2 diabetes mellitus and colon cancer was examined in these rats. The carcinogen 1,2-dimethylhydrazine was administered subcutaneously once weekly for 10 weeks, and the animals were killed and necropsied in week 29. All OLETF rats and 80% of the LETO rats developed cancer. The number of colon cancers per rat ... Read More »
» Published in J Int Med Res. 2006 Jul-Aug;34(4):385-9.
2. Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus: the atherosclerosis risk in communities study.
Match Strength: 9.902
The authors analyzed data from a prospective, community-based cohort to assess the risk of incident type 2 diabetes mellitus associated with coffee and sweetened beverage consumption. They included 12,204 nondiabetic, middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) Study (1987-1999). Consumption of each beverage was assessed by food frequency questionnaire and classified into categories of cups per day. They found an inverse association, after adjusting for potential confounders, between increased coffee consumption and risk of type 2 diabetes mellitus in men (for ... Read More »
» Published in Am J Epidemiol. 2006 Dec 1;164(11):1075-84. Epub 2006 Sep 18.
3. Clinical characteristics and diabetes associated autoantibodies in patients with both type 1 diabetes mellitus and asthma.
Match Strength: 9.070
OBJECTIVE: Type 1 diabetes mellitus (DM1) and asthma are mediated by opposite arms of the cellular immune system, namely T helper (Th)1 and Th2 CD4+ cells, respectively. It is not known whether their coexistence affects their clinical manifestations. METHODS: The number of asthma exacerbations, frequency of hypoglycemic events, HbA1c levels, diabetes associated autoantibody status and diabetes associated late complications were determined in three paired groups of patients (n = 11) matched by gender and age: DM1 and asthma, asthma only, and DM1 only. RESULTS: Patients with both diseases had a ... Read More »
» Published in J Pediatr Endocrinol Metab. 2006 Aug;19(8):1001-6.
4. Diabetes mellitus and the elderly: special considerations for foot ulcer prevention and care.
Match Strength: 9.052
The risk of lower extremity amputation in persons with diabetes mellitus increases with advanced age, necessitating clinical vigilance. Individualized and comprehensive prevention efforts are required to address the complicated and diverse nature of the diabetic foot in the elderly patient, including promotion of lifestyle changes to offset diabetes, attention to cognitive deficits and economic limitations, and provision of foot care education and management (eg, emphasizing the need for appropriate foot wear). If an ulcer develops, physiologic and socioeconomic factors may influence its ... Read More »
» Published in Ostomy Wound Manage. 2006 Sep;52(9):50-2, 54, 56.
5. The impact of diabetes mellitus on postoperative morbidity in laryngeal surgery.
Match Strength: 8.786
The main aim of this study was to analyse risk factors of postoperative morbidity after extended laryngeal surgery comparing patients with diabetes mellitus and non-diabetic patients. In retrospective study 69 patients (63 male and 6 female), who underwent partial laryngo-pharyngectomy and total laryngectomy between 2003 and 2004, were evaluated. 13 % of the total group of examined patients had concurrent diabetes, while 87% were nondiabetic patients. We performed partial laryngopharyngectomy in 39 out of 69 patients (56.5%) and total laryngectomy in 30 patients (43.5%). Secondary wound ... Read More »
» Published in Acta Chir Iugosl. 2006;53(1):51-5.
6. Cardiovascular risk in the spectrum of type 2 diabetes mellitus.
Match Strength: 8.748
The clinical importance of the metabolic syndrome is that this group of risk factors greatly increases the likelihood of cardiovascular events, the major source of disease morbidity and mortality in patients with obesity and type 2 diabetes. Recent studies have helped clarify the mechanisms underlying the vascular dysfunction that leads to cardiovascular outcomes in diabetes. This vascular dysfunction is correlated with visceral adiposity, insulin resistance and alterations in the levels of a variety of circulating factors. The vascular effects of overt hyperglycemia also play an important ... Read More »
» Published in Mt Sinai J Med. 2006 Sep;73(5):759-68.
7. WHO diagnostic criteria as a validation tool for the diagnosis of diabetes mellitus: a study in five European countries.
Match Strength: 8.583
OBJECTIVE: In 1999, the World Health Organization (WHO) published new diagnostic criteria for diabetes mellitus (DM). The cut-off value of the fasting plasma glucose concentration was lowered from 7.8 to 7.0 mmol/l. The WHO criteria were used to validate the diagnosis made by the general practitioner, and to compare the diagnostic validity of diabetes mellitus in different countries. METHODS: We retrospectively analysed 2556 newly diagnosed diabetics. Incidence was calculated according to the 1999 WHO criteria. Data were collected in general practice networks in five European countries or ... Read More »
» Published in Eur J Gen Pract. 2006;12(3):108-13.
8. Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus.
Match Strength: 7.846
Patients with type 2 diabetes mellitus have increased risk of cardiovascular disease. Epidemiological studies have shown a correlation between diet and incidence of coronary heart disease. The aim of the study is to determine the effect of a traditional Greek Mediterranean diet on platelet aggregation induced by ADP, arachidonic acid (AA), and especially platelet-activating factor (PAF) on patients with type 2 diabetes mellitus as well as on healthy volunteers. The patients were randomized into two subgroups, A and B. The lipid extracts from traditional Greek Mediterranean-type meals were ... Read More »
» Published in J Med Food. 2006 Fall;9(3):356-62.
9. Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus.
Match Strength: 7.745
The aim of the study was to determine whether a recommendation to walk 10000 steps per day would result in significant improvements in glycemic control, insulin sensitivity, and cardiovascular risk in patients with type 2 diabetes mellitus. The study was a 6-week randomized controlled trial that included 30 patients with type 2 diabetes mellitus. After 10 days of baseline activity, patients were randomized into 2 groups: control and active. The control group (n = 15) was instructed to continue with their baseline activity for 6 weeks. The active group (n = 15) was instructed to walk at least ... Read More »
» Published in Metabolism. 2006 Oct;55(10):1382-7.
10. Type 1 diabetes mellitus associated with nephrotic syndrome.
Match Strength: 7.679
Nephrotic syndrome (NS) in a patient with diabetes mellitus (DM) first suggests the diagnosis of diabetic nephropathy. However, glomerular diseases other than diabetic nephropathy have been reported in patients with DM. We present a child with type 1 DM (DM1) associated with NS. A 3 year-old boy who was diagnosed with DM1 developed proteinuria in nephrotic range at the 10th month of follow-up. He had remission on steroid treatment without any problem in glycemic control as he was given tapered daily doses instead of an alternate day regimen. He relapsed at the 7th month of follow-up, and ... Read More »
» Published in J Pediatr Endocrinol Metab. 2006 Aug;19(8):1045-8.
11. Long- and short-haul travel by air: issues for people with diabetes on insulin.
Match Strength: 7.594
OBJECTIVE: To determine what problems are experienced by people with diabetes mellitus traveling abroad using insulin, whether appropriate and consistent advice is available to them, and if necessary, how this advice could be improved or enhanced. DESIGN: Census study by self-administered questionnaire of patients with diabetes who use insulin attending an outpatient clinic. SETTING: Grampian Diabetes Centre, Woolmanhill Hospital, Aberdeen. PARTICIPANTS: A total of 493 patients using insulin who attended the clinic in Aberdeen over a period of 3 months. MAIN OUTCOME MEASURES: Determination of ... Read More »
» Published in J Travel Med. 2006 Sep-Oct;13(5):255-60.
12. NFkappaB and its inhibitor IkappaB in relation to type 2 diabetes and its microvascular and atherosclerotic complications.
Match Strength: 7.332
Nuclear factor kappa B (NFkappaB) is an important transcription factor that together with its inhibitor (IkappaB) participates in the activation of genes involved in immune responses. We examined the CA repeat polymorphism of the NFKB1 gene (encoding for NFkappaB) and A/G point variation in the 3'UTR region of the nuclear factor kappa B inhibitor alpha (NFKBIA) gene (encoding for IkappaB) in Czech and German patients with type 2 diabetes. The sample consisted of 211 patients, both with and without kidney complications, and 159 controls. Additionally, 152 patients with systemic lupus ... Read More »
» Published in Hum Immunol. 2006 Sep;67(9):706-13. Epub 2006 Jun 22.
13. Effects of treatment for diabetes mellitus on circulating vascular progenitor cells.
Match Strength: 7.150
The circulating endothelial progenitor cells (EPCs) have an important role in angiogenesis, and the smooth muscle progenitor cells (SMPCs) participate in atherosclerosis. However, little is known about the effects of treatment of diabetes mellitus (DM) on EPCs and SMPCs. Therefore, we investigated the relations between the number of circulating vasucular progenitor cells before and after the treatment for DM. Ten previously untreated DM patients were enrolled in this study. Blood samples were collected before and after treatment. The peripheral mononuclear cells were purified and cultured to ... Read More »
» Published in J Pharmacol Sci. 2006 Sep;102(1):96-102.
14. Activation of protein kinase a improves vascular endothelial dysfunction.
Match Strength: 7.135
The study has been designed to investigate the effect of 8-Br-cAMP, an activator of protein kinase A (PKA), in diabetes mellitus- and hyperhomocysteinemia-induced vascular endothelial dysfunction. Streptozotocin (55 mg kg-1, i.v.) and methionine (1.7% w/w, p.o., 4 weeks) were administered to rats to produce diabetes mellitus (serum glucose >200 mg dL-1) and hyperhomocysteinemia (serum homocysteine >10 microM), respectively. Vascular endothelial dysfunction was assessed using isolated aortic ring preparation, electron microscopy of thoracic aorta, and serum concentration of nitrite ... Read More »
» Published in Endothelium. 2006 Jul-Aug;13(4):267-77.
15. Low-density lipoproteins are more electronegatively charged in type 1 than in type 2 diabetes mellitus.
Match Strength: 6.852
Multifactorial etiology is involved in premature atherosclerosis related to diabetes. Most of the mechanisms that are responsible for the etiology in diabetes have remained unsolved so far. Type 1 diabetes is associated with a favorable lipid pattern and with microangiopathy, which is not true for type 2 diabetes, which is related to dyslipidemia and macroangiopathy. The aim of this work was to evaluate the degree of LDL modification related to the types of diabetes. The question is whether the LDL could be differently modified since the pathogenesis of type 1 and type 2 diabetes is different. ... Read More »
» Published in Lipids. 2006 Jun;41(6):529-33.
16. Prevalence of diabetes in Pakistan.
Match Strength: 6.822
The prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) and the contributing risk factors were estimated by performing a cross-sectional survey conducted earlier in the rural and urban areas of all the four provinces of Pakistan. The statistical analysis was performed from the obtained results by using SPSS version 12.0. The total number of subjects examined were 5433 which included 1893 males (1208 in rural and 685 in urban areas) and 3540 females (2243 in rural and 1297 in urban areas). The prevalence of diabetes in the urban versus the rural areas was 6.0% in men and 3 ... Read More »
» Published in Diabetes Res Clin Pract. 2006 Sep 25;
17. Tacrolimus (Pan Graf) as de novo therapy in renal transplant recipients in India.
Match Strength: 6.792
The safety and efficacy of tacrolimus in transplantation is well established. However, tacrolimus has only recently been available in India. We report an initial experience using tacrolimus as de novo therapy in a living related renal transplant program. Fifty-two consecutive recipients of living renal allografts were treated with tacrolimus, mycophenolate mofetil, or azathioprine and steroids. The dose of tacrolimus was adjusted to keep trough levels at 10 to 12 ng/mL in the first 3 months, 8 to 10 ng/mL in the next 3 months, and 5 to 8 ng/mL thereafter. Any evidence of graft dysfunction was ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2029-31.
18. Effects of type 2 diabetes mellitus on cochlear structure in humans.
Match Strength: 6.750
OBJECTIVE: To evaluate the effects of type 2 diabetes mellitus on cochlear elements in humans. DESIGN: Comparative study of the histopathologic characteristics of human temporal bones. SETTING: Otopathology laboratory in a tertiary academic medical center. PATIENTS: Temporal bones from 18 patients with type 2 diabetes mellitus were divided into 2 groups according to the method of management of diabetes: insulin in 11 patients (mean age, 51.9 years; age range, 44-65 years) and oral hypoglycemic agents in 7 patients (mean age, 54.4 years; age range, 45-64 years). The diabetic groups and 26 age ... Read More »
» Published in Arch Otolaryngol Head Neck Surg. 2006 Sep;132(9):934-8.
19. Relationship between polymorphisms 804C/A and 252A/G of lymphotoxin-alpha gene and -308G/A of tumor necrosis factor alpha gene and diabetic retinopathy in Japanese patients with type 2 diabetes mellitus.
Match Strength: 6.552
To clarify whether polymorphisms of the lymphotoxin-alpha (LTA) gene and tumor necrosis factor alpha (TNF-alpha) gene were related to diabetic retinopathy (DR), we performed a case-control study in 251 Japanese patients with type 2 diabetes mellitus participating in a multicenter research protocol. Genetic analyses were performed by using a fluorescent allele-specific DNA primer assay system. Diabetic retinopathy was diagnosed in a masked manner by an independent ophthalmologist using fundus photographs and was classified as nondiabetic retinopathy (NDR), nonproliferative retinopathy (NPDR), ... Read More »
» Published in Metabolism. 2006 Oct;55(10):1406-10.
20. The effectiveness of intensive glycemic control for the prevention of vascular complications in diabetes mellitus.
Match Strength: 6.279
Obesity and type 2 diabetes mellitus have reached epidemic proportions in the US, and indeed, globally. While microvascular complications contribute to considerable morbidity, much of the excess mortality (around 70%) is due to macrovascular disease. Hyperglycemia has predictable toxic effects on multiple organs ('glucotoxicity') including the pancreas, where it impairs insulin secretion and insulin gene expression through mechanisms that lead to glucose densensitization and beta-cell exhaustion, eventually resulting in irreversible beta-cell failure. There is robust evidence to suggest that ... Read More »
» Published in Treat Endocrinol. 2006;5(5):273-86.
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