Diabetes 2007Matching Summaries of Recent
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Peer Reviewed Scientific Research Reports.
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Match Strength: 7.747
We conducted a systematic review of the risk of pancreatic cancer in people with type I and young-onset diabetes. In three cohort and six case-control studies, the relative risk for pancreatic cancer in people with (vs without) diabetes was 2.00 (95% confidence interval 1.37-3.01) based on 39 cases with diabetes.British Journal of Cancer (2007) 96, 507-509. doi:10.1038/sj.bjc.6603571 www.bjcancer.com Published online 16 January 2007 ... Read More »
» Published in Br J Cancer. 2007 Feb 12;96(3):507-9. Epub 2007 Jan 16.
2. The economic burden of diabetes.
Match Strength: 7.062
New research provides revised comprehensive estimates that suggest that the U.S. national economic burden of pre-diabetes and diabetes reached $218 billion in 2007. This estimate includes $153 billion in higher medical costs and $65 billion in reduced productivity. The average annual cost per case is $2,864 for undiagnosed diabetes, $9,975 for diagnosed diabetes ($9,677 for type 2 and $14,856 for type 1), and $443 for pre-diabetes (medical costs only). For each American, regardless of diabetes status, this burden represents a cost of approximately $700 annually. These results underscore the ... Read More »
» Published in Health Aff (Millwood). 2010 Feb;29(2):297-303. Epub 2010 Jan 14.
3. Undertreatment Of Mental Health Problems In Adults With Diagnosed Diabetes And Serious Psychological Distress: The Behavioral Risk Factor Surveillance System, 2007.
Match Strength: 6.554
AbstractObjectives: To assess the prevalence and correlates of undertreatment for mental health problems among adults with diabetes and serious psychological distress (SPD). Research Design and Methods: We analyzed data of adults aged >/=18 years from the 2007 Behavioral Risk Factor Surveillance System. SPD was assessed with the K6 scale. Results: The prevalence of untreated SPD was estimated to be 2.1% (SE, 0.1), 3.4% (SE, 0.3), and 2.0% (SE, 0.1) in the total population, diabetic population, and non-diabetic population, respectively. Among people with SPD, those with diagnosed diabetes had a ... Read More »
» Published in Diabetes Care. 2010 Feb 25. [Epub ahead of print]
4. Age at onset of type 1 diabetes in parents and recurrence risk in offspring.
Match Strength: 6.453
OBJECTIVE: Our aim was to study the recurrence risk of type 1 diabetes in the offspring of parents with adult-onset (15-39 years) type 1 diabetes and to evaluate the transmission of diabetes within a continuum of parental age at onset of diabetes from childhood to adulthood. RESEARCH DESIGN AND METHODS: Diabetes status of all offspring (n = 9,636) in two Finnish cohorts of parents with type 1 diabetes was defined until the end of year 2007. Cumulative incidences of type 1 diabetes among the offspring were estimated, and several factors contributing to the risk were assessed. RESULTS: During ... Read More »
» Published in Diabetes. 2010 Jan;59(1):210-4. Epub 2009 Oct 15.
5. Advancing Evidence-Based Care For Diabetes: Lessons From The Veterans Health Administration.
Match Strength: 6.366
The Veterans Health Administration (VHA) is a unique laboratory for using the electronic health record (EHR) to transform health care and accelerate discovery. This is particularly evident in the care of veterans with diabetes, who constitute a quarter of those served by the VHA. Although EHRs have enabled rapid learning, additional factors were necessary, including the lead participation of clinician-investigators, accountability through performance measurement, a delivery system focused on population health, and favorable economic externalities. "Off-the-shelf" technology is unlikely to ... Read More »
» Published in Health Aff (Millwood). 2007 Jan 26;
6. An overview of regular dialysis treatment in Japan (as of 31 December 2007).
Match Strength: 6.359
A nationwide statistical survey of 4098 dialysis facilities was conducted at the end of 2007, and 4052 facilities (98.88%) participated. The number of patients undergoing dialysis at the end of 2007 was determined to be 275 242, an increase of 10 769 patients (4.1%) compared with that at the end of 2006.The number of dialysis patients per million at the end of 2007 was 2154. The crude death rate of dialysis patients at the end of 2007 from the end of 2006 was 9.4%. The mean age of new patients begun on dialysis was 66.8 years and the mean age of the entire dialysis patient population was 64 ... Read More »
» Published in Ther Apher Dial. 2009 Dec;13(6):457-504.
7. Pedometer use among adults at high risk of type 2 diabetes, Finland, 2007-2008.
Match Strength: 6.276
INTRODUCTION: A pedometer helps adults exercise more, but sedentary adults need instruction and advice to be motivated to use one. We conducted this qualitative study to describe the experiences of participants at high risk of type 2 diabetes who began using a pedometer. METHODS: A total of 74 people at high risk of type 2 diabetes participated in 6 months of group counseling. From April 2007 to April 2008, we collected data through questionnaires, theme interviews (n = 22) and video recordings of counseling sessions. From October 2007 through June 2008, we analyzed the data. RESULTS: ... Read More »
» Published in Prev Chronic Dis. 2010 Mar;7(2):A37. Epub 2010 Mar 15.
8. Stroke Associated with Diabetes among Canadians: Sex and Age Differences.
Match Strength: 6.240
Objective: To determine the age and sex variations in the relationship between diabetes and stroke. Methods: This analysis was based on data from 61,327 Canadians >/=45 years of age who participated in the Canadian Community Health Survey in 2000-2001. Logistic regression analysis was conducted to evaluate the association between diabetes and stroke, and effect modification by age and sex. Results: The association between diabetes and stroke was stronger in the 45- to 64-year age group than the >/=65 year age group in men but not in women. The increased risk of stroke associated with ... Read More »
» Published in Neuroepidemiology. 2006 Dec 8;28(1):46-49
9. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
Match Strength: 5.958
Genome-wide association studies identified noncoding SNPs associated with type 2 diabetes and obesity in linkage disequilibrium (LD) blocks encompassing HHEX-IDE and introns of CDKAL1 and FTO [Sladek R, et al. (2007) Nature 445:881-885; Steinthorsdottir V, et al. (2007) Nat. Genet 39:770-775; Frayling TM, et al. (2007) Science 316:889-894]. We show that these LD blocks contain highly conserved noncoding elements and overlap with the genomic regulatory blocks of the transcription factor genes HHEX, SOX4, and IRX3. We report that human highly conserved noncoding elements in LD with the risk SNPs ... Read More »
» Published in Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):775-80. Epub 2009 Dec 22.
10. Ethnic disparities in causes of death among diabetes patients in the Waikato region of New Zealand.
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AIM: Assist health service planning by: (1) estimating the causes and disparities in mortality among people with diabetes in Waikato and (2) examining the differences in recording of diabetes. METHOD: A retrospective cohort study of diabetes patients registered with the Waikato Regional Diabetes Service. Deaths from 2003-2007 were identified among patients diagnosed with diabetes before 2003. Causes of death were obtained from the NZHIS. Mortality rates were compared with the general New Zealand population. Cox's proportional-hazards-model was used to estimate the all-cause and cause-specific ... Read More »
» Published in N Z Med J. 2010 Mar 5;123(1310):19-29.
11. The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program.
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Aims Retinopathy is considered the complication most closely associated with and characteristic of diabetes mellitus. Hyperglycaemia below levels diagnostic of diabetes, so called pre-diabetes, is associated with a low prevalence of 'diabetic' retinopathy. However, few longitudinal studies of non-diabetic populations have performed repeated measures of glycaemia and screened for retinopathy to determine its occurrence in the non-diabetic population and the onset of retinopathy in new-onset diabetic patients. We determined the prevalence of retinopathy characteristically seen in diabetes in ... Read More »
» Published in Diabet Med. 2007 Feb;24(2):137-44.
12. North Carolina Emergency Department data: January 1, 2007-December 31, 2007.
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BACKGROUND: The purpose of this paper is to describe patient characteristics and clinical conditions seen in North Carolina emergency departments (EDs) in 2007. METHODS: Data were analyzed from a static database of all 2007 ED visits in the North Carolina Disease Event Tracking and Epidemiologic Collection Tool (NC DETECT). Data were captured from 80% of North Carolina EDs on January 1, 2007 and 93% as of December 31, 2007. ED visits were analyzed by age, sex, method of ED arrival, return and repeat ED visits, expected source of payment, and ED disposition. Data were also analyzed by selected ... Read More »
» Published in N C Med J. 2010 Jan-Feb;71(1):15-25.
13. Does an advanced insulin education programme improve outcomes and health service use for people with Type 2 diabetes? A 5-year follow-up of the Newcastle Empowerment course.
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OBJECTIVE: To show that an advanced diabetes education programme delivers sustained benefits to people with diabetes prescribed insulin and healthcare providers over and above those provided by basic diabetes education. METHODS: An historical cohort study of 68 people with Type 1 and 51 people with Type 2 diabetes on insulin who attended the 4-day Newcastle Empowerment programme in 2001 and 2002 compared with 71 people with Type 1 and 312 people with Type 2 diabetes who attended only the basic 4-day insulin education programme over the same period, followed until 2007. Primary outcome was all ... Read More »
» Published in Diabet Med. 2009 Dec;26(12):1277-81.
14. Klebsiella pneumoniae bacteraemia in a region of Canada.
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The second case of magA+ rmpA+ hypermucoviscosity phenotype Klebsiella pneumoniae infection was documented in Canada, in an immigrant from Algeria. To ascertain whether this represented recent importation of the strain or local transmission within Canada, a retrospective study of K. pneumoniae bacteraemia was conducted in the region, from 1997 to 2007, and 411 episodes were identified. No epidemiological evidence for local transmission of this strain was found. However, for the first time, the population incidence of K. pneumoniae bacteraemia was determined, which increased by 82% between 1997 ... Read More »
» Published in Clin Microbiol Infect. 2010 Feb;16(2):141-6. Epub 2009 Aug 8.
15. Quality of life and associated factors among Jordanian adolescents with type 1 diabetes mellitus.
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OBJECTIVES: Quality of life (QoL) is a significant indicator of the outcome of the treatment in chronic diseases. The purpose of the study was to assess the QoL of Jordanian adolescents with type 1 diabetes mellitus and its associated factors. METHODS: A total of 145 adolescents with type 1 diabetes mellitus were invited to participate in the study during their regular visits to outpatient clinics. The subjects were recruited from the National Center for Diabetes, Endocrine and Genetic Diseases in Amman, the capital of Jordan, and from three main hospitals in the north of Jordan between ... Read More »
» Published in J Diabetes Complications. 2010 Jan-Feb;24(1):43-7. Epub 2009 May 22.
16. Perinatal risk factors for early onset of Type 1 diabetes in a 2000-2005 birth cohort.
Match Strength: 5.567
AIMS: To examine perinatal risk factors for the onset of Type 1 diabetes before 6 years of age, in a 2000-2005 Australian birth cohort. METHODS: Data from longitudinally linked delivery and hospital admission records (until June 2007) were analysed. Diabetes in mothers and children was identified from International Classification of Diseases 10 diagnosis codes in the hospital records. RESULTS: There were 272 children admitted to hospital with a first diagnosis of diabetes out of 502 040 live births. Incidence for the infants born in 2000 was 16.0 per 100 000 person-years. Maternal Type 1 ... Read More »
» Published in Diabet Med. 2009 Dec;26(12):1193-7.
17. Trends in vascular risk factors and medication use in patients with various manifestations of vascular diseases or type 2 diabetes mellitus from 1996 to 2007: the Second Manifestations of ARTerial disease study.
Match Strength: 5.541
AIMS: To investigate time trends in vascular risk factors and medication use for patients referred to a vascular specialist with manifest vascular disease or type 2 diabetes mellitus (DM2). METHODS AND RESULTS: Change in risk factor profile and medication use at referral over a 12-year period was evaluated and compared between patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease, abdominal aortic aneurysm, and DM2, who participated in the Second Manifestations of ARTerial disease study in the period of 1996-2007. A total of 4731 patients were included ... Read More »
» Published in Eur J Cardiovasc Prev Rehabil. 2010 Mar 17. [Epub ahead of print]
18. Children Diagnosed with Diabetes during Infancy Have Unique Clinical Characteristics.
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Objective: Characterizing clinical and biochemical features of children diagnosed with diabetes mellitus between the ages of 6-24 months. Design and Methods: Medical records of 42 children diagnosed with diabetes mellitus at age of 6-24 months were reviewed for gender, ethnic origin, family medical history, clinical and biochemical features at onset of diabetes compared with 60 diabetic patients diagnosed at age 5-16 years. Results: Children diagnosed at 6-24 months had at onset more symptoms of apathy, restlessness, hyperglycemia during acute illness and a lower rate of remission than those ... Read More »
» Published in Horm Res. 2006 Dec 14;67(6):263-267
19. Admission trends over 8 years for diabetic foot ulceration in a specialized diabetes unit in cameroon.
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High rates of foot complications have been reported in people with diabetes in sub-Saharan Africa (SSA). However, there is a paucity of data in support of the changing pattern with time. We report here data on trends in hospitalization for foot ulceration over an 8-year consecutive period in a specialized diabetes unit in SSA. Admission and discharge registers of the diabetes and endocrine unit of the Yaounde Central hospital, Cameroon, were reviewed for the period 2000 through 2007. Data were collected on the status for diabetes, presence of foot ulcer, age, sex, duration of hospitalization ... Read More »
» Published in Int J Low Extrem Wounds. 2009 Dec;8(4):180-6.
20. Prevalence of diabetes among men and women in China.
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BACKGROUND: Because of the rapid change in lifestyle in China, there is concern that diabetes may become epidemic. We conducted a national study from June 2007 through May 2008 to estimate the prevalence of diabetes among Chinese adults. METHODS: A nationally representative sample of 46,239 adults, 20 years of age or older, from 14 provinces and municipalities participated in the study. After an overnight fast, participants underwent an oral glucose-tolerance test, and fasting and 2-hour glucose levels were measured to identify undiagnosed diabetes and prediabetes (i.e., impaired fasting ... Read More »
» Published in N Engl J Med. 2010 Mar 25;362(12):1090-101.
21. The global diabetes pandemic: the Tunisian experience.
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Objective:The prevalence of diabetes mellitus is known to be increasing rapidly worldwide, but few population-based surveys have been undertaken in Africa or the Middle East. The aims of this study are to report the prevalence of diabetes mellitus and impaired fasting glucose (IFG) in Tunisia, to compare the prevalence to previous studies and to analyse the relationship between diabetes and age, sex, area of residency and body mass index (BMI).Subjects and setting:We have used data from the Tunisian National Nutrition Survey, a cross-sectional health study providing a large nationally ... Read More »
» Published in Eur J Clin Nutr. 2007 Feb;61(2):160-5. Epub 2006 Aug 9.
22. Prevalence of diabetic retinopathy in Tehran province: a population-based study.
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BACKGROUND: To determine the prevalence and characteristics of diabetic retinopathy (DR) among Iranian patients with diabetes. METHODS: Design: population-based cross-sectional study.Participants: patients with diabetes aged 25 to 64 years in Tehran province, Iran. This survey was conducted from April to October 2007. The study sample was derived from the first national survey of risk factors for non-communicable disease. Diabetes mellitus was defined as a fasting plasma glucose of >or= 7.0 mmol/l (126 mg/dl) or more, use of diabetic medications, or a physician's diagnosis of diabetes. All ... Read More »
» Published in BMC Ophthalmol. 2009 Oct 16;9:12.
23. Determination of non-treatment with statins of high risk patients in The Netherlands.
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OBJECTIVE: To determine in the Netherlands what proportions of high risk patients with established cardiovascular disease (CVD) or diabetes mellitus type 2 (DM2) who were not treated with statins on 1 January 2007 and which characteristics were associated with non-treatment. METHODS: From the IPCI GP database patients were selected who were registered with a GP on 1 January 2007 who had a history of either CVD (CVD patients), DM2 (diabetics) or both (diabetics with CVD). The proportion of patients using statins around 1 January 2007 was determined. Associations of patient characteristics with ... Read More »
» Published in Curr Med Res Opin. 2010 Feb;26(2):271-8.
24. Glibenclamide-related excess in total and cardiovascular mortality risks: data from large Ukrainian observational cohort study.
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OBJECTIVE: To compare mortality risks among type 2 diabetes (T2D) patients being treated with glibenclamide, gliclazide, or glimepiride. METHODS: Retrospective observational cohort studies of primary care-based diabetes register were carried out. Risk of total and cardiovascular (CVD) mortality was evaluated in cohort of T2D patients that were treated with either glibenclamide (n=50,341), glimepiride (n=2479) or gliclazide (n=11,368). Cox regression was used for multifactor evaluation. A cross-sectional evaluation of oral anti-diabetic drug (OAD) structure for 2005 and 2007 was also performed, ... Read More »
» Published in Diabetes Res Clin Pract. 2009 Dec;86(3):247-53. Epub 2009 Sep 30.
25. Midtrimester Amniotic Fluid Leptin and Insulin Levels and Subsequent Gestational Diabetes.
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Aims: To evaluate midtrimester amniotic fluid leptin levels in pregnancies subsequently complicated by gestational diabetes. Methods: We studied 32 pregnant women with gestational diabetes and a control group of 43 normal pregnancies with an adequate gestational age fetus. All underwent a midtrimester amniocentesis: leptin and insulin were measured in the amniotic fluid. Data were compared with the Mann-Whitney U-test. Results: Median leptin concentrations in the amniotic fluid of the gestational diabetes mellitus patients were significantly higher than in the control group (15.1 vs. 7.9 ng/ml ... Read More »
» Published in Gynecol Obstet Invest. 2007 Jan 30;64(2):65-68
26. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes.
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RATIONALE: Obstructive sleep apnea (OSA), a treatable sleep disorder that is associated with alterations in glucose metabolism in individuals without diabetes, is a highly prevalent comorbidity of type 2 diabetes. However, it is not known whether the severity of OSA is a predictor of glycemic control in patients with diabetes. OBJECTIVES: To determine the impact of OSA on hemoglobin A1c (HbA1c), the major clinical indicator of glycemic control, in patients with type 2 diabetes. METHODS: We performed polysomnography studies and measured HbA1c in 60 consecutive patients with diabetes recruited ... Read More »
» Published in Am J Respir Crit Care Med. 2010 Mar 1;181(5):507-13. Epub 2009 Dec 17.
27. Predictive value of albuminuria in american Indian youth with or without type 2 diabetes.
Match Strength: 5.197
OBJECTIVE: To examine the prognostic significance of elevated albuminuria in youth with type 2 diabetes. PATIENTS AND METHODS: Cross-sectional and prospective studies were conducted on Pima Indian youth aged 5 to 19 years at baseline who were examined between July 1, 1982, and December 31, 2007. Prevalence and sequential changes in the level of microalbuminuria (30 < or = albumin-to-creatinine ratio [ACR] < 300 mg/g) and macroalbuminuria (ACR > or = 300 mg/g) and incidence of macroalbuminuria were computed according to the presence or absence of type 2 diabetes. RESULTS: The prevalence of ... Read More »
» Published in Pediatrics. 2010 Apr;125(4):e844-51. Epub 2010 Mar 1.
28. Projecting the future diabetes population size and related costs for the U.S.
Match Strength: 5.180
OBJECTIVE: We developed a novel population-level model for projecting future direct spending on diabetes. The model can be used in the federal budget process to estimate the cost implications of alternative policies. RESEARCH DESIGN AND METHODS: We constructed a Markov model simulating individuals' movement across different BMI categories, the incidence of diabetes and screening, and the natural history of diabetes and its complications over the next 25 years. Prevalence and incidence of obesity and diabetes and the direct spending on diabetes care and complications are projected. The study ... Read More »
» Published in Diabetes Care. 2009 Dec;32(12):2225-9.
29. Prevalence of pancreatic diabetes in patients carrying mutations or polymorphisms of the PRSS1 gene in the Han population.
Match Strength: 5.175
OBJECTIVE: This study updated the estimated prevalence of type 3c diabetes damage to the pancreas through different genotypes of PRSS1 and their clinical characteristics in the Han population. SUBJECTS AND METHODS: Cross-sectional analysis was performed of the most recent (2003-2007) patients with pancreatitis from six hospitals of the Han population in South China (n = 253). RESULTS: There were 32 patients with pancreatitis carrying a PRSS1 gene abnormality within intron region among 253 cases of pancreatitis, including 27 patients carrying novel single nucleotide polymorphisms, namely, IVS 3 ... Read More »
» Published in Diabetes Technol Ther. 2009 Dec;11(12):799-804.
30. Inflammation and the incidence of type 2 diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA).
Match Strength: 5.120
OBJECTIVE: Many studies have documented associations between inflammation and type 2 diabetes incidence. We assessed potential variability in this association in the major U.S. racial/ethnic groups. RESEARCH DESIGN AND METHODS: Incident type 2 diabetes was assessed among men and women aged 45-84 years without prior clinical cardiovascular disease or diabetes in the prospective Multi-Ethnic Study of Atherosclerosis. Interleukin (IL)-6, fibrinogen, and C-reactive protein (CRP) were measured at baseline (2000-2002); fasting glucose and diabetes medication use was assessed at baseline and three ... Read More »
» Published in Diabetes Care. 2010 Apr;33(4):804-10. Epub 2010 Jan 22.
31. Neonatal Diabetes: How Research Unravelling the Genetic Puzzle Has both Widened Our Understanding of Pancreatic Development whilst Improving Children's Quality of Life.
Match Strength: 5.102
It has become increasingly apparent over the last few years that the seemingly ubiquitous auto-immune aetiology to pre-pubertal diabetes does not apply to those diagnosed under 6 months of age. In this age group, disease appears, in the vast majority of cases, to be conferred by single gene disorders mainly related to pancreatic development. The unravelling of these disorders has resulted in a far greater understanding of pancreatic development and some startling changes in treatment, resulting in improved quality of life and diabetes control. The progress made in our scientific and clinical ... Read More »
» Published in Horm Res. 2006 Oct 17;67(2):77-83
32. International Diabetes Federation: An update of the evidence concerning the prevention of type 2 diabetes.
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This article aims to provide an updated summary of diabetes prevention efforts by reviewing relevant literature published between 2007 and 2009. These include results from the long-term follow-up of diabetes prevention trials and the roll-out of community-based interventions in "real world" settings. Some countries have begun to implement population-based strategies for chronic disease prevention, but investment in developing and evaluating population-level interventions remains inadequate. By focussing on the "small change" approach and involving a number of different agencies, it may be ... Read More »
» Published in Diabetes Res Clin Pract. 2010 Feb;87(2):143-9. Epub 2009 Nov 12.
33. Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells.
Match Strength: 5.100
Islet cell replacement is considered as the optimal treatment for type I diabetes. However, the availability of human pancreatic islets for transplantation is limited. Here, we show that human bone marrow-derived mesenchymal stem cells (hMSCs) could be induced to differentiate into functional insulin-producing cells by introduction of the pancreatic duodenal homeobox-1 (PDX-1). Recombinant adenoviral vector was used to deliver PDX-1 gene into hMSCs. After being infected with Ad-PDX-1, hMSCs were successfully induced to differentiate into insulin-secreting cells. The differentiated PDX-1(+) ... Read More »
» Published in J Cell Physiol. 2007 Apr;211(1):36-44.
34. Relationship between A1C and glucose levels in the general Dutch population: the new Hoorn study.
Match Strength: 5.069
OBJECTIVE: To investigate the relationship among A1C, fasting plasma glucose (FPG), and 2-h postload plasma glucose in the Dutch general population and to evaluate the results of using A1C for screening and diagnosis of diabetes. RESEARCH DESIGN AND METHODS: In 2006-2007, 2,753 participants of the New Hoorn Study, aged 40-65 years, who were randomly selected from the population of Hoorn, the Netherlands, underwent an oral glucose tolerance test (OGTT). Glucose status (normal glucose metabolism [NGM], intermediate hyperglycemia, newly diagnosed diabetes, and known diabetes) was defined by the ... Read More »
» Published in Diabetes Care. 2010 Jan;33(1):61-6. Epub 2009 Oct 6.
35. Polymorphisms of KCNJ11 (Kir6.2 gene) are associated with Type 2 diabetes and hypertension in the Korean population.
Match Strength: 5.066
Aims Kir6.2 is found in the pancreatic B-cell, cardiac and skeletal muscle and non-vascular smooth muscle. KCNJ11, encoding Kir6.2, has been shown to be associated with both Type 2 diabetes mellitus and cardiovascular disease in several populations. In this study, we investigated whether polymorphisms in KCNJ11 are associated with Type 2 diabetes and other metabolic phenotypes in the Korean population. Methods We sequenced KCNJ11 to identify common polymorphisms using 24 Korean DNA samples. Of the 14 polymorphisms found in KCNJ11, six common ones [genomic sequence (g.)-1709A>T, g.-1525T> ... Read More »
» Published in Diabet Med. 2007 Feb;24(2):178-86.
36. An unplanned delay between control visits influences the metabolic status in children with diabetes: an observational study.
Match Strength: 5.056
Abstract Aim: To evaluate whether the metabolic status had been influenced by the longer interval between visits because of a strike at the diabetes outpatient clinic. Methods: During the strike from April 16 to June 15, 2008 all routine visits were cancelled. The HbA1c values from the last two visits prior to and the first two visits after the strike were compared with the values from the same periods the previous year. Danish speaking patients answered a questionnaire. Results: For 155 children included, the mean HbA1c values before the strike were 8.1 and 8.1 (p = 0.39), while the value ... Read More »
» Published in Acta Paediatr. 2010 Jan 8. [Epub ahead of print]
37. Medical student patient experiences before and after duty hour regulation and hospitalist support.
Match Strength: 5.056
BACKGROUND/OBJECTIVE: With the growth of hospitalist services and the reduction in residency work hours, medical education has changed dramatically. The objective of this study was to examine changes in junior medical student-patient encounters after initiation of residency work hours and implementation of a large hospitalist practice at our academic medical center. DESIGN: Medicine clerkship students from 2002-2007 recorded the number of hospital patients and their principal diagnoses cared for during a 6-week block rotation. Comparisons were made between clerkship experiences among students ... Read More »
» Published in J Gen Intern Med. 2010 Mar;25(3):207-10. Epub 2009 Dec 1.
38. Maternal and perinatal characteristics in relation to neuroblastoma.
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BACKGROUND.: Neuroblastoma is the most common malignancy among infants, but risk factors remain poorly understood. Because most patients present in the first few years of life, it has been hypothesized that prenatal and perinatal exposures may contribute to the pathogenesis of neuroblastoma. METHODS.: A population-based case-control study was conducted by using linked birth and cancer registry records from 1980 to 2004 in Washington State. Maternal and infant characteristics from birth and hospital discharge records for 240 cases of neuroblastoma and 2400 controls were compared. RESULTS.: ... Read More »
» Published in Cancer. 2007 Feb 6;
39. The Effect of a Diabetes Curriculum on Internal Medicine Resident Knowledge.
Match Strength: 5.021
Objective - The failure of physicians to meet established standards of diabetes care suggests an urgent need to improve diabetes training, especially in the inpatient setting. A diabetes knowledge questionnaire was administered to Internal Medicine (IM) residents to evaluate the effectiveness of postgraduate inpatient diabetes education.Methods - The questionnaire was given to residents (n=91) at the beginning and end of the 2007-2008 academic year. As controls, the questionnaire was administered to IM attendings (n=25) and diabetes care providers (n=11). The curriculum included order sets, ... Read More »
» Published in Endocr Pract. 2010 Jan 9:1-19. [Epub ahead of print]
40. Incidence of Type 2 diabetes in England and its association with baseline impaired fasting glucose: The Ely study 1990-2000.
Match Strength: 5.013
Aim To determine the incidence of Type 2 diabetes and to examine the effect of different cut-points for impaired fasting glucose (IFG) on diabetes incidence. Methods Population-based longitudinal study (1990-2000) with clinical, anthropometric and biochemical measurements, including an oral glucose tolerance test (OGTT), in 1040 non-diabetic adults aged 40-69 years at baseline. Baseline glucose status was defined as normoglycaemia < 5.6, IFG-lower 5.6-6.0 and IFG-original 6.1-6.9 mmol/l. The all-IFG group included fasting glucose values of 5.6-6.9 mmol/l. Results The 10-year cumulative ... Read More »
» Published in Diabet Med. 2007 Feb;24(2):200-7.
41. Changes in secondary prevention of coronary artery disease in the post-discharge period over the decade 1997-2007. Results of the Cracovian Program for Secondary Prevention of Ischaemic Heart Disease and Polish parts of the EUROASPIRE II and III surveys.
Match Strength: 5.010
BACKGROUND: Both in the European and Polish guidelines, the highest priority for preventive cardiology was given to patients with established coronary artery disease (CAD). The Cracovian Program for Secondary Prevention of Ischaemic Heart Disease was introduced in 1996 to assess and improve the quality of clinical care in secondary prevention. Departments of cardiology of five participating hospitals serving the area of the city of KrakÃ³w and surrounding districts (former KrakÃ³w Voivodship) inhabited by a population of 1 200 000 took part in the surveys. In 1999/2000 and 2006/2007 the same ... Read More »
» Published in Kardiol Pol. 2009 Dec;67(12):1353-9.
42. Impact of heart failure management unit on heart failure-related readmission rate and mortality.
Match Strength: 5.010
BACKGROUND: Heart failure is the leading cause of hospital admissions and an economic burden. In accordance with European guidelines, a dedicated heart failure unit was created in RenÃ© Dubos Hospital (Pontoise, France) in 2002. AIM: To evaluate the impact of an in-hospital heart failure management unit on heart failure prognosis. METHODS: We conducted a descriptive study of all-cause in-hospital mortality and heart failure related readmission rates in the year after the first admission for heart failure, from January 1997 to December 2007. The Chi(2) test, a trend test and linear regression ... Read More »
» Published in Arch Cardiovasc Dis. 2010 Feb;103(2):90-6. Epub 2010 Feb 26.
43. An infant with combination gene mutations for Monogenic Diabetes of Youth (MODY) 2 and 4, presenting with Diabetes Mellitus Requiring Insulin (DMRI) at 8 months of age.
Match Strength: 4.958
Monogenic Diabetes of Youth (MODY) is an autosomal dominant form of diabetes. [Fajans SS, et al. NEJM 2001: 345: 971-980.] There are at least six different types of MODY, all of which involve a loss of function gene mutation that results in diminished insulin production. MODY2 results from a mutation in the glucokinase gene (GCK), which decreases enzyme activity. MODY4 results from a mutation in the insulin promoter factor-1 (IPF-1) gene, a transcription factor which regulates the transcription of insulin. [Sperling M, et al. NEJM 2006: 355: 507-510.] TJ presented at 8 months of age with ... Read More »
» Published in Pediatr Diabetes. 2009 Dec;10(8):550-3. Epub 2009 Jun 10.
44. The New KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and CKD.
Match Strength: 4.946
Background/Aims: The National Kidney Foundation (NKF) recently published new guidelines and clinical practice recommendations for the diagnosis and management of patients with diabetes and chronic kidney disease (CKD). Methods: Guidelines were developed using an evidence-based approach. When sufficient evidence was lacking, recommendations were developed that reflect expert opinion. Results: Guidelines describe the process for screening and diagnosis of kidney disease in the setting of diabetes and the management of hyperglycemia, hypertension, dyslipidemia, and nutrition. Recommendations ... Read More »
» Published in Blood Purif. 2007;25(1):112-4. Epub 2006 Dec 14.
45. Effects of a vitamin D(3) analog on diabetes in the bio breeding (BB) rat.
Match Strength: 4.941
Non-hypercalcemic analogs of vitamin D(3) modulate the immune response through antigen-presenting cells (APCs) and activated T-cells. A large population-base case-control showed that vitamin D(3) intake significantly decreases the risk of type 1 diabetes development. The aim of this study was, therefore, to observe the in vivo effects of a vitamin D(3) analog administered to Bio Breeding (BB) rats. 1,25-Dihydroxy-16,23Z-diene-26,27-hexafluoro-19-nor vitamin D(3) (BXL-219, formerly Ro 26-2198) (BioXell, Milan, Italy) was administered in vivo to BB rats from days 42 to 110 of life at 0.2 microg ... Read More »
» Published in J Cell Biochem. 2007 Feb 15;100(3):808-14.
46. Non-genomic transgenerational inheritance of disease risk.
Match Strength: 4.922
That there is a heritable or familial component of susceptibility to chronic non-communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non-genomically and that the processes whereby environmental influences act during early development to shape disease risk in later life can have effects beyond a single generation. Such heritability may operate through epigenetic mechanisms involving regulation of either imprinted or non-imprinted genes but also through ... Read More »
» Published in Bioessays. 2007 Feb;29(2):145-54.
47. Enhanced Primary Care pilot program benefits Type II diabetes patients.
Match Strength: 4.905
Background.?The Australian Government Medicare Enhanced Primary Care (EPC) initiative for chronic disease management (CDM) supports integrated allied health (AH) and general medical practitioner (GP) care. There are limited examples of how to operationalise this initiative in private practice, and minimal evidence of expected service utilisation or acceptability to patients. This paper reports on a 2007 Australian integrated GP/private sector AH pilot program, based on Medicare EPC guidelines for Type II diabetes ... Read More »
» Published in Aust Health Rev. 2010 Feb;34(1):18-24.
48. Blood pressure control in diabetes: temporal progress yet persistent racial disparities: national results from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
Match Strength: 4.891
OBJECTIVE: Despite widespread dissemination of target values, achieving a blood pressure of <130/80 mmHg is challenging for many individuals with diabetes. The purpose of the present study was to examine temporal trends in blood pressure control in hypertensive individuals with diabetes as well as the potential for race, sex, and geographic disparities. RESEARCH DESIGN AND METHODS: We analyzed baseline data from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, a national, population-based, longitudinal cohort study of 30,228 adults (58% European American and 42% ... Read More »
» Published in Diabetes Care. 2010 Apr;33(4):798-803. Epub 2010 Jan 22.
49. Influence of acute alcohol ingestion on the hormonal responses to modest hypoglycaemia in patients with Type 1 diabetes.
Match Strength: 4.886
Aims To determine whether mild alcohol intoxication (45-50 mg/dl) influences counterregulatory hormone responses to moderate hypoglycaemia (2.8 mmol/l) in patients with Type 1 diabetes. Methods Seventeen subjects (14 male, age range 21-46 years) with Type 1 diabetes underwent four hyperinsulinaemic glucose clamps: euglycaemia with placebo; euglycaemia with alcohol (0.4 g/kg); hypoglycaemia (2.8 mmol/l for 65 min) with placebo; and hypoglycaemia (2.8 mmol/l for 65 min) with alcohol (0.4 g/kg). Arterialized venous blood samples were taken for measurement of insulin and counterregulatory hormones ... Read More »
» Published in Diabet Med. 2007 Jan 29;
50. Impaired glucose homeostasis in renal transplant recipients receiving basiliximab.
Match Strength: 4.885
BACKGROUND: The pathogenesis of new onset diabetes after transplantation (NODAT) is multifactorial. Suppression of regulatory T lymphocytes may have a negative impact on pancreatic beta-cells. Induction with basiliximab affects regulatory T-cell function and may therefore, theoretically, also affect glucose homeostasis in renal transplant recipients. METHODS: All kidney recipients > or =50 years of age without diabetes mellitus transplanted from 1 January 2005 to 31 December 2007 were included in a single-centre retrospective study. Immunosuppression consisted of steroids, mycophenolate ... Read More »
» Published in Nephrol Dial Transplant. 2010 Apr;25(4):1289-93. Epub 2009 Nov 23.
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