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Peer Reviewed Scientific Research Reports.
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1. Evaluating an Interpersonal Model of Depression among adults with Down syndrome.
Match Strength: 6.162
The Interpersonal Model of Depression (IMD) based on the Theory of Human Relatedness (Hagerty, Lynch-Sauer, Patusky, & Bouwsema, 1993) is evaluated among adults with Down syndrome. One hundred subjects participated, with 32% having elevated depression scores and 40% stating they felt lonely. The relationship between depression, perceived social support, loneliness, and life satisfaction is statistically significant, F(6, 172) = 4.36, p < .001. Loneliness, social isolation, loss of sense of well-being, self-hate, and social withdrawal are important interpersonal manifestations and represent ... Read More »
» Published in Res Theory Nurs Pract. 2006 Fall;20(3):229-46.
2. Depression and older people.
Match Strength: 6.054
Nearly a third of older people admitted for acute hospital care experience depression. Rates of depression are even higher in care homes. The purpose of this article is to raise awareness among nurses of this debilitating condition and its potentially fatal consequences, and to suggest interventions that can bring about improvement. Although challenging for nurses, detecting and treating depression can bring enormous benefits for older people and, in some cases, can mean the difference between life and death. Publication Types: ... Read More »
» Published in Nurs Older People. 2006 Sep;18(8):27-30.
3. Clinical assessment and therapy for depression.
Match Strength: 5.927
The occurrence of depression in multiple sclerosis (MS) patients is very high, with a lifetime prevalence of up to 50%. This co-occurrence has important negative consequences for MS patients. Until now, questions about the appropriateness of classification criteria and the reliability of assessment instruments have not been completely answered. At this time, it seems worthwhile to try to clarify these points considering their relevance for clinical and therapeutic approaches to treat MS and particularly to treat depression in MS. The risk of underestimating depressive symptoms is noted and ... Read More »
» Published in Neurol Sci. 2006 Sep;27 Suppl 4:s341-3.
4. It's like being in a labyrinth: Hispanic immigrants' perceptions of depression and attitudes toward treatments.
Match Strength: 5.818
This study aimed to describe Hispanic immigrants' perceptions of depression and attitudes toward treatments and to examine how demographics, acculturation, clinical factors, and past service use were associated with their perceptions and attitudes. A convenience sample of 95 Hispanic immigrant patients was presented a vignette depicting an individual with major depression. Structured interviews that included standardized instruments and open-ended questions were used to query patients about their views of depression and its treatments. Findings showed that Hispanic immigrants perceived ... Read More »
» Published in J Immigr Minor Health. 2007 Jan;9(1):1-16.
5. Reducing depression stigma using a web-based program.
Match Strength: 5.714
OBJECTIVE: This study was designed to investigate the efficacy and feasibility of a web-based depression stigma education tool for healthcare professionals. METHODS: A web-based depression stigma program utilizing adult learning theories was developed. Forty-two consecutive subjects were enrolled from University of Maryland staff and graduate students. Primary outcomes were Bogardus Social Distance Scale with a vignette on major depression disorder (BSDS-MDD) and the Depression Stigma Scale (DSS) administered before and after the intervention. RESULTS: Internet-based education significantly ... Read More »
» Published in Int J Med Inform. 2006 Sep 19;
6. Variations in the experiences and expressions of depression among ethnic minorities.
Match Strength: 5.619
The purpose of this paper is to examine the ethnic differences in the experiences and expressions of depressive symptoms. Also, a discussion is presented regarding the effects that depression has on the individual and consequently the adverse impact it will have on society. Because the expressions of depression are so varied, appropriate measures are required to account for the differences of these expressions in individuals in order to facilitate appropriate diagnosing Both in the United States and throughout the world, depression accounts for a significant proportion of psychiatric disorders ... Read More »
» Published in J Natl Black Nurses Assoc. 2006 Jul;17(1):29-35.
7. The association of insomnia with anxiety disorders and depression: exploration of the direction of risk.
Match Strength: 5.512
The purpose of this study is to explore the direction of the association between insomnia and anxiety disorders and major depression among a community-based sample of adolescents to better understand their potential etiologic relationships. Data come from a community-based sample of 1,014 youth aged 13-16. Structured interviews were conducted to assess DSM-IV diagnoses. Retrospectively reported ages of onset were used in Proportional Hazards models to estimate increased risk of one disorder associated with prior onset of the others. The lifetime associations of DSM-IV insomnia with each ... Read More »
» Published in J Psychiatr Res. 2006 Dec;40(8):700-8. Epub 2006 Sep 15.
8. Gender disparities in the treatment of late-life depression: qualitative and quantitative findings from the IMPACT trial.
Match Strength: 5.364
OBJECTIVES: The objectives of this study were to examine gender differences in recruitment, depression presentation, and depression treatment history in a large effectiveness trial; and to use qualitative data to generate hypotheses about reasons for observed gender differences. METHODS: Data from IMPACT, a multisite trial of a disease management program for late-life depression in primary care were used to examine gender differences quantitatively. Qualitative interviews were conducted with 30 key informants from IMPACT (referring physicians, depression care managers, and study recruiters) to ... Read More »
» Published in Am J Geriatr Psychiatry. 2006 Oct;14(10):884-92.
9. Sensitivity of computerized neuropsychological screening in depressed university students.
Match Strength: 5.341
This study examined the sensitivity of a computerized neuropsychological screening (ImPACT) to the cognitive effects of depression in a sample of 20 students with suspected depression and 20 healthy university students matched for gender, age, and education. Students with depression had slower reaction times (p < .02; d = .82, large effect) and processing speeds (p < .03; d = .77, large effect). The brevity and sensitivity of ImPACT to the cognitive effects of depression warrants further research with psychiatric populations. Publication Types: Comparative Study, Research Support, Non-U ... Read More »
» Published in Clin Neuropsychol. 2006 Dec;20(4):695-701.
10. Validation of the Retardation Rating Scale for detecting depression in geriatric inpatients.
Match Strength: 5.309
OBJECTIVES: Validation in the elderly of the Retardation Rating Scale (RRS), which includes items related to motor and mental retardation but not vegetative items, and may be particularly well-suited for the diagnosis of depression in the elderly. METHODS: One hundred and sixty-five geriatric inpatients (105 depressed), aged 65 and over, without dementia, neuroleptic medication and increased risk of slowed mobility, were assessed with the RRS and three validated 'gold-standard' scales for geriatric depression (Hamilton Depression Rating Scale, Montgomery and Asberg Depression Rating Scale, ... Read More »
» Published in Int J Geriatr Psychiatry. 2007 Jan;22(1):68-76.
11. Geriatric heart failure, depression, and nursing home admission: an observational study using propensity score analysis.
Match Strength: 5.203
OBJECTIVE: Heart failure (HF) and depression are both common in older adults, and the presence of depression is known to worsen HF outcomes. For community-dwelling older adults, admission to a nursing home (NH) is associated with loss of independent living and poor outcomes. The objective of this study was to examine the effect of depression on NH admission for older adults with HF. METHODS: Using the 2001-2003 National Hospital Discharge Survey datasets, the authors identified all community-dwelling older adults who were discharged alive with a primary discharge diagnosis of HF. The authors ... Read More »
» Published in Am J Geriatr Psychiatry. 2006 Oct;14(10):867-75.
12. Anxious-depressive comorbidity: effects on HPA axis and CNS noradrenergic functions.
Match Strength: 5.099
Psychiatric comorbidity is all too common. An important example is the high comorbidity frequency of depressive and anxiety disorders, 25%-50%, much higher than the 5% or less expected by chance. Possible reasons for this comorbidity include definitional, environmental, and biological factors. Few previous studies have assessed, with proper methodology, potential biological changes associated with this co-occurrence. We assessed both hypothalamic-pituitary-adrenocortical axis (HPA) responses to the Trier Social Stress Test and growth hormone (GH) responses to clonidine, a centrally active ... Read More »
» Published in Essent Psychopharmacol. 2006;7(1):24-34.
13. Abnormal personality and the mood and anxiety disorders: Implications for structural models of anxiety and depression.
Match Strength: 5.052
Substantial overlap exists between the mood and anxiety disorders. Previous research has suggested that their comorbidity can be explained by a shared factor (negative emotionality), but that they may also be distinguished by other unique components. The current study explicated these relations using an abnormal personality framework. Current diagnoses of major depression and several anxiety disorders were assessed in 563 Gulf War veterans. Participants also completed the schedule for nonadaptive and adaptive personality (SNAP) to determine how these disorders relate to abnormal personality ... Read More »
» Published in J Anxiety Disord. 2006 Sep 13;
14. Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial.
Match Strength: 4.701
RATIONALE: Despite established links between nicotine dependence and depression, little research has examined the effects of nicotine on depression symptoms. OBJECTIVE: This study evaluated the acute and chronic effects of transdermal nicotine in nonsmokers with baseline depression symptoms during a 4-week, double-blind, placebo-controlled trial. METHODS: Nonsmokers with scores >or=10 on the Center for Epidemiological Studies Depression scale (CES-D) were recruited from the community. Mood and cognitive performance were measured at baseline (day 0) and at 1, 8, 21, and 28 days. Participants ... Read More »
» Published in Psychopharmacology (Berl). 2006 Nov;189(1):125-33. Epub 2006 Sep 15.
15. Descriptive epidemiology of major depression in Canada.
Match Strength: 4.462
OBJECTIVE: The Canadian Community Health Survey: Mental Health and Well-Being (CCHS 1.2) is the first national study to use a full version of the Composite International Diagnostic Interview. For this reason, and because of its large sample size, the CCHS 1.2 is capable of providing the best currently available description of major depression epidemiology in Canada. Using the CCHS 1.2 data, our study aimed to describe the epidemiology of major depression in Canada. METHOD: All estimates used appropriate sampling weights and bootstrap variance estimation procedures. The analysis consisted of ... Read More »
» Published in Can J Psychiatry. 2006 Feb;51(2):84-90.
16. The utility of supplemental oxygen during emergency department procedural sedation and analgesia with midazolam and fentanyl: a randomized, controlled trial.
Match Strength: 4.442
STUDY OBJECTIVE: To determine whether supplemental oxygen reduces the incidence of hypoxia by 20% in study patients receiving midazolam and fentanyl for emergency department procedural sedation and analgesia. METHODS: Patients were randomized to receive either supplemental oxygen or compressed air by nasal cannula at 2 L per minute. Physicians were blinded to the gas used and end-tidal carbon dioxide (ETCO2) data. Respiratory depression was defined a priori as oxygen saturation less than 90%, ETCO2 level greater than 50 mm Hg, an absolute change from baseline of 10 mm Hg, or loss of the ETCO2 ... Read More »
» Published in Ann Emerg Med. 2007 Jan;49(1):1-8. Epub 2006 Sep 15. Comment in: Ann Emerg Med. 2007 Jan;49(1):31-6.
17. Ampakines alleviate respiratory depression in rats.
Match Strength: 4.430
RATIONALE: There is a need for improved therapeutic interventions to treat both drug- and sleep-induced respiratory depression. Increased understanding of the neurochemical control of respiration will help identify a basis for advances. Activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors positively modulates respiratory drive and rhythmogenesis in several brain regions including the pre-Botzinger complex. Ampakines are a diverse group of small molecules that activate subsets of these receptors. OBJECTIVE: We determined whether the ampakine ... Read More »
» Published in Am J Respir Crit Care Med. 2006 Dec 15;174(12):1384-91. Epub 2006 Sep 14.
18. Depression in assisted living is common and related to physical burden.
Match Strength: 4.396
OBJECTIVE: The objective of this study was to obtain a direct estimate of the prevalence of depression, its associated factors, and rates of treatment among residents of assisted living (AL) facilities in central Maryland. METHOD: One hundred ninety-six AL residents were recruited from 22 (10 large and 12 small) randomly selected AL facilities in the city of Baltimore and seven Maryland counties. Chart review, staff and family history, comprehensive in-person resident evaluation, and the Cornell Scale for Depression in Dementia (CSDD) were administered by an experienced team of geriatric ... Read More »
» Published in Am J Geriatr Psychiatry. 2006 Oct;14(10):876-83.
19. A comparative study of pregnant women attending a tertiary obstetric unit and a district general hospital with a previous history of postnatal depression.
Match Strength: 4.354
The aim of this study was to compare pregnant women with a previous history of postnatal depression, attending a Tertiary Obstetric Unit in Belfast and a District General Hospital in Newry. Women with a previous history of postnatal depression recorded at booking for their most current pregnancy were studied between January 2001 and May 2002. A total of 443 women (6.6%) in Belfast had a history of postnatal depression, compared with 113 women (6%) in Newry. The most common age range was 31 - 35 years in both centres. Some 69% of women in Belfast compared with 81% of women in Newry were given ... Read More »
» Published in J Obstet Gynaecol. 2006 Aug;26(6):514-7.
20. Clinicians on the front line: active management of depression and anxiety in primary care.
Match Strength: 4.335
Primary-care practitioners confront myriad issue in managing their patients with depression and/or anxiety. Understanding the scope and epidemiology of these disorders is essential to understanding their shared characteristics. Do we always recognize these patients in practice? What are the barriers to diagnosis and treatment, and how can they overcome? What are the treatment options of these sometimes life-altering conditions, and how do we choose from among the many that exist? Publication Types: Case Reports, ... Read More »
» Published in JAAPA. 2006 Jul;Suppl:4-21; quiz 22.
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