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Peer Reviewed Scientific Research Reports.
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1. Biosynthesis and secretion of mugineic acid family phytosiderophores in zinc-deficient barley.
Match Strength: 5.527
Mugineic acid family phytosiderophores (MAs) are metal chelators that are produced in graminaceous plants in response to iron (Fe) deficiency, but current evidence regarding secretion of MAs during zinc (Zn) deficiency is contradictory. Our studies using HPLC analysis showed that Zn deficiency induces the synthesis and secretion of MAs in barley plants. The levels of the HvNAS1, HvNAAT-A, HvNAAT-B, HvIDS2 and HvIDS3 transcripts, which encode the enzymes involved in the synthesis of MAs, were increased in Zn-deficient roots. Studies of the genes involved in the methionine cycle using microarray ... Read More »
» Published in Plant J. 2006 Oct;48(1):85-97.
2. A 1,3-diacylglycerol-rich oil induces less atherosclerosis and lowers plasma cholesterol in diabetic apoE-deficient mice.
Match Strength: 5.046
OBJECTIVE: Recent studies have demonstrated that 1,3-diacylglycerol (1,3-DAG) has several metabolic advantages over triacylglycerol (TAG) in humans and in animal models despite both oils having a similar fatty acid composition. In our current study, we have examined the effects of long-term feeding of a 1,3-DAG-rich oil on the dyslipidemia and atherosclerosis in the experimental model of the diabetic apolipoprotein E (apoE)-deficient mouse that develops accelerated atherosclerosis. METHODS AND RESULTS: Diets containing 1,3-DAG-rich oil or TAG oil were administered to control non-diabetic apoE ... Read More »
» Published in Atherosclerosis. 2006 Sep 20;
3. Defective coupling of apical PTH - receptors to phospholipase C prevents internalization of the Na+/phosphate cotransporter NaPi-IIa in NHERF1 deficient mice.
Match Strength: 4.862
Phosphate reabsorption in the renal proximal tubule occurs mostly via the type-IIa sodium-phosphate cotransporter (NaPi-IIa) in the brush border membrane (BBM). The activity and localization of NaPi-IIa is regulated among other factors by parathyroid hormone (PTH). NaPi-IIa interacts in-vitro via its last three C-terminal amino acids with the PDZ-protein Na(+)/H(+)-Exchanger isoform 3 Regulating Factor 1 (NHERF1). Renal phosphate reabsorption in NHERF1 deficient mice is altered and NaPi-IIa expression in the BBM is reduced. In addition, it has been proposed that NHERF1 and NHERF2 are important ... Read More »
» Published in Am J Physiol Cell Physiol. 2006 Sep 20;
4. Individual and group housing in N-type Ca2+ channel alpha1B subunit-deficient mice differently affect motor activity.
Match Strength: 4.741
N-type Ca2+ channel alpha1B-deficient mice have increased activity (ambulation, repetitive behavior, and rearing combined), suggesting contribution by the N-type Ca2+ channel, localized in the plasma membrane and essential for neurotransmitter release, on motor activity. We evaluated the effect of a 6-wk postweaning period of either individual or group housing on the activity displayed in a novel environment with or without previous habituation. Without habituation, male homozygous alpha1B-deficient mice showed significantly higher activity than wild-type controls, with no influence of the ... Read More »
» Published in J Am Assoc Lab Anim Sci. 2006 Sep;45(5):44-7.
5. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior.
Match Strength: 4.679
Secretin is a peptide hormone released from the duodenum to stimulate the secretion of digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the brain, and exogenous administration has been reported to alleviate symptoms in some patients with autism. We have generated secretin receptor-deficient mice to explore the relationship between secretin signaling in the brain and behavioral phenotypes. Secretin receptor-deficient mice are overtly normal and fertile; however, synaptic plasticity in the hippocampus is impaired and there are slightly fewer dendritic spines ... Read More »
» Published in Hum Mol Genet. 2006 Nov 1;15(21):3241-50. Epub 2006 Sep 28.
6. Characteristics of Staphylococcus aureus strains isolated in Poland in 1996 to 2004 that were deficient in species-specific proteins.
Match Strength: 4.418
One hundred seventy Staphylococcus aureus isolates, collected in 1996 to 2004, were reidentified by phenotypic and genotypic methods. One hundred ten of these (65%) were confirmed, as previously denoted, to be clumping factor (CF)- or free coagulase-deficient S. aureus, based on their phenotype. Based on the CF or coagulase production, three groups of phenotypically deficient S. aureus isolates were distinguished. Group 1 encompassed CF-positive and coagulase-deficient isolates, group 2 consisted of CF-deficient and coagulase-positive isolates, and group 3 included isolates that were CF ... Read More »
» Published in J Clin Microbiol. 2006 Nov;44(11):4018-24. Epub 2006 Sep 27.
7. Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice.
Match Strength: 4.269
This study was designed to determine the effects of vitamin C deficiency on the immune response to infection with influenza virus. l-Gulono-gamma-lactone oxidase gene-inactivated mice (gulo-/- mice) require vitamin C supplementation for survival. Five-wk-old male and female gulo-/- mice were provided water or water containing 1.67 mmol/L vitamin C for 3 wk before inoculation with influenza A/Bangkok/1/79. There were no differences in lung influenza virus titers between vitamin C-adequate and -deficient mice; however, lung pathology in the vitamin C-deficient mice was greater at 1 and 3 d after ... Read More »
» Published in J Nutr. 2006 Oct;136(10):2611-6.
8. Defect internalization and tyrosine kinase activation in Aire deficient antigen presenting cells exposed to Candida albicans antigens.
Match Strength: 4.244
Patients with Autoimmune polyendocrine syndrome type I (APS I) present with multiple endocrine failures due to organ-specific autoimmune disease, thought to be T-cell-mediated. Paradoxically, APS I patients suffer from chronic mucocutaneous candidiasis. The mutated gene has been identified as the Autoimmune regulator (AIRE). Aire is expressed in medullary epithelial cells of the thymus and in antigen presenting cells in the periphery. T cells from Aire deficient mice and men displayed an enhanced proliferative response against Candida antigen in vitro, suggesting that Aire deficient T cells ... Read More »
» Published in Clin Immunol. 2006 Dec;121(3):265-73. Epub 2006 Sep 18.
9. Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264.
Match Strength: 4.123
Mycobacterium tuberculosis open reading frame Rv1264 encodes an adenylate cyclase that exhibits its highest enzymatic activity at an acidic pH of 6.0. This is the pH M. tuberculosis encounters in the phagosome. Consequently Rv1264 has been suggested to sense the phagosomal milieu resulting in adaption of M. tuberculosis to its intracellular niche. A targeted knock-out mutant deficient in Rv1264, however, exhibits wild-type virulence. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Int J Med Microbiol. 2006 Dec;296(8):563-6. Epub 2006 Sep 26.
10. Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight.
Match Strength: 4.048
This study tested whether elevated levels of IGF-II in the postnatal period can rescue the dwarfism in IGF-I-deficient mice. Heterozygous Igf1 mutant mice [I(+/-) II(wt)] were crossed with heterozygous Igf1 mutant, phosphoenolpyruvate carboxykinase promoter IGF-II transgenic mice [I(+/-) II(tg)], and [I(+/+) II(wt)], [I(+/+) II(tg)], [I(-/-) II(wt)], and [I(-/-) II(tg)] offspring were investigated. IGF-II levels were 11- and 6-fold higher in male and female [I(-/-) II(tg)] vs. [I(-/-) II(wt)] animals. Western ligand blot analysis revealed markedly reduced activities of 30- and 32-kDa IGF ... Read More »
» Published in Endocrinology. 2007 Jan;148(1):441-51. Epub 2006 Sep 28.
11. Spectral analysis of EEG in normal and sulfite oxidase deficient rats under sulfite administration.
Match Strength: 4.002
This article investigated the possible neurotoxic effect of sulfite in normal and sulfite oxidase (SOX) deficients rats by evaluating EEG spectral analysis. Rats were divided into four groups: control (C), sulfite treated (25 mg/kg) (ST), SOX deficient (SD), and sulfite treated SOX deficient (STSD) groups. The qEEG spectral analyses of two spectral parameters including power and relative power were performed. The mean power of SD group was found to be increased compared to the all other groups and returned to control levels after sulfite administration. The power of the four frequency bands ... Read More »
» Published in Int J Neurosci. 2006 Nov;116(11):1359-73.
12. T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation.
Match Strength: 3.991
The development of asthma and other atopic diseases is influenced by cytokines produced by Th2 effector T cells. How effector T cell responses are regulated once these cell populations are established remains unclear. The recently described T cell and airway phenotype regulator locus, containing the T cell, Ig domain, mucin domain (TIM) genes, is genetically associated with Th2 cytokine production and Th2-dependent immune responses. In this study, we report the phenotype of the TIM-2 gene-deficient mouse, and demonstrate exacerbated lung inflammation in an airway atopic response model. Immune ... Read More »
» Published in J Immunol. 2006 Oct 1;177(7):4311-21.
13. The role of CD69 in acute neutrophil-mediated inflammation.
Match Strength: 3.972
The leukocyte activation marker CD69 functions as a negative regulator of the immune response, both in NK-dependent tumor rejection and in the inflammation associated with lymphocyte-dependent collagen-induced arthritis. In contrast, it has been reported that CD69-deficient mice are refractory to the neutrophil-dependent acute inflammatory response associated with anti-type II collagen antibody-induced arthritis (CAIA), suggesting a positive regulatory role for CD69 in neutrophil function during arthritis induction. To clarify this discrepancy, the CAIA response was independently analyzed in ... Read More »
» Published in Eur J Immunol. 2006 Oct;36(10):2632-8.
14. Multidrug-resistance-associated protein 1 (Mrp1) is probably not required for murine Th cell activation.
Match Strength: 3.963
Previously, we have demonstrated that multidrug-resistance-associated protein 1 (Mrp1) represents an activation marker for murine Th1 cells and is constitutively expressed by Th2 cells. Using the inhibitor MK571, we and others also suggested that Mrp1 is necessary for Th cell activation. However, herein, we show that Mrp1-deficient Th cells can be differentiated to a similar extent to Th1 and Th2 cells in vitro and, upon re-stimulation, produce comparable amounts of IL-2, IFNgamma and IL-4. Mrp1-deficient mice are equally susceptible than wild-type mice to infection with the protozoan parasite ... Read More »
» Published in Int Immunol. 2006 Nov;18(11):1603-6. Epub 2006 Sep 28.
15. Omega-3 fatty acids and rodent behavior.
Match Strength: 3.933
This paper reviews the role of the n-3 fatty acids in the regulation of cognitive functions, locomotor and exploratory activity and emotional status in rodents. There are disparate data on the performance of n-3 fatty acid deficient animals in the open field test and elevated plus maze. Results obtained in our laboratory indicated slower habituation to the open field in deficient mice, which affects total locomotor and exploratory parameters. We also observed no change in plus maze performance of deficient mice under low-stress but elevated anxiety under high-stress conditions. There is some ... Read More »
» Published in Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):271-89. Epub 2006 Sep 14.
16. Posterior instability near extension is related to clinical disability in isolated posterior cruciate ligament deficient patients.
Match Strength: 3.902
The purpose of this study is to evaluate the relationship between the magnitude of knee laxity and posterior instability at different knee flexion angles and clinical disability in isolated posterior cruciate ligament (PCL) deficient patients. Knee laxity at 20 degrees and 70 degrees of knee flexion were evaluated using KT-2000 arthrometer, and the posterior instability at 20 degrees, 45 degrees and 90 degrees of flexion were evaluated using stress radiography. We assessed the differences in the knee laxity and the tibial translation between isolated PCL deficient knees and normal knees, and ... Read More »
» Published in Knee Surg Sports Traumatol Arthrosc. 2006 Sep 28;
17. Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey.
Match Strength: 3.851
OBJECTIVE: Differences in iodine intake could account for the variable prevalences reported for somatic TSH receptor (TSHR) mutations in toxic thyroid nodules (TTNs). However, this question has not been settled, since no study has yet determined the TSHR mutation prevalence in regions with different iodine supplies in the same population using the same methodology. Therefore, we studied the prevalence of somatic TSHR mutations in TTNs from patients living in iodine-deficient or -sufficient regions in Turkey. DESIGN AND METHODS: We screened 74 TTNs for somatic TSHR mutations. Exons 9 and 10 of ... Read More »
» Published in Eur J Endocrinol. 2006 Oct;155(4):535-45.
18. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy.
Match Strength: 3.820
The lysosomal membrane proteins LAMP-1 and LAMP-2 are estimated to contribute to about 50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 or LAMP-2 are viable and fertile. However, mice deficient in both LAMP-1 and LAMP-2 have an embryonic lethal phenotype. These results show that these two major lysosomal membrane proteins share common functions in vivo. However, LAMP-2 seems to have more specific functions since LAMP-2 single deficiency has more severe consequences than LAMP-1 single deficiency. Mutations in LAMP-2 gene cause a lysosomal glycogen ... Read More »
» Published in Mol Aspects Med. 2006 Oct-Dec;27(5-6):495-502. Epub 2006 Sep 14.
19. Plasmin/plasminogen is essential for the healing of tympanic membrane perforations.
Match Strength: 3.803
Plasminogen has been proposed to play an important role in different tissue remodeling processes such as wound healing and tissue regeneration after injuries. The healing of tympanic membrane perforations is a well-organized chain of inflammatory events, with an initial invasion of inflammatory cells followed by reparative and restoration phases. Here we show that the healing of tympanic membrane perforations is completely arrested in plasminogen-deficient mice, with no signs of any healing even 143 days after perforation. Inflammatory cells were recruited to the wounded area, but there were ... Read More »
» Published in Thromb Haemost. 2006 Oct;96(4):512-9.
20. Evidence for reprogramming global gene expression during zinc deficiency in the HUT-78 cell line.
Match Strength: 3.774
OBJECTIVE: Investigations using cell lines, primary cells, animal models, and human subjects have provided data to indicate that zinc-deficient conditions affect immune functioning of myeloid and lymphoid cells. We hypothesized that zinc-deficient conditions alone may induce the expression of genes in lymphoid cells, which favor enhanced responses to myeloid molecules even in the absence of myeloid cells or myeloid factors. Our objective was to investigate the effects of low zinc-induced alterations in gene expression in a single lymphoid cell line in the absence of influences from growth ... Read More »
» Published in Nutrition. 2006 Oct;22(10):1045-56. Epub 2006 Sep 18.
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