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 << Prev 50  Showing 1 to 27 of 27 Matches Next 50 >>

1. Dandruff-associated smouldering alopecia: a chronobiological assessment over 5 years.
Match Strength: 14.948

BACKGROUND: In some individuals, dandruff may be recurrent and even chronic. This represents a difficult-to-treat condition. Excessive hair shedding and diffuse alopecia may develop. OBJECTIVES: To evaluate the chronobiological aspects of dandruff, hair shedding and alopecia. METHODS: This study was performed in eight men suffering from such a scalp condition. They were examined 40 times at regular intervals for five consecutive years. Hair-density assessments and trichograms were performed at least twice per trimester on the parietal region of the scalp, corresponding to an area where ... Read More »
» Published in Clin Exp Dermatol. 2006 Jan;31(1):23-6.

2. Dandruff has an altered stratum corneum ultrastructure that is improved with zinc pyrithione shampoo.
Match Strength: 13.635

Transmission electron microscopy of scalp tape strips indicates that dandruff scalp possesses abnormal stratum corneum (SC) ultrastructure that is normalized by treatment with small-particle zinc pyrithione (ZPT). Similar abnormalities occur throughout the scalp of those with dandruff, even where no flaking is present. SC abnormalities are consistent with hyperproliferation, including parakeratosis, lipid droplets within corneocytes, few desmosomes, corneocyte membrane interdigitation, and excessive disorganized intercellular lipid. Reversal of SC abnormalities would require treatment of the ... Read More »
» Published in J Am Acad Dermatol. 2001 Dec;45(6):897-903.

Match Strength: 13.486

Objective: To assess the knowledge, attitude and practice regarding dandruff among soldiers. Design: Cross-sectional study. Place and Duration of Study: Departments of Dermatology at Combined Military Hospitals, Abbottabad, Malir and Gujranwala from January 2006 to March 2006. Patients and Methods: Serving male soldiers posted at Abbottabad, Malir and Gujranwala Cantonments were included in the study. Convenience sampling was used to distribute the questionnaire. All soldiers included in the study were asked or assisted by the trained staff to fill the close-ended questionnaire in Urdu, which ... Read More »
» Published in J Coll Physicians Surg Pak. 2007 Marach;17(3):128-131.

4. Dandruff, seborrheic dermatitis, and psoriasis drug products containing coal tar and menthol for over-the-counter human use; amendment to the monograph. Final rule.
Match Strength: 11.756

The Food and Drug Administration (FDA) is issuing a final rule amending the final monograph (FM) for over-the-counter (OTC) dandruff, seborrheic dermatitis, and psoriasis drug products to include the combination of 1.8 percent coal tar solution and 1.5 percent menthol in a shampoo drug product to control dandruff. FDA did not receive any comments or data in response to its previously proposed rule to include this combination. This final rule is part of FDA's ongoing review of OTC drug products ... Read More »
» Published in Fed Regist. 2007 Mar 6;72(43):9849-52.

5. Enhanced delivery of an anti-dandruff active in a shampoo vehicle.
Match Strength: 10.711

Formulating a delivery vehicle to enhance activity can potentially give higher activity or allow for adjustment to a lesser percent of active. A study was conducted in which the anti-dandruff active, Octopirox, INCI Piroctone Olamine [1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone], was incorporated into a simple shampoo base at two levels as well as in the same base with an added amphiphilic surfactant blend (Biobase SMC) at the lower level. A group of thirty (30) male subjects with moderate to severe dandruff were divided into three groups each of which evaluated one of three ... Read More »
» Published in J Cosmet Sci. 2004;55 Suppl:S207-14.

6. Malassezia globosa and restricta: breakthrough understanding of the etiology and treatment of dandruff and seborrheic dermatitis through whole-genome analysis.
Match Strength: 10.640

Dandruff and seborrheic dermatitis (D/SD) share an etiology dependent upon three factors: sebum, microbial metabolism (specifically, Malassezia yeasts), and individual susceptibility. Advances in microbiological and analytical techniques permit a more detailed understanding of these etiologic factors, especially the role of Malassezia. Malassezia are lipid-dependent and demonstrate adaptation allowing them to exploit a narrow niche on sebum-rich skin. Work in our and our collaborators' laboratories has focused on understanding these adaptations by detailed analysis of biochemistry and gene ... Read More »
» Published in J Investig Dermatol Symp Proc. 2007 Dec;12(2):15-9.

7. A non-invasive tape absorption method for recovery of inflammatory mediators to differentiate normal from compromised scalp conditions
Match Strength: 10.140

BACKGROUND/AIMS: A simple non-invasive tape (Sebutape) adsorption method was used to recover inflammatory proteins from normal and compromised human scalp (i.e. dandruff and seborrheic dermatitis) in order to assess the inflammatory and immunologic changes relevant to these clinical conditions. METHODS: The scalps of subjects identified by a dermatologist as having either dandruff (n = 18), seborrheic dermatitis (n = 19) or normal scalp (n = 16) were visually graded to obtain total adherent scalp flaking scores (TASFS). Sebutape samples were then collected from both the high and low TASFS ... Read More »
» Published in Skin Res Technol. 2002 Aug;8(3):187-93.

8. Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo.
Match Strength: 9.662

As part of research exploring the feasibility of using antibody fragments to inhibit the growth of organisms implicated in dandruff, we isolated antibody fragments that bind to a cell surface protein of Malassezia furfur in the presence of shampoo. We found that phage display of llama single-domain antibody fragments (VHHs) can be extended to very harsh conditions, such as the presence of shampoo containing nonionic and anionic surfactants. We selected several VHHs that bind to the cell wall protein Malf1 of M. furfur, a fungus implicated in causing dandruff. In addition to high stability in ... Read More »
» Published in Appl Environ Microbiol. 2005 Jan;71(1):442-50.

9. The Role of Sebaceous Gland Activity and Scalp Microfloral Metabolism in the Etiology of Seborrheic Dermatitis and Dandruff
Match Strength: 9.242

Most common scalp flaking disorders show a strong correlation with sebaceous gland (SG) activity. Early SG activity in the neonate results in microfloral colonization and cradle cap. After maternal hormonal control subsides, there is little SG activity until puberty, when the SG turns on under sex hormone control. When the SG activity increases, the present but low Malassezia population has a new food source and proliferates, resulting in the scalp itching and flaking common to greater than 50% of adults. Dry scalp flaking, dandruff, and seborrheic dermatitis are chronic scalp manifestations ... Read More »
» Published in J Investig Dermatol Symp Proc. 2005 Dec;10(3):194-7.

10. Fluorescein dye improves microscopic evaluation and counting of demodex in blepharitis with cylindrical dandruff.
Match Strength: 7.645

PURPOSE:: To show whether fluorescein dye helps detect and count Demodex embedded in cylindrical dandruff (CD) of epilated eyelashes from patients with blepharitis. METHODS:: Two eyelashes with CD were removed from each lid of 10 consecutive patients with blepharitis and subjected to microscopic examination with and without fluorescein solution to detect and count Demodex mites. RESULTS:: Of 80 eyelashes examined, 36 (45%) lashes retained their CD after removal. Before addition of the fluorescein solution, the mean total Demodex count per patient was 14.9 +/- 10 and the mean Demodex count per ... Read More »
» Published in Cornea. 2007 Jul;26(6):697-700.

11. Shampoos: ingredients, efficacy and adverse effects.
Match Strength: 7.356

Shampoos are the most frequently prescribed treatment for the hair and scalp. The different qualities demanded from a shampoo go beyond cleansing. A cosmetic benefit is expected, and the shampoo has to be tailored to variations associated with hair quality, age, hair care habits, and specific problems related to the condition of the scalp. The reciprocal relationship between cosmetic technology and medical therapy is reflected in the advances of shampoo formulation that has made applications possible that combine benefits of cosmetic hair care products with efficacy of medicinal products. A ... Read More »
» Published in J Dtsch Dermatol Ges. 2007 May;5(5):356-65.

12. Contact dermatitis to a canine anti-dandruff shampoo.
Match Strength: 6.847

A 40-year-old teacher presented after her third episode of acute facial oedema within 4 months. Each episode occurred 1-2 days after visiting her mother's house. Patch testing showed positive reactions to miconazole and econazole nitrate. The patient denied use of any antifungal creams, but it transpired that her mother's dog was being shampooed weekly with an antifungal shampoo containing miconazole. No further episodes were recorded after discontinuing the antifungal shampoo ... Read More »
» Published in Australas J Dermatol. 2007 Feb;48(1):62-3.

13. Seborrheic dermatitis: an overview.
Match Strength: 6.516

Seborrheic dermatitis affects the scalp, central face, and anterior chest. In adolescents and adults, it often presents as scalp scaling (dandruff). Seborrheic dermatitis also may cause mild to marked erythema of the nasolabial fold, often with scaling. Stress can cause flare-ups. The scales are greasy, not dry, as commonly thought. An uncommon generalized form in infants may be linked to immunodeficiencies. Topical therapy primarily consists of antifungal agents and low-potency steroids. New topical calcineurin inhibitors (immunomodulators) sometimes are administered. Publication Types: ... Read More »
» Published in Am Fam Physician. 2006 Jul 1;74(1):125-30.

14. Malassezia Baillon, emerging clinical yeasts.
Match Strength: 6.457

The human and animal pathogenic yeast genus Malassezia has received considerable attention in recent years from dermatologists, other clinicians, veterinarians and mycologists. Some points highlighted in this review include recent advances in the technological developments related to detection, identification, and classification of Malassezia species. The clinical association of Malassezia species with a number of mammalian dermatological diseases including dandruff, seborrhoeic dermatitis, pityriasis versicolor, psoriasis, folliculitis and otitis is also discussed. Publication Types: ... Read More »
» Published in FEMS Yeast Res. 2005 Dec;5(12):1101-13. Epub 2005 Jul 12.

15. Clinical Diagnosis of Common Scalp Disorders
Match Strength: 6.357

Scalp skin is unique on the body due to the density of hair follicles and high rate of sebum production. These features make it susceptible to superficial mycotic conditions (dandruff, seborrheic dermatitis, and tinea capitis), parasitic infestation (pediculosis capitis), and inflammatory conditions (psoriasis). Because these scalp conditions share similar clinical manifestations of scaling, inflammation, hair loss, and pruritus, differential diagnosis is critically important. Diagnostic techniques and effective treatment strategies for each of the above conditions will be discussed ... Read More »
» Published in J Investig Dermatol Symp Proc. 2005 Dec;10(3):190-3.

16. A practical guide to scalp disorders.
Match Strength: 5.498

The scalp is unique among skin areas in humans, with high follicular density and a high rate of sebum production. The relatively dark and warm environment on the scalp surface provides a welcoming environment for the superficial mycotic infections associated with many scalp conditions and for parasitic infestation. Infections and infestations can occur when items such as fingers, combs, hats, or styling implements come into contact with the hair and scalp and introduce microorganisms. Inflammatory conditions may also produce changes in the scalp. Many common scalp conditions have similar ... Read More »
» Published in J Investig Dermatol Symp Proc. 2007 Dec;12(2):10-4.

17. The use of hydroxy acids on the skin: characteristics of C8-lipohydroxy acid.
Match Strength: 5.403

The hydroxy acids are widely used in skin creams because of their exfoliating and rejuvenating effect on photoaged skin. As a member of this family, the salicylic acid derivative known in the literature as 2-hydroxy-5-octanoyl benzoic acid or beta-lipohydroxy acid has also been proposed as an exfoliant and as a treatment of photoaged skin and acne. This article reviews the effects of the hydroxy acids and compares them to those of the salicylic acid derivative. We propose the name C(8)-lipohydroxy acid (C8-LHA) for this derivative to differentiate it from other related compounds. The ... Read More »
» Published in J Cosmet Dermatol. 2007 Mar;6(1):59-65.

18. Antifungal and antioxidant activities of the phytomedicine pipsissewa, Chimaphila umbellata.
Match Strength: 5.266

Bioassay-guided fractionation of Chimaphila umbellata (L.) W. Bart (Pyrolaceae) ethanol extracts led to the identification of 2,7-dimethyl-1,4-naphthoquinone (chimaphilin) as the principal antifungal component. The structure of chimaphilin was confirmed by (1)H and (13)C NMR spectroscopy. The antifungal activity of chimaphilin was evaluated using the microdilution method with Saccharomyces cerevisiae (0.05mg/mL) and the dandruff-associated fungi Malassezia globosa (0.39mg/mL) and Malassezia restricta (0.55mg/mL). Pronounced antioxidant activity of C. umbellata crude extract was also identified ... Read More »
» Published in Phytochemistry. 2008 Feb;69(3):738-46. Epub 2007 Oct 22.

19. Zinc in skin pathology and care.
Match Strength: 4.880

OBJECTIVES: To assess the significance of zinc in the etiology of various dermatological conditions and examine the role of zinc as a mode of treatment for a wide range of dermatoses. METHODS: Review of existing literature through searches using the PubMed site with zinc and the dermatosis in question as search words. RESULTS: Severe zinc deficiency states such as acrodermatitis enteropathica are associated with a variety of skin manifestations, such as perioral, acral and perineal dermatitis. These syndromes can be reversed with systemic zinc repletion. In addition to skin pathologies which ... Read More »
» Published in J Dermatolog Treat. 2006;17(4):205-10.

20. Isolation and Expression of a Malassezia globosa Lipase Gene, LIP1.
Match Strength: 4.391

Dandruff and seborrheic dermatitis (D/SD) are common hyperproliferative scalp disorders with a similar etiology. Both result, in part, from metabolic activity of Malassezia globosa and Malassezia restricta, commensal basidiomycete yeasts commonly found on human scalps. Current hypotheses about the mechanism of D/SD include Malassezia-induced fatty acid metabolism, particularly lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids. We report that lipase activity was detected in four species of Malassezia, including M. globosa. We isolated lipase activity by ... Read More »
» Published in J Invest Dermatol. 2007 Apr 26;

21. Efficacy of Different Concentrations of Ciclopirox Shampoo for the Treatment of Seborrheic Dermatitis of the Scalp: Results of a Randomized, Double-Blind, Vehicle-Controlled Trial
Match Strength: 4.349

BACKGROUND: Seborrheic dermatitis is a common inflammatory skin disorder affecting 1-3% of the population. It is thought to be linked to dandruff via a common etiology, yeasts of the genus Malassezia. Ciclopirox is a broad-spectrum, hydroxypyridone-derived, synthetic antifungal agent with anti-inflammatory properties. METHODS: A total of 203 patients were enrolled in this vehicle-controlled, double-blind, randomized study designed to compare vehicle with three different concentrations of ciclopirox shampoo: 0.1%, 0.3% and 1%, with each applied twice a week. The main efficacy parameters were ... Read More »
» Published in Int J Dermatol. 2004 Jul;43 Suppl 1:9-12.

22. Clobetasol propionate shampoo 0.05% in the treatment of seborrheic dermatitis of the scalp: results of a pilot study.
Match Strength: 4.297

Seborrheic dermatitis (SD), a common dermatosis associating hyperseborrhea, erythema, itching, and dandruff, has frequent scalp involvement. Malassezia furfur infection seems to play an important role in the condition's etiopathology. Treatment of SD usually consists of corticosteroids or antifungals, such as ketoconazole. The aim of this multicenter, randomized, investigator-blinded, parallel-group pilot study was to evaluate the efficacy and safety of clobetasol propionate shampoo 0.05% after different short-contact application times compared with its vehicle and ketoconazole foaming gel 2% ... Read More »
» Published in Cutis. 2007 May;79(5):397-403.

23. Influence of light in acute toxicity bioassays of imidacloprid and zinc pyrithione to zooplankton crustaceans.
Match Strength: 4.275

The acute toxicity of imidacloprid, a neonicotinoid insecticide, and zinc pyrithione (Zpt), a biocide used in anti-dandruff shampoos and protective antifouling paints, to three species of ostracods and two waterfleas, including Daphnia magna, was determined and compared under light and dark conditions. Under normal laboratory conditions, UV light had no significant influence on the outcome of toxicity bioassays, although in the case of imidacloprid both EC(50) and LC(50) calculated values were twice as high under the light as in the dark. No influence of UV light was observed on bioassays ... Read More »
» Published in Aquat Toxicol. 2006 Jun 30;78(3):262-71. Epub 2006 Apr 18.

24. Occupational nonsolar risk factors of squamous cell carcinoma of the skin: a population-based case-controlled study.
Match Strength: 4.274

The purpose of this study was to investigate associations between occupation, nonsolar environmental exposures, and risk of squamous cell carcinoma (SCC) of the skin. Data from the Southeastern Arizona Health Study-2 were used. This was a population-based case-controlled study [n = 795) conducted during 1992-1996 in southeastern Arizona to primarily assess the risk of skin SCC in relation to sun exposure. Multivariate logistic regression was used to calculate odd ratios as the estimate of effect. High-risk occupations were identified through literature review. There was evidence of a slightly ... Read More »
» Published in Dermatol Online J. 2005 Aug 1;11(2):5.

25. Increased hair shedding may be associated with the presence of Pityrosporum ovale.
Match Strength: 4.270

BACKGROUND AND OBJECTIVE: Although the available data show that hair loss is an important cosmetic problem worldwide, the pathogenesis of common hair shedding is not fully understood. The aim of this study was to evaluate the association between hair shedding and cutaneous Malassezia infection. Malassezia fungi have been the suspected cause of dandruff for more than a century. Previously referred to as Pityrosporum ovale or P. orbiculare, these fungi are now known to consist of at least seven species. METHODS: Over a 4-year period, we obtained 300 hair samples from medical students. Based on ... Read More »
» Published in Am J Clin Dermatol. 2006;7(4):263-6.

26. A nationwide survey of Trichophyton tonsurans infection among combat sport club members in Japan using a questionnaire form and the hairbrush method.
Match Strength: 4.196

BACKGROUND: The emerging outbreak of Trichophyton tonsurans infection among members of combat sports clubs in Japan during the last 4 years has become a serious public health problem. To overcome this outbreak, a survey for T. tonsurans infection in Japan may be essential. OBJECTIVES: We sought to clarify the prevalence of T. tonsurans infection among members of combat sports clubs in Japan. METHODS: We conducted a survey of members of participating combat sports clubs using a standardized questionnaire to assess background factors and using the hairbrush method to identify T. tonsurans ... Read More »
» Published in J Am Acad Dermatol. 2006 Apr;54(4):622-6. Epub 2006 Feb 7.

27. Risk factors and co-morbidity of skin disorders among female schoolchildren in Eastern Saudi Arabia.
Match Strength: 4.091

The aim of this study was to determine the risk factors of skin disorders among female schoolchildren in primary and intermediate schools in Al-khobar city, Eastern Saudi Arabia. This is a cross-sectional study conducted in Al-Khobar city during the period of January to March 2003. It involved 2239 female schoolchildren randomly selected from 30 regular public and private primary and preparatory schools. A multi-stage stratified random sampling technique with proportional allocation was used. Data was collected using a pre-designed structured questionnaire and clinical examination. Dandruff ... Read More »
» Published in Invest Clin. 2007 Jun;48(2):199-212.

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